-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-adults-executive-130408.pdf
April 01, 2013 - .14,15 Drug choices
in clinical practice are based on many drug-related factors
such as familiarity, efficacy … Efficacy of nonpharmacologic
preventive treatments was beyond our scope. … What are the efficacy and comparative effectiveness
of pharmacologic treatments for preventing migraine … Analytical framework
KQ = Key Question; SES = socioeconomic status
KQ 1: What are the efficacy and … What are the efficacy and comparative
effectiveness of pharmacological treatments
for preventing
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
January 01, 2012 - ............................................................................ 22
Minimum Clinical Efficacy … The efficacy of a
pharmacologic intervention is often established in placebo-controlled randomized … Minimum clinical efficacy assesses benefit by comparing benefits and harms on a probability
scale … Minimum clinical efficacy can consider relative utilities, but a
limitation includes the inability … A review of
quantitative risk-benefit methodologies for
assessing drug safety and efficacy-report
-
effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - Background: Randomized controlled trials (RCTs) remain the ac-
cepted “gold standard” for determining the efficacy … trial as the “gold standard.”4 Although such a hierarchy
serves us well for answering questions of efficacy … Assessing harms can be particularly problematic in
efficacy trails. … Roles of Different Types of Data in Medical Decision Making
Study Design Advantages
Efficacy trials
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-anxiety-children_0.pdf
October 01, 2018 - They mentioned that they were unaware of some of the facts
reported in the cards, such as efficacy data … having such contextual information accompanying evidence synthesis reports that usually focus
on efficacy … • Health systems find most evidence synthesis reports that focus on efficacy to have
limited utility … usually the focus of the reports):
8
o Information not usually available in reports that focus on efficacy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_644-03-07-2013.pdf
January 01, 2013 - Topic 0545 Behav Health Int for Dementia NSD FINAL SJ
Behavioral Health Interventions for Depression,
Anxiety, and Agitation in persons with Dementia
Nomination Summary Document
…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
December 14, 2017 - the Methods section: “Single-arm
extensions of RCTs were included to
describe long-term changes in efficacy … -20
and their 5-year, single-arm extension
studies,21-23 provided outcomes related
to safety and efficacy … All published studies have demonstrated efficacy and very few
studies go to the lengths performed to … standard of care and the sham
controlled trial were done well and all have suggested
significant efficacy … These data further demonstrate efficacy of BT
within this more severe population.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-disposition-120516.pdf
October 01, 2011 - Yes – pg. 403 of the Goldstein 2010
publication states that all efficacy analyses were
performed on … A fixed-
dose combination of naproxen and esomeprazole
magnesium (VIMOVO™) has comparable
efficacy … Yes – pg. 403 of the Goldstein 2010
publication states that all efficacy analyses were
performed on … The primary efficacy outcome for knee
osteoarthritis was the Huskisson’s VAS and for
psoriasis was … Regarding the primary efficacy variable for
osteoarthritis, treatment with chondroitin sulphate
was
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
June 12, 2013 - studied for at least 12 weeks; these conditions are minimums
consistent with trials used to define efficacy … Acknowledging
this approach, when trials examining efficacy for ameliorating menopausal symptoms but … Minimum trial duration to reasonably assess long-term efficacy of
nonhormonal hot flash therapies. … studied for at
least 12 weeks; these
conditions are
minimums consistent
with trials used to
define efficacy … for
Based on evidence that
efficacy treating
vasomotor symptoms
with these agents is
demonstrable
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
January 01, 2017 - Older, first-generation antipsychotics (FGAs), such as
haloperidol, have proven efficacy but adverse … Clozapine had fewer
discontinuations due to lack of efficacy than risperidone
and quetiapine. … Efficacy, acceptability,
and tolerability of antipsychotics in treatment-resistant
schizophrenia: a … Efficacy of olanzapine in
comparison with clozapine for treatment-resistant schizophrenia:
evidence … Efficacy of
psychological therapy in schizophrenia: conclusions from meta-
analyses.
