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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/pneumonia-antibiotic-treatment_research-protocol.pdf
    July 19, 2013 - dosing of antibiotics has been associated with poorer clinical outcomes and increased incidences of drug … PK is the study of the time course of drug absorption, distribution, metabolism, and excretion. … Antibiotics for which PK/PD measures could be used Drug Class Drug Group Drug* Aminoglycosides … Optimizing drug exposure to minimize selection of antibiotic resistance. … Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'.
  2. effectivehealthcare-admin.ahrq.gov/products/pneumonia-antibiotic-treatment/research-protocol
    July 19, 2013 - dosing of antibiotics has been associated with poorer clinical outcomes and increased incidences of drug … PK is the study of the time course of drug absorption, distribution, metabolism, and excretion. … Antibiotics for which PK/PD measures could be used   Drug Class Drug Group Drug* … Optimizing drug exposure to minimize selection of antibiotic resistance. … Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'.
  3. effectivehealthcare-admin.ahrq.gov/products/juvenile-arthritis-dmards/research-protocol
    March 09, 2010 - Furthermore, there are a large number of DMARDs that cannot simply be grouped by drug class. … Failure with a drug in one particular class does not necessarily predict failure with another drug in … and the drug is relatively inexpensive. … corticosteroids and NSAIDs FDA approval status for JIA, and examples of significant warnings from the drug … Generic Name US Trade Name Drug Type Approved by FDA for JIA Warnings – Increased Risk
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0255_06-25-2010.pdf
    January 01, 2010 - interventions (e.g., atherectomy, brachytherapy) 2) Patients undergoing PCI, with either bare metal or drug-eluting … intravascular techniques with a literature sample that mirrors contemporary treatment practices (e.g., drug-eluting … patients with coronary artery disease and patients undergoing a PCI with either a bare metal stent or a drug-eluting
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - Experts deemed three topics as having high-impact potential: An oral drug for treating patients with … Because it has been approved for treating plaque psoriasis, cost of the drug is available. … High cost could be prohibitive and limit patient access to drug if third-party payers do not cover … The drug was administered in three loading doses as an IV infusion, 10 mg/kg, at baseline, 2 weeks, … Food and Drug Administration (FDA) approved secukinumab for treating adults with moderate-to-severe
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/research-gaps-womens-health-22.pdf
    April 01, 2022 - .................................................................................... 10 Long-Term Drug … Therapies and Drug Holidays for Osteoporosis Fracture Prevention ................................... … https://effectivehealthcare.ahrq.gov/products/infertility/research 11 Long-Term Drug Therapies … • This report was used to inform a NIH Pathways to Prevention workshop, Appropriate Use of Drug … Key Findings • Evidence on the effects of long-term osteoporosis drug treatment and drug continuation
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
    June 01, 2010 - a class switch to a different drug in the same class. … Food and Drug Administration and the Center for Medicare and Medicaid Services. … Challenges and opportunities for pharmacoepidemiology in drug-therapy decision making. … Drug Effectiveness Review Project. … Drug class review on the triptans: Drug Effectiveness Review Project.
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
    June 01, 2010 - a class switch to a different drug in the same class. … Food and Drug Administration and the Center for Medicare and Medicaid Services. … Challenges and opportunities for pharmacoepidemiology in drug-therapy decision making. … Drug Effectiveness Review Project. … Drug class review on the triptans: Drug Effectiveness Review Project.
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
    January 01, 2015 - Food and Drug Administration. … Food and Drug Administration. … Food and Drug Administration. … Food and Drug Administration. … Food and Drug Administration.
