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Showing results for "efficacy".

361. Hi Les, (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
     January 01, 2009 - Trials may have already demonstrated the efficacy of treatment among cases detected by the existing … A long-term RCT of the entire new test-plus-treatment strategy is not needed because the efficacy of … Randomized comparisons are needed to assess the efficacy of converting from BCS to mastectomy in women … RCTs are needed to assess the efficacy of an existing treatment for the extra cases detected by a new … more sensitive test, just as they are needed to assess the efficacy of new treatments.

362. Disposition of Comments for Child Exposure to Trauma: Comparative Effectiveness of Interventions Addressing Maltreatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_disposition-comments.pdf
     April 15, 2013 - Conclusions regarding efficacy are limited by the fact that there are not enough large-scale and methodologically … Regarding the issue of efficacy vs. … effectiveness studies: The vast majority of included studies were efficacy trials, and the Results … We also address the issue of efficacy and effectiveness in the Research Gaps and Future Research Needs … We differentiated efficacy from effectiveness trials based on guidance provided in Gartlehner, 2006

363. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
     November 22, 2011 - Despite the proven efficacy of clopidogrel, not all patients appear to respond to the drug. … Prasugrel and ticagrelor have similar or superior efficacy compared to clopidogrel for preventing major … Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and … Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of … Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel

364. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
     December 20, 2011 - for many clinical conditions; however, little published data exists on the efficacy of hypnosis in … Where one report found evidence to suggest efficacy of a particular treatment, another report deemed … the underlying evidence inadequate to address efficacy and, therefore, was unable to make a recommendation … PTSD concluded that the evidence on specific pharmacological drugs was inadequate to determine efficacy … We feel that the results should not be used to make decisions about efficacy/effectiveness.

365. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/04_dementia_potential_high_impact_june_2012.pdf
     January 01, 2012 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Experts stated that their enthusiasm is predicated on an assumption of efficacy in modifying the rate … without the allele. 33 In completed and ongoing clinical trials investigating intranasal insulin’s efficacy … Several experts stated that the available clinical trial data are not yet robust enough to assume efficacy … Despite this skepticism about efficacy, most experts agreed that if the drug were proven to be effective

366. Mental-Illness-Heart Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
     April 01, 2013 - Quality ratings and efficacy–effectiveness ratings (see below) were completed independently by two … 15 of 35 trials were conducted in the United States, and most studies (n=21) were classified as efficacy … addressed one or more CVD risk factors in patients with SMI, and most studies were skewed toward efficacy … Efficacy and safety of bupropion for smoking cessation and reduction in schizophrenia: systematic review … Efficacy of behavioural interventions in managing atypical antipsychotic weight gain.

367. Venous-Ulcers-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
     January 01, 2014 - premarket evaluation and study protocol evaluation; however, premarketing testing for safety and efficacy … This has clearly impacted the quality of potential efficacy data. … Understanding the efficacy of surgical approaches is complicated by the lack of prospective clinical … Besides the efficacy questions, our review could not answer many of the practical aspects of caring … These experts could create templates for study designs that better demonstrate efficacy.

368. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
     December 22, 2014 - Waning efficacy, safety concerns, and poor risk-to-reward ratio for patients in the United States were … It purportedly has broad efficacy against multiple HCV genotypes and is being evaluated as part of … Interventions used for all-oral HCV treatment have been reported in trials to show high efficacy and … The high efficacy of sofosbuvir and sofosbuvir in combination with daclatasvir observed thus far in … Additional research comparing the safety and efficacy of emerging all-oral treatment regimens would

369. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/04_dementia_potential_high_impact_2012-12-10.pdf
     January 01, 2012 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Experts stated that their enthusiasm is predicated on an assumption of efficacy in modifying AD progression … patients without it. 32 In completed and ongoing clinical trials investigating intranasal insulin’s efficacy … Several experts stated that the available clinical trial data are not yet robust enough to assume efficacy … Despite this skepticism about efficacy, most experts agreed that if the drug were proven to be effective

370. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - be within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … endpoints in late-stage trials, and many novel neuropsychological therapies have shown inconsistent efficacy

371. #06 Developmental Delays ADHD, and Autism (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_autism_potential_high_impact_june_2012.pdf
     January 01, 2012 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … However, the efficacy of these treatments is unpredictable and varies widely, and when they do work

372. Diagnosis and Management of Gout: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_clinician.pdf
     January 01, 2017 - significant differences in overall adverse events ��� Subgroup of 1 RCT 2269 Age and race do not affect the efficacy … Effectiveness of therapy for gout in subpopulations ��The efficacy of pharmacological therapies for gout

373. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … and the lack of long-term data on safety and efficacy. … Several experts noted that the lack of available safety and efficacy data could limit clinician adoption … But most experts who commented were less certain of POEM’s efficacy, because of a lack of randomized … The LINX reflux management system: confirmed safety and efficacy now at 4 years.

374. Alcohol-Misuse Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_executive.pdf
     April 28, 2010 - Very few studies have examined the efficacy of brief interventions for alcohol dependence in a primary … Brief physician advice for problem drinkers: long-term efficacy and benefit-cost analysis. … The Healthy Moms Study: the efficacy of brief alcohol intervention in postpartum women. … Efficacy of physician-delivered brief counseling intervention for binge drinkers. … Alcohol screening and brief intervention in primary care: Absence of evidence for efficacy in people

375. Disposition of Comments for CER 176 Management of Gout (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-management-disposition-160721.pdf
     March 15, 2016 - “lack of evidence for efficacy” vs. … “evidence of no efficacy.”): In general, I think that you could be a little bit crisper with how you … In terms of the evidence for the efficacy of Vitamin C supplementation, a Cochrane review evaluation … Clinical efficacy and safety of successful longterm urate lowering with febuxostat of Allopurinol in … Despite the limited evidence for the efficacy of non-pharmacological interventions that the systematic

376. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd_executive.pdf
     September 01, 2011 - In addition, the report examined the relative efficacy of these interventions in specific patient subgroups … To evaluate the comparative efficacy of different therapies (Key Question 1), we analyzed the subjective … 2, we focused on the following baseline patient characteristics that may have influenced treatment efficacy … However, some uncertainty remains in the true estimates of the efficacy of surgery vs. medical treatment … Implications for Future Research • Longer term followup is necessary to determine the efficacy of laparoscopic

377. Cystic-Fibrosis-Hgh Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
     August 01, 2012 - still considered valid • There are no new significant safety concerns • Evaluation of the safety and efficacy … Up-to-date Up-to-date Duration: 9 pooled RCTs identified a trend toward increased efficacy for … Up-to-date Up-to-date Key Question 7: In patients with CF, how do the efficacy, effectiveness, safety … No new studies Key Question 7: In patients with CF, how do the efficacy, effectiveness, safety … Age: A patient’s age may impact rhGH efficacy, as seen in an analysis with individual patient data

378. Multidisciplinary Postacute Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults Disposition of Comments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_disposition-comments.pdf
     October 07, 2012 - That means conclusions about the efficacy of postacute rehabilitation were formed based on less than … And many payers adopt the stance that the burden of proof is on the field to show efficacy, not shared … between the field and the payer, to support the services that are the “best guess” for efficacy in … : April 2012 26 Commentator & Affiliation Section Comment Response Peer Reviewer #10 General Efficacy … In the absence of firm efficacy data, however, we don’t know whether this means that both programs

379. 8 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
     November 01, 2008 - and executed randomized controlled trials (RCTs) are considered the ―gold standard‖ for evaluating efficacy … Even when harms are appropriately assessed and reported, the applicability of efficacy trials to general … Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence … Selective publication of antidepressant trials and its influence on apparent efficacy. … Does quality of reports of randomised trials affect estimates of intervention efficacy reported in

380. 8 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
     November 01, 2008 - and executed randomized controlled trials (RCTs) are considered the ―gold standard‖ for evaluating efficacy … Even when harms are appropriately assessed and reported, the applicability of efficacy trials to general … Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence … Selective publication of antidepressant trials and its influence on apparent efficacy. … Does quality of reports of randomised trials affect estimates of intervention efficacy reported in