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Total Results: 1,134 records

Showing results for "efficacy".

421. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … introduced in 1985 and withdrawn from the U.S. market in 1992 because of concerns about safety and efficacy … that “the use of the gastric balloon is not covered under Medicare, since the long term safety and efficacy … Experts noted the balloons’ relative safety and efficacy in reducing weight based on available trial … durable weight loss and like any other short term treatment, there is a concern regarding overall efficacy

422. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
     August 18, 2011 - Self-efficacy (modeling, practice, verbal persuasion, coping responses, graded tasks, reattribution … grades reflect the strength of the body of evidence to answer KQs on the comparative effectiveness, efficacy … Grades do not refer to the general efficacy or effectiveness of interventions. … Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA … Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to

423. rheumatoid-arthritis-medicine-update-protocol-170515 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine-update_research-protocol.pdf
     May 15, 2017 - EULAR advocates for the efficacy of conventional synthetic DMARDs (csDMARDs) (hydroxychloroquine, leflunomide … biologic DMARDs as similarly effective (with the exception of anakinra, which has not shown strong efficacy … Few data are available on efficacy for these drugs; even less is known about how their effectiveness … hydroxychloroquine, leflunomide, methotrexate, sulfasalazine).21 There were also no studies comparing efficacy … Grades reflect the strength of the body of evidence to answer the KQs on the comparative effectiveness, efficacy

424. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Experts reviewing this intervention cited the weak efficacy data, surgical risk, and high adverse event … Food and Drug Administration (FDA) in July 2014 after the pivotal trial met its primary efficacy endpoints … market in 1992 because of concerns about safety and efficacy due to frequent complications.14 A 2007 … A prospective, randomized multicenter study to evaluate the safety and efficacy of the ReShape Duo

425. CER 221 Disposition of Comments: Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-221-copd-comments_0.pdf
     October 11, 2019 - However, in most cases, the authors explicitly indicate they evaluate the “efficacy” of interventions … Such a concept needs to account for the multi-criteria efficacy to effectiveness study design continuum … Please note that RCTs can be mostly effectiveness oriented (so-called pragmatic trials) or mostly efficacy … Peer reviewer #6 General Comments I believe the phrase “comparative efficacy” is more appropriate in

426. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
     June 15, 2010 - It may also reflect heterogeneity across studies evaluating the efficacy of SSRIs within this patient … 15, 2010 fail to improve either fully, partially, or have no response, what is the benefit (efficacy … From a design hierarchy perspective, comparative group designs provide stronger evidence for efficacy … Question 4: How does the efficacy/effectiveness vary between the different monotherapies and combined

427. Binge-Eating Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_research-protocol.pdf
     July 21, 2014 - improve the evidence base for treatment guidelines, further research is needed regarding the long-term efficacy … of pharmacological interventions, efficacy of CAM treatments, treatment efficacy in diverse groups … and costs-benefit assessments of different treatments, treatment stepped-care models, and treatment efficacy … The efficacy of self-help group treatment and therapist-led group treatment for binge eating disorder … The efficacy of a short version of a cognitive-behavioral treatment followed by booster sessions for

428. FRN 29: Future Research Needs on Procalcitonin-Guided Antibiotic Therapy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
     August 01, 2014 - Level 4 • Treatment efficacy: The impact of the test results on treatment choices or other procedures … Level 6 • Societal efficacy: The test is efficacious to the extent that it is an efficient use of societal … The conceptual framework of evaluating the efficacy of procalcitonin (Figure 3) was useful in guiding … F-2 Research Needs and Preliminary Research Questions Total Votes* Weighed Total Technical Efficacy … * Responses from nine (of nine) panel members ** Assumption: This column on Technical efficacy (Level

429. S50 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s50.pdf
     October 01, 2007 - Unfortunately, results of ITT analyses do not reflect efficacy of the treatment being studied, because … differences in the actual practice of care.5 Unlike an RCT, it does not alter the treatment to evaluate efficacy … , and outcome measures Database Limited to the variables needed Comprehensive and detailed Result Efficacy

430. Microsoft Word - Comp Eff 10.doc (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-2007_research-2007-1.pdf
     January 01, 2007 - Key Points • There was no clear difference in the blood pressure lowering efficacy between ACEIs … Overall, there was no clear difference in the blood pressure lowering efficacy between the two classes … The prospective, randomized investigation of the safety and efficacy of telmisartan versus ramipril … Efficacy and safety of telmisartan, a selective AT1 receptor antagonist, compared with enalapril in … Antihypertensive efficacy and tolerability of once daily losartan potassium compared with captopril

431. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
     March 10, 2010 - with another lipid-modifying agent could be an alternative provided short and long-term safety and efficacy … b) "…safety and efficacy are established with evidence." … These studies discussed heretofore underscore the clinical efficacy of combination therapy and urgent … Under the surrogate efficacy measures, add the LDL-C lowering results from Stein (reference 104). … If this description is insufficient, the study protocol (on file with the FDA) states "For the efficacy

432. AHRQ Evidence-based Practice Center Program Research Gaps Summary: Primary Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
     March 01, 2022 - • Studies to understand the role of patient health behaviors, such as self-efficacy, health literacy … Evidence Gaps Study Populations • Studies evaluating the efficacy of acute treatments in specific … • Trials that evaluate the long-term efficacy and safety using various doses of antipsychotics and … global outcome measures, patient quality of life, and caregiver outcomes, and investigate treatment efficacy … direct comparison among antidepressants requiring assessment of comparative harms and comparative efficacy

433. Topic Brief: Antenatal Care (pdf file)
     effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-antenatal-care.pdf
     April 01, 2021 - One of these reviews explored the safety and efficacy of home blood pressure monitoring during pregnancy … Comparing the Efficacy of a Mobile Phone-Based Blood Glucose Management System With Standard Clinic … One of these reviews explored the safety and efficacy of home blood pressure monitoring during pregnancy

434. Disposition of Comments Technical Brief 41: Evaluation of Mental Health Mobile Applications (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-mobile-apps-disposition-of-comments.pdf
     May 20, 2022 - For example, the evidence section asks whether a randomized trial showing efficacy exists but not whether … funded by industry and then published in an open-access, non-peer reviewed journal may not demonstrate efficacy … The efficacy should be clinically relevant and clearly attributable to the app. … The Framework was created and refined to address concerns with safety, efficacy, data privacy and consumer

435. Disposition of Comments Report for Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
     July 08, 2014 - Current evidence is insufficient to address comparative efficacy in pregnant women. … Current evidence is insufficient to address comparative efficacy in pregnant women. … Current evidence is insufficient to address comparative efficacy in pregnant women. … support further interventions studies in an area (antidepressant treatment of depression) in which efficacy … reveals serious reporting bias in antidepressant studies compared to placebo drawing the assumption of efficacy

436. Gastric-Cancers-Supplementary-App-D (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
     January 01, 2023 - "While safety and treatment tolerance are reported in this paper, preliminary efficacy results have … investigators but have been reviewed by the IDSMC to ensure there is not clear evidence of lack of efficacy

437. Disposition of Comments Report for Acute Migraine Treatment in Emergency Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_disposition-comments.pdf
     November 27, 2012 - efficacy of oral agents for acute migraine therapy. … efficacy of parenteral agents is appealing to both patients and clinicians. … know duration of headache prior to treatment as duration of headache does effect abortive medication efficacy … after reading it, I was still not sure what the authors meant in text and graphs that discussed the efficacy … state, “While alternative phenothiazines exist, prochlorperazine is usually preferred due to its efficacy

438. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
     December 31, 2022 - These outcome metrics, termed “protection,” are analogous to the efficacy endpoints used in studies … of vaccine efficacy.16, 17 Here, however, incident infections detected during the followup period in … A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. … Clinical Endpoints for Evaluating Efficacy in COVID-19 Vaccine Trials. … SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy

439. Disposition of Comments for CER 196 The Role of Immunotherapy in the Treatment of Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-196-disposition-comments-immunotherapy-asthma.pdf
     March 23, 2018 - There is no clinical data that suggests that multiple allergen SLIT drops is efficacy in asthma. … It is important to mention the lack of data regarding efficacy of SLIT with multiallergens. ( Nelson … the different types of SLIT, since there is no reference to any direct head to head comparison of efficacy … Seasonal asthma in northern California: allergic causes and efficacy of immunotherapy. … Almost all US clinical trial data supporting efficacy of SLIT is based on the FDA approved SLIT tablets

440. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_disposition-comments.pdf
     March 10, 2010 - effectiveness review advised the researchers to use only randomized controlled trials to determine efficacy … A major problem here and throughout the analysis is the absence of conclusions about efficacy in premenopausal … Although in the report is the statement, "We detected no significant differences (in efficacy of tamoxifen … and the primary outcome of fracture make this trial inadequate for any broad statement about the efficacy … established cancer patients is extensive, well known, and eye opening and is a major impediment to its efficacy