-
effectivehealthcare.ahrq.gov/products/back-pain-treatment/research-protocol
October 08, 2014 - , the consistency of results from new studies compared to the pooled estimate, and the likelihood that … Moderate—We are moderately confident that the estimate of effect lies close to the true effect for this … Low—We have limited confidence that the estimate of effect lies close to the true effect for this outcome … Insufficient—We have no evidence, we are unable to estimate an effect, or we have no confidence in the … estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bundled-payments-quality-effects_research-protocol.pdf
June 23, 2011 - Further research is
very unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … the
estimate. … • Precise
• Imprecise
A precise estimate is an estimate that
would allow a clinically useful conclusion … An imprecise estimate is one for which the
confidence interval is wide enough to
include clinically
-
effectivehealthcare.ahrq.gov/products/bundled-payments-quality-effects/research-protocol
June 23, 2011 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate. … is an estimate that would allow a clinically useful conclusion.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-2015.pdf
January 01, 2015 - The high-end of the 1-year health care cost estimate for these 53 potential high-impact
interventions … Analysts estimate that by 2025, pembrolizumab could generate sales of about $6
billion. … We
estimate the annual cost of treating 316 adults at about $110 million. … No cost estimate provided No cost estimate provided
Total estimated annual costs of these therapies … We adopted a conservative estimate of
100,000 women undergoing lumpectomy each year.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/improved-cancer-outcomes-protocol_0.pdf
December 01, 2021 - consistency (similarity of effect direction and size); (4) precision (degree of certainty around
an estimate … An imprecise estimate is one for which the confidence interval is wide
enough to include clinically … • Moderate: Moderately confident that estimate of effect lies close to true effect. … Additional evidence necessary before concluding that
findings are stable or that estimate of effect … • Insufficient: No evidence, unable to estimate an effect, or no confidence in estimate of
effect
-
effectivehealthcare.ahrq.gov/products/pressure-ulcer-treatment/research-protocol
November 08, 2011 - not applicable)
Directness (direct or indirect)
Precision (precise or imprecise)
We will also estimate … Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change the confidence in the estimate of effect and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/pressure-ulcer-treatment_research-protocol.pdf
November 08, 2011 - applicable)
Directness (direct or indirect)
Precision (precise or imprecise)
We will also estimate … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change the confidence in the estimate of effect and is likely to change … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-fatigue_research-protocol.pdf
May 01, 2014 - The prevalence of ME/CFS is also difficult to estimate given the uncertainty of the
case definition. … • Moderate — We are moderately confident that the estimate of effect lies close
to the true effect … • Low — We have limited confidence that the estimate of effect lies close to the
true effect for … • Insufficient — We have no evidence, we are unable to estimate an effect, or
we have no confidence … in the estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol.pdf
May 20, 2024 - The four levels are:
9
• High—Very confident that the estimate of effect lies close to the … • Moderate—Confident that the effect estimate lies close to the true effect for this outcome. … Additional
evidence is needed before concluding that the findings are stable or that the estimate of … Investigators are unable to estimate an effect or have no confidence
in the estimate of the effect of … Precision is the degree of certainty surrounding an effect estimate concerning a given
outcome, based
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_clinician.pdf
February 01, 2016 - Further research is very unlikely to change our confidence in the estimate
of effect. … Further research may change our confidence in the estimate of effect
and may change the estimate. … Further research is likely to change our confidence in the estimate of effect
and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_clinician.pdf
March 01, 2016 - Further research is very unlikely to change
our confidence in the estimate of effect. … Further research may change
our confidence in the estimate of effect and may
change the estimate. … Further research is likely to change our
confidence in the estimate of effect and is likely to
change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_11-user-guide-to-ocer_130129.pdf
January 03, 2012 - Analyses are available that
can be used to estimate a study result in the presence of an hypothesized … the original analysis to provide quantitative assessment of the robustness (i.e.,
“how much does the estimate … However, violations in assumptions
that result in meaningful effect estimate changes
provide insight … If this check does not influence the
estimate of the association, then it is unlikely that
there is … ‘asa1c’ asa1c 1 -1/ exp;
estimate ‘nsaid1c’ nsaid1c 1 -1/ exp;
estimate ‘cox21c’ cox21c 1 -1/ exp;
-
effectivehealthcare.ahrq.gov/products/celiac-disease/research-protocol
June 11, 2014 - Strength of Evidence Definitions
SOE
Definition
High
We are very confident that the estimate … Insufficient
We have no evidence, we are unable to estimate an effect, or we have no confidence in … the estimate of effect for this outcome. … Score dichotomously as one of two levels of precision:
Precise
Imprecise
A precise estimate is … an estimate that would allow a clinically useful conclusion.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
May 01, 2013 - significance of
the effect, which is also reflected by the confidence interval
around the summary estimate … influencing the
significance of the effect (or p-value) include the number
of studies contributing to the estimate … flow diagram
9
of and variation in subgroup analyses precluded the
calculation of any overall estimate … of antiplatelet
therapy for adults with PADa
Comparison Population Outcome SOE
Results or Effect Estimate … Comparative effectiveness and safety of
treatments for ICa
Comparison
Outcome
SOE
Results or Effect Estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
January 01, 2014 - Further research may change our confidence in the estimate of the effect and may change the estimate. … the estimate. … Further research may change our confidence in the estimate of the effect and may change the estimate. … the estimate. … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
November 01, 2013 - In some
cases, reviewers may be able to conduct a meta-analysis to provide a quantitative estimate of … Score as one of two levels:
• Precise
• Imprecise
A precise estimate is one that would
allow … Judging Precision
When EPCs have conducted a quantitative synthesis and calculated a pooled estimate … estimate of effect for this outcome. … that is more conservative (i.e., closer to the null) than a random effects estimate.
-
effectivehealthcare.ahrq.gov/products/prehospital-airway-management/protocol
February 19, 2020 - Moderate—we are moderately confident that the estimate of effect lies close to the true effect for this … Low—we have limited confidence that the estimate of effect lies close to the true effect for this outcome … that additional evidence is needed before concluding either that the findings are stable or that the estimate … Insufficient—we have no evidence, we are unable to estimate an effect, or we have no confidence in the … estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
January 01, 2021 - initial study design, we will assign the SOE rating as high,
moderate, low, or insufficient evidence to estimate … High: We are very confident that the estimate of effect lies close to the true effect (i.e.,
the body … Moderate: We are moderately confident that the estimate of effect lies close to the true
effect (i.e … Low: We have limited confidence that the estimate of effect lies close to the true effect
(i.e., the … Insufficient: We have no evidence, are unable to estimate an effect, or have no confidence
in the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/risk-cardiovascular-disease.pdf
January 01, 2023 - initial study design, we will assign the SOE rating as high,
moderate, low, or insufficient evidence to estimate … an effect
High: We are very confident that the estimate of effect lies close to the true effect (i.e … Moderate: We are moderately confident that the estimate of effect lies close to the true
effect (i.e … Low: We have limited confidence that the estimate of effect lies close to the true effect
(i.e., the … Insufficient - We have no evidence, are unable to estimate an effect, or have no confidence
in the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-vaccines-update-evidence-summary.pdf
May 01, 2021 - Further research is
very unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is
likely to change our confidence in the estimate of effect and is likely to change … the
estimate … insufficient evidence for rare potential
adverse events for which very large samples would be needed to estimate