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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
July 01, 2019 - Learning objective
Statistical heterogeneity
• Statistical heterogeneity occurs when estimates across … According to the 2019 Cochrane handbook, I2 describes the percentage of the variability in
effect estimates
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
January 01, 2010 - were based upon Kaplan-Meier estimates for treatment-specific
censoring distributions; whereas adjusted … estimates were based upon weights that were
functions of Kaplan-Meier censoring estimates and propensity … score estimates.17,18
Adjusted hazard ratios were calculated according to the inverse probability … These models served to
validate the adjusted hazard ratio estimates from the IPW Cox regression model … Such misclassification and underreporting should be non-
differential, however, and should bias our estimates
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
January 01, 2021 - meta-analysis is appropriate (i.e., more than 2 studies address
the same PICOTS and provide point estimates … If a
meta-analysis is deemed appropriate, we plan to use random-effects models to pool estimates
from … comparison have
high or unclear risk of bias or when sensitivity analyses show substantial difference in
estimates … derived from high or unclear risk of bias studies versus estimates derived from
studies at low risk
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
September 01, 2012 - Meta-Analysis
We conducted a Bayesian meta-analysis to provide
aggregate estimates of the effectiveness … We calculated meta-analysis estimates by using RCTs
grouped by progestogen formulation (17OHP, oral, … For neonatal mortality, aggregate estimates indicated no
formulation was effective at reducing risk … However, all
formulations were effective at reducing the risk of preterm
birth (meta-estimates: OR17OHP … In general, studies have also
been too small to provide valid estimates of factors that
may modify
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effectivehealthcare-admin.ahrq.gov/health-topics/alcohol
November 07, 2023 - An Empirical Evaluation of the Impact of Choice of Mean Difference Estimates
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effectivehealthcare-admin.ahrq.gov/products/effect-dietary-digestible/protocol
December 01, 2023 - a meta-analysis is appropriate (i.e., more than 2 studies address the same PICOTS and provide point estimates … If a meta-analysis is deemed appropriate, we plan to use random-effects models to pool estimates from … comparison have high or unclear risk of bias or when sensitivity analyses show substantial difference in estimates … derived from high or unclear risk of bias studies versus estimates derived from studies at low risk
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bereaved-persons-research-executive-summ.pdf
March 01, 2025 - /A Insufficient
Peer Support Depression symptoms Both studies reported positive effects, but
the estimates … Insufficient
Self-help
intervention
Quality of life Both studies reported positive effects, but
the estimates … Comprehensive
Provider Support
Quality of life Both studies reported positive effects, but
the estimates
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
September 07, 2012 - As above, we find the aggregate estimates of
benefit among those with prior preterm birth to
be squarely … We take some reassurance that providing
summary evidence is sufficient since the
meta-estimates for … Meta-estimates added to results
section. … Point estimates and 95% confidence intervals
are not consistently reported. … A summary table including all meta-estimates might be
helpful.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ems-911-workforce-mental-health-executive-summary.pdf
February 01, 2025 - health or occupational stress issues:
o Among telecommunicators during routine practice, prevalence estimates … o Among EMS clinicians during routine practice, prevalence estimates were:
suicidal ideation 33 percent … For KQ1, there was considerable variation in
prevalence and severity estimates across studies for various
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effectivehealthcare-admin.ahrq.gov/products/pressure-ulcer-treatment/research-protocol
December 01, 2019 - Estimates of the incidence of pressure ulcers vary according to the setting and range from 0.4 to 38.0 … patients to full functioning. 2 Data on the costs of treatment for a pressure ulcer vary, but some estimates … Meta-analyses will be conducted to summarize data and obtain more precise estimates on outcomes for which … The Q statistic and/or the I 2 statistic (the proportion of variation in study estimates due to heterogeneity
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-infertility_research.pdf
June 01, 2017 - ............................... 7
v
Background and Objectives
Selective reporting can bias estimates … CT.gov for detecting selective
reporting, and to determine the impact of selective reporting on the estimates … Therefore, our project coordinator sent regular
queries to co-investigators asking for estimates of … These estimates were tracked in an Excel spreadsheet.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s131.pdf
October 01, 2007 - of restrictions
for use in pharmacoepidemiology and examines to what extent they
change rate ratio estimates … RR estimates adjusted for age and sex also steadily
increased. … For all earlier
restrictions, it is less clear how much the observed change in
RR estimates result from … We found that this
change resulted in an observable but not substantial change in
RR estimates in our … A, Unadjusted mortality rate ratio estimates; B, Multi-
variate adjusted mortality rate ratio estimates
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effectivehealthcare-admin.ahrq.gov/products/grant-manuscripts/randomized-clinical-trials-abstract
June 01, 2024 - Skip to main content
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
November 20, 2013 - Empirical Bayes estimates
generated in a hierarchical summary ROC analysis
agreed closely with those … For diagnostic questions this means
either ‘can the sensitivity and specificity estimates found in … or ‘do these
sensitivity and specificity estimates tell me that the patient
will benefit from this … What is the direction of
sensitivity estimates, for example? … But
sensitivity and specificity estimates lay between 0% and
100%.
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-bias/methods
December 01, 2019 - aspects of data analysis, applicability, whether ethics approval is specified, and whether sample size estimates … Therefore, demographic features or disease severity may lead to variations in estimates of test performance … Context bias
Prevalence of the target condition varies according to setting and may affect estimates … results to be positive more frequently in settings with higher disease prevalence, which may also affect estimates … change over time as a result of technological improvement or the experience of the operator of the test, estimates
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/pressure-ulcer-treatment_research-protocol.pdf
November 08, 2011 - Estimates of the incidence of pressure ulcers vary according to the setting and
range from 0.4 to 38.0 … patients to full
functioning.
2
Data
on the costs of treatment for a pressure ulcer vary, but some estimates … Meta-analyses will be conducted to summarize data and obtain more precise estimates on
outcomes for … The Q statistic and/or the I
2
statistic (the proportion of variation in
study estimates due to heterogeneity
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - Quantitative Synthesis Chapter 3. Choice of Statistical Model for Combining Studies
Quantitative Synthesis
Chapter 3. Choice of Statistical Model for Combining Studies
Prepared for:
The Agency for Healthcare Research and Quality (AHRQ)
Training Modules for Systematic Reviews Methods Guide
www.ahrq.gov
Presenter…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-485-09-03-2013.pdf
January 01, 2013 - advance care plan
Key Questions
from Nominator:
Will a decision aid, using individualized estimates
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effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-adult-patients-with-bipolar-disorder-including-bipolar-i-and-bipolar-ii-disorder-what-is-the-comparative-effectiveness-of-available-treatments-including-psychotherapy-other-psychosocial-treatments-medications-and-other-s
November 01, 2017 - and about 1% meet diagnostic criteria for bipolar II disorder (Merikangas et al. 2007), with other estimates … from community samples yielding estimates of up to approximately 4% for both bipolar I and II (Kessler … These estimates of prevalence are considered conservative, because of differences in diagnostic definitions
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-grading-strength/methods
December 01, 2019 - quantity of evidence, directness (or indirectness) of evidence, consistency of evidence, and precision of estimates … reasons, EPCs should also present information that will help decisionmakers judge the risk of bias in the estimates … strength from different types of studies—specifically on the four required domains—and it displays estimates … Had these estimates been precise and consistent (e.g., narrower CI for the RCT, consistent cohort studies