-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
February 01, 2018 - are themselves unmeasured
means that (in general) this issue cannot be addressed in analysis and the estimate … misperception that complete case analysis of a dataset with MNAR data will necessarily result in
a biased estimate … confounding by
age (in a final regression model using imputed values) and thus a biased final effect estimate … Marginal structural models to estimate the
causal effect of zidovudine on the survival
of HIV-positive
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - high-THC to CBD ratio products versus placebo, crossing
the threshold from moderate (prior pooled estimate … -1.15 on a 0 to 10 scale, 95%
confidence interval [CI] -1.99 to -0.54) to small (updated pooled estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research-2013.pdf
January 01, 2013 - does not lead to this same set of consistency equation; the imputation allows us to independently
estimate … In this approach, we estimate the absolute treatment effect size, , not
the relative effect size, . … F
estimate if we set
covariance matrix. … However, Riley et al. discussed when we can estimate within-study correlation and
thus produce estimates … Using
mixed treatment comparisons and meta-
regression to perform indirect comparisons
to estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-nursing-home-characteristics_research-protocol.pdf
November 03, 2011 - evidence reflects the true effect: Further research is
very unlikely to change our confidence in the estimate … confidence that the evidence reflects the true effect: Further research
may change our confidence in the estimate … of the effect and may change the
estimate. … the evidence reflects the true effect: Further research is
likely to change our confidence in the estimate … of the effect and is likely to
change the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/trauma-interventions-maltreatment-child_research-protocol.pdf
January 12, 2012 - evidence reflects the true effect: Further research is very unlikely to
change our confidence in the estimate … confidence that the evidence reflects the true effect: Further research may change
our confidence in the estimate … of the effect and may change the estimate. … the evidence reflects the true effect: Further research is likely to change
our confidence in the estimate … of the effect and is likely to change the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_executive.pdf
January 01, 2015 - consistency (similarity of effect direction and size);
and (4) precision (degree of certainty around an estimate … • Moderate: Moderate confidence that the estimate
reflects the true effect. … may change
estimates and our confidence in the estimates.
5
• Low: Limited confidence that the estimate … Further research is likely
to change confidence in the estimate of effect and may
change the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
July 01, 2013 - Further research is
very unlikely to change our confidence in the estimate
of effect. … Further
research may change our confidence in the estimate of
effect and may change the estimate. … Further research is
likely to change the confidence in the estimate of effect
and is likely to change … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_executive.pdf
March 01, 2015 - Because the goal of any pooling is to
estimate unconditional effects,14 random-effects models
5 … the
I2 metric and because between-trial variances are more
intuitively interpreted on the effect-estimate … Although
multiple scales were employed and heterogeneity noted in
the pooled estimate for vaginal route
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adults-trauma-interventions_research-protocol.pdf
November 08, 2012 - For all analyses, we will
use random-effects models to estimate pooled or comparative effects. … Further research is very
unlikely to change our confidence in the estimate of effect. … Further research may
change our confidence in the estimate of the effect and may change the estimate … Further research is likely to
change our confidence in the estimate of the effect and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
April 18, 2017 - in question is intermediary or clinical),
precision (the degree of certainty surrounding an effect estimate … i.e., another study would
not change the conclusions
Moderate We are moderately confident that the estimate … findings are likely to be stable, but
some doubt remains
Low We have limited confidence that the estimate … of effect is
close to the true effect
Insufficient We have no evidence, we are unable to estimate … an
effect, or we have no confidence in the estimate of
effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
November 01, 2014 - For all
analyses, we used random-effects models to estimate
pooled or comparative effects. … Further research is very unlikely to change our
confidence in the estimate of effect. … Further research may change our confidence in
the estimate of the effect and may change the estimate … Further research is likely to change our confidence in
the estimate of the effect and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive-2016.pdf
January 01, 2016 - The
most recent estimate of prevalence
among adults in the United States, based
on data from the … of effect and may change the estimate … • Low = Further research is very likely to have an
important impact on our confidence in the estimate … of effect and is likely to change the estimate … • Very low/insufficient = Any estimate of effect is very
uncertain.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
April 01, 2021 - covered both instances of no evidence and instances of evidence being
present but insufficient to estimate … ) Evidence-based Practice Center (EPC) Program to
indicate, “We have no evidence, we are unable to estimate … an effect, or we have no confidence in
the estimate of effect for this outcome. … The true effect is likely to be substantially
different from the estimate of effect.”2
The term … Combination of indirect
evidence only (indirect
comparison in NMA) and
imprecise estimate.
2.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
June 01, 2021 - standardized mean differences (SMDs)
together with a 95 percent confidence interval (CI) of the effect estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
July 01, 2016 - potential causal relationship would be more efficient if case reports emphasized criteria used to
estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_disposition-comments.pdf
April 18, 2013 - direct head-to-head
comparisons, we conducted indirect
comparisons using statistical techniques to
estimate … pediatric), lack of
understanding of migraine literature so missed at the
least 50 DB-PC RCT by my estimate … beta blockers, and
four patients to enroll one
subject in RCTs of
antidepressants
how did you estimate … We downgraded strength of evidence from a
single small RCT to low due to imprecise
treatment estimate … Pooled estimate was homogeneous (non
statistical tests for heterogeneity).
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-comments.pdf
May 21, 2020 - Disposition of Comments for CER 225: Substance Abuse Disorders in Adolescents
Comparative Effectiveness Review Disposition of Comments Report
Research Review Title: Interventions for Substance Use Disorders in Adolescents:
A Systematic Review
Draft report available for public comment from Octob…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-research-executive-summ.pdf
March 01, 2025 - We did not combine studies in meta-analysis to derive a single estimate of the
association for any outcome
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - strength of evidence grades
Strength of Evidence Description
High Very confident that the effect estimate … Moderate Moderately confident that the estimate of effect lies close to the true effect for
this outcome … Low Limited confidence that the effect estimate lies close to the true effect for this
outcome. … Additional
evidence is needed before concluding that the findings are stable or that the
estimate of … Insufficient No confidence in the estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-fracture-prevention-evidence-summary.pdf
April 01, 2019 - raloxifene-
calcitonin group (0.08%) suggested a possibly increased risk, we manually recalculated the estimate … clinical fractures, especially
for hip fractures, and statistical power often was
low to precisely estimate … Randomized
trials will continue to have limited statistical power
to estimate the risk of rare treatment … use consensus case
definitions,64, 65 standard non-case and exposure
controls, cohort designs to estimate … An estimate of the worldwide
prevalence and disability associated with osteoporotic
fractures.