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effectivehealthcare.ahrq.gov/products/treatment-effects-estimates-tool
December 02, 2009 - Development of a Software Tool for Obtaining Doubly Robust Estimate of Treatment Effects
Timeline
January 01, 2005
Topic Initiated
December 02, 2009
Research Report
Development of a Software Tool for Obtaining Doubly Robust Estimate of Treatment Effects
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effectivehealthcare.ahrq.gov/products/treatment-effects-estimates-tool/research
December 02, 2009 - We have developed a simple SAS® macro for obtaining doubly robust estimates.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - late
harms
1; RCT; n=585 No significant difference, imprecise
estimates. … Moderate
DM (up to 5 yrs) 1; RCT; n=682 No significant difference, precise
estimates. … Low
PFS, CR 1; RCT; n=940 No significant difference, precise
estimates. … Low
Late harms 1; RCT; n=682 No significant difference, imprecise
estimates. … Low
Acute derm, GI,
GU harms
1; RCT; n=144 No significant difference, imprecise
estimates.
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effectivehealthcare.ahrq.gov/products/choice-of-mean/white-paper
April 20, 2015 - An Empirical Evaluation of the Impact of Choice of Mean Difference Estimates
White Paper April 20, … using either the change score from the baseline or the followup scores would produce biased effect estimates … of mean difference, while the ANCOVA model provides the least biased estimates. … also evaluated whether the impact qualitatively varied by the comparator and alternative random effect estimates … Choice of mean difference estimates could impact meta-analysis conclusions.
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effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
January 01, 2011 - 161
Abstract
The identification process is an a priori assessment of the treatment effect estimates … Risk adjustment (RA) methods produce these
estimates. … Assumptions Required To
Yield Unbiased Estimates
For RA estimators to yield unbiased estimates
of … of ATT
from RA estimators or estimates of LATE from IV
estimators. … Understanding instrumental variables
estimates of treatment effects.
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effectivehealthcare.ahrq.gov/health-topics/alcohol
April 20, 2015 - An Empirical Evaluation of the Impact of Choice of Mean Difference Estimates
White Paper
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effectivehealthcare.ahrq.gov/sites/default/files/s123.pdf
October 01, 2007 - ORIGINAL ARTICLE
Heterogeneity and the Interpretation of Treatment Effect
Estimates From Risk Adjustment … Results: Risk adjustment models yielded average survival estimates
similar to trial results. … and
these estimates varied with the instrument specification. … Including both instruments in the specification
yielded estimates between the estimates found with the … Understanding
instrumental variables estimates of treatment effects.
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effectivehealthcare.ahrq.gov/products/continuous-outcomes-correlation/research
November 19, 2012 - data reported, and simulates the effect of using different correlation values on meta-analysis summary estimates … We assessed the bias on estimates of within-group change SEs by comparing reported SEs with imputed SEs … We simulated meta-analyses, assessing the bias, coverage, and accuracy of the summary estimates derived … Imputing values in meta-analyses where some or all within-group correlation estimates are not reported
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-effects-estimates-tool_research.pdf
April 18, 2007 - We have developed a simple SAS® macro
for obtaining doubly robust estimates. … Specifically, one
estimates the probability that a particular patient receives a given treatment as
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
September 01, 2015 - For each
of the 160 documents, we determined whether estimates remained stable as subsequent studies … Thus, we used these estimates as “gold standards” to
determine the predictive validity. … estimates of the gradeable
documents with the high SOE estimates from the Cochrane reports (the gold … Conversely,
substantially more low or insufficient SOE estimates than expected remained stable. … The circles in the columns reflect the point
estimates.
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effectivehealthcare.ahrq.gov/products/choice-of-mean
April 20, 2015 - An Empirical Evaluation of the Impact of Choice of Mean Difference Estimates
Timeline … An Empirical Evaluation of the Impact of Choice of Mean Difference Estimates
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper-2015.pdf
January 01, 2015 - Modified Bland-Altman diagram comparing the point estimates of the first trials
with the point estimates … Assessing Concordance in Effect Estimates
To assess the concordance or discordance of effect estimates … between the point estimates of first trials and point estimates
of the pooled subsequent trials was … 4 displays a modified Bland-Altman diagram comparing point estimates of first
trials with point estimates … Modified Bland-Altman diagram comparing the point estimates of the first trials with
the point estimates
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/bivariate-methods-utility_research.pdf
November 01, 2012 - Overall, point estimates from the two methods are similar, however the uncertainty around the
estimates … BREMA
estimates obtained from
ML methods; interval
estimates from the
posterior distribution with … to obtain the graph*/
matrix estimates = e(b)
local beta_sroc_unweighted = estimates[1,1]
local … = estimates[1,1]
local alpha_sroc_weighted = estimates[1,2]
local a_w = `alpha_sroc_weighted'/( … = e(b)
matrix variances = e(V)
local mean_se = estimates[1,1]
local mean_sp = estimates[1,2
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effectivehealthcare.ahrq.gov/products/bivariate-methods-utility/research
November 19, 2012 - Fixed effects univariate analyses produced estimates with narrower confidence intervals compared to random … Methods using the normal approximation (both univariate and bivariate, inverse variance and ML) produced estimates … Point estimates from univariate and bivariate random effects meta-analyses were similar when performing … Fitting the bivariate model using ML and fully Bayesian methods produced almost identical point estimates … sensitivity and specificity; however, Bayesian results indicated additional uncertainty around summary estimates
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effectivehealthcare.ahrq.gov/sites/default/files/s166.pdf
October 01, 2007 - Results: Estimates for comparisons tended to be clinically and
statistically similar across methods. … Estimates obtained through indirect
comparisons were not biased and were similar to those obtained
through … than of direct estimates
(assuming similar sample sizes). … Perhaps we need not have been so modest in our
presentation of these earlier indirect estimates. … �ib � Normal�0,10000 Prior distribution for study
level estimates.
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effectivehealthcare.ahrq.gov/health-topics/alcoholism-and-alcohol-abuse
January 17, 2012 - An Empirical Evaluation of the Impact of Choice of Mean Difference Estimates
White Paper
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effectivehealthcare.ahrq.gov/products/transparency-infertility/research
June 28, 2017 - Protocol: Management of Infertility (2015)
Background and Objectives
Selective reporting can bias estimates … CT.gov for detecting selective reporting, and to determine the impact of selective reporting on the estimates
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effectivehealthcare.ahrq.gov/products/treatment-effects-bias/research
September 29, 2014 - comprehensively and systematically review and compare empirical evaluations of specific types of bias on effect estimates … Some studies concerned the effect of more than one type of bias on effect estimates. … When the bias was present, commonly the treatment effect was increased, but rarely were the estimates
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-5.pdf
February 01, 2018 - Learning objective
Network meta-analysis
• Decision-makers want head-to-head estimates of different … for
the same treatment comparison.3,4
► In closed loops, direct and indirect estimates of treatment … • The simple indirect comparison approach is to qualitatively
compare the point estimates and overlap … ► The approach involves presenting the 3 estimates for each comparison
(direct, indirect, and network … estimates), then rating strength of evidence
separately fore ach one.
13.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-performance_methods.pdf
July 01, 2012 - “imperfect” reference standard), the typical (“naïve”)
estimates of sensitivity and specificity are … Qualify the interpretation of naïve estimates of the index
test’s performance. … of the bias of these naïve estimates. … Adjust or correct the naïve estimates of sensitivity
and specificity. … the naïve estimates of sensitivity and specificity in the
ROC space (see Figure 9–3).