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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
January 01, 2012 - Comparisons The estimates of effect from a study may reflect the beneficial effect of one intervention … concerning harm tend to have more uncertainty
compared with estimates of benefit. … The fifth step consists of
sensitivity analyses to explore the effects of changing the estimates or … However, the ―T‖ score has no uncertainty
estimates. … The reviewers need
to indicate the time periods that relate to the estimates.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
May 01, 2013 - Incidence estimates for the first 3
postpartum months were up to 6.5 percent for major depression alone … We will present summary estimates, standard
errors, and confidence intervals. … An
example of such a subgroup analysis would be a comparison of effectiveness estimates for RCTs
versus … observational studies or a comparison of estimates of the association between a history of
intimate … Specific benefits include
estimates of treated depression, maternal and infant health care visits, and
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/s116.pdf
October 01, 2007 - to estimate treatment effects; how-
ever, IV methods require strong assumptions to yield consistent
estimates … cian was unassociated with major medical comorbidities in the
current patient, suggesting that the IV estimates … study outcome and also influence
treatment choice, standard statistical methods may result in
biased estimates … This model
yielded adjusted estimates of risk differences. … Even if these condi-
tions are met, however, IV methods can result in biased
estimates of treatment effects
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
December 01, 2015 - .58,59 We used the model estimates to
calculate summary positive and negative likelihood ratios
(LRs … Estimates of
test performance often appeared to be affected by
characteristics of study design that … Summary estimates of test performance of laboratory values for the
diagnosis of acute appendicitis … CT
had high sensitivity (summary estimates ranging from
0.95 to 1) and specificity (0.91 to 0.99 … Summary estimates of test performance of diagnostic imaging
for acute appendicitis
Test Population
-
effectivehealthcare-admin.ahrq.gov/products/diagnostic-errors-emergency-updated/research
August 01, 2023 - were comments about the study authors' approaches to calculating confidence intervals around their estimates … of diagnostic errors and associated harms and the extrapolation of these estimates to the U.S. population … We synthesized results for each question and extrapolated U.S. estimates.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cell-free-dna-draft-report.pdf
December 01, 2024 - estimates); the strength of evidence for accuracy was insufficient. … Estimates)
Specificity
Range
(No. Estimates)
PPV Range
(No. Estimates)
NPV Range
(No. … Estimates)
AUC Range
(No. Estimates)
Accuracy of
Tissue of Origin
Predictiona
(No. … For the accuracy (e.g., sensitivity) estimates
for MCST tests, the study used the estimates from the … Estimates of stage-specific
preclinical sojourn time across 21
cancer types.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
October 01, 2014 - Most likelihood ratio estimates fell into
or near the “moderately useful” range (positive likelihood … One study that
directly compared use of Doppler vs. no Doppler showed no clear effect on
estimates … Lesion depth and body mass index had no effect on
estimates of sensitivity.
Table C. … Estimates were similar when studies that used diffusion-weighted
imaging were excluded. … of diagnostic accuracy and
found no clear effects on estimates.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
December 01, 2015 - Relative risk estimates: 0.89 to 1.2. … Women: No difference in relative risk estimates for SVR
•! Blacks vs. … Non-Black patients: No clear difference in relative risk estimates. … Relative risk estimates: 0.89 to
1.2. … Non-Black patients: No
clear difference in relative risk
estimates.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
December 01, 2015 - Relative risk estimates: 0.89 to 1.2. … Women: No difference in relative risk estimates for SVR
•! Blacks vs. … Non-Black patients: No clear difference in relative risk estimates. … Relative risk estimates: 0.89 to
1.2. … Non-Black patients: No
clear difference in relative risk
estimates.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_executive.pdf
January 01, 2014 - We present summary estimates, standard errors, and CIs
in our data synthesis. … Summary strength of evidence and effect estimates:
upstream versus deferred glycoprotein inhibitor … Summary strength of evidence and effect estimates:
upstream versus deferred glycoprotein inhibitor … Summary strength of evidence and effect estimates:
clopidogrel upstream (pretreatment) and deferred … Summary strength of evidence and effect estimates:
clopidogrel upstream (pretreatment) and deferred
