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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_policymaker.pdf
    August 01, 2016 - Further research is very unlikely to change our confidence in the estimate of effect. ��� MODERATE–Moderate … Further research may change our confidence in the estimate of effect and may change the estimate. � … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate. ��� INSUFFICIENT–Evidence either is unavailable or does not permit a conclusion.
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_policymaker.pdf
    August 01, 2016 - Further research is very unlikely to change our confidence in the estimate of effect. ��� MODERATE–Moderate … Further research may change our confidence in the estimate of effect and may change the estimate. � … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate. ��� INSUFFICIENT–Evidence either is unavailable or does not permit a conclusion.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_clinician-2016.pdf
    January 01, 2016 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate. … the intervention; the duration of the interventions ranged between 1.5 to 25.0 months. †† This point estimate
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_clinician.pdf
    May 01, 2016 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate. … Sensitivity is an estimate of the proportion of all cases of cancer that are identified by a diagnostic
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper-2015.pdf
    January 01, 2015 - estimate of the subsequent trials. … (confidence interval ) N Effect Estimate (confidence interval) Effect Estimate (confidence … (Confidence Interval ) N Effect Estimate (Confidence Interval) Effect Estimate (Confidence … (Confidence Interval ) N Effect Estimate (Confidence Interval) Effect Estimate (Confidence … (Confidence Interval ) N Effect Estimate (Confidence Interval) Effect Estimate (Confidence
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-strength_methods.pdf
    July 01, 2009 - Substantial variability does not necessarily render an estimate imprecise. … or actually change that estimate. … is an estimate that would allow a clinically useful conclusion. … Further research may change our confidence in the estimate of effect and may change the estimate. … the estimate.
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
    April 01, 2010 - In the IV literature, this is termed the reduced form estimate. … In a placebo-controlled RCT with non-compliance, the reduced form estimate will be a biased estimate … IV approaches can provide such an estimate under certain assumptions. … Thus, an IV estimate of the effect of a high dose may be exaggerated. … and the IV estimate to conclude that the conventional estimate is biased.
  8. effectivehealthcare-admin.ahrq.gov/products/methods-guidance-quantitative-synthesis/methods
    December 01, 2019 - Investigators should avoid statements such as “We conducted a meta-analysis to obtain a combined estimate … of…” Rather, explain the reason a combined estimate might be useful to decision makers who might use … C, Bucher’s method should be enough to get the indirect estimate of A vs. B. … However, a combined estimate can be obtained using the Peto method, the Mantel-Haenszel method, or a … Calculation of NNT/NNH should include both point estimate and confidence interval.
  9. effectivehealthcare-admin.ahrq.gov/products/heart-failure-transition-care/policymaker
    December 01, 2019 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate.
  10. effectivehealthcare-admin.ahrq.gov/products/alcohol-misuse-drug-therapy/policymaker
    January 01, 2021 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate.
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/grading.ppt
    January 01, 2010 - Substantial variability does not necessarily render an estimate imprecise. … Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … the estimate. … or actually change that estimate.
  12. effectivehealthcare-admin.ahrq.gov/products/acs-pci-adjunctive-devices/research-protocol
    December 01, 2019 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate. … A precise estimate is an estimate that would allow a clinically useful conclusion.
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
    July 01, 2024 - Moderate certainty (⨁⨁⨁◯): We are moderately confident in the effect estimate; the true effect is likely … to be close to the effect estimate, but there is a possibility that it is substantially different. … different from the estimate of the effect. … Very low certainty (⨁◯◯◯): We have very little confidence in the effect estimate: the true effect is … likely to be substantially different from the estimate of effect.
  14. effectivehealthcare-admin.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
    March 01, 2020 - For trials that are judged sufficiently clinically similar to warrant meta-analysis, we will estimate … a pooled random-effects estimate of the overall mean difference in outcome measure. … effect and may change the estimate. … effect and is likely to change the estimate. … Very Low: Any estimate of effect is very uncertain.
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
    October 01, 2010 - of …‖ Rather, explain the reason a combined estimate might be useful to decision makers who might … C, Bucher‘s method should be enough to get the indirect estimate of A vs. B. … For OR, a logistic random effects model is another option. 37 When the estimate of between-study … However, a combined estimate can be obtained using the Peto method, the Mantel-Haenszel method, or … Calculation of NNT/NNH should include both point estimate and confidence interval. 5.
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
    September 01, 2015 - an effect, or we have no confidence in the estimate of effect for this outcome. … We deemed an estimate of effect as stable when (1) statistical significance did not change and (2) the … magnitude of treatment effects remained similar to the high SOE estimate of the Cochrane report. … Calibration refers to the 8 ability to estimate correctly the likelihood of a future event. … More than half of estimates graded as insufficient (defined as “we have no confidence in the estimate
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
    October 01, 2010 - of …‖ Rather, explain the reason a combined estimate might be useful to decision makers who might … C, Bucher‘s method should be enough to get the indirect estimate of A vs. B. … For OR, a logistic random effects model is another option. 37 When the estimate of between-study … However, a combined estimate can be obtained using the Peto method, the Mantel-Haenszel method, or … Calculation of NNT/NNH should include both point estimate and confidence interval. 5.
  18. S123 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/s123.pdf
    October 01, 2007 - Therefore, the estimate of ã1 in Eq. (4) should be interpreted as an upper-bound estimate of the average … A 2-stage approach is used to estimate IV models. … Using this process, only the variation in S that stems from changes in Z is used to estimate a1. … of a1—â1IV —is a consistent estimate of the survival effects of BCSI relative to mastectomy. … Relative to Figure 1, this estimate of â1 can be interpreted as an upper-bound estimate of the average
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-risk-of-bias.pdf
    December 01, 2017 - congruence between research questions and designs of included studies ► The precision of an effect estimate … between research questions and designs of included studies, determining the precision of an effect estimate … It may not always be possible but determining if a bias is likely to work against the noted effect estimate … is different than a bias that would tend to magnify an effect estimate. … Similarly, a bias that may have a major impact on the effect estimate is more concerning than a bias
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_clinician.pdf
    October 01, 2015 - Further research is very unlikely to change our confidence in the estimate of effect. … Further research may change our confidence in the estimate of effect and may change the estimate. … Further research is likely to change our confidence in the estimate of effect and is likely to change … the estimate.

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