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Showing results for "drug".

581. Ch 4-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_4-user-guide-to-ocer_130129.pdf
     January 01, 2010 - In clinical trials of medications, drug levels may be monitored, pill counts may be performed, and … ascertainment is often based on medication dispensing records, and only under rare exceptions will drug … pharmacodynamics (the effects of medication on the body), and the pharmacokinetics (the process of drug … Pharmacoepidemiol Drug Saf. 2002;11:663-9. 12. Suissa S. … Immeasureable time bias in observational studies of drug effects on mortality.

582. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
     January 01, 2006 - Food and Drug Administration (FDA) as pharmaceuticals, including glucosamine and chondroitin, as well … treatment, and what is the evidence that alternative dosage strategies, such as intermittent dosing and drug … dosing strategies (such as alternate day dosing, once daily versus twice daily dosing, or periodic drug … with osteoarthritis of the knee, with topical diclofenac (often with dimethyl sulphoxide [DMSO], a drug … • The effects of alternative dosing strategies such as intermittent dosing or drug holidays have not

583. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/menopause_research-protocol.pdf
     March 25, 2012 - Food and Drug Administration (FDA) in 1942 for treating menopausal symptoms, by 1947 the Physician’s … Food Drug Law J 2008;63(2):459-91. PMID: 18561473. 22. Patsner B. … “therapy” [Subheading] OR “Therapeutics”[Mesh] OR “Estrogen Replacement Therapy”[Mesh] OR “Drug Therapy … effects” [Subheading]) OR “Drug Toxicity”[Mesh] AND (“Ovarian Neoplasms”[Mesh] OR “Breast Neoplasms … ”[Mesh] OR “Endometrial Neoplasms/drug therapy”[Mesh] OR “Endometrial Neoplasms/therapy”[Mesh])

584. Reduction in Medication Use after Bariatric Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bariatric-surgery_research.pdf
     June 01, 2010 - codes, International Classification of Disease-9 Clinical Modification (ICD-9-CM) codes, National Drug … We tabulated the number of unique therapeutic classes of drug that the patient had ―on hand‖ at the … We knew the date that each prescription was filled and the number of days of drug supplied. … If this supply would result in the patient having sufficient drug ―on hand‖ to overlap with a seven … For medication categories with only one drug (e.g., levothyroxine), these are equivalent.

585. Disposition of Comments Report for Treatment for Hepatitis C Virus Infection in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
     November 27, 2012 - However, it only included cohort studies for Question 4 on harms or drug safety. … contrast to Telaprevir’s association with dermatological adverse events, which are unique to this drug … We have have made distinctions in our report regarding the adverse events for each drug. … : "HCV is primarily acquired by large or repeated percutaneous exposures to blood, with injection drug … dosage information does not specify a particular pegylated interferon (alfa-2a or -2b) for either drug

586. Disposition of Comments for Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
     November 24, 2014 - Peer Reviewer #2 Introduction Page 3, line 55 – discussing the increasing incidence of multi drug … Studies that evaluated therapeutic drug monitoring after the availability of measured drug concentration … In this review, we have evaluated the effect of therapeutic drug monitoring and adjustments downstream … As nosocomial pneumonia is associated with a wider spectrum of pathogens, a greater degree of drug … Again, readers of such a review are likely looking for guidance on dosing antibiotics for multi- drug

587. Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin - Executive Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-199-skin-cancer.pdf
     December 01, 2017 - Lack of histologic clearance A,B C D E F H A,B: surgery/MMS C: heat/cold D: radiation E: PDT F: drug … = photodynamic therapy A,B C D E F I,J A,B: surgery/MMS C: heat/cold D: radiation E: PDT F: drug … surgery; PDT = photodynamic therapy C E F I,J A,B: surgery/MMS C: heat/cold D: radiation E: PDT F: drug … of SCC lesions (A) Recurrence C E F I,J A,B: surgery/MMS C: heat/cold D: radiation E: PDT F: drug … For SCCIS, only 4 RCTs (348 lesions) compared 4 types of interventions, namely a drug (imiquimod),

588. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
     January 01, 2013 - The direction of the confounding by asthma severity would tend to make the drug look bad (as if it is … Pharmacoepidemiol Drug Saf 2007 Aug;16(8):850-3. … general population or a population-based approach is preferred, but selected populations such as a drug … Paradoxical relations of drug treatment with mortality in older persons. … A meta-analysis of the association between adherence to drug therapy and mortality.

589. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb_surveillance.pdf
     July 06, 2015 - Food and Drug Administration (FDA), Health Canada, and Medicines and Healthcare Products Regulatory … facie evidence that a conclusion was out of date, such as the withdrawal of a drug … clearly renders conclusions from the original report out of date, such as the addition or removal of a drug … Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies … disease; RR=relative risk; CAD=coronary artery disease; ESRD=end-stage renal disease; FDA=food and drug

590. DEcIDE 34 - Developing a Registry of Patient Registries: Options for the Agency for Healthcare Research and Quality (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/registry-of-patient-registries-development_research_0.pdf
     February 01, 2012 - All efficacy drug trials conducted under Investigational New Drug applications for “serious or life-threatening … The trials are being conducted in all 50 states in the U.S. and in 167 countries.3 The Food and Drug … Food and Drug Administration Modernization Act of 1997, Public Law No. 105-115, 1997. 3. … Food and Drug Administration Amendments Act of 2007, Public Law 110-85. … Food and Drug Administration. U.S. Department of Health and Human Services. March 2002.

