Results

Total Results: 1,134 records

Showing results for "efficacy".

161. Appendix-Table-B-1-Observational-Studies (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendix-table-B-1-observational-studies.xlsx
     March 20, 2021 - 2021 SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy … 129 or 3.8% asympomatic*) *only 8 reinfections had documented symptom severity 42,915 3,185 146,738 Efficacy … (23) 3 Any (% asymptomatic NR) 525,339 11,068 514,271 72 (% asymptomatic NR) 10,996 16,819 497,452 Efficacy … residents, weekly for staff) 3 Any (% asymptomatic NR) 161 88 73 0 (% asymptomatic NR) 44 15 25 Efficacy … PCR+) 0 Any (44/498 or 8.8% asymptomatic) 1,494 498 996 5 (1/5 or 20% asymptomatic) 493 154 842 Efficacy

162. Systematic Review on Opioid Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
     April 01, 2022 - Model-based Meta-analysis to Compare Primary Efficacy-endpoint, Efficacy-time Course, Safety, and Tolerability … Efficacy of tapentadol prolonged release for pre- and post-operative low back pain: a prospective … Comparative Efficacy of Therapeutics for Chronic Cancer Pain: A Bayesian Network Meta-Analysis. … Safety and efficacy of the unique opioid buprenorphine for the treatment of chronic pain. … Efficacy and safety of morphine hydrochloride in cancer patients with chronic pain.

163. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-intro.ppt
     June 01, 2012 - Study Objective Terms Used Examples Test conforming to technical specifications • Technical efficacy … curve Test directing clinical management and improving patient outcomes • Diagnostic thinking efficacy … • Therapeutic efficacy • Patient outcome efficacy • Clinical utility • Impact on mortality or morbidity … The efficacy of diagnostic imaging. Med Decis Making 1991 Apr-Jun;11(2):88-94. … The efficacy of diagnostic imaging. Med Decis Making 1991 Apr-Jun;11(2):88-94. PMID: 1907710.

164. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-intro.ppt
     June 01, 2012 - Study Objective Terms Used Examples Test conforming to technical specifications • Technical efficacy … curve Test directing clinical management and improving patient outcomes • Diagnostic thinking efficacy … • Therapeutic efficacy • Patient outcome efficacy • Clinical utility • Impact on mortality or morbidity … The efficacy of diagnostic imaging. Med Decis Making 1991 Apr-Jun;11(2):88-94. … The efficacy of diagnostic imaging. Med Decis Making 1991 Apr-Jun;11(2):88-94. PMID: 1907710.

165. Comparative Effectiveness of Second Generation Antidepressants in the Pharmacologic Treatment of Adult Depression—An Update to a 2007 Report. (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_disposition-comments.pdf
     December 01, 2011 - there are no substantial differences between second generation antidepressant medications for either efficacy … Peer Reviewer #5 Methods Pg 33, line 19-20 “Outcomes for efficacy or effectiveness,…” Comment: remove … “efficacy or” We have changed the wording. … #5 Results KQ1 Page 87 or page 72, line 42-43 Two studies provide mixed evidence about the general efficacy … The Trivedi study is a pooled analysis, and was therefore ineligible for the efficacy section of this

166. Disposition of Comments Report for CER 134 Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_disposition-comments.pdf
     May 13, 2014 - In some ways this is more like effectiveness evaluation rather than efficacy evaluation. … The report has clear clinical implications because it provides a detailed summary of the efficacy of … Consequently, we would like to comment on, and make note of the following: • Efficacy with respect … Our review was more focused on efficacy. … Evidence about efficacy, comparative effectiveness, and harms is important information.

167. The series of articles beginning with this issue of the Journal form the most up-to-date version of the Guide for Conducting Comparative Effectiveness Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-principles_methods.pdf
     August 01, 2009 - Efficacy trials (explanatory trials) determine whether an intervention produces the expected result … stringent eligibility criteria, assess health outcomes, and have longer followup periods than most efficacy … Characteristics of efficacy trials that limit the applicability of their results include: • Homogeneous … • Short-term head-to-head trials that use surrogate (efficacy) measures. … Challenges in systematic reviews that evaluate drug efficacy or effectiveness [review].

168. Disposition of Comments Report for Recurrent Nephrolithiasis in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
     July 26, 2012 - The authors chose clinical outcomes as the most important when evaluating efficacy of treatments. … There is no clearly agreed upon end point for evaluating the efficacy of stone prevention; however … The authors chose clinical outcomes as the most important when evaluating efficacy of treatments. … There is no clearly agreed upon end point for evaluating the efficacy of stone prevention; however … A priori, we judged stone growth to be a secondary efficacy outcome measure, and one that deserves

169. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
     September 01, 2014 - While statin plus ezetimibe has not proven superior efficacy, this is not representative of all other … The relative efficacy and dose ranges for individual statin drugs is shown in Table 4 of the report … The report does not clearly differentiate between pharmacodynamic efficacy and potency. … Problems with adherence must be considered both a safety and efficacy issue in my view. … If high drop-out rates due to the drug, efficacy will by necessity by more limited.

