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Showing results for "efficacy".

41. Comparative Effectiveness Review No. 262_Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-summary.pdf
    November 01, 2023 - Relatively limited evidence from well-controlled trials does not adequately support the efficacy of … Key Question 1: Efficacy and Comparative Effectiveness for Improving Consumption Outcomes. … prior report, relatively limited evidence from well-controlled trials does not adequately support the efficacy … studies have found that shorter treatment periods may yield misleading conclusions about treatment efficacy … Although medication efficacy does not depend on setting, there may be meaningful differences with regard

42. White Paper: Enhancing Systematic Review Methods by Incorporating Unpublished Drug Trials (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
    December 01, 2024 - This can lead to inflated efficacy estimates and underestimated harms or burdens, as unpublished studies … often document negative efficacy outcomes and/or harms. … Our findings suggest a potential overestimation of paroxetine efficacy in published literature. … Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature … Efficacy and safety of mifepristone in the treatment of male US veterans with posttraumatic stress

43. Diagnosis and Treatment of Clinical Alzheimer's-type Dementia (CATD) (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
    November 02, 2018 - The efficacy of some older nonprescription agents has been evaluated in RCTs and systematic reviews, … KQ 1a: In adults with CATD, does the efficacy of prescription pharmacological interventions versus … KQ 4b: In adults with CATD and BPSD, does the efficacy of prescription pharmacological interventions … Key Questions Subquestions combined efficacy and comparative effectiveness. … Separated out efficacy and comparative effectiveness subquestions.

44. Insomnia Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_executive.pdf
    December 01, 2015 - Further supporting efficacy are differences in mean ISI and PSQI scores. … Four RCTs (n = 220) studied the efficacy of CBT-I in older adults. … Four RCTs (n = 132) studied the efficacy of CBT-I in adults with pain. … One RCT (n = 829) studied the efficacy of ramelteon in older adults. … Most trials assessed efficacy in the general adult population.

45. Kidney-Stone-Prevention Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_executive.pdf
    March 01, 2013 - For questions related to the efficacy of diet therapy, we included RCTs of at least 12 months duration … RCTs addressing efficacy must have reported stone recurrence and/or other clinical outcomes relevant … We explored the feasibility of performing subgroup analyses for treatment efficacy and adverse events … We evaluated the overall strength of RCT evidence regarding the efficacy of diet and pharmacological … Further results indicated no significant difference in efficacy between allopurinol doses of 100 and

46. Assessing Applicability (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability.ppt
    January 01, 2009 - A simple and valid tool distinguished efficacy from effectiveness studies. … First, judge whether or not a study is an effectiveness trial or an efficacy trial. … If efficacy and effectiveness trials are available, they should be compared and contrasted. … A simple and valid tool distinguished efficacy from effectiveness studies. … A simple and valid tool distinguished efficacy from effectiveness studies.

47. Long-Term Drug Therapy and Drug Holidays for Osteoporotic Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
    October 05, 2018 - The identification of factors that predict long-term osteoporosis drug treatment efficacy and harms … Potentially important modifiers of efficacy and/or harms may include patient and drug characteristics … KQ 2: Predictors of long-term treatment efficacy Men and postmenopausal women aged >50 years … For each treatment comparison, strength of evidence will be graded for the efficacy/effect outcomes … of osteoporosis drug treatment holidays on …” Efficacy also was use in several other places to

48. Glaucoma-Treatment Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_surveillance.pdf
    January 01, 2013 - Randomized clinical trial of the efficacy and safety of preservative-free tafluprost and timolol in … : Both preparations showed similar significant efficacy (decrease from 23.1 to 18.9) Safety: AEs: … : Both demonstrated comparably efficacy Safety: No significant differences were seen between the … BPLx12 weeks Mean change in IOP Efficacy: T2345 showed non-inferiority to BPL from day 15. … (IOP reductions) and tolerability Efficacy: 18 eligible trials had 23 comparisons of FC vs.

49. Fourth Symposium on Comparative Effectiveness Research Methods: From Efficacy to Effectiveness | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/cer-methods-4th-symposium/overview

50. #05 DEPRESSION (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Several ongoing, large clinical trials are investigating ketamine’s efficacy for treating MDD, BPD, … Two ongoing clinical trials continue to study scopolamine’s antidepressant efficacy.17 Manufacturer … Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled … Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized

51. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
    October 01, 2011 - We included studies that evaluate the safety, efficacy, or effectiveness of the included medications … We included studies that evaluate the safety, efficacy, or effectiveness of the previously mentioned … many randomized withdrawals due to lack of efficacy. … Nabumetone was similar in efficacy to nonselective NSAIDs in two trials. … A simple and valid tool distinguished efficacy from effectiveness studies.

52. The Role of Immunotherapy and the Management of Asthma: Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy_research-protocol.pdf
    September 14, 2016 - Objectives: The current review focuses on the efficacy and safety of AIT for allergic asthma. … What is the evidence for the efficacy of Sublingual Immunotherapy (SLIT), in tablet and aqueous form … Home The efficacy (KQ1) and safety (KQ2) of subcutaneous immunotherapy (SCIT) administered in the … The 2013 AHRQ JHU EPC report26 on AIT covered few measures of efficacy, effectiveness, and safety of … SCIT efficacy in the clinic or home setting will be evaluated separately, since it may be different

53. #05 DEPRESSION (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - Unfortunately, these therapeutic options have limited and inconsistent efficacy. … Although some studies have reported treatment efficacy in followups conducted up to 18 months after … treatment, other trials failed to show sustained efficacy at later time points.73 Manufacturer and … Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled … Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized

54. Acute Treatments for Episodic Migraine: Surveillance Report 3 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
    August 01, 2022 - Efficacy of onabotulinumtoxinA in migraine. 2020 March 13. PMID: n/a. … Efficacy and safety of cutting therapy in the treatment of migraine. … Lasmiditan efficacy in migraine attacks with mild vs. moderate or severe pain. … The efficacy of dihydroergotamine vs emerging acute migraine medications. … Lasmiditan efficacy in mild versus moderate or severe migraine headaches (1811).

55. Case Study Comparing Bayesian and Frequentist Approaches for Multiple Treatment Comparisons (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research.pdf
    March 01, 2013 - While frequentist and Bayesian analyses produced broadly comparable odds ratios of safety and efficacy … Efficacy and tolerability of fesoterodine in women with overactive bladder. … Efficacy and safety of tolterodine in patients with detrusor instability: a dose-ranging study. … Efficacy and tolerability of fesoterodine in women with overactive bladder. … Efficacy, safety and tolerability of fesoterodine for overactive bladder syndrome.

56. Comparative Effectiveness Review No. 272_Genitourinary Syndrome of Menopause: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
    July 01, 2024 - Evidence does not demonstrate the efficacy of vaginal or systemic testosterone, vaginal oxytocin, oral … Evidence does not demonstrate the efficacy of energy-based therapies (carbon dioxide [CO2] or Erbium-doped … Evidence does not demonstrate efficacy of vaginal or systemic testosterone, vaginal oxytocin, oral raloxifene … Long-term followup for efficacy, tolerability, and safety represents a critical gap needed to guide … Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal

57. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
    April 23, 2019 - The evidence on the efficacy of trials of 3 years or shorter was reviewed in a prior AHRQ review. … Our review did not evaluate and does not include a section on the efficacy of short-term osteoporosis … Discussion Public Commenter #7 (ASBMR) Evidence review of efficacy of short‐term treatment – defined … Limited information about short-term efficacy was included in the introduction to provide context for … Discussion Public Commenter #7 (ASBMR) The discussion around efficacy in osteoporosis and osteopenia

58. Ptsd-Adults-Trauma-Interventions Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
    April 01, 2013 - Scope and Key Questions This review compares the efficacy, effectiveness, and harms of psychological … Throughout the report, we use the terms “efficacy” and “comparative effectiveness.” … By efficacy, we mean the efficacy or effectiveness of an intervention tested against some type of inactive … KQ 1: Efficacy and Comparative Effectiveness of Inter- ventions To Prevent PTSD Efficacy Thirteen studies … Critical incident stress debriefing (CISD): Efficacy in question. NSPB. 2005;3(2):49-70. 38.

59. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label-update_disposition-comments.pdf
    September 01, 2011 - Comparative Effectiveness Research Review Disposition of Comments Report Research Review Title: Efficacy … on a thorough and systematic, even encyclopedic, compilation of information on treatment patterns, efficacy … Efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in the … Efficacy and safety of once-daily extended release quetiapine fumarate (quetiapine XR) as an adjunct … I can't reconcile the fact that this is placed in the "moderate evidence for efficacy" category with

60. Systematic Review on Acute Treatments for Episodic Migraine: Surveillance Report 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-1.pdf
    June 01, 2022 - Lasmiditan efficacy in migraine attacks with mild vs. moderate or severe pain. … Lasmiditan efficacy in migraine attacks with mild vs. moderate or severe pain. … The efficacy of dihydroergotamine vs emerging acute migraine medications. … The efficacy of acupuncture for treating menstrual migraine: a systematic review. … Efficacy of onabotulinumtoxinA in migraine. 2020 March 13. PMID: n/a.