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/s149.pdf
October 01, 2007 - This
choice can lead to unstable estimates due to small sample
sizes, especially for skewed data such … Construct estimates of treatment
effects such as absolute E{Y(EEE)} � E{Y(III)}or relative
E{Y(EEE)}/ … The
outcome estimates were qualitatively similar to the results pre-
sented in the article. … However, estimates from
our methodology should approximate the upper limit of effec-
tiveness of a medication … Best estimates
of diabetes prevalence in the Department of Veterans Affairs based on
computerized patient
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/fraenkel.pdf
December 26, 2012 - Preferences
• Specific probabilities vs Gist
o R example
• Average vs individualized probability estimates … Atrial Fibrillation
Slide 27: Know the
Numbers
• Atrial Fibrillation
o Individualized probability estimates
-
effectivehealthcare-admin.ahrq.gov/products/indirect-comparisons/research-2013
November 01, 2017 - Ignoring missing data or correlation between outcomes can produce biased MTC estimates leading to high … , to traditional contrast-based approaches, and thus in obtaining more precise and robust parameter estimates
-
effectivehealthcare-admin.ahrq.gov/products/cancer-ovarian-contraceptives/research-protocol
December 01, 2019 - The model will allow greater flexibility in exploring the potential effects of these issues on estimates … Precision (precise or imprecise), based primarily on the size of the confidence intervals of effect estimates … For each outcome, we will use currently available estimates of lifetime risk, prevalence of OC use, and … relative risk (or relative risk reduction) for that outcome in OC users to generate estimates of the … We will summarize these estimates in tables providing the number of expected outcomes per 100,000 women
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
October 01, 2015 - When few studies were available for an analysis,
we used the moment estimates of correlation between … Estimates
from one trial for progression (RR, 2.11; 95% CI, 0.40
to 11.06), noncancer mortality (RR … epirubicin: All-
cause mortality
Low Estimates favored BCG for all-cause mortality,
but differences … epirubicin:
Progression
Low Estimates favored BCG for bladder cancer
progression, but differences … lower doses, but most estimates were imprecise
and did not reach statistical significance.
-
effectivehealthcare-admin.ahrq.gov/products/safety-emerging-methods/overview
November 01, 2017 - Heterogeneity and the Interpretation of Treatment Effect Estimates From Risk Adjustment and Instrumental … Heterogeneity and Treatment Effect Estimates from Risk-Adjustment and Instrumental Variable Methods:
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/s5.pdf
October 01, 2007 - testing
stages.17 Some debate continues about the strengths and
limitations of risk adjustment versus IV estimates … IV estimates are useful in assess-
ing the effect of treatment rate changes, but decisionmakers
need … Increasing
restrictions will change rate ratio estimates and reduce bias in
studies of treatment effects … benefit from using these approaches in examining com-
parative effectiveness or safety or developing estimates … Heterogeneity and the interpretation of
treatment effect estimates from risk adjustment and instrumental
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests_executive.pdf
February 01, 2006 - ratio 0.33 NC 0.16 0.21
Negative predictive value at
20% prevalence 92.4% NC 96.2% 95.0%
Stability of estimates … likelihood ratio NC 0.41 NC NC
Negative predictive value
at 20% prevalence NC 90.7% NC NC
Stability of estimates … likelihood ratio NC NC NC NC
Negative predictive value
at 20% prevalence NC NC NC NC
Stability of estimates
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-205-predictors-trauma-care-evidence-summary.pdf
April 01, 2018 - In cases with few studies, lack of data, or
when data were only available as adjusted risk estimates … Tables A, B, and C consolidate the key estimates of the
predictive utility of each identified measure … When we were able to pool
data, the pooled estimates are given in bold; when data
were not pooled, … However, the out-of-hospital estimates are from
fewer studies and patients and the estimates are less … While the diversity
across the studies meant heterogeneity was high in the
pooled estimates and the
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_disposition-comments.pdf
January 15, 2016 - We have emphasized in our discussion of meta-analysis findings that the
estimates provide relative ranking … We have also noted in the report’s Conclusions that the estimates provided
are most important as relative … The estimates provide a relative ranking of anticipated
rates of lesion clearance among treatment options … Therefore, the difference
between any two estimates is the comparative effectiveness. … Peer reviewer #4 Results Figure 6, note that estimates of sigma are typically smaller
for smaller effect