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1512.pdf
December 01, 2015 - within 0–3 years of potential diffusion (e.g., in
phase III trials or for which some preliminary efficacy … So once there are published papers that
validate the efficacy of this technology—and this information … Treatments are aimed at symptomatic relief, but questions of safety and efficacy
remain. … regimen up to two more times.34
Clinical trials: In April 2015, Chey and colleagues35 reported on efficacy … be moderate, depending on the
number of irritable bowel syndrome patients in the practice and the efficacy
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1406.pdf
June 01, 2014 - within 0–3 years of potential diffusion (e.g., in
phase III trials or for which some preliminary efficacy … that use standardized MSC preparation methods and report longer followup are needed to
determine efficacy … facilities in the United States offer the
Regenexx procedure.21
Diffusion and cost: Although the efficacy … MSC therapy is investigational because of
insufficient evidence or insufficient long-term safety or efficacy … Experts generally
agreed that additional data to confirm efficacy will be required for payer coverage
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-fatigue_executive.pdf
July 01, 2016 - numbers of participants based on appropriate
power calculations for primary outcomes to
determine efficacy … Randomized
clinical trial to evaluate the efficacy and safety of valganciclovir
in a subset of patients … Lack of efficacy in a placebo-controlled
trial. N Engl J Med. 1988;319(26):1692-8. … A randomised,
controlled, triple-blind trial of the efficacy of homeopathic
treatment for chronic fatigue … Efficacy of a multi-component treatment for
people with chronic fatigue syndrome.
-
effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
October 01, 2007 - of follow-up regardless of actual statin use during
follow-up, providing a conservative estimate of efficacy … Observational methods such as we used in this study
may offer an alternative for answering questions of efficacy … However, observational studies
of efficacy must address concerns of bias—especially con-
founding by
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_surveillance.pdf
December 01, 2012 - orthopedic surgery (total hip or knee replacement, hip fracture
surgery), what is the comparative efficacy … Uptodate
19
confirm efficacy outcomes were included as
opposed to less rigorous criteria … placebo (n=102;NA)
11-14 days primary efficacy
outcome was the
incidence of
VTE (lower-extremity … Enoxaparin
During Treatment Period:
Primary efficacy outcome [# of pts
with event/total # (%, … a 7–10-day
treatment
The primary efficacy
endpoint was a
Semuloparin vs.
-
effectivehealthcare.ahrq.gov/products/asthma-immunotherapy/research
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0583-131115.pdf
March 13, 2013 - Cyclosporine, has a narrow therapeutic window between efficacy and
toxicity, thereby requiring monitoring
-
effectivehealthcare.ahrq.gov/sites/default/files/ijzerman_ahrq-webinar-mcda.pdf
January 01, 2011 - and attempted suicide
Other serious adverse events
Response
Remission
No relapse
Efficacy
-
effectivehealthcare.ahrq.gov/sites/default/files/braddock.pdf
January 01, 2011 - three sequences:
• Far left:
What, Why, How, When, Who
• Middle: Sense of Control and Self-‐efficacy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
October 26, 2012 - home/extended
care resident
(clinical indicators
vs. surveillance)
Yes
No
Technical
Efficacy … Societal
Efficacy
Toxigenic
culture
Cell
cytotoxin
assay
Immuno-
assays for … home/extended
care resident
(clinical indicators
vs. surveillance)
Yes
No
Technical
Efficacy … Societal
Efficacy
Toxigenic
culture
Cell
cytotoxin
assay
Immuno-
assays for … Safety and Efficacy Study of VP20621 for Prevention of Recurrent
Clostridium Difficile Infection.
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
October 01, 2015 - Additionally, the drug has been ineffectual in some
patients or has had waning efficacy. … Additionally, the drug has been ineffectual in some patients or has had waning efficacy. … data, as well as long-term efficacy and survival data, to support use of the OCS Lung
system. … Efficacy and
safety of pirfenidone for idiopathic pulmonary
fibrosis. … Efficacy
and safety of nintedanib in idiopathic pulmonary
fibrosis.