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effectivehealthcare-admin.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - Usual care control groups better estimate the effectiveness of
a new intervention relative to current … When there is substantial
dropout or crossover, however, intention-to-treat can under-
estimate both … Administrative database Estimates of major harms across large populations; detection of rare events; estimate … higher-
risk women, however, confirms the WHS findings that aspirin
use reduces risk of stroke (pooled estimate … 17% reduction)
but increases risk of serious GI bleeding (pooled estimate
68% increase—see Table 5 for
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antidepressants-seniors-pneumonia_research.pdf
May 01, 2008 - We then examined each potential confounding factor
individually using a change-in-estimate criterion … ten percent or more, we considered it to be a confounding factor and retained it in the
“change-in-estimate … The change-in-estimate adjusted ORs for cyclic agents and
SSRI/SSNRIs were also similar to the corresponding … of the large number of cases of hospitalization for depression, and the narrow
CIs for this effect estimate … prior six months 0.72 (1.13) 0.13 (0.49)
N (%) N (%)
Minimally adjusted
OR (95% CI)*
Change-in-estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/bladder-cancer-non-muscle-invasive_research-protocol.pdf
July 21, 2014 - and weighing the combined results of the above domains:
• High — We are very confident that the estimate … • Moderate — We are moderately confident that the estimate of effect lies close
to the true effect … • Low — We have limited confidence that the estimate of effect lies close to the
true effect for … • Insufficient — We have no evidence, we are unable to estimate … an effect, or
we have no confidence in the estimate of effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/products/alcohol-use-disorders/research
May 01, 2024 - When possible, we conducted quantitative analyses using random-effects models to estimate pooled effects … that the evidence reflects the true effect; further research is likely to change our confidence in the estimate … of the effect and is likely to change the estimate. … of the effect and may change the estimate. … evidence reflects the true effect; further research is very unlikely to change our confidence in the estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s116.pdf
October 01, 2007 - Variable
Study of Neuroleptics
Can Between-Physician Differences in Prescribing Patterns Be
Used to Estimate … variable
(IV) methods that exploit differences in prescribing patterns be-
tween physicians may be used to estimate … In this article, we have evaluated the plausibility of the
conditions necessary for an estimate of a … “monotonicity,” is required to justify the use of conventional
IV estimators2 and in such cases the estimate
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol.pdf
June 10, 2024 - • Imprecision: Describes the level of certainty of the estimate of effect for a particular
outcome … , where a precise estimate is one that allows a clinically useful conclusion. … • Moderate: We are moderately confident that the estimate of effect lies close to the true
effect … • Insufficient: We have no evidence, we are unable to estimate an effect, or we have no
confidence … in the estimate of effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol-amendment.pdf
January 08, 2025 - • Imprecision: Describes the level of certainty of the estimate of effect for a particular
outcome … , where a precise estimate is one that allows a clinically useful conclusion. … • Moderate: We are moderately confident that the estimate of effect lies close to the true
effect … • Insufficient: We have no evidence, we are unable to estimate an effect, or we have no
confidence … in the estimate of effect for this outcome.
-
effectivehealthcare-admin.ahrq.gov/products/management-adhd-adults/protocol
February 01, 2025 - Imprecision: Describes the level of certainty of the estimate of effect for a particular outcome, where … a precise estimate is one that allows a clinically useful conclusion. … Moderate: We are moderately confident that the estimate of effect lies close to the true effect for this … Insufficient: We have no evidence, we are unable to estimate an effect, or we have no confidence in the … estimate of effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/opioid-treatments-chronic-pain-protocol.pdf
December 19, 2018 - • Moderate—We are moderately confident that the estimate of effect lies close to
the true effect for … • Low—We have limited confidence that the estimate of effect lies close to the true
effect for this … that additional evidence is needed before concluding either that the
findings are stable or that the estimate … is close to the true effect.
