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effectivehealthcare.ahrq.gov/products/quantitative-synthesis-expanded-methods/methods
March 13, 2013 - This bias is caused by measurement error in the control rate estimate and correlation between the control … placebo-controlled studies of Alzheimer’s drugs using standardized mean different and the combined estimate … The estimate of rate takes into account both the number of new cases, and followup time of population … Specify the scale to estimate the quality of the study and how internal and external validity of the … If study results are not quantitatively combined, a forest plot without a summary estimate can still
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effectivehealthcare.ahrq.gov/sites/default/files/study-eligibility-criteria.ppt
January 01, 2000 - Bias in This Context
Distortion of the estimate of effect that comes from how studies are selected for … When bias is discussed in this context, it is defined as “distortion of the estimate of effect that comes … different etiology for those issues and could have a different response to treatment could bias the overall estimate … with less than 75 percent women was appropriate for reducing the possibility of obtaining a biased estimate
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effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research-protocol
May 18, 2011 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change the confidence in the estimate of effect and is likely to change … the estimate.
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effectivehealthcare.ahrq.gov/products/labor-nitrous-oxide/research-protocol
May 11, 2011 - evidence reflects the true effect and further research is very unlikely to change our confidence in the estimate … confidence that the evidence reflects the true effect and further research may change our confidence in the estimate … of effect and may change the estimate); “low” (indicating low confidence that the evidence reflects … the true effect and further research is likely to change our confidence in the estimate of effect and … is likely to change the estimate); or “insufficient” (indicating that evidence is either unavailable
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effectivehealthcare.ahrq.gov/products/cesarean-birth-2010/research-protocol
May 06, 2011 - reflects the true effect and that further research is very unlikely to change our confidence in the estimate … that the evidence reflects the true effect and that further research may change our confidence in the estimate … of effect and may change the estimate), “low” (indicating low confidence that the evidence reflects … the true effect and that further research is likely to change our confidence in the estimate of effect … and is likely to change the estimate), or “insufficient” (indicating that evidence is either unavailable
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effectivehealthcare.ahrq.gov/products/type-2-diabetes-medications-update/research-protocol
April 05, 2010 - evidence reflects the true effect and further research is very unlikely to change our confidence in the estimate … confidence that the evidence reflects the true effect and further research may change our confidence in the estimate … of the effect and may change the estimate); (3) “low” grade (indicating low confidence that the evidence … reflects the true effect and further research is likely to change our confidence in the estimate of … the effect and is likely to change the estimate); and (4) “insufficient” grade (evidence is unavailable
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effectivehealthcare.ahrq.gov/products/hip-fracture-pain/research-protocol
December 09, 2009 - evidence reflects the true effect and further research is very unlikely to change or confidence in the estimate … confidence that the evidence reflects the true effect and further research may change our confidence in the estimate … of effect and may change the estimate); (3) “low” (indicating low confidence that the evidence reflects … the true effect and further research is likely to change our confidence in the estimate of effect and … is likely to change the estimate); and (4) “insufficient” (indicating that evidence is either unavailable
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effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research-protocol
May 02, 2011 - precision (precise or imprecise) of the evidence based on the degree of certainty surrounding an effect estimate … A precise estimate is an estimate that would allow a clinically useful conclusion. … An imprecise estimate is one for which the confidence interval is wide enough to include clinically distinct … If the studies do not directly compare the tests of interest, we will use network analysis to estimate
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effectivehealthcare.ahrq.gov/sites/default/files/s23.pdf
October 01, 2007 - additional ischemic stroke per
year per 24,000 women using OC.12 The study also reported a
relative risk estimate … Because this was a case–control
study, we note that analysts could not use their data to estimate
the … Lawrence
Brass, put his estimate for the chance of hemorrhagic stroke as
“perhaps 1 in 500,000” users … Using the Peto method to
calculate the odds ratio yields an estimate for harm of 7.8
(P � 0.01). … months of taking the medication, the annual occur-
rence of stroke would be at least comparable to this estimate
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/undescended-testicle_research-protocol.pdf
September 02, 2011 - evidence reflects the true effect and further research is very unlikely to change our confidence in
the estimate … that the evidence reflects the
true effect and further research may change our confidence in the estimate … of effect and may
change the estimate); “low” (indicating low confidence that the evidence reflects … the true effect
