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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - NPP_Pain
Table F-1a. Pain severity for neuropathic pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 Drug 2 Measure Name Measure Scale Assessment Time (Wk) Time Category Grp 1 Baseline N Grp 1 Baseline Mean Pain Score Grp1 Baseline Variance Type Grp1 Baseline Variance Grp1 Baseline Lower Limi…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - NPP_Pain
Table F-1a. Pain severity for neuropathic pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 Drug 2 Measure Name Measure Scale Assessment Time (Wk) Time Category Grp 1 Baseline N Grp 1 Baseline Mean Pain Score Grp1 Baseline Variance Type Grp1 Baseline Variance Grp1 Baseline Lower Limi…
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effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
October 01, 2007 - Key Words: cohort studies, propensity scores, observational
research
(Med Care 2007;45: S143–S148)
Drugs … Statins inhibit endogenous cholesterol synthesis, and ther-
apy with these drugs improves lipoprotein … including
ambulatory care, approved specialists and outside referrals,
laboratory work, and prescription drugs
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - NPP_Pain
Table F-1a. Pain severity for neuropathic pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 Drug 2 Measure Name Measure Scale Assessment Time (Wk) Time Category Grp 1 Baseline N Grp 1 Baseline Mean Pain Score Grp1 Baseline Variance Type Grp1 Baseline Variance Grp1 Baseline Lower Limi…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
June 01, 2018 - have been diagnosed
with delirium using a validated instrument
• Interventions:
o Antipsychotic drugs … , risperidone, ziprasidone)
o We will only include studies where the effects of the antipsychotic drugs … quetiapine,
risperidone, ziprasidone)
• We will exclude studies where the
effects of the antipsychotic drugs
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-protocol-acute-pain-treatments.pdf
August 08, 2019 - therapy versus: 1) nonopioid
pharmacologic therapy (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs … effectiveness of nonopioid pharmacologic therapy (e.g.,
acetaminophen, nonsteroidal anti-inflammatory drugs … nonopioid pharmacological
therapy used for acute pain (acetaminophen, nonsteroidal anti-inflammatory
drugs … Opioid analgesics—risky drugs, not risky patients. … A systematic review and meta-analysis comparing the efficacy of
nonsteroidal anti-inflammatory drugs
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-end-of-life-quality-meaures_research.pdf
April 01, 2010 - New chemotherapy regimen was defined only for the
retrospective cohort using Medicare J-codes for drugs … used by Earle.8 Additional J-codes for
chemotherapy were identified for chemotherapy drugs that had … • PACE/ PAAD NDC codes for drugs listed in
Appendix 2. … • PACE/ PAAD NDC codes for drugs listed in
Appendix 2. … • PACE/ PAAD NDC codes for drugs listed in
Appendix 2.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/multiple-sclerosis_executive.pdf
April 01, 2015 - The overview and network analysis were too recent to
include the newest approved drugs, such as fingolimod … to
correlate with the frequency and severity of side effects.7
The injectable treatments, the IFN drugs … There are no class A drugs (drugs safe
for use during pregnancy according to the FDA) for MS. … one that is more effective or more tolerable, and
studies have found high rates of switching between drugs … Newly approved drugs, such as fingolimod, and drugs
in the development pipeline are emphasizing oral
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_disposition-comments.pdf
July 17, 2013 - This has been corrected in the “Description of
Included Studies” for this comparison, in Table 10 (Drugs … in pregnancy at least for orally inhaled
cromolyn
Sentence revised to list Pregnancy Category B drugs … :
“Preferred treatments are Pregnancy Category B drugs
(nasal cromolyn, budesonide, and ipratropium … before an intranasal
corticosteroid or an intranasal antihistamine to increase
delivery of these drugs … before an intranasal
corticosteroid or an intranasal antihistamine to increase
delivery of these drugs
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/disposition-of-comments-cer-192-anxiety-in-children.pdf
August 31, 2017 - 2017
Commentator &
Affiliation
Section Comment Response
TEP 2
Methods p. 15 CBT vs Drugs … Results Page 25, key points: the authors might
clarify that both of the RCTs comparing
CBT to drugs … At a
minimum, it would be helpful to indicate
what class of drugs each comparison
comes from (e.g. … For example, in
the section “CBT combined with drugs”
and subsection “Sertraline vs. … Of
note, the original Walkup et al. 2008
study is cited in other comparisons of
interest (drugs versus
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
July 08, 2014 - #10