170. Ch 1-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_1-user-guide-to-ocer_130129.pdf
     August 13, 2012 - Specifically, investigators should summarize in the protocol what is known about the efficacy, effectiveness … The evidence generated in each phase is reviewed to make interim decisions about the safety and efficacy … If the FDA approves, human testing for safety and efficacy can begin. … Unlike efficacy trials, in which clinical endpoints and surrogate measures are frequently used to determine … efficacy, effectiveness may need to be determined based on several measures, many of which are not

171. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
     October 01, 2010 - I think it is necessary here (and probably elsewhere, as in the discussion about efficacy of catheter … The data for safety and efficacy in the future will depend on what kinds of labs are doing the majority … Long-term single procedure efficacy of catheter ablation of atrial fibrillation. … Efficacy, safety, and outcome of atrial fibrillation ablation in septuagenarians. … Long-term clinical efficacy and risk of catheter ablation for atrial fibrillation in the elderly.

172. Management of Insomnia Disorder in Adults: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_clinician.pdf
     August 01, 2017 - The systematic review assessed the efficacy, comparative effectiveness, and adverse effects of a broad … outcomes, primarily in older patients (low to moderate SOE). �� Evidence regarding the long-term efficacy … Evidence regarding their longer-term efficacy and safety is limited or lacking. �� Outcome reporting … a large placebo response was observed in some studies. �� Evidence was insufficient to assess the efficacy

173. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia_executive.pdf
     May 01, 2006 - What are the comparative efficacy and safety of epoetin (alfa or beta) and darbepoetin? 2. … How do alternative dosing strategies affect the comparative efficacy and safety of epoetin and darbepoetin … initiating treatment or alternative criteria for discontinuing therapy or duration of therapy affect the efficacy … Conclusions Comparative efficacy and safety of epoetin and darbepoetin Three sets of trials were summarized

174. Future Research Needs for Hematopoietic Stem-Cell Transplantation in the Pediatric Population (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children-future_research.pdf
     February 01, 2012 - To determine the efficacy and toxicity of these regimens in these patients. … Safety/Efficacy Study 25 6/2009- 6/2014 United States FU: 2 years 2 cycles of HDCT/SCT 2 … Safety/Efficacy Study 30 7/2006 – 2/2017 United States FU: 15 years Radiotherapy followed … Safety/Efficacy Study 40 (16 to 60 years) 8/2005 – 8/2013 United States FU: 5 years AHSCT … Safety/Efficacy Study 50 (up to 60 years) 4/2001 – 4/2011 United States FU: 5 years Immune

175. Future Research Needs for Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), or Direct Renin Inhibitors (DRIs) for Treating Hypertension (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-future_research.pdf
     March 01, 2012 - Retrospective analysis of real-world efficacy of angiotensin receptor blockers versus other classes … Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: a meta-analysis. … Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in … Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in … Retrospective analysis of real-world efficacy of angiotensin receptor blockers versus other classes

176. Topic 0613 Tympanostomy Tubes NSD FINAL (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0765-150129.pdf
     November 03, 2014 - However, the appropriateness and efficacy of tympanostomy tube surgery has been questioned due to limited … There are also concerns regarding the efficacy of tympanostomy tubes for recurrent AOM; the nominator

177. Disposition of Comments for CER 161 Major Depressive Disorder (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/major-depressive-disorder-disposition-160504.pdf
     December 08, 2015 - However, a Cochrane review of SJW vs placebo clearly demonstrates SJW efficacy. … If the latter, this may temper the findings on acupuncture efficacy. … However, our focus in this review is on comparative efficacy and harms. … General efficacy and harms are beyond the scope of this review. … The comment is about efficacy, not comparative efficacy (ie. when research has demonstrated efficacy

178. Hypertension-Pulmonary-Arterial Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
     April 01, 2013 - and therapeutic efficacy (clinician judgment about diagnosis or prognosis or choice of treatment) … • We found no studies addressing diagnostic thinking efficacy, therapeutic efficacy, or harms (insufficient … – Improved data on efficacy of early PAH treatment would strengthen linkage to data on efficacy of … • Data on the efficacy of combination treatments are limited. … • The duration of controlled trial efficacy data are limited.

179. Treatment of Osteoarthritis of the Knee: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-update_research-protocol.pdf
     June 15, 2016 - As a result of the divergent findings of several recent systematic reviews on the efficacy and safety … Efficacy and effectiveness must be established before examining comparative effectiveness questions … We will limit included studies for assessment of efficacy to randomized controlled trials, with the … (or unclear evidence of efficacy) will be excluded. … Relative efficacy of knee osteoarthritis treatments: are all placebos created equal?

180. Dietary-Supplements Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_surveillance.pdf
     January 01, 2013 - Clinical cardiovascular effectiveness/ efficacy outcomes (e.g., mortality and specific cardiovascular … Vitamin E An efficacy trial of vitamin E plus aspirin versus aspirin alone in patients with previous … No evidence on outcomes of clinical efficacy/effectiveness was found for Echinacea, garlic, ginger, … Intermediate cardiovascular efficacy outcomes of cardiovascular drug(s) plus supplement versus drug(s … Vascepa decreased triglycerides, non-HDL, LDL, CRP more in those on higher-efficacy statins that