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Total Results: 1,134 records

Showing results for "efficacy".

921. Dementia-Agitation-Aggression Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
     November 13, 2014 - Further, antipsychotic medications have limited evidence for efficacy and high risk for adverse effects … www.effectivehealthcare.ahrq.gov Published online: November 13, 2014 7 Evidence synthesis on the efficacy … We will try to use MIDs to assess the efficacy and comparative effectiveness of outcomes with well-established … Placebo--efficacy and adverse effects in controlled clinical trials.

922. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
     June 22, 2017 - following TKR, the orthopaedic community has adopted the latter as the appropriate outcome measure for efficacy … Therefore, we do not believe that an analysis that assesses the efficacy of VTE prophylaxis regimens … Zarski, JD) Methods A second concern regards the balance between efficacy and safety in selecting … Your review has missed numerous publications related to the efficacy of aspirin for prevention of VTE … In fact, a recent systematic review published in British Joint Journal on the efficacy of various

923. Integrating Stakeholder Preferences in Comparative Effectiveness Research: Potential Uses of Multi-Criteria Decision Analysis Techniques (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/mcda_webinar_transcript2.pdf
     August 27, 2012 - We came up finally with a decision structure with three main criteria, the efficacy, adverse events … If you look at efficacy of the antidepressant treatment, we looked at the response of the drug, the … There may be lots of evidence about the efficacy of therapies when studied in research studies but … They worried or they were interested in the quality of the evidence in efficacy studies before deciding … We have two efficacy attributes, pain and stiffness, and this is for osteoarthritis.

924. S3 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s3.pdf
     October 01, 2007 - Reduction in burden of illness: a new efficacy measure for prevention trials.

925. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1306.pdf
     June 01, 2013 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … of patients are homozygous.7 Additionally, the manufacturer is sponsoring a study to evaluate the efficacy … Forthcoming information regarding third-party payer coverage, patient copayments, real-world clinical efficacy … Also, if physicians observe limited efficacy in clinical practice, they could be hesitant to prescribe

926. Disposition of Comments for CER 195 Management of Uterine Fibroids (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
     December 14, 2017 - Allergan believes that data from these publications will be used to support efficacy and safety assessment … Large, well-controlled studies should be used in determining efficacy and not small, biased samples … Determination of efficacy and safety should focus on large, well-controlled studies such as the Donnez … Public Reviewer (Allergen) Results There is a high level of evidence to support efficacy and safety … with long-term treatment studies (Donnez et al 2014 and Donnez et al 2015) provide key Ulipristal efficacy

927. MS Protocol draft_12_12-13 clean[2] (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
     December 17, 2013 - Unfortunately, the efficacy level of MS treatments appears to correlate with the frequency and severity … Typical RCTs for MS efficacy or comparative effectiveness are 2 to 3 years. … Weber MS, Mente T, Lehmann-Horn K, et al., Current treatment strategies for multiple sclerosis—Efficacy

928. Disposition of Comments Report for Enzyme-Replacement Therapies for Lysosomal Storage Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
     January 01, 2014 - The 2006 publication addresses safety and efficacy outcomes that support the main label claims. … Data for the important efficacy outcomes of improvement in walking and stair climbing capacity are … Patients often develop anti-ERT antibodies that seem to not impact ERT efficacy. … Monitoring of patients for efficacy of treatment. 4. Relevance of developing IgG Abs. 5. … The purpose of the report was to commment on the efficacy and safety of ERT.

929. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
     August 22, 2008 - KQ 6: In patients with CF, how is efficacy, effectiveness, safety or adverse events impacted by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety or adverse events of treatment … be conducted to assess the effect age, gender, and baseline clinical status on the intervention’s efficacy

930. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
     March 08, 2012 - Efficacy and safety beyond 3 weeks in patients with SAR have not been established.32 5. … Because pregnancy is often an explicit exclusion criterion for clinical trials, data demonstrating efficacy … Reasons most often cited for not including a specific comparison were differential efficacy for specific … ; uncontrolled studies are prone to increased risk of bias due to the subjective reporting of both efficacy … The efficacy of intranasal antihistamines in the treatment of allergic rhinitis.

931. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Also, if physicians observe limited efficacy in clinical practice, they could hesitate to prescribe … could result in better health outcomes for patients; however, experts called for more safety and efficacy … data, as well as long-term efficacy data, to support this claim. … Long- term safety and efficacy of Ivacaftor in patients with cystic fibrosis who have the G551D-CFTR

932. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/11_peptic_ulcer_potential_high_impact_2012-12-111.pdf
     January 01, 2012 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … One expert representing a clinical perspective stated that if TSO continues to demonstrate efficacy … However, if TSO shows efficacy in that difficult-to-treat patient population, it could greatly add … TSO’s impact is perceived to be dependent on further demonstration of safety and efficacy and the extent … Excluding this clinical expert, most experts who commented were less certain of POEM’s efficacy because

933. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
     December 01, 2015 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Phase III trials have shown it to have broad and high efficacy (>85% SVRs) against several HCV genotypes … Interventions used for all-oral HCV treatment have been reported in trials to show high efficacy and … The high efficacy of Sovaldi and Sovaldi in combination with Daklinza observed thus far in HCV genotypes … The high efficacy of Sovaldi thus far in HCV genotypes 2, 3, and 4 and the potential for treating HCV

934. A Bayesian Missing Data Framework for Multiple Continuous Outcome Mixed Treatment Comparisons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research-2013.pdf
     January 01, 2013 - NICE DSU Technical Support Document 7: Evidence Synthesis of Treatment Efficacy in Decision Making: … The efficacy of home based progressive strength training in older adults with knee osteoarthritis: … The efficacy of a muscle exercise program to improve functional performance of the knee in patients … A 3- month, randomized, double-blind, placebo- controlled study to evaluate the safety and efficacy … Efficacy of 2 non-weight-bearing interventions, proprioception training versus strength training,

935. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
     January 01, 2007 - experts consider the alpha- glucosidase inhibitors to be inferior to the other drug classes in terms of efficacy … medications lower hemoglobin A1c (HbA1c) by an absolute reduction of 1-2 percent,1 with equivalent efficacy … This report summarizes the available evidence comparing the efficacy and safety of oral diabetes medications

936. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pregnancy_hi_impact.pdf
     January 01, 2012 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary efficacy … In 2010, Sullivan and colleagues presented data from a study evaluating the efficacy of an exclusively … Overall, experts agreed that while more safety and efficacy studies must be performed to determine … The trial was stopped for efficacy of prenatal surgery after the recruitment of 183 of a planned 200 … Overall, experts opined further studies need to be conducted to properly evaluate the efficacy and

937. Disposition of Comments for CER 177 Agitation Aggression Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-agitation-aggression_disposition-comments.pdf
     March 21, 2016 - The revised text now states: “Antipsychotic medications have limited efficacy and significantly increase … one should start with a non-pharmacological or pharmacological treatment based on factors including efficacy … Given the limited evidence of efficacy in the available studies, this perception might not be inaccurate … The assumption is that an RCT is both necessary and sufficient to provide “hard” evidence of the efficacy … In addition, many disciplines recognize alternative methods of showing efficacy (as well as effectiveness

938. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
     January 01, 2012 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … most/all of the texts, and replying to the texts.” 4 Although no clinical trials investigating the efficacy … particularly strong, stating that the 14.3% quit rate is not particularly impressive and that long term efficacy

939. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia_horizon-scan-high_impact-1306-revised.pdf
     July 09, 2013 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Experts stated that their enthusiasm is predicated on an assumption of efficacy in insulin’s potential … Experts stated that the available clinical trial data are not yet robust enough to assume efficacy … Health care delivery infrastructure and patient management: Despite this skepticism about efficacy,

940. Disposition of Comments Report for Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_disposition-comments.pdf
     June 05, 2013 - We discuss efficacy and comparative effectiveness findings (KQ 1, 2, and 5) first, then adverse events … Regarding the BPD statement in your comment, the SOE is for efficacy in treating diabetes in the short … Again, the SOE for efficacy refers to “treating diabetes” as a whole, taking into consideration ALL … not the case, as the combination of a relatively high operative complication rate and questionable efficacy … We agree that cholesterol and blood pressure outcomes are extremely important in evaluating efficacy