-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - of the effect and may change the
estimate); (3) low grade (indicating low confidence that
the evidence … reflects the true effect, and further research is
likely to change our confidence in the estimate of … the effect
and is likely to change the estimate); and (4) insufficient
(indicating evidence is unavailable … glucagon-like peptide-1 agonists; H = high; M = moderate; Met = metformin; PL = profile likelihood estimate … Chronic kidney disease in US
adults with type 2 diabetes: an updated national estimate of
prevalence
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0316_03-12-2009.pdf
January 01, 2009 - Repeated measurement can provide a more accurate estimate of
blood pressure.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - studies with zero events in one arm, or studies with sparse binary data
but no zero events, obtain an estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
June 01, 2012 - there is no gold standard, describe sources of bias when an imperfect reference standard is used to estimate … The further the reference test deviates from the truth, the less accurate the estimate of the index test … Both graphs show the naïve estimate of the index test on the y-axis. … Their average measurements are considered the best estimate of the true unobserved value.
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
June 01, 2012 - there is no gold standard, describe sources of bias when an imperfect reference standard is used to estimate … The further the reference test deviates from the truth, the less accurate the estimate of the index test … Both graphs show the naïve estimate of the index test on the y-axis. … Their average measurements are considered the best estimate of the true unobserved value.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
September 03, 2019 - By definition, a low SOE means “We have
limited confidence that the estimate of effect lies
close to … that additional
evidence is needed before concluding either
that the findings are stable or that the estimate … By definition, a low SOE
means “We have limited confidence that the
estimate of effect lies close to … The quality of the evidence has been
considered and when the research team was
unable to estimate an … effect (when there was no
evidence at all) or had no confidence in the
estimate of the effect because
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/respectful-maternity-care-protocol.pdf
September 16, 2022 - the strength of evidence grades
Strength of
Evidence
Description
High Very confident that the estimate … Moderate Moderately confident that the estimate of effect lies close to the
true effect for this outcome … Low Limited confidence that the estimate of effect lies close to the true
effect for this outcome. … Additional evidence is needed
before concluding either that the findings are stable or that the
estimate … Insufficient Investigators are unable to estimate an effect, or have no
confidence in the estimate of
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
September 01, 2022 - Risk of bias refers to the likelihood that the estimate of an
intervention’s effect obtained from a … The approach
adjusts the treatment effect estimate for factors other than the intervention that may … A heavily biased estimate can be worse than no
estimate because it could lead to erroneous conclusions … The
advantages of conducting meta-analysis include the attainment of a singular overall estimate of … Graphical displays,
such as forest plots without an overall summary estimate, can be used to visually
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
September 01, 2022 - Risk of bias refers to the likelihood that the estimate of an
intervention’s effect obtained from a … The approach
adjusts the treatment effect estimate for factors other than the intervention that may … A heavily biased estimate can be worse than no
estimate because it could lead to erroneous conclusions … The
advantages of conducting meta-analysis include the attainment of a singular overall estimate of … Graphical displays,
such as forest plots without an overall summary estimate, can be used to visually
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - Executive Summary_Comparative Effectiveness Review No. 273_Treatment of Stages I-III Squamous Cell Anal Cancer: A Systematic Review
Comparative Effectiveness Review
Number 273
Treatment of Stages I–III Squamous
Cell Anal Cancer: A Systematic Review
Executive Summary
Main Points
• For the ini…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
January 01, 2012 - (e.g., 95% confidence interval) around the benefit and harm comparison estimate if and when
they … decide such a benefit and harm comparison estimate is useful for decisionmakers. … Thus, for each effect estimate, the probabilities of an effect can be calculated based on the
published … The method depends heavily on the availability of measurements that
estimate the length of time without … Reviewers may not have enough
40
information to estimate the potential effects of all sources
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-research-executive-summ.pdf
March 01, 2025 - effect (SMD -0.03; CI -0.30,
0.24)
Insufficient
Peer Support Grief symptoms No systematic effect (estimate … Insufficient
Peer Support Unintended
consequences of the
intervention
No systematic effect (estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
January 01, 2011 - epidemiologic terms (continued)
Term Definition Comments
Selection bias Distortion of treatment effect estimate … Information bias Distortion of treatment effect estimate as a
result of measurement error in any variable … the estimation of the odds ratio
in a case-control study is a computationally more
efficient way to estimate … A
conditional Poisson regression is used to estimate
the incidence rate ratio within individuals. … Flexible matching
strategies to increase power and efficiency to
detect and estimate gene-environment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
July 01, 2012 - Typically patients are classified as diagnostic test positive or negative to estimate the
test’s accuracy … development sample) by using the data to define cutoff levels or model its relationships to the
outcome and estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
January 01, 2023 - • Head-to-head comparisons between the different PBI modalities showed
insufficient evidence to estimate … Head-to-head comparisons between the different PBI
modalities showed insufficient SOE to estimate an
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypertension-pulmonary-arterial_research-protocol.pdf
January 30, 2013 - An echocardiogram is a
noninvasive test that provides an estimate of pulmonary artery pressures at rest … Further research is
very unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is
likely to change the confidence in the estimate of effect and is likely to change … the
estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ankyloglossia_research-protocol.pdf
June 30, 2014 - Strength of evidence grades and definitions10
Grade Definition
High We are very confident that the estimate … Moderate We are moderately confident that the estimate of effect lies close to the true
effect for this … Low We have limited confidence that the estimate of effect lies close to the true
effect for this outcome … Insufficient We have no evidence, we are unable to estimate an effect, or we have no
confidence in the … estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
May 31, 2017 - • Moderate—We are moderately confident that the estimate of effect lies close to
the true effect … • Low—We have limited confidence that the estimate of effect lies close to the true
effect for this … that additional evidence is needed before concluding either
that the findings are stable or that the estimate … • Insufficient—We have no evidence, we are unable to estimate an effect, or we
have no confidence … in the estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
January 01, 2010 - Published Online: October 24, 2011
□ Summary measures
□ Sample variability measures
□ Precision of estimate … Further research is very unlikely
to change our confidence in the estimate of effect. … Further research may
change our confidence in the estimate of effect and may change the estimate. … Further research is likely to
change our confidence in the estimate of effect and is likely to change … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
September 13, 2012 - with the DerSimonian and Laird formula.9 For dichotomous outcomes, we will
calculate a pooled effect estimate … reflects the true effect and that further research is
very unlikely to change our confidence in the estimate … of the effect and may change the estimate); 3) “low”
grade (indicating low confidence that the evidence … reflects the true effect and that further
research is likely to change our confidence in the estimate … of the effect and is likely to change the
estimate); and 4) “insufficient” grade (evidence is unavailable