and further research is likely to change our confidence in the estimate of effect … and is likely to
change the estimate); or “insufficient” (indicating that evidence is either unavailable
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
May 18, 2011 - Further research is very unlikely to change our confidence in
the estimate of effect. … Further research may change our confidence in the estimate of
effect and may change the estimate. … Further research is likely to change the confidence in the
estimate of effect and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
April 06, 2010 - evidence reflects the true effect and further
research is very unlikely to change our confidence in the estimate … confidence that the evidence reflects the true effect and further
research may change our confidence in the estimate … of the effect and may change the estimate);
(3) “low” grade (indicating low confidence that the evidence … reflects the true effect and further
research is likely to change our confidence in the estimate of … the effect and is likely to change the
estimate); and (4) “insufficient” grade (evidence is unavailable
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cesarean-birth-2010_research-protocol.pdf
January 01, 2010 - reflects the true effect and that further research is very unlikely to change our
confidence in the estimate … the
evidence reflects the true effect and that further research may change our confidence in the
estimate … of effect and may change the estimate), “low” (indicating low confidence that the
evidence reflects … the true effect and that further research is likely to change our confidence in the
estimate of effect … and is likely to change the estimate), or “insufficient” (indicating that evidence
is either unavailable
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effectivehealthcare.ahrq.gov/products/depression-harms/research-protocol
February 07, 2018 - (2) Moderate—We are moderately confident that the estimate of effect lies close to the true effect … (3) Low—We have limited confidence that the estimate of effect lies close to the true effect for this … that additional evidence is needed before concluding either that the findings are stable or that the estimate … (4) Insufficient—We have no evidence, we are unable to estimate an effect, or we have no confidence … in the estimate of the effect for this outcome.
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effectivehealthcare.ahrq.gov/products/restless-legs/research-protocol
December 16, 2011 - direct link between intervention and outcome)
Precision (degree of certainty surrounding an effect estimate … evidence reflects the true effect; further research is very unlikely to change the confidence in the estimate … of effect and may change the estimate. … that the evidence reflects the true effect; further research is likely to change the confidence in the estimate … of effect and is likely to change the estimate.
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effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - Usual care control groups better estimate the effectiveness of
a new intervention relative to current … When there is substantial
dropout or crossover, however, intention-to-treat can under-
estimate both … Administrative database Estimates of major harms across large populations; detection of rare events; estimate … higher-
risk women, however, confirms the WHS findings that aspirin
use reduces risk of stroke (pooled estimate … 17% reduction)
but increases risk of serious GI bleeding (pooled estimate
68% increase—see Table 5 for
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-depression-research-protocol.pdf
February 07, 2018 - pertaining to each KQ will be classified into four categories:
1) High – We are very confident that the estimate … another study would not change the conclusions.
2) Moderate – We are moderately confident that the estimate … that additional evidence is needed before concluding either that the
findings are stable or that the estimate … of effect is close to the true effect.
4) Insufficient – We have no evidence, we are unable to estimate … an effect, or we have
no confidence in the estimate of the effect for this outcome.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-seniors-pneumonia_research.pdf
May 01, 2008 - We then examined each potential confounding factor
individually using a change-in-estimate criterion … ten percent or more, we considered it to be a confounding factor and retained it in the
“change-in-estimate … The change-in-estimate adjusted ORs for cyclic agents and
SSRI/SSNRIs were also similar to the corresponding … of the large number of cases of hospitalization for depression, and the narrow
CIs for this effect estimate … prior six months 0.72 (1.13) 0.13 (0.49)
N (%) N (%)
Minimally adjusted
OR (95% CI)*
Change-in-estimate
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effectivehealthcare.ahrq.gov/products/arthritis-knee-physical-therapy/research-protocol
March 02, 2011 - We will include observational studies when trial data are insufficient to estimate the benefits and harms … Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change the confidence in the estimate of effect and is likely to change … the estimate.
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effectivehealthcare.ahrq.gov/products/home-based-care/research-protocol
November 19, 2014 - Moderate —We are moderately confident that the estimate of effect lies close to the true effect for this … Low—We have limited confidence that the estimate of effect lies close to the true effect for this outcome … that additional evidence is needed before concluding either that the findings are stable or that the estimate … Insufficient—We have no evidence, we are unable to estimate an effect, or we have no confidence in the … estimate of effect for this outcome.