-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-information-exchange_research-protocol.pdf
April 20, 2015 - • Moderate-We are moderately confident that the estimate of effect lies close to
the true effect … • Low-We have limited confidence that the estimate of effect lies close to the
true effect for this … that additional evidence is needed before
concluding either that the findings are stable or that the estimate … • Insufficient- We have no evidence, we are unable to estimate an effect, or we
have no confidence … in the estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
September 01, 2010 - We will estimate treatment effects
relative to the reference treatment (basic parameters, i.e. comparisons … evidence reflects the true effect and further
research is very unlikely to change our confidence in the estimate … of the effect and may change the
estimate); (3) “low” grade (indicating low confidence that the evidence … reflects the true effect
and further research is likely to change our confidence in the estimate of … the effect and is likely
to change the estimate); and (4) “insufficient” grade (evidence is unavailable
-
effectivehealthcare.ahrq.gov/sites/default/files/s77.pdf
October 01, 2007 - detailed records regarding both phar-
macy utilization and means testing, it is possible to formally
estimate … copayments are tied to the
cost of their specific drugs, the actual list of medications
would be required to estimate … With the most conser-
vative estimate, assuming all brand name usage and no
prescription fills for longer
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
December 20, 2011 - of
18.7 percent and a current PTSD prevalence estimate of 9.1 percent
4
among Vietnam
veterans. … For all analyses, we will
use random-effects models to estimate pooled or comparative effects. … Further research is very
unlikely to change our confidence in the estimate of effect. … Further research may
change our confidence in the estimate of the effect and may change the estimate … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/integrating-evidence_methods.pdf
February 01, 2015 - A new quantitative
synthesis (i.e., pooled estimate) is needed if new studies would change conclusions … or strength of
evidence judgements, or to obtain a more precise or more up-to-date estimate.
8 … A new quantitative synthesis (i.e., pooled estimate) is needed if new studies would change
conclusions … or strength of evidence judgements, or to obtain a more precise or more up-to-date estimate. … established for when the prior estimates
would be acceptable or thresholds for determining when a new estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epc-evidence-reviews-federal-agencies.pdf
July 01, 2020 - Federal agencies should estimate about 5 months from agreement on the scope of work to the start of the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
February 07, 2025 - We will use
the restricted maximum likelihood approach to estimate the heterogeneity variance parameter … interaction term derived from a regression model
or subgroup-specific effects which could be used to estimate … Lacking such data, we will consider meta-regression to estimate
associations between these factors and … Precision is the degree of certainty surrounding an effect estimate with respect
to a given outcome, … based on the width of confidence intervals relative to a clinically
important effect estimate, sufficiency
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
August 19, 2011 - precision (precise or imprecise) of the evidence based on the degree of
certainty surrounding an effect estimate … A precise estimate is an estimate that would allow a
clinically useful conclusion. … An imprecise estimate is one for which the confidence interval is
wide enough to include clinically … If
the studies do not directly compare the tests of interest, we will use network analysis to estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-treatment_research-protocol.pdf
February 10, 2010 - Further
research is very unlikely to change our confidence in the estimate of
effect. … Further research may change our confidence in the estimate of
effect and may change the estimate. … Further
research is likely to change the confidence in the estimate of effect
and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/disparities-quality-improvement_research-protocol.pdf
February 23, 2012 - evidence reflects the true effect and further research is very unlikely to
change our confidence in the estimate … that the evidence reflects the true effect and further research may change
our confidence in the estimate … of effect and may change the estimate), “low”
(indicating low confidence that the evidence reflects … the true effect and further
research is likely to change our confidence in the estimate of effect … and is likely to
change the estimate), or “insufficient” (indicating that evidence is either unavailable
-
effectivehealthcare.ahrq.gov/sites/default/files/s38.pdf
October 01, 2007 - Results: Investigators can use available information from an auto-
mated database to estimate the amount … To estimate �, we calculate the
between mean square (BMS) as BMS � �
i�1
k m�y�i � y��2/
�k � 1�, … Often the goal of a study is to estimate the average
value of Y among all subjects in a given treatment … to detect the hypothesized effect.14
Planning for a cluster-randomized trial requires an a
priori estimate … example we presented considered the
observed outcome during a cluster-randomized trial, a pretrial
estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
November 28, 2012 - Because the goal of any pooling is to estimate
unconditional effects,47 random-effects models will be … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change our confidence in the estimate of effect and is likely to change … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - authors excluded data from
the DREAM trial,5 which was conducted in adults with
prediabetes, the pooled estimate … However, the pooled estimate suggested a potential difference when
comparing pioglitazone with sulfonylureas … estimates;
Moderate = further research is likely to have an important impact on our confidence in the estimate … of effect and may change
the estimate; Low = further research is likely to have an important impact … on our confidence in the estimate of effect and is
likely to change the estimate; Very low = any estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-nonsurgical-therapies_research-protocol.pdf
February 22, 2012 - Because the goal of any pooling is to estimate unconditional effects,39
random-effects models will be … Further research is very
unlikely to change our confidence in the estimate of effect. … Further research
may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to
change our confidence in the estimate of effect and is likely to change … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/ch-7-user-guide-to-ocer_130129.pdf
March 29, 2012 - When the
goal of CER is to estimate the total causal effect
of the treatment on the outcome, adjustment … mediation analysis, the investigator intentionally
measures and adjusts intermediate variables to
estimate … types
statistically behave like confounders, which are the
only structural type needing adjustment to estimate … Adjusting for a proxy or mismeasured confounder
will reduce bias relative to the unadjusted
estimate … predicted probability
is then used as a balancing score or matching
variable across treatment groups to estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
July 24, 2013 - We will also estimate publication bias by examining whether studies with smaller sample sizes
tended … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change the confidence in the estimate of effect and is likely to change … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
January 01, 2015 - If this is not reported, we will calculate the point estimate using the
mean difference from baseline … that the evidence reflects the true effect
but further research could change our confidence in the estimate … of the effect and may
change the estimate); (3) “low” grade (indicating low confidence that the evidence … reflects
the true effect and further research is likely to change our confidence in the estimate of … the
effect and is likely to change the estimate); and (4) “insufficient” grade (indicating evidence
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
January 01, 2024 - We will use
the restricted maximum likelihood approach to estimate the heterogeneity variance parameter … interaction term derived from a regression model
or subgroup-specific effects which could be used to estimate … Lacking such data, we will consider meta-regression to estimate
associations between these factors and … Precision is the degree of certainty surrounding an effect estimate with respect
to a given outcome, … based on the width of confidence intervals relative to a clinically
important effect estimate, sufficiency
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/safety-vaccines-protocol.pdf
January 30, 2020 - , the 95 percent confidence
interval, and the statistical significance of the summary estimate. … Precision is operationalized as the
confidence interval surrounding the point estimate. … Further
research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and
may change the estimate. … the estimate
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
February 01, 2014 - To estimate the risk of death we relied on 2007
estimates from the U.S. … To
estimate the incidence rate we assumed a 50 percent increase from age category 65-74 years based … Gail/NCI index to estimate the relative weighted number of harm minus benefit outcomes
Gail/NCI benefit … However, little research
has been done so far to estimate the impact of joint distributions of outcomes … The USPSTF proposed to use risk prediction equations
to estimate the absolute 10-year risks of MI.