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effectivehealthcare-admin.ahrq.gov/products/heart-failure-transition-care/research
December 01, 2019 - We conducted meta-analyses using random-effects models to estimate pooled effects.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
July 01, 2012 - prevailing reasoning, across studies sensitivity and specificity are likely
negatively correlated: as one estimate … positive estimated correlation between sensitivity and specificity (e.g., based on the
correlation estimate … It is also informative to estimate “summary” negative (or
positive) predictive values for this test.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
January 01, 2014 - Further research may change our confidence in the estimate of the effect and may change the estimate. … the estimate. … Further research may change our confidence in the estimate of the effect and may change the estimate. … the estimate. … the estimate.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_executive.pdf
January 01, 2014 - Any subgroup
summary estimate based on fewer than three studies is
noted as such and should be interpreted … When the summary estimate and CI
were precise and crossed 1, we looked at the particular
studies to … effect estimates:
300 mg versus 600 mg clopidogrel loading dose
Outcome and Timing SOEa and Effect Estimate … versus fondaparinux (percutaneous coronary intervention cohort)
Outcome and Timing SOEa and Effect Estimate … single antiplatelet versus dual antiplatelet therapy (continued)
Outcome and Timing SOEa and Effect Estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
November 28, 2012 - Because the goal of any pooling is to estimate
unconditional effects,47 random-effects models will be … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change our confidence in the estimate of effect and is likely to change … the estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
January 01, 2015 - If this is not reported, we will calculate the point estimate using the
mean difference from baseline … that the evidence reflects the true effect
but further research could change our confidence in the estimate … of the effect and may
change the estimate); (3) “low” grade (indicating low confidence that the evidence … reflects
the true effect and further research is likely to change our confidence in the estimate of … the
effect and is likely to change the estimate); and (4) “insufficient” grade (indicating evidence
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/inguinal-hernia_disposition-comments.pdf
August 17, 2012 - The SOE
relates to the certainty of the estimate, not the estimate itself. … sure the rating matches up about this: High strength of
evidence indicates high confidence in the estimate … and may change the estimate. … the evidence reflects the true effect;
further research is likely to change our confidence in the estimate … and is likely to change the estimate.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - authors excluded data from
the DREAM trial,5 which was conducted in adults with
prediabetes, the pooled estimate … However, the pooled estimate suggested a potential difference when
comparing pioglitazone with sulfonylureas … estimates;
Moderate = further research is likely to have an important impact on our confidence in the estimate … of effect and may change
the estimate; Low = further research is likely to have an important impact … on our confidence in the estimate of effect and is
likely to change the estimate; Very low = any estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
July 24, 2013 - We will also estimate publication bias by examining whether studies with smaller sample sizes
tended … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change the confidence in the estimate of effect and is likely to change … the estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/lung-cancer-nonsurgical-therapies_research-protocol.pdf
February 22, 2012 - Because the goal of any pooling is to estimate unconditional effects,39
random-effects models will be … Further research is very
unlikely to change our confidence in the estimate of effect. … Further research
may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to
change our confidence in the estimate of effect and is likely to change … the estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
May 01, 2013 - We can,
however, readily estimate the number of false-positive screening test results, or total referrals … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change the confidence in the estimate of effect and is likely to change … the estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-future-value-of-information_research.pdf
June 01, 2011 - Techniques to prospectively estimate of the value of research could potentially improve
the outcomes … Our results confirm that minimal approaches to VOI can be readily applied to estimate the
expected benefits … trial.2
3
Theoretical Framework
Value of information analysis for health research seeks to estimate … To do so, it begins with a person-level estimate of the
value of research to reduce uncertainty surrounding … To estimate
EVPI for costs and effectiveness, we assumed a cost distribution in which the variance of
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_executive.pdf
July 01, 2009 - The summary
estimate was derived from meta-analysis of three RCTs
that assessed the rhythm control of … The summary estimate was derived
from meta-analysis of six RCTs. … The evidence is
insufficient to estimate the predictive value of abnormal
EF or LAD on recurrence rates … The
evidence is insufficient to estimate the predictive value
of young or very old age.
4
5
There
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-liver-metastases-therapies_research-protocol.pdf
September 27, 2012 - estimation results)
Test used
Summary measures
Sample variability measures
Precision of estimate … Further research is very
unlikely to change our confidence in the estimate of effect. … Further
research may change our confidence in the estimate of effect and may change the
estimate. … Further research is likely
to change our confidence in the estimate of effect and is likely to change … the estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-pharmacologic-treatment_research-protocol.pdf
December 27, 2016 - another study
would not change the conclusions.
2) Moderate – We are moderately confident that the estimate … findings are likely to be stable, but some
doubt remains.
3) Low – We have limited confidence that the estimate … that additional evidence is
needed before concluding either that the findings are stable or that the
estimate … of effect is close to the true effect.
4) Insufficient – We have no evidence, we are unable to estimate … an effect, or
we have no confidence in the estimate of the effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
December 01, 2012 - that the evidence reflects
the true effect, and further research may change our
confidence in the estimate … of effect and may change
the estimate); “low” (indicating low confidence that the
evidence reflects … the true effect, and further research is
likely to change our confidence in the estimate of effect … and is likely to change the estimate); or “insufficient”
(indicating that evidence is either unavailable … FS, and 89.1 percent for primary orchiopexy, slightly
lower in all types of surgery than the pooled estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
March 31, 2010 - analyses by
omitting one study at a time to assess the influence of any single study on the pooled
estimate … that the evidence
reflects the true effect and further research may change our confidence in the estimate … of the effect and may change the estimate); (3) “low” grade (indicating low
confidence that the … evidence reflects the true effect and further research is likely to
change our confidence in the estimate … of the effect and is likely to change the
estimate); and (4) “insufficient” grade (evidence is unavailable
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diabetic-neuropathy_research-protocol.pdf
May 09, 2016 - Objectives for the Systematic Review
Background
Diabetic peripheral neuropathy
According to an estimate … that the evidence reflects
the true effect but further research could change our confidence in the estimate … of the effect and
may change the estimate);
(3) “low” strength of evidence (indicating low confidence … the evidence reflects the true
effect and further research is likely to change our confidence in the estimate … of the effect and is
likely to change the estimate); and
(4) “insufficient” strength of evidence (
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effectivehealthcare-admin.ahrq.gov/products/heart-failure-seniors-estimators/research
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effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
September 01, 2022 - Risk of bias refers to the likelihood that the estimate of an
intervention’s effect obtained from a … The approach
adjusts the treatment effect estimate for factors other than the intervention that may … A heavily biased estimate can be worse than no
estimate because it could lead to erroneous conclusions … The
advantages of conducting meta-analysis include the attainment of a singular overall estimate of … Graphical displays,
such as forest plots without an overall summary estimate, can be used to visually