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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopausal-symptoms-protocol-final.pdf
    October 15, 2024 - Moderate There is moderately confidence that that the true value of the estimate of interest is on one … The true value of the estimate may deviate slightly from the target of the certainty rating (i.e. may … Low There is low confidence that that the true value of the estimate of interest is on one side of a … The true value of the estimate may deviate from the target of the certainty rating (i.e. likely fall … Very Low There is very-low confidence that that the true value of the estimate of interest is on one
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_executive.pdf
    November 01, 2013 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change the confidence in the estimate effect and is likely to change … the estimate … for sensitivity of 95 percent (95% confidence interval [CI], 93 to 97%) and a pooled estimate for
  3. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-health-children_research-protocol.pdf
    December 11, 2015 - For all analyses, we will use random-effects models to estimate pooled or comparative effects. … Moderate We are moderately confident that the estimate of effect lies close to the true effect for this … Low We have limited confidence that the estimate of effect lies close to the true effect for this outcome … Insufficient We have no evidence, we are unable to estimate an effect, or we have no confidence in the … estimate of effect for this outcome.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
    June 12, 2013 - Because the goal of any pooling is to estimate unconditional effects,51 random-effects models will be … Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely the change the confidence in the estimate of effect and is likely to change … the estimate
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/multiple-sclerosis_executive.pdf
    April 01, 2015 - factors, the overall evidence for each outcome was rated as follows:16 • High—Very confident that estimate … • Moderate—Moderately confident that estimate of effect lies close to true effect. … • Low—Limited confidence that estimate of effect lies close to true effect; major or numerous deficiencies … Additional evidence necessary before concluding that findings are stable or that estimate of effect … • Insufficient—No evidence, unable to estimate an effect, or no confidence in estimate of effect.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/pelvic-pain_research-protocol.pdf
    February 16, 2011 - evidence reflects the true effect and further research is very unlikely to change our confidence in the estimate … confidence that the evidence reflects the true effect and further research may change our confidence in the estimate … of effect and may change the estimate), “low” (indicating low confidence that the evidence reflects … the true effect and further research is likely to change our confidence in the estimate of effect and … is likely to change the estimate), or “insufficient” (indicating that evidence is either unavailable
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/abnormal-uterine-bleeding_research-protocol.pdf
    November 21, 2011 - evidence reflects the true effect and further research is very unlikely to change our confidence in the estimate … that the evidence reflects the true effect and further research may change our confidence in the estimate … of effect and may change the estimate); “low” (indicating low confidence that the evidence reflects … the true effect and further research is likely to change our confidence in the estimate of effect … and is likely to change the estimate); or “insufficient” (indicating that evidence is either unavailable
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-grading_methods.pdf
    July 01, 2012 - Precision Precision is the degree of certainty surrounding an effect estimate with respect to a given … Score dichotomously as one of two levels of precision: • Precise • Imprecise A precise estimate is … an estimate that would allow a clinically useful conclusion. … An imprecise estimate is one for which the confidence interval is wide enough to include clinically … Publication bias indicates that studies may have been published selectively, with the result that the estimate
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
    January 30, 2012 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change the confidence in the estimate of effect and is likely to change … the estimate
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
    March 29, 2011 - evidence reflects the true effect and further research is very unlikely to change our confidence in the estimate … confidence that the evidence reflects the true effect and further research may change our confidence in the estimate … of effect and may change the estimate), “low” (indicating low confidence that the evidence reflects … the true effect and further research is likely to change our confidence in the estimate of effect and … is likely to change the estimate), or “insufficient” (indicating that evidence is either unavailable
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
    October 01, 2015 - The point estimate of the risk ratio indicated a clinically unimportant difference in the risk of CIN … was higher for statins than for high-dose N-acetylcysteine despite having a lower pooled risk ratio estimate … The pooled estimate of the risk ratio for statins plus N-acetylcysteine versus N-acetylcysteine alone … The pooled estimate of the effect of ascorbic acid compared with N-acetylcysteine demonstrated a statistically
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
    July 01, 2012 - underlying disease processes to such an extent that we are unable to develop a credible model to estimate … importantly, preexisting models will not have had the benefit of the current systematic review to estimate … The systematic review could synthesize available evidence, identify gaps, and estimate many necessary … Evidence exists to estimate the benefits and harms of pharmacologic therapy in those with and without
  13. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/pbi-protocol.pdf
    August 09, 2021 - initial study design, we will assign SOE rating as high, moderate, low, or ‘insufficient evidence’ to estimate … an effect. 10 High - We are very confident that the estimate of effect lies close to … Moderate - We are moderately confident that the estimate of effect lies close to the true effect (the … Low - We have limited confidence that the estimate of effect lies close to the true effect (the body … Insufficient - We are unable to estimate an effect or have no confidence in the estimate of effect.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-protein-intake-protocol-amendment.pdf
    November 29, 2023 - consistency (similarity of effect direction and size); (4) precision (degree of certainty around an estimate … An assessment of high indicates strong confidence that the estimate of effect lies close to true effect … An assessment of insufficient indicates no evidence was located, and we were unable to estimate an … effect or had no confidence in the estimate of effect in the body of evidence, if one exists, and precludes
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-protocol-amendment.pdf
    November 28, 2023 - consistency (similarity of effect direction and size); 4) precision (degree of certainty around an estimate … An assessment of High indicates strong confidence that the estimate of effect lies close to true effect … An assessment of Insufficient indicates no evidence was located, and we were unable to estimate an … effect or had no confidence in the estimate of effect; the body of evidence, if one exists, precludes
  16. effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
    January 01, 2013 - Violations in assumptions that result in meaningful effect estimate changes provide insight into the … approach to see how different an “as-treated” analysis would be even if intention to treat is the main estimate … consider the use of more than one cohort definition or statistical approach to ensure that the effect estimate
  17. effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
    September 21, 2012 - For example, investigators may not be able to estimate the power or precision of their proposed comparisons … Describe: - The primary outcome on which the study size or power estimate is based.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-195-uterine-fibroids-final.pdf
    December 01, 2017 - cancer dissemination following morcellation of fibroids, this review also includes literature to estimate … across all trials of medical management, UAE, or myomectomy that included subsequent treatment to estimate … We fit a 11 Bayesian binomial random effects model to update the estimate of prevalence of identifying … When we limit the analysis to retrospective studies, the estimate is 0.09 percent (95% credible interval … Additionally, such studies will be better able to estimate both common and rare harms, including the
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_executive.pdf
    November 01, 2012 - reflects the true effect and that further research is very unlikely to change our confidence in the estimate … of effect and will not change the estimate. … the evidence reflects the true effect and that further research may change our confidence in the estimate … of effect and may change the estimate. … of effect and is likely to change the estimate.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
    January 01, 2024 - feasible, we will also analyze multiple intake thresholds using generalized least square models to estimate … will assign a consensus strength of evidence (SoE) rating of high, moderate, low, or insufficient to estimate … This approach is consistent with the concept that for imprecise evidence “any estimate of effect is

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