-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
August 18, 2011 - to 50 percent are not taken as
prescribed.
11
Across the many studies that have been conducted to estimate … Further research is very
unlikely to change our confidence in the estimate of effect. … Further research may
change our confidence in the estimate of the effect and may change the estimate … Further research is likely to
change our confidence in the estimate of the effect and is likely to change … the
estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
December 05, 2018 - For all analyses, we will use random
effects models to estimate pooled or comparative effects; unlike … Further research is very
unlikely to change our confidence in the estimate of effect. … Further research may
change our confidence in the estimate of the effect and may change the estimate … Further research is likely to
change our confidence in the estimate of the effect and is likely to change … the
estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-medical-update_research-protocol.pdf
February 16, 2016 - Moderate Moderately confident that the estimate of effect lies close to the true effect … Low Limited confidence that the estimate of effect lies close to the true effect for … Additional evidence is
needed before concluding that the findings are stable or that the estimate … Insufficient No evidence or unable to estimate an effect. … No confidence in the estimate of effect for this
outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
March 01, 2017 - For the cognitive training
interventions we did use Cohen’s D to estimate effect size
where possible … consistency (similarity
of effect direction and size); and (4) precision (degree of
certainty around an estimate … • Moderate: Moderate confidence that the estimate
reflects the true effect. … • Low: Limited confidence that the estimate of effect lies
close to true effect. … Further research is likely to change
confidence in the estimate of effect, and may change
the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
March 01, 2017 - For the cognitive training
interventions we did use Cohen’s D to estimate effect size
where possible … consistency (similarity
of effect direction and size); and (4) precision (degree of
certainty around an estimate … • Moderate: Moderate confidence that the estimate
reflects the true effect. … • Low: Limited confidence that the estimate of effect lies
close to true effect. … Further research is likely to change
confidence in the estimate of effect, and may change
the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
June 01, 2012 - Further research is very unlikely to change
our confidence in the estimate of effect. … Further research may change our
confidence in the estimate of effect and may change the
estimate. … Further research is likely to change the
confidence in the estimate of effect and is likely to
change … the estimate … Of these 94 studies, 78 studies included sufficient
data to estimate the sensitivity and specificity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
October 01, 2011 - ; the directness of the evidence linking the
intervention and health outcomes; the precision of the
estimate … reflects the true effect and
that further research is very unlikely to change our
confidence in the estimate … of effect and may change the
estimate; a “low” grade indicates low confidence that
the evidence reflects … the true effect and further research
is likely to change the confidence in the estimate of
effect and … is likely to change the estimate; an
“insufficient” grade indicates evidence either is
unavailable or
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
December 31, 2013 - with the DerSimonian and Laird formula for
continuous outcomes.37 We will calculate a pooled effect estimate … that the evidence reflects the true effect,
and further research may change our confidence in the estimate … of the effect and may change
the estimate); (3) “low” grade (indicating low confidence that the evidence … reflects the true
effect, and further research is likely to change our confidence in the estimate of … the effect and
is likely to change the estimate); and (4) “insufficient” grade (evidence is unavailable
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management_research-protocol.pdf
January 01, 2014 - For all analyses, we will use random-effects models to
estimate pooled or comparative effects. … Further research is very unlikely to
change our confidence in the estimate of effect. … Further research may change
our confidence in the estimate of the effect and may change the estimate … Further research is likely to change
our confidence in the estimate of the effect and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
February 01, 2014 - www.effectivehealthcare.ahrq.gov/
reports/final.cfm.
6
very unlikely to change our confidence in the estimate … of the effect and may change the estimate); (3) “low”
grade (indicating low confidence that the evidence … reflects
the true effect and further research is likely to change
our confidence in the estimate of … the effect and is likely
to change the estimate); and (4) “insufficient” grade (no
evidence identified … In some instances, the studies
did not report a mean difference or point estimate, stating
only that
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar-2010_research-protocol.pdf
January 01, 2010 - the DerSimonian and Laird formula.
