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effectivehealthcare.ahrq.gov/sites/default/files/pdf/traumatic-brain-injury-rehabilitation_research-protocol.pdf
October 25, 2010 - By one estimate, 2 percent of the U.S. population lives with TBI-related
disabilities.
9
Source … evidence reflects the true effect; further research is very
unlikely to change the confidence in the estimate … of effect and may change the estimate.
3. … the evidence reflects the true effect; further research is likely
to change the confidence in the estimate … of effect and is likely to change the estimate.
4.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-provider-adherence_research-protocol.pdf
March 02, 2012 - with the DerSimonian
and Laird formula for continuous outcomes.36 We will calculate a pooled effect estimate … that the evidence reflects the true effect, and further research may
change our confidence in the estimate … of the effect and may change the estimate); 3) “low” grade
(indicating low confidence that the evidence … reflects the true effect, and further research is likely to
change our confidence in the estimate of … the effect and is likely to change the estimate); and 4)
“insufficient” grade (evidence is unavailable
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nppv-respiratory-failure_research-protocol.pdf
April 21, 2011 - effectiveness, confounding by indication makes it unlikely that these studies
would yield a valid estimate … Further research is very
unlikely to change our confidence in the estimate of effect. … Further research
may change our confidence in the estimate of effect and may change the estimate. … Further research is likely
to change the confidence in the estimate of effect and is likely to change … the estimate.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
June 01, 2018 - when there is higher heterogeneity.24 For
dichotomous outcomes, we will calculate a pooled effect estimate … that the evidence reflects the true
effect but further research could change our confidence in the estimate … of the effect
and may change the estimate); (3) “low” grade (indicating low confidence that the
evidence … reflects the true effect and further research is likely to change our
confidence in the estimate of … the effect and is likely to change the estimate); and (4)
“insufficient” grade (indicating evidence
-
effectivehealthcare.ahrq.gov/products/obesity-research-methods/research-protocol
February 09, 2017 - features, approaches to linking data sources, or analytic methods) would help to strengthen efforts to estimate … just below the cutoff are assumed to be very similar, so comparing these groups allows for a valid estimate … intervention status; analysis compares those just above the cutoff to those just below the cutoff to estimate … KQ4: What are the important gaps related to the methods used to estimate the effect of programs, policies … KQ5: What are the important gaps related to risks of bias in population-level data sources used to estimate
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-protocol.pdf
April 08, 2024 - • Precision (precise or imprecise)
o Describes the level of certainty of the effect estimate for … a particular outcome with a
precise estimate being one that allows a clinically useful conclusion. … Low Limited confidence that the estimate of effect lies close to the true effect
for this outcome. … Additional evidence is needed before concluding
either that the findings are stable or that the estimate … Insufficient Investigators are unable to estimate an effect or have no confidence in the
estimate of
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
February 01, 2014 - To estimate the risk of death we relied on 2007
estimates from the U.S. … To
estimate the incidence rate we assumed a 50 percent increase from age category 65-74 years based … Gail/NCI index to estimate the relative weighted number of harm minus benefit outcomes
Gail/NCI benefit … However, little research
has been done so far to estimate the impact of joint distributions of outcomes … The USPSTF proposed to use risk prediction equations
to estimate the absolute 10-year risks of MI.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/rt-bone-metatases-final-protocol.pdf
February 10, 2022 - for a particular
outcome with a precise estimate being one that allows a clinically useful
conclusion … Moderate We are moderately confident that the estimate of effect lies close to the true
effect for this … Low We have limited confidence that the estimate of effect lies close to the true effect
for this outcome … that additional evidence is needed before concluding either
that the findings are stable or that the estimate … Insufficient We are unable to estimate an effect, or we have no confidence in the estimate of
effect
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cervical-degenerative-protocol.pdf
January 12, 2022 - for a particular
outcome with a precise estimate being one that allows a clinically useful
conclusion … strength of evidence grades
Strength of
Evidence
Description
High We are very confident that the estimate … Moderate We are moderately confident that the estimate of effect lies close
to the true effect for this … Low We have limited confidence that the estimate of effect lies close to
the true effect for this outcome … an effect, or we have no confidence in
the estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-muscle-invasive_research-protocol.pdf