ES 5 (p. 13) Interventions Reword 2nd sentence to avoid using double
“nots”
Changed to: “Drugs … risk
of neonatal withdrawal symptoms or pulmonary hypertension with
maternal use of antidepressant drugs … to improve some symptoms based on
evidence in nonpregnant patients, it is possible that individual drugs … to improve some symptoms based on
evidence in nonpregnant patients, it is possible that individual drugs … to improve some symptoms based on
evidence in nonpregnant patients, it is possible that individual drugs
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/abnormal-uterine-bleeding_research-protocol.pdf
November 21, 2011 - progestogens, combination (estrogen and progestogen)
hormonal formulations, nonsteroidal anti-inflammatory drugs … longer commonly prescribed for related indications (e.g., the synthetic androgen–
Danazol) nor for drugs … Interventions
1
: Medical therapies
o Nonsteroidal anti-inflammatory drugs
o Antifibrinolytics … compounds that are no longer commonly prescribed, such as the
synthetic androgen Danazol, as well as drugs … Interventions for Abnormal Uterine Bleeding
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Ibuprofen
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children_research-protocol.pdf
June 04, 2010 - We were asked to study the use of these drugs for the following conditions: 1) pervasive
developmental … Intervention drugs of interest
The intervention drug must be an FDA-approved first or second generation … These drugs include: aripiprazole, asenapine, clozapine, iloperidone, olanzapine,
paliperidone, quetiapine … Comparison drugs of interest
http://www.effectivehealthcare.ahrq.gov/�
Source: www.effectivehealthcare.ahrq.gov … co-morbidities, use of concurrent standard medical therapies),
details of the intervention and comparator (drugs
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
February 17, 2016 - history of abnormal surgical bleeding or bleeding
disorder, prior medications (including antiplatelet drugs … of abnormal surgical bleeding or bleeding disorder
o Prior medications (especially antiplatelet drugs … surgical
bleeding
History of bleeding disorder
Prior medications (especially
antiplatelet drugs … Available drugs are anticoagulants that lower the likelihood
that blood clots.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label_executive.pdf
January 01, 2007 - These drugs have been studied for
off-label use in the following conditions:
dementia and severe geriatric … How do
atypical antipsychotic medications
compare with other drugs for treating off-
label indications … Effectiveness and comparison with other drugs
Dementia-agitation and behavioral disorders
A recent … Both
drugs were associated with an increase in EPS
(OR: 2.53 and 2.82, respectively) compared to
placebo
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
July 13, 2011 - These
drugs work, at least in part, through their effects on neurotransmitters such as serotonin,
norepinephrine … somatization), KQ4 focuses on safety issues (adverse effects, adherence) with each of
the different study drugs … or combinations of study drugs.
-
effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Coordinating Council for Comparative Effectiveness Research, AHRQ is interested in innovations
in drugs … health care sector, horizon
scanning pertains to identification of new (and new uses of existing) pharmaceuticals … For purposes of horizon scanning, AHRQ’s interests are broad and encompass drugs,
devices, procedures … Information is compiled for expert comment on topics at a granular
level (i.e., similar drugs in the … Results
The table below lists the two topics for which (1) preliminary phase III data for drugs or
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/autoimmune-disease-rapid-research.pdf
November 01, 2024 - studies had patients who were on either conventional or biologic
disease-modifying anti-rheumatic drugs … A class of
therapeutic agents called DMARDs (disease-modifying anti-rheumatic drugs) has been in use … yr
12.2%
Abbreviations: csDMARDs: conventional synthetic disease-modifying anti-rheumatic drugs … ; DMARDs: disease-modifying anti-rheumatic drugs; mo: month; NR: not reported;
NSAIDs: nonsteroidal … Mechanisms of Action of Disease
Modifying Antirheumatic Drugs. J
Rheumatol Suppl 1992, 32, 100–103
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effectivehealthcare.ahrq.gov/sites/default/files/diverticulitis-nomination-extra.pdf
May 29, 2025 - Management of Acute Diverticulitis Additional Information for Topic Nomination
Table 1. Key Questions and PICOTS
KQ1: Antibiotics KQ1: Antibiotics vs.
No Antibiotics
KQ2: Diagnostic
imaging
KQ3: Follow-up
colonoscopy
KQ4: Surgical and
interventional
management
KQ5: Prevention of
recurrence
Populat…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0583-131115.pdf
March 13, 2013 - A systematic review will outline the most effective choices among new
drugs and monitoring strategies