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Showing results for "drugs".

201. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1306.pdf
     January 01, 2016 - San Diego (CA): Amylin Pharmaceuticals, Inc.; 2010 Jun 15 [accessed 2011 Feb 22]. [3 p]. … Amylin Pharmaceuticals. … San Diego (CA): Amylin Pharmaceuticals, Inc.; 2012 Jan 27 [accessed 2012 Feb 20]. [4 p]. … San Diego (CA): Amylin Pharmaceuticals, Inc.; 2012 Jan 27. 11 p. … Get drugs straight to the eye. [internet].

202. Treatment for Restless Legs Syndrome Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_disposition-comments.pdf
     November 27, 2012 - Peer Reviewer #1 Introduction The gabapentin- pregabalin group of drugs is called “GABA analogs”. … This complication can occur in 9- 17% of RLS patients using these drugs. … First, FDA approved drugs include rotigotine (probably approved after submission) and gabapentin enacarbil … was not identified as a therapy commonly used and we identified no eligible studies examining these drugs … Since most of the report does not actually compare drugs, why can these not be included?

203. Newer Medications for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostatic-hyperplasia-medications_research-protocol.pdf
     April 21, 2015 - Prescribing behavior has changed with the approval of new drugs and the availability of new evidence … for efficacy, comparative effectiveness, and harms.6 Table 1 provides a list of drugs commonly used … and enlarged prostates with either agent are supported by systematic reviews.10, 13 Recently, newer drugs … A new AB, silodosin, was approved for the treatment of BPH in 2008.7 Several anticholinergics drugs … symptoms such as urgency, frequency, and nocturia, which may or may not be causally related.15 These drugs

204. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
     January 01, 2009 - Background—In drug development, a four-phase hierarchical model for the clinical evaluation of new pharmaceuticals … Analogous to the four-phase model for the evaluation of new drugs, these models require that certain … Why have the phases in the clinical evaluation of drugs become so well engrained in our thinking, and … The four phases in the development of drugs and devices have shown their merit. … Trials in humans take place only after drugs have been tested thoroughly in the laboratory in animal

205. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-tests-proposals_research.pdf
     January 01, 2009 - Background—In drug development, a four-phase hierarchical model for the clinical evaluation of new pharmaceuticals … Analogous to the four-phase model for the evaluation of new drugs, these models require that certain … Why have the phases in the clinical evaluation of drugs become so well engrained in our thinking, and … The four phases in the development of drugs and devices have shown their merit. … Trials in humans take place only after drugs have been tested thoroughly in the laboratory in animal

206. ADHD Medications and Risk of Serious Coronary Heart Disease in Yough and Middle-Aged Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-heart-disease-children_research.pdf
     January 01, 2023 - The study drugs included all medications with a label indication for treatment of ADHD as of December … Study Medications ADHD medications and other drugs of interest were identified from pharmacy records … person-day of follow-up for cohort members was classified according to probable use of study ADHD drugs … ADHD drugs and cardiovascular risk. N Engl J Med 2006 Apr 6;354(14):1445-8. 6. … Atypical antipsychotic drugs and the risk of sudden cardiac death.

207. Disposition of Comments for CER 178 Newer Medications for Lower Urinary Tract Symptoms (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/prostatic-hyperplasia-medications_disposition-comments.pdf
     May 26, 2016 - Included trials did not report the impact of the combination of these drugs on blood pressure and we … We revised the sentence to clarify: “Recently, newer drugs and drug in other classes approved for … All drugs are FDA-approved and therefore likely to have trials published in English. … We included drugs ‘newly used’ to treat LUTS attributable to BPH. … Drugs with insufficient evidence were added to the anticholinergics paragraph.

208. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1306.pdf
     October 01, 2014 - In the health care sector, horizon scanning pertains to identifying new (and new uses of existing) pharmaceuticals … Information is compiled for expert comment on topics at a granular level (i.e., similar drugs in the … after administration.35 Manufacturer and regulatory status: The drug was launched in 1966 by King Pharmaceuticals … Drugs Future. 2009;34(3):217-21. 31. Research suggests new drug targets for depression. … In: Drugs@FDA [internet]. Silver Spring (MD): U.S.

209. Restless-Legs Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_executive.pdf
     November 01, 2012 - Pharmacologic interventions included drugs approved for use (for any condition) in the United States … Pharmacologic interventions were limited to drugs approved for use (for any condition) in the United … We assessed statistical heterogeneity between trials and for subgroups of drugs using the I2 test and … The drugs did not differ with regard to any study withdrawals. … Augmentation, a drug-induced exacerbation of the disease, can occur with dopaminergic drugs.

210. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
     May 01, 2012 - All dispensings of the two drugs were identified, and subjects who received glimepiride who did not … In this example, we assume that there are nine individual drugs of interest, six traditional NSAIDs … Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. … COX-2 selective non-steroidal anti- inflammatory drugs and risk of serious coronary heart disease. … Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.

211. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/01_-arthritis_potential_high_impact_june_2012.pdf
     January 01, 2012 - Coordinating Council for Comparative Effectiveness Research, AHRQ is interested in innovations in drugs … In the health care sector, horizon scanning pertains to identifying new (and new uses of existing) pharmaceuticals … For purposes of horizon scanning, AHRQ’s interests are broad and encompass drugs, devices, procedures … Information is compiled for expert comment on topics at a granular level (i.e., similar drugs in the … Tofacitinib (CP-690,550) in combination with traditional disease-modifying anti- rheumatic drugs:

212. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
     January 01, 2013 - Example: When comparing the adverse metabolic effects of antipsychotic drugs, body mass index is a potential … study assessing the risk of cancer in statin users, an active comparator group of patients on glaucoma drugs … Although device or drug registries may provide detailed data on the use of drugs, biologics, and devices … Different Treatment Modalities (1 of 3) Confounding by Indication or Severity For some conditions, drugs … Adherence to Drugs and Device Failure or Removal Patients who are on medications could have various degrees

213. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
     October 01, 2006 - comparing angioplasty with stent placement and “aggressive” medical treatment with currently available drugs … after revascularization do occur in a small percentage of patients, and each of the antihypertensive drugs … blood pressure generally decreased by 20-50/8-42 mm Hg with combinations of multiple antihypertensive drugs … eligibility criteria reported analyses of whether other periprocedural interventions, such as different drugs … eligibility criteria reported analyses of whether other periprocedural interventions, such as different drugs

214. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
     September 01, 2014 - In fact, after reading the Introduction and all of the difficulties in evaluating these alternate drugs … In some ways there is more harm in adding these drugs as compared to raising the dose of the statins … The relative efficacy and dose ranges for individual statin drugs is shown in Table 4 of the report … Finally, as the report notes there is little to no evidence that adding these alternative drugs to … Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.

215. Finding Evidence for Comparing Medical Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-finding-evidence_methods.pdf
     January 01, 2011 - These approval documents—which can be found at Drugs@FDA.gov—may help identify publication bias even … Ottawa: Canadian Agency for Drugs and Technologies in Health; 2008. 46. … Ottawa: Canadian Agency for Drugs and Technologies in Health. … an pharmaceuticals, more non-U.S. coverage than MEDLINE Avenell, 2001 Minozzi, 2000 Sampson, … and pharmaceuticals Fishman, 1996 Wolfe, 2002 MANTIS (Manual Alternative and Natural Therapy Index

216. Executive Summary_Comparative Effectiveness Review No. 263: Management of Postpartum Hypertensive Disorders of Pregnancy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-263-postpartum-hypertensive-pregnancy-executive-summary.pdf
     May 01, 2023 - Two RCTs specifically evaluated end-organ protective effects of two antihypertensive drugs in patients … Because the studies evaluated a large variety of specific drugs and evaluated disparate outcomes, we … evidence related to maternal morbidity and mortality (among two small studies that evaluated different drugs … Trials are needed for the numerous antihypertensive drugs commonly used in practice to allow better

217. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
     January 01, 2006 - Common oral medications for osteoarthritis include nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen … Food and Drug Administration (FDA) as pharmaceuticals, including glucosamine and chondroitin, as well … In addition, efficacy and safety may vary for individual drugs within a class. … For this report, we defined the terms “selective NSAIDs” or “COX-2 selective NSAIDs” as drugs in the … We defined “partially selective NSAIDs” as other drugs shown to have partial in vitro COX-2 selectivity

218. Drug Safety | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/drug-safety

219. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - health care sector, horizon scanning pertains to identification of new (and new uses of existing) pharmaceuticals … For purposes of horizon scanning, AHRQ’s interests are broad and encompass drugs, devices, procedures … Information is compiled for expert comment on topics at a granular level (i.e., similar drugs in the … drug in some state Medicare drug plan formularies, which is the highest pricing tier for specialty pharmaceuticals … San Diego (CA): Amylin Pharmaceuticals, Inc.; 2012 Jan 27 [accessed 2014 Apr 10]. [5 p].

220. Ced-Topic-Refinement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-topic-refinement.pdf
     November 01, 2022 - Medicare beneficiaries.1 Thus, CMS makes decisions about providing insurance coverage for use of these drugs … For studies that involve researching the safety and effectiveness of new drugs and biological products … For studies that involve researching the safety and effectiveness of new drugs and biological products … there may not be the extensive clinical trial record that is generated during regulatory approval of pharmaceuticals … Specification for Cancer Drugs Fund data collection arrangements.