591. An analytical framework for quantifying components of variability in prescriber decisions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
     April 01, 2010 - We anticipate that IV methods will be often underpowered for drug safety studies of very rare outcomes … The new drug is added to the formulary in some hospitals; however, because of cost and concerns about … Variation in formularies, hospital capacity, and prescription drug benefit plan structure can also … Pharmacoepidemiol Drug Saf 2009;18:932-940. 37. Korn EL, Baumrind S. … Drug copayment and adherence in chronic heart failure: effect on cost and outcomes.

592. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - However, clopidogrel metabolism is also influenced by drug-drug interactions such as PPIs, calcium channel … While concluding their argument, the authors ignored many important things including the role of drug-drug … We agree that drug-drug, gene-drug, or other interactions are potentially affecting the prognostic value … Ticagrelor is a direct drug although the active metabolite is as potent as native clopidogrel. … Therefore, it is important for measurement of the drug effect to be highly specific.

593. Acs-Pci-Adjunctive-Devices Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
     April 01, 2013 - would produce prima facie evidence that a conclusion was out of date, such as the withdrawal of a drug … Is the portion of the CER that is probably or certainly out of date an issue of safety (a drug withdrawn … from the market, a black box warning) or the availability of a new drug within class (the latter being … original key questions, the conclusions of the original report, the results of the literature and drug … aspiration thrombectomy Vink, 20125 (PASSION) Post hoc analysis of RCT Patients being randomized to drug

594. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-2007_executive.pdf
     January 01, 2007 - We assessed statistically each of the 66 possible drug comparisons of second-generation antidepressants … Direct evidence from head-to-head trials was considered sufficient to conduct meta-analyses for four drug-drug … Issues We found no studies that identified reliable predictors of individual responses to a specific drug … , many patients try multiple antidepressant medications before finding an effective, well-tolerated drug … , but predicting which drug will be most effective or best tolerated in any given individual is not yet

595. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
     November 30, 2011 - .); effects of dose and duration of therapy; and benefits and harms of different combinations of drug … Population(s):  Non-co-infected adults with HCV infection who have not had previous antiviral drug … US Food and Drug Administration. FDA approves Incivek for hepatitis C. … US Food and Drug Administration. FDA approves Victrelis for hepatitis C. … Drug Class Review on Pegylated Interferons for Hepatitis C. 2007.

596. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_executive.pdf
     July 01, 2009 - study in 1998, Haissaguerre and colleagues studied 45 patients with paroxysmal AF (PAF) refractory to drug … comparing 8 mm tip catheters to irrigated (closed or open) tip catheters in patients undergoing PVI for drug … There is a low level of evidence suggesting no differences in rhythm control in patients with drug- refractory … patients in each trial did not show significant differences in the outcomes of PVI in patients with drug-refractory

597. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb-disposition.pdf
     March 10, 2010 - The EPC first looks at the universe of studies of ACE inhibitors and ARBs before assessing the two drug … One cannot assume that two different classes of drug are interchangeable, thus justifying combining … providing an initial analysis with both ACE inhibitors and ARBs and then providing them with each drug … - aldosterone system (RAAS) antagonists provide benefits and there are only two RAAS antagonistic drug … The initial and target doses vary for each drug, depending on whether it is used for HTN, HF, or left

598. Comparative Effectiveness of Coronary Bypass Surgery and Percutaneous Coronary Interventions for Multivessel Disease: A Pooled Analysis of Individual Patient Data from Ten Randomized Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_addendum.pdf
     February 01, 2010 - As part of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, Congress directed … We have no data on concomitant drug treatment or on control of coronary risk factors during follow-up … None of the ten trials included in this study used drug-eluting stents for PCI. … stents,36 trials that compare CABG with PCI by use of drug-eluting stents are still in progress.33,37 … A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents.

599. Menopause-Protocol-130612 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
     June 12, 2013 - Food and Drug Administration (FDA) in 1942 for treating menopausal symptoms, by 1947 the Physician’s … Food Drug Law J. 2008;63(2):459-91. PMID: 18561473. 22. Patsner B. … “therapy” [Subheading] OR “Therapeutics”[Mesh] OR “Estrogen Replacement Therapy”[Mesh] OR “Drug Therapy … effects” [Subheading]) OR “Drug Toxicity”[Mesh] AND (“Ovarian Neoplasms”[Mesh] OR “Breast Neoplasms … ”[Mesh] OR “Endometrial Neoplasms/drug therapy”[Mesh] OR “Endometrial Neoplasms/therapy”[Mesh]) 3

600. Mental-Illness-Heart Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
     April 01, 2013 - identify relevant gray literature: (1) a request for scientific information packets submitted to drug … The drug classes in our review sometimes included drugs with diverse mechanisms of action. … When results varied by drug, we assigned separate SOE. … Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. … Pharmacoepidemiol Drug Saf. 2011;20(1):66-75. PMID: 21182154. 62.