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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
    November 13, 2014 - consistency (similarity of effect direction and size); (4) precision (degree of certainty around an estimate … An imprecise estimate is one for which the confidence interval is wide enough to include clinically … the overall strength of evidence for each outcome will be rated as:41 • High: Very confident that estimate … Additional evidence necessary before concluding that findings are stable or that estimate of effect … • Insufficient: No evidence, unable to estimate an effect, or no confidence in estimate of effect
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
    March 14, 2024 - and the initial study design, we will assign SOE rating as high, moderate, low, or insufficient to estimate … High: We are very confident that the estimate of effect lies close to the true effect (the body of evidence … Moderate: We are moderately confident that the estimate of effect lies close to the true effect (the … Low: We have limited confidence that the estimate of effect lies close to the true effect (the body … Insufficient: We are unable to estimate an effect or have no confidence in the estimate of effect.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
    December 17, 2013 - consistency (similarity of effect direction and size); and (4) precision (degree of certainty around an estimate … • Moderate: Moderately confident that estimate of effect lies close to true effect. … • Low: Limited confidence that estimate of effect lies close to true effect; major or numerous deficiencies … Additional evidence necessary before concluding that findings are stable or that estimate of effect … • Insufficient: No evidence, unable to estimate and effect, or no confidence in estimate of effect
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/child-growth-development-outcomes-protocol-amended.pdf
    November 18, 2024 - (e.g., National Health and Nutrition Examination Survey), use this database to estimate usual nutrient … • Precision (precise or imprecise) o This describes the level of certainty of the effect estimate … for a particular outcome with a precise estimate being one that allows a clinically useful conclusion … Low Limited confidence that the estimate of effect lies close to the true effect for this outcome. … Insufficient Investigators are unable to estimate an effect or have no confidence in the estimate of
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-executive-summary.pdf
    November 01, 2024 - When more than two studies were available, different designs and/or methods to calculate the estimate … Studies without a protein or amino acid requirement estimate (k=6) reported outcomes such as growth,
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
    January 09, 2020 - initial study design, we will assign SOE rating as high, moderate, low, or ‘insufficient evidence to estimate … High - We are very confident that the estimate of effect lies close to the true effect (the body of … deficiencies and is judged to be stable). 11 Moderate - We are moderately confident that the estimate … Low - We have limited confidence that the estimate of effect lies close to the true effect (the body … Insufficient - We have no evidence, are unable to estimate an effect, or have no confidence in the estimate
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/vaccines-safety-protocol-130325.pdf
    September 18, 2012 - For groups of events that appear in at least three trials, a meta-analysis can estimate the odds ratio … Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/emt-naloxon_research-protocol.pdf
    November 29, 2016 - Opioid overdoses have serious adverse health consequences, even when not fatal; although difficult to estimate … • Moderate—We are moderately confident that the estimate of effect lies close to the true effect … • Low—We have limited confidence that the estimate of effect lies close to the true effect for this … • Insufficient—We have no evidence, we are unable to estimate an effect, or we have no confidence … in the estimate of effect for this outcome.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-treatments-revised-protocol.pdf
    March 29, 2023 - • Moderate—We are moderately confident that the estimate of effect lies close to the true effect … • Low—We have limited confidence that the estimate of effect lies close to the true effect for this … that additional evidence is needed before concluding either that the findings are stable or that the estimate … • Insufficient—We have no evidence, we are unable to estimate an effect, or we have no confidence … in the estimate of effect for this outcome.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-protocol.pdf
    February 01, 2023 - sign) • Precision (precise or imprecise): Describes the degree of certainty surrounding an effect estimate … given outcome, based on the width of confidence intervals relative to a clinically important effect estimate … Moderate We are moderately confident that the estimate of effect lies close to the true effect for this … Low We have limited confidence that the estimate of effect lies close to the true effect for this outcome … Insufficient We are unable to estimate an effect, or we have no confidence in the estimate of effect
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
    July 19, 2023 - • Precision: Describes the level of certainty of the estimate of effect for a particular outcome, … where a precise estimate is one that allows a clinically useful conclusion. … • Moderate: We are moderately confident that the estimate of effect lies close to the true effect … • Insufficient: We have no evidence, we are unable to estimate an effect, or we have no confidence … in the estimate of effect for this outcome.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_executive.pdf
    February 01, 2014 - or when the reported effect estimate appeared to contradict the reported events per person-time. … reflects the true effect and further research is likely to change our confidence in the estimate of … the effect and is likely to change the estimate • “Insufficient” grade: evidence is unavailable; … HSTCL (insufficient data to estimate incidence) Insufficient We identified 37 unique cases of HSTCL … All cancers (insufficient data to estimate incidence) Low The risk of other cancers did not differ
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
    June 01, 2023 - • Precision: Describes the level of certainty of the estimate of effect for a particular outcome, … where a precise estimate is one that allows a clinically useful conclusion. … • Moderate: We are moderately confident that the estimate of effect lies close to the true effect … • Insufficient: We have no evidence, we are unable to estimate an effect, or we have no confidence … in the estimate of effect for this outcome.
