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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
    January 09, 2020 - screening; (5) use of prescription drug monitoring program data; (6) availability of close follow-up … screening • Use of prescription drug monitoring program data • Availability of close follow-up • … And others KQ 2: Any oral, injection, infusion, topical nonopioid abortive drug, including: • … Drug Healthc Patient Saf. 2018;10:37-43. doi: 10.2147/DHPS.S151073. PMID: 29760569. 17. … Canadian Headache Society Guideline: acute drug therapy for migraine headache.
  2. effectivehealthcare.ahrq.gov/sites/default/files/dementia_horizon-scan-high_impact-1306-revised.pdf
    July 09, 2013 - A new drug application for flutemetamol was submitted to the U.S. … Food and Drug Administration (FDA) in January 2013. … Food and Drug administration (FDA) accepted a new drug application for flutemetamol.16 The U.S. … methods have been used, including needleless syringes inserted into alternating nostrils, a nasal drug … Food and Drug Administration (FDA); 2010 Dec 20. 86 p.
  3. effectivehealthcare.ahrq.gov/sites/default/files/arthritis_hi_impact.pdf
    January 01, 2014 - Ann estimated 750,000 gout patients initiate uric acid-lowering drug therapy in the U.S. annually. … The drug is a genetically engineered form of recombinant porcine urate oxidase, an enzyme not found …  Key Expert Comments: Overall, experts thought that the drug might address the unmet need for a … Nat Rev Drug Discov 2009 Sep;8(9):688. PMID: 19721439 79. Helms S, Darbishire PL. … Positive phase III results for benlysta as lupus drug. Immunotherapy 2009 Sep;1(5):729. 85.
  4. PEPTIC ULCER #11 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1406.pdf
    June 01, 2014 - Food and Drug Administration (FDA) approval. … Food and Drug Administration (FDA). FDA approves Gattex to treat short bowel syndrome. … Food and Drug Administration (FDA); 2012 Dec 21 [accessed 2013 Jun 05]. [2 p]. … Aetna non-Medicare prescription drug plan: Subject: Gattex (teduglutide). [internet]. … Specialty drug list. [internet].
  5. #05 DEPRESSION (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1406.pdf
    June 01, 2014 - Food and Drug Administration (FDA). … Drug Enforcement Administration. … Research suggests new drug targets for depression. … Washington (DC): Drug Enforcement Administration, U.S. … Food and Drug Administration (FDA) [accessed 2013 Aug 19]. [2 p].
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
    December 17, 2013 - Food and Drug Administration; IV = intravenous; PRMS = primary progressive multiple sclerosis; RRMS … □ For studies that examined discontinuing DMT in patients taking Natalizumab for purposes of drug … • What drug should I start with? … • When should I switch a patient to a new drug and what should that drug be? … MS/Drug Holiday: Database: Ovid MEDLINE Search Strategy: ------------------------------ ---------
  7. effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1506.pdf
    November 01, 2016 - similar drugs in the same class are read separately), and then topics in the same class of a device, drug … spontaneous preterm birth, interventions intended to target both the pregnant woman and fetus (a drug … AbbVie expects to complete the pivotal trials by November 2016 and is expected to submit a new drug … If elagolix gains marketing approval, third-party payers may decline to cover the drug without data … Experts also noted that patients may prefer this oral drug over injectable alternatives.
  8. effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-e-1.xlsx
    January 01, 2009 - Inpatient: After administration of the study drug a further minimum of 20 minutes or more of electronic … Outpatient: After administration of the study drug patients underwent 40 minutes of electronic fetal … After administration of study drug, all patients underwent continuous FHR monitoring for 3 hours. … There is no mention of fetal monitoring following the administration of the study drug. … Placebo (Provider NR) -See protocol for intervention 1 NA NA All patients Four hours after the drug
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0250_05-20-2010.pdf
    January 01, 2010 - implanted cardioverters), procedures (cardioversion, surgical, ablation) Comparator(s): Different drug
  10. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - Food and Drug Administration (FDA) in the first half of 2016. … Afrezza is also listed as a tier 5 drug in some state Medicare drug plan formularies, which is the … Food and Drug Administration (FDA); 2012 Aug 3 [accessed 2012 Jun 18]. [2 p]. … Food and Drug Administration (FDA); 2014 Jun 27 [accessed 2015 Jan 23]. [5 p]. … Food and Drug Administration (FDA); 2014 Jun 30 [accessed 2015 Feb 09]. [5 p].