17
• Insufficient—We have no evidence, we are unable to estimate … an effect, or we
have no confidence in the estimate of effect for this outcome.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-protocol-acute-pain-treatments.pdf
August 08, 2019 - • Moderate—We are moderately confident that the estimate of effect lies close to the true
effect … • Low—We have limited confidence that the estimate of effect lies close to the true effect
for this … that additional evidence is needed before concluding either that the findings are
stable or that the estimate … • Insufficient—We have no evidence, we are unable to estimate an effect, or we have no
confidence … in the estimate of effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
March 22, 2023 - For all
pooled analyses, we will estimate the magnitude of treatment effects as small, moderate, or … strength of evidence grades
Strength of Evidence Description
High We are very confident that the estimate … Moderate We are moderately confident that the estimate of effect lies close to the true effect
for this … Low We have limited confidence that the estimate of effect lies close to the true effect for
this outcome … an effect, or we have no confidence in the estimate of
effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/telehealth-women-protocol.pdf
June 21, 2021 - The four levels are:
• High—Very confident that the estimate of effect lies close to the true effect … • Moderate—Confident that the estimate of effect lies close to the true effect for this
outcome. … • Low—Limited confidence that the estimate of effect lies close to the true effect for this
outcome … Additional evidence is needed before concluding either that the findings are stable or
that the estimate … Investigators are unable to estimate an effect, or have no
confidence in the estimate of effect for
-
effectivehealthcare-admin.ahrq.gov/products/treatments-acute-pain/protocol
February 01, 2020 - Moderate—We are moderately confident that the estimate of effect lies close to the true effect for this … Low—We have limited confidence that the estimate of effect lies close to the true effect for this outcome … that additional evidence is needed before concluding either that the findings are stable or that the estimate … Insufficient—We have no evidence, we are unable to estimate an effect, or we have no confidence in the … estimate of effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/products/rheumatoid-arthritis-medicine-update/research-protocol
September 01, 2019 - Moderate
We are moderately confident that the estimate of effect lies close to the true effect for … Low
We have limited confidence that the estimate of effect lies close to the true effect for this outcome … that additional evidence is needed before concluding either that the findings are stable or that the estimate … Insufficient
We have no evidence, we are unable to estimate an effect, or we have no confidence in … the estimate of effect for this outcome.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
March 01, 2013 - This bias is
caused by measurement error in the control rate estimate and correlation between the control … placebo-controlled studies of Alzheimer’s drugs using standardized mean different and
the combined estimate … The estimate
of rate takes into account both the number of new cases, and followup time of population … Specify the scale to estimate the quality of the study and how
internal and external validity of the … If study results are not
quantitatively combined, a forest plot without a summary estimate can still
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effectivehealthcare-admin.ahrq.gov/products/mental-health-pregnant/research
July 01, 2024 - that the evidence reflects the true effect; further research is likely to change our confidence in the estimate … of the effect and is likely to change the estimate. … confidence that the evidence reflects the true effect; further research could change our confidence in the estimate … of the effect and may change the estimate. … evidence reflects the true effect; further research is very unlikely to change our confidence in the estimate
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_executive.pdf
March 01, 2013 - of effect and may change the estimate; (3) low confidence indicated that further research is very likely … to have
an important impact on the confidence in the estimate of effect and is likely to change the … of effect and may change the estimate; (3) low confidence indicated that further research is very likely … to have
an important impact on the confidence in the estimate of effect and is likely to change the … • Modeling studies should be performed to estimate the
effectiveness, cost-effectiveness and harms
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effectivehealthcare-admin.ahrq.gov/sites/default/files/mcda-ijzerman.pdf
January 01, 2011 - Based on their response it is possible to estimate the part-worth utility of the
levels and to … estimate attribute weights
E.g. if Thai food is presented in X scenarios and if a respondent picks
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-221-copd-evidence-summary_0.pdf
October 01, 2019 - SOE was
rated as high when we were very confident that
the estimate of effect lies close to the true … SOE was rated as
moderate when we were moderately confident that
the estimate of effect lies close … SOE was rated as low
when we had limited confidence that the estimate
of effect lies close to the true … SOE was rated as insufficient
when we had no evidence, were unable to estimate
an effect, or had no … confidence in the estimate of
effect.
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effectivehealthcare-admin.ahrq.gov/products/procalcitonin/research-protocol
December 01, 2019 - estimation results)
Test used
Summary measures
Sample variability measures
Precision of estimate … Further research is very unlikely to change our confidence in the estimate of effect.
Moderate. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate.