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Total Results: 1,134 records

Showing results for "efficacy".

221. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - numbers of clinical events to reliably determine the efficacy of ticagrelor versus clopidogrel. … Peer Reviewer 2 Methods The authors should consistently report separately efficacy and safety. … One of the 2 studies cited (DISPERSE-2) was not designed to evaluate the efficacy of ticagrelor. … numbers of clinical events to reliably determine the efficacy of ticagrelor versus clopidogrel. … numbers of clinical events to reliably determine the efficacy of ticagrelor versus clopidogrel.

222. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
     January 01, 2006 - In addition, efficacy and safety may vary for individual drugs within a class. … • In one short-term trial, salsalate and aspirin did not differ significantly in efficacy for pain … • No studies evaluated the comparative efficacy of salsalate or aspirin vs. a nonaspirin NSAID. … • No studies compared efficacy of COX-2s other than celecoxib and rofecoxib. … • There is no evidence that the comparative safety or efficacy of specific selective or nonselective

223. PowerPoint Presentation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/krishnan_ahrq-mcda-presentation.pdf
     August 27, 2012 - Impact on patient centered outcomes in efficacy studies 3. … Quality of evidence in efficacy studies 4. Variability in care in real world settings 5.

224. Introduction-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/introduction-user-guide-to-ocer_130129.pdf
     April 26, 2012 - In addition, therapies that demonstrate efficacy in well-controlled experimental settings like randomized … Moreover, efficacy studies designed to optimize internal validity often make tradeoffs with respect … In addition, new drugs and other interventions often lack comparative efficacy data to quantify a therapy … Availability of comparative efficacy data at the time of drug approval in the United States.

225. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
     June 01, 2010 - Existing systematic reviews vary significantly in the use of observational studies for questions of efficacy … CERs expand the scope of a typical systematic review, which focuses 2 on the efficacy or effectiveness … observational studies in a CER for a question of benefit occurs when all RCTs can be classified as efficacy … In Table 2, example 5, a large number of head-to-head efficacy trials were available, but they provided … A simple and valid tool distinguished efficacy from effectiveness studies.

226. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
     June 01, 2010 - Existing systematic reviews vary significantly in the use of observational studies for questions of efficacy … CERs expand the scope of a typical systematic review, which focuses 2 on the efficacy or effectiveness … observational studies in a CER for a question of benefit occurs when all RCTs can be classified as efficacy … In Table 2, example 5, a large number of head-to-head efficacy trials were available, but they provided … A simple and valid tool distinguished efficacy from effectiveness studies.

227. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
     January 01, 2005 - It summarizes the available evidence comparing the efficacy and safety of medical, surgical, and endoscopic … endoscopic treatments with continued (or intensified) use of PPIs are needed to better understand their efficacy … More efficacy and safety data on new endoscopic approaches tested against a sham procedure with adequate

228. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0107_05-19-2009.pdf
     January 01, 2009 - Additionally, there may be some focus on the efficacy of subcutaneous immunotherapy in isolation.

229. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-cough_research-protocol.pdf
     October 22, 2012 - a measurement method could also be clinically useful to practicing clinicians when evaluating the efficacy … of age) and children (<14 years of age), what is the comparative diagnostic accuracy, therapeutic efficacy … , and patient outcome efficacy of instruments used to assess cough? … • Change in clinical practice • Impact on patient and provider decisionmaking Patient outcome efficacy … , and patient outcome efficacy of instruments used to assess cough?

230. Phenylketonuria Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_executive.pdf
     February 01, 2012 - known as Phenoptin) for the treatment of PKU under the stipulation that studies regarding the drug’s efficacy … use of BH4 as an adjuvant therapy in PKU management consists of small, tightly controlled multisite efficacy … Long-term efficacy outcomes beyond 22 weeks and safety outcomes beyond 3 years are currently unavailable … Finally, publicly funded studies to confirm and expand on reported efficacy and effectiveness data are … Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine

231. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Experts wanted to see additional clinical trial data assessing baclofen’s long-term safety and efficacy … Experts commented that available clinical trial data thus far showed inconsistent efficacy, and little-to-no … Experts wanted to see more convincing clinical trial data demonstrating topiramate’s efficacy and optimal … Efficacy of intranasal naloxone as a needleless alternative for treatment of opioid overdose in the

232. Methods Research Report: Creating Efficiencies in the Extraction of Data From Randomized Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-creating-efficiencies-extraction-data.pdf
     August 01, 2021 - Nearly all (n = 70/75, 93.3%) randomized trials were efficacy/superiority trials. … C-6 Sentence Ranking Sentence 4 Efficacy and Safety of Letibotulinum Toxin A for the Treatment of … Efficacy and safety of letibotulinum toxin A for the treatment of dynamic equinus foot deformity in … Efficacy and safety of an over-the-counter 1% colloidal oatmeal cream in the management of mild to … Evaluation of efficacy and safety of Lactobacillus rhamnosus in children aged 4-48 months with atopic

233. Microsoft Word - 3-DKE274__ACEI-ARB-DRI__Comments_Disposition_Table-21_Jan_2011 cyk _2_.docx (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
     October 07, 2011 - adds greatly to the body of evidence considered and also allows “effectiveness” conclusions beyond “efficacy … 28-30: It is inappropriate to postulate that DRIs may have more favorable side effect profiles and efficacy … than ACEIs or ARBs – they may have more side effects and less efficacy. … We agree and have modified this to indicate that their comparative efficacy and side- effects are not … safety profiles [4], and varying degrees of beneficial effects [5] may play a significant role in efficacy

234. Kidney-Stone-Prevention Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-prevention_research-protocol.pdf
     June 15, 2011 - In addition, questions were added to address whether the efficacy of therapies differs according to … baseline biochemical measures and whether the efficacy of therapies as measured by stone outcomes … The rationale for the minimum of 1-year followup for treatment efficacy is that we believe a shorter … considered to address the KQs related to the adverse effects of the various treatments (but not for efficacy … treatments, subgroup analyses that will be performed if feasible include evaluation of treatment efficacy

235. Chicago-Area DEcIDE Center (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/off-label-use-research-priorities_research.pdf
     May 01, 2009 - Food and Drug Administration (FDA) drug approval process requires clinical trials that demonstrate efficacy … of specific drugs.18 DRUGDEX provides an assessment in three important evaluation dimensions: (1) efficacy … (in four categories: “effective,” “evidence favors efficacy,” “evidence is inconclusive,” and “ineffective … Future research to evaluate the efficacy and safety of off-label use should focus on these medications … Post- marketing studies of drug efficacy: why? Am J Med 1985;78:475-80. 8. Adams C, Young A.

236. Future Research Needs for Childhood Obesity Prevention Programs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/child-obesity-future_research.pdf
     March 31, 2010 - Study design: Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: … Study design: Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: … Study design: Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: … Study design: Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: … Study design: Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model:

237. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - within 0–3 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … Experts stated that their enthusiasm is predicated on an assumption of efficacy in insulin’s potential … interventions are effective for some but not all patients and also may have a limited duration of therapeutic efficacy … Experts stated that the available clinical trial data are not yet robust enough to assume efficacy … Health care delivery infrastructure and patient management: Despite skepticism about efficacy, most

238. Depression SSRI Surveillance Assessment_CER 62_Low-1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_surveillance.pdf
     January 01, 2013 - How does efficacy/effectiveness vary among the different monotherapies and combined therapies? … A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone … Efficacy of dose increase among nonresponders to low-dose aripiprazole augmentation in patients with … inadequate response to antidepressant treatment: a randomized, double-blind, placebo- controlled, efficacy … How does efficacy/effectiveness vary among the different monotherapies and combined therapies?

239. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_june_2012.pdf
     January 01, 2012 - within 0–4 years of potential diffusion (e.g., in phase III trials or for which some preliminary efficacy … unsatisfactory trial data thus far are a reflection of poor trial design and not necessarily the efficacy … Depending on DBS treatment efficacy in individuals, DBS might allow some patients to use lower drug … Experts suggested that because of the rapid efficacy of ketamine, this agent may be most useful in … Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled

240. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression_hi_impact.pdf
     October 01, 2014 - III trials for pharmaceuticals or biotechnologies or in phase II or a trial with some preliminary efficacy … Depending on DBS treatment efficacy in individuals, DBS might allow some patients to use lower drug … Thus, MDMA is proposed as a tool for improving the efficacy of psychotherapy sessions in patients with … Government has approved clinical trials assessing the safety and efficacy of MDMA for the treatment … The safety and efficacy of {+/-}3,4- methylenedioxymethamphetamine-assisted psychotherapy in subjects