29
For dichotomous outcomes, we will
calculate a pooled effect estimate … the evidence reflects the true effect and that further
research may change our confidence in the estimate … of the effect and may change the estimate);
3) “low” grade (indicating low confidence that the evidence … reflects the true effect and that
further research is likely to change our confidence in the estimate … of the effect and is likely to
change the estimate); and 4) “insufficient” grade (evidence is unavailable
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
September 24, 2024 - Moderate We are moderately confident that the estimate of effect lies close to the true effect for
this … Low We have limited confidence that the estimate of effect lies close to the true effect for
this outcome … that additional evidence is needed before concluding either that the findings are
stable or that the estimate … Insufficient We have no evidence, we are unable to estimate an effect, or we have no confidence in
the … estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
May 01, 2013 - We can,
however, readily estimate the number of false-positive screening test results, or total referrals … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change the confidence in the estimate of effect and is likely to change … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-afib-update_research-protocol-amended.pdf
October 27, 2017 - for the Management of Patients with Atrial Fibrillation
recommends the use the CHADS2-VASc score to estimate … • Moderate—We are moderately confident that the estimate of effect lies close
to the true effect … that additional evidence is needed before
concluding either that the findings are stable or that the estimate … • Insufficient—We have no evidence, we are unable to estimate an effect, or
we have no confidence … in the estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
July 01, 2012 - prevailing reasoning, across studies sensitivity and specificity are likely
negatively correlated: as one estimate … positive estimated correlation between sensitivity and specificity (e.g., based on the
correlation estimate … It is also informative to estimate “summary” negative (or
positive) predictive values for this test.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2011_research.pdf
January 01, 2011 - specified
depending on the area of research)
6±2 5±2
Is necessary information usually available to estimate … 5±2 4±2
Is subjective decision needed to estimate validity? 5±2 6±2
10
Table 2. … Systematic reviews should incorporate quality into the synthesis of evidence to estimate how it
affects … sample
Not reported Poor reporting
The authors did not assess sampling
bias
Minor flaw
Estimate … Reporting of prevalence
Not clear Poor reporting
Point prevalence Minor flaw
Precision of estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/people-with-disabilities-protocol.pdf
January 16, 2024 - The four levels
are:
• High—Very confident that the estimate of effect lies close to the true effect … • Moderate—Confident that the estimate of effect lies close to the true effect for this outcome. … • Low—Limited confidence that the estimate of effect lies close to the true effect for this outcome … Additional evidence is
needed before concluding either that the findings are stable or that the estimate … Investigators are unable to estimate an effect, or have no confidence
in the estimate of effect for
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
January 01, 2010 - meta-analyses,9-11,23-28 other more recent
studies have demonstrated a DES survival advantage with a point-estimate … Utilizing
propensity scores to estimate causal
treatment effects with censored time-
lagged data. … Model
OR>1 indicates more DES; OR<1 indicates more BMS
Odds Ratio Estimates
Effect
Point
Estimate … Effective Health Care Research Report Number 17
29
Odds Ratio Estimates
Effect
Point
Estimate … Effective Health Care Research Report Number 17
30
Odds Ratio Estimates
Effect
Point
Estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-value-of-information_research.pdf
June 01, 2011 - Techniques to prospectively estimate of the value of research could potentially improve
the outcomes … Our results confirm that minimal approaches to VOI can be readily applied to estimate the
expected benefits … trial.2
3
Theoretical Framework
Value of information analysis for health research seeks to estimate … To do so, it begins with a person-level estimate of the
value of research to reduce uncertainty surrounding … To estimate
EVPI for costs and effectiveness, we assumed a cost distribution in which the variance of
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/wheelchair-users-amended-protocol.pdf
June 21, 2019 - evaluating and weighing the
combined results of the above domains:
• High: Very confident that the estimate … • Moderate: Moderately confident that the estimate of effect lies close to the true
effect for this … • Low: Limited confidence that the estimate of effect lies close to the true effect for
this outcome … Additional evidence is needed before concluding either that the findings are stable
or that the estimate … • Insufficient: No evidence, unable to estimate an effect, or have no confidence in
the estimate