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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
July 01, 2019 - Learning objective
Statistical heterogeneity
• Statistical heterogeneity occurs when estimates across … According to the 2019 Cochrane handbook, I2 describes the percentage of the variability in
effect estimates
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effectivehealthcare.ahrq.gov/products/horizon-scan/research-2015
October 01, 2015 - Report of a Pilot Project: Rapid Cost Analyses of Selected Potential High-Impact Intervention Reports
Research Report October 1, 2015 Download Main Document PDF 404.8 KB
This report is available in PDF (405 kB) only. People using assistive technology may not be able to fully access information in this…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
January 01, 2010 - were based upon Kaplan-Meier estimates for treatment-specific
censoring distributions; whereas adjusted … estimates were based upon weights that were
functions of Kaplan-Meier censoring estimates and propensity … score estimates.17,18
Adjusted hazard ratios were calculated according to the inverse probability … These models served to
validate the adjusted hazard ratio estimates from the IPW Cox regression model … Such misclassification and underreporting should be non-
differential, however, and should bias our estimates
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effectivehealthcare.ahrq.gov/products/rheumatoid-arthritis-medicine-1/research
March 30, 2009 - data and although the overall and age-stratified changes in patterns of medication use were similar, estimates … Given the body of evidence supporting the benefits of DMARD therapies, these estimates would suggest … In contrast to previous estimates of DMARD utilization that were based on prevalence of use at any time
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
January 01, 2021 - meta-analysis is appropriate (i.e., more than 2 studies address
the same PICOTS and provide point estimates … If a
meta-analysis is deemed appropriate, we plan to use random-effects models to pool estimates
from … comparison have
high or unclear risk of bias or when sensitivity analyses show substantial difference in
estimates … derived from high or unclear risk of bias studies versus estimates derived from
studies at low risk
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
September 01, 2012 - Meta-Analysis
We conducted a Bayesian meta-analysis to provide
aggregate estimates of the effectiveness … We calculated meta-analysis estimates by using RCTs
grouped by progestogen formulation (17OHP, oral, … For neonatal mortality, aggregate estimates indicated no
formulation was effective at reducing risk … However, all
formulations were effective at reducing the risk of preterm
birth (meta-estimates: OR17OHP … In general, studies have also
been too small to provide valid estimates of factors that
may modify
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effectivehealthcare.ahrq.gov/products/coronary-stents-outcomes/research
February 10, 2010 - were based upon Kaplan-Meier estimates for treatment-specific censoring distributions; whereas adjusted … estimates were based upon weights that were functions of Kaplan-Meier censoring estimates and propensity … score estimates. 17,18 Adjusted hazard ratios were calculated according to the inverse probability … These models served to validate the adjusted hazard ratio estimates from the IPW Cox regression model … Such misclassification and underreporting should be non-differential, however, and should bias our estimates
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effectivehealthcare.ahrq.gov/products/continuous-outcomes-quantitative-synthesis/methods
July 25, 2013 - of continuous outcomes measured in RCTs: choice of effect measures of continuous outcomes, choice of estimates
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
September 07, 2012 - As above, we find the aggregate estimates of
benefit among those with prior preterm birth to
be squarely … We take some reassurance that providing
summary evidence is sufficient since the
meta-estimates for … Meta-estimates added to results
section. … Point estimates and 95% confidence intervals
are not consistently reported. … A summary table including all meta-estimates might be
helpful.
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effectivehealthcare.ahrq.gov/sites/default/files/considerations-for-statistical-chapter-10.pptx
January 01, 2013 - However, the DRS estimates the probability or rate of disease occurrence as a function of the covariates … If subjects with missing data differ from subjects with complete data, then exposure estimates may be
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effectivehealthcare.ahrq.gov/products/pressure-ulcer-treatment/research-protocol
November 08, 2011 - Estimates of the incidence of pressure ulcers vary according to the setting and range from 0.4 to 38.0 … patients to full functioning. 2 Data on the costs of treatment for a pressure ulcer vary, but some estimates … Meta-analyses will be conducted to summarize data and obtain more precise estimates on outcomes for which … The Q statistic and/or the I 2 statistic (the proportion of variation in study estimates due to heterogeneity
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-infertility_research.pdf
June 01, 2017 - ............................... 7
v
Background and Objectives
Selective reporting can bias estimates … CT.gov for detecting selective
reporting, and to determine the impact of selective reporting on the estimates … Therefore, our project coordinator sent regular
queries to co-investigators asking for estimates of … These estimates were tracked in an Excel spreadsheet.
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effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
October 01, 2007 - of restrictions
for use in pharmacoepidemiology and examines to what extent they
change rate ratio estimates … RR estimates adjusted for age and sex also steadily
increased. … For all earlier
restrictions, it is less clear how much the observed change in
RR estimates result from … We found that this
change resulted in an observable but not substantial change in
RR estimates in our … A, Unadjusted mortality rate ratio estimates; B, Multi-
variate adjusted mortality rate ratio estimates
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effectivehealthcare.ahrq.gov/products/health-outcomes-competing-risks/abstract
February 11, 2010 - Developing Methods to Assess Health Outcomes in the Presence of Competing Risks for Effectiveness Research
Research Report February 11, 2010
Findings from this study were published in the following journal articles.
1. Weiss CO, Segal JB, Varadhan R. Assessing the applicability of trial evidence to a…
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effectivehealthcare.ahrq.gov/products/glycemic-control/abstract
December 15, 2009 - Inverse-probability-of-treatment-weighted estimation for marginal structural models will be utilized to derive valid effect estimates
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
November 20, 2013 - Empirical Bayes estimates
generated in a hierarchical summary ROC analysis
agreed closely with those … For diagnostic questions this means
either ‘can the sensitivity and specificity estimates found in … or ‘do these
sensitivity and specificity estimates tell me that the patient
will benefit from this … What is the direction of
sensitivity estimates, for example? … But
sensitivity and specificity estimates lay between 0% and
100%.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/pressure-ulcer-treatment_research-protocol.pdf
November 08, 2011 - Estimates of the incidence of pressure ulcers vary according to the setting and
range from 0.4 to 38.0 … patients to full
functioning.
2
Data
on the costs of treatment for a pressure ulcer vary, but some estimates … Meta-analyses will be conducted to summarize data and obtain more precise estimates on
outcomes for … The Q statistic and/or the I
2
statistic (the proportion of variation in
study estimates due to heterogeneity
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - Quantitative Synthesis Chapter 3. Choice of Statistical Model for Combining Studies
Quantitative Synthesis
Chapter 3. Choice of Statistical Model for Combining Studies
Prepared for:
The Agency for Healthcare Research and Quality (AHRQ)
Training Modules for Systematic Reviews Methods Guide
www.ahrq.gov
Presenter…
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effectivehealthcare.ahrq.gov/products/dementia-agitation-aggression/research
March 21, 2016 - We analyzed pooled estimates to assess efficacy and comparative effectiveness.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-485-09-03-2013.pdf
January 01, 2013 - advance care plan
Key Questions
from Nominator:
Will a decision aid, using individualized estimates