July 21, 2014 - combined estimate … • Moderate — We are moderately confident that the estimate of effect lies close
to the true effect … • Low — We have limited confidence that the estimate of effect lies close to the
true effect for … • Insufficient — We have no evidence, we are unable to estimate an effect, or
we have no confidence … in the estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/products/insomnia/research-protocol
April 03, 2014 - the overall strength of evidence for each outcome will be rated as: 39
High : Very confident that estimate … Moderate : Moderately confidence that estimate of effect lies close to true effect. … Low : Limited confidence that estimate of effect lies close to true effect; major or numerous deficiencies … Additional evidence necessary before concluding that findings are stable or that estimate of effect is … Insufficient : No evidence, unable to estimate an effect, or no confidence in estimate of effect.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_protocol-140716.pdf
April 03, 2014 - the
overall strength of evidence for each outcome will be rated as:39
• High: Very confident that estimate … • Moderate: Moderately confidence that estimate of effect lies close to true
effect. … • Low: Limited confidence that estimate of effect lies close to true effect; major
or numerous deficiencies … Additional evidence necessary
before concluding that findings are stable or that estimate of effect … • Insufficient: No evidence, unable to estimate an effect, or no confidence in
estimate of effect
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_research-protocol.pdf
April 03, 2014 - the
overall strength of evidence for each outcome will be rated as:39
• High: Very confident that estimate … • Moderate: Moderately confidence that estimate of effect lies close to true
effect. … • Low: Limited confidence that estimate of effect lies close to true effect; major
or numerous deficiencies … Additional evidence necessary
before concluding that findings are stable or that estimate of effect … • Insufficient: No evidence, unable to estimate an effect, or no confidence in
estimate of effect
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-prevention_research-protocol.pdf
June 15, 2011 - link between intervention and outcome);
and 4) precision (degree of certainty surrounding an effect estimate … A precise
estimate is one that would yield a clinically meaningful conclusion. … of effect and may change the estimate.
3. … that the evidence reflects the true effect; further research is likely to
change confidence in the estimate … of effect and is likely to change the estimate.
4.
-
effectivehealthcare.ahrq.gov/products/opioids-chronic-pain/protocol
February 27, 2019 - Moderate—We are moderately confident that the estimate of effect lies close to the true effect for this … Low—We have limited confidence that the estimate of effect lies close to the true effect for this outcome … that additional evidence is needed before concluding either that the findings are stable or that the estimate … Insufficient—We have no evidence, we are unable to estimate an effect, or we have no confidence in the … estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
March 01, 2016 - In particular, we hope to estimate probabilities of an
outcome associated with potential trajectories … These random effects will allow estimates
of overall (population) effects as well as an estimate of … Moderate We are moderately confident that the estimate of effect lies close to the true … Insufficient We have no evidence, we are unable to estimate an effect, or we have no … confidence in the
estimate of effect for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-5.pdf
February 01, 2018 - Statistical models exist that assume consistency (consistency models) and
which allow for direct/indirect estimate … • Side-splitting: A node is a treatment and a side/edge is a
comparison.12
► Compares the pooled estimate … from direct evidence only to the pooled
estimate including both direct and indirect evidence.
12
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effectivehealthcare.ahrq.gov/products/renal-function/research-protocol
June 13, 2013 - Does a troponin elevation help to estimate prognosis after ACS in the following subgroups? … the DerSimonian and Laird formula. 31 For dichotomous outcomes, we will calculate a pooled effect estimate … of the effect and may change the estimate); (3) “low” grade (indicating low confidence that the evidence … reflects the true effect and that further research is likely to change our confidence in the estimate … of the effect and is likely to change the estimate); and (4) “insufficient” grade (evidence is unavailable
-
effectivehealthcare.ahrq.gov/products/osteoporosis-fracture-prevention/research-protocol
April 12, 2018 - An imprecise estimate is one for which the confidence interval is wide enough to include clinically distinct … Moderate: Moderately confident that estimate of effect lies close to true effect. … Low: Limited confidence that estimate of effect lies close to true effect; major or numerous deficiencies … Additional evidence necessary before concluding that findings are stable or that estimate of effect is … Insufficient: No evidence, unable to estimate an effect, or no confidence in estimate of effect.
-
effectivehealthcare.ahrq.gov/products/blood-clots-hip-knee-surgery/research-protocol
August 06, 2010 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate. … A precise estimate is an estimate that would allow a clinically useful conclusion.