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_overview.pdf
    March 27, 2014 - Topic Coming Back CER 28 DMARDs in Children with JIA NSD _SJ Clean …
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-treatments-chronic-pain-protocol.pdf
    December 19, 2018 - Intermediate outcomes such as pharmacokinetic and pharmacodynamic measures, drug-drug interaction markers … The DAWN Report: Highlights of the 2010 Drug Abuse Warning Network (DAWN) findings on drug-related emergency … Drug Overdose/ 25. or/17-24 26. risk$.ti,ab,kf. 27. … Drug Monitoring/ 21. (urine adj7 (screen$ or test$ or detect$)).ti,ab,kf. 22. … Drug Overdose/ 27. or/17-26 28. Substance Abuse Detection/ 29.
  13. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1406.pdf
    September 26, 2014 - The drug-device combination has been approved in Europe. … Food and Drug Administration (FDA). … Food and Drug Administration (FDA); 2012 Nov 9. 63 p. … Food and Drug Administration (FDA). … Autoimmune Drug Focus; 2012 Oct 22. 1 p. 56.
  14. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
    October 01, 2011 - Food and Drug Administration (FDA) as pharmaceuticals, including glucosamine and chondroitin.5 Opioid … We used relatively broad searches, combining terms for drug names with terms for relevant research designs … any blinded or open, parallel, or crossover randomized controlled trial that compared one included drug … At this time, no drug or supplement is known to modify the course of disease, though some data suggest … • The effects of alternative dosing strategies such as intermittent dosing or drug holidays have not
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
    September 01, 2011 - Doses and routes for each drug are specified in the evidence table for each study. … in the placebo arm patients is not always mentioned in the text summarizing the findings for each drug … One patient experiences a hematoma occurring on day 108 which was deemed unrelated to the study drug … I think the section would be more readable and informative if it were structured by drug class (e.g … At the moment one has to go back and forth among drug paragraphs to get some idea of the comparative
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0316_03-12-2009.pdf
    January 01, 2009 - It can also be used to adjust anti-hypertensive drug therapy and reduce clinic visits with patients. … Use of anti-hypertensive drug therapy iv. BP control 3. … Use of anti-hypertensive drug therapy iv. BP control 4.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-2.xlsx
    September 30, 2015 - the trial did not indicate clear differences between treatments for pain, functioning, depression, or drug … Excluded patients with history of psychosis Substance use: Excluded patients with history of illicit drug … stroke, and intracranial hemorrhage), major depression, cancer, and those without previous related drug … applicable; NR = not reported; NRS = numeric rating scale; NSAID = non-steroidal anti-inflammatory drug … ; OAT = opioid agonist therapy; OR = odds ratio; OUD = opioid use disorder; PDMP = prescription drug
  18. effectivehealthcare.ahrq.gov/sites/default/files/cer-236-mental-health-pregnancy-evidence-summary.pdf
    April 01, 2021 - more inclusive and included studies with comparator arms comprising women with prior exposure to the drug … Studies of multiple drug exposures presented results for each exposure but did not always present results … separately for the women with multiple drug exposures. … studies with overlapping arms, we were not able to attribute the effect of the intervention to a single drug
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-evidence-summary-corticosteroids-asthma.pdf
    October 01, 2017 - At least one LAMA has gained Food and Drug Administration (FDA) approval for the long-term maintenance … salmeterol,a vilanterol,a,c LAMA Aclidinium, glycopyrrolate, tiotropium,a umeclidinium FDA = Food and Drug … effectiveness is an important part of decision- making, this report did not include harms associated with drug
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
    November 01, 2012 - The strongest risk factor for HCV infection is injection drug use. … The prevalence of HCV infection in injection drug users varies widely depending on age, duration of … injection drug use, and other factors (such as availability and use of needle exchange programs).15 … Prevalences range from less than 50 percent in more recent studies of younger injection drug users … Drug Alcohol Depend. 2009;105(1-2):160-3. PMID: 19647375. 80.

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