  14. effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
    February 01, 2016 - 2 RCTs Insufficient Unable to estimate 2 RCTs Insufficient Antiseizure medications No evidence -- -- … NSAID Unable to estimate 1 RCT Insufficient Unable to estimate 1 RCT Insufficient NSAID vs. … NSAID Unable to estimate 1 RCT Insufficient Unable to estimate 1 RCT Insufficient NSAID vs. … NSAID Unable to estimate 1 RCT Insufficient Unable to estimate 1 RCT Insufficient NSAID vs. … Unable to estimate 1 SR (13 RCTs) Insufficient Unable to estimate 1 SR (13 RCTs) Insufficient Kinesio
  15. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/child-growth-development-outcomes-protocol.pdf
    August 19, 2024 - (e.g., National Health and Nutrition Examination Survey), use this database to estimate usual nutrient … • Precision (precise or imprecise) o This describes the level of certainty of the effect estimate … for a particular outcome with a precise estimate being one that allows a clinically useful conclusion … Low Limited confidence that the estimate of effect lies close to the true effect for this outcome. … Insufficient Investigators are unable to estimate an effect or have no confidence in the estimate of
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostatic-hyperplasia-medications_research-protocol.pdf
    April 21, 2015 - similarity of effect direction and size among studies); (4) precision (degree of certainty around an estimate … An imprecise estimate is one for which the confidence interval is wide enough to include clinically … • Moderate: Moderately confident that estimate of effect lies close to true effect. … Additional evidence necessary before concluding that findings are stable or that estimate of effect … • Insufficient: No evidence, unable to estimate an effect, or no confidence in estimate of effect.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
    September 01, 2012 - OR=0.66; 95% Bayesian credible interval [BCI]: 0.53, 0.82) and neonatal mortality (meta-estimate OR … Among the trials in the meta-estimate, the risk of preterm birth was 46.6 percent among women in the … The aggregate estimate suggests progestogen treatment in women with preterm labor decreases the risk … of preterm birth before 37 weeks (meta-estimate OR=0.26; 95% BCI: 0.10, 0.49). … Among the trials in the meta-estimate, the risk of preterm birth was 47.5 percent among women in the
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_executive.pdf
    May 01, 2013 - Further research is unlikely to change our confidence in the estimate of the effect. … Further research may change our confidence in the estimate of the effect and may change the estimate. … the estimate. … Further research may change our confidence in the estimate of the effect and may change the estimate. … the estimate.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-protocol-amendment.pdf
    February 03, 2025 - sign) • Precision (precise or imprecise): Describes the degree of certainty surrounding an effect estimate … given outcome, based on the width of confidence intervals relative to a clinically important effect estimate … Moderate We are moderately confident that the estimate of effect lies close to the true effect for this … Low We have limited confidence that the estimate of effect lies close to the true effect for this outcome … Insufficient We are unable to estimate an effect, or we have no confidence in the estimate of effect
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement.pdf
    February 05, 2025 - and the initial study design, we will assign SOE rating as high, moderate, low, or insufficient to estimate … High: We are very confident that the estimate of effect lies close to the true effect (the body of evidence … Moderate: We are moderately confident that the estimate of effect lies close to the true effect (the … Low: We have limited confidence that the estimate of effect lies close to the true effect (the body … Insufficient: We are unable to estimate an effect or have no confidence in the estimate of effect.

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