  10. effectivehealthcare-admin.ahrq.gov/products/hypertension-therapy/abstract
    January 01, 2005 - Besides its high prevalence, hypertension generally requires drug treatment – and control to desired … levels often requires more than one drug – so that the population impact of prevalence, compounded by … Specific aims are: to describe patterns of antihypertensive drug use; to compare the changes in
  11. effectivehealthcare-admin.ahrq.gov/health-topics/immune-system-and-disorders?page=2
    May 02, 2011 - Asthma Research Protocol Archived December 6, 2010 Comparative Effectiveness of Drug … Report Research Protocol Archived December 6, 2010 Comparative Effectiveness of Drug … Arthritis Systematic Review Archived November 19, 2007 Comparative Effectiveness of Drug
  12. #05 DEPRESSION (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - Personalized drug therapy has traditionally lagged behind behavioral therapy in this regard because … Biopharm Drug Dispos. 2003 Jan;24(1):37-43. Also available: http://dx.doi.org/10.1002/bdd.336. … Drug Enforcement Administration. … Research suggests new drug targets for depression. … Washington (DC): Drug Enforcement Administration, U.S.
  13. effectivehealthcare-admin.ahrq.gov/products/osteoarthritis-pain/research-protocol
    August 05, 2010 - evidence that standard dosing as labeled or alternative dosage strategies, such as intermittent dosing and drugDrug (any trade name) Labeled indications Dosing Dose adjustments for special populations … will also include studies that report safety in patients with rheumatoid arthritis or were taking the drug … We will use relatively broad searches, combining terms for drug names with terms for relevant research … sources may include reference lists of review articles and unpublished materials from the US Food and Drug
  14. effectivehealthcare-admin.ahrq.gov/health-topics/D
    Digestive Diseases Disabilities Diverticulosis and Diverticulitis Domestic Violence Down Syndrome Drug … Abuse Drug Reactions Drugs and Young People Dual Diagnosis Back to Top
  15. effectivehealthcare-admin.ahrq.gov/health-topics/d
    Digestive Diseases Disabilities Diverticulosis and Diverticulitis Domestic Violence Down Syndrome Drug … Abuse Drug Reactions Drugs and Young People Dual Diagnosis Back to Top
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pilot-projects-supplementing-white-paper.pdf
    December 01, 2024 - and Drug Holiday for Osteoporosis Fracture Prevention9 Improve applicability of evidence*; … Benefits and harms of drug treatments. BMJ. 2004 Jul 3;329(7456):2-3. … Long- Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review … Long- Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention … Should pregnant women be included in phase IV clinical drug trials?
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/dementia_hi_impact.pdf
    January 01, 2012 - similar drugs in the same class are read separately), and then topics in the same class of a device, drug … Phase III clinical trials for florbetapir have been completed and a new drug application was submitted … Food and Drug Administration (FDA) in January 2011 that FDA considered and led to ongoing controversy … Committee briefing document: Peripheral and central nervous system drugs advisory committee: New drug … Food and Drug Administration (FDA); 2010 Dec 20. 86 p.
  18. Topic-Brief3-Sud (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/topic-brief3-SUD.pdf
    April 01, 2021 - Pain perception in drug-free and in methadone-maintained human ex- addicts. … Drug overdose deaths in the United States, 1999– 2018. NCHS Data Brief No. 356. … Drug Alcohol Depend. 2018 Dec 1;193:142-7. doi: 10.1016/j.drugalcdep.2018.10.002. … Drug Alcohol Depend. 2004 Jan 7;73(1):23-31. doi: 10.1016/j.drugalcdep.2003.08.007. … Drug and alcohol dependence. 2019;203:61-5. PMID: CN-01978075. 50.
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1406.pdf
    June 01, 2014 - This drug was approved for marketing in January 2012 and is now classified as diffused according to … Patients treated with the drug were reported to have a longer median time to the first exacerbation … about $44, so the drug would be relatively inexpensive for long-term, prophylactic use … could reduce the cost of the drug for patients who struggle with the cost of drug co- payments. … Food and Drug Administration (FDA) [accessed 2012 Jun 28]. [2 p].
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-229-opioid-treatments-chronic-pain-evidence-summary.pdf
    April 01, 2020 - Annual Surveillance Report of Drug-Related Risks and Outcomes--United States, 2017. … Drug Abuse Warning Network. … The DAWN Report: Highlights of the 2010 Drug Abuse Warning Network (DAWN) findings on drug-related … Drug Alcohol Depend. 2015 Jun 01;151:47-55. doi: 10.1016/j. drugalcdep.2015.02.033. … Food & Drug Administration, Drug Safety Communications; 2019.

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