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21. For patients with PKU, there is now a pharmaceutical drug to treat this condition. In the past is was treated by medical foods that eliminated the harmful substance phenylalanine. The cost of the new drug is $70K year. The cost to treat… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-patients-with-pku-there-is-now-a-pharmaceutical-drug-to-treat-this-condition-in-the-past-is-was-treated-by-medical-foods-that-eliminated-the-harmful-substance-phenylalanine-the-cost-of-the-new-drug-is-70k-year-the-cost-t
    November 01, 2017 - The cost of the new drug is $70K year. … For patients with PKU, there is now a pharmaceutical drug to treat this condition. … The cost of the new drug is $70K year. … This drug will be reimbursed at a cost that is 10 times that of medical food. Why? … The cost of this drug would make it prohibited in the Medicaid population.

22. Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/rheumatoid-arthritis-medicine-update/final-report-update-2018
    October 01, 2019 - EHC FAQs Home Evidence Reports Drug … Contents Purpose of Review Compare benefits and harms of drug … Comparative Effectiveness of Combining MTX with Biologic Drug Therapy Versus Either MTX or Biologics … Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update. … Project Timeline Drug Therapy for Early Rheumatoid Arthritis in Adults – An Update Mar 29, 2017

23. CER 218 Evidence Summary: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-fracture-prevention-evidence-summary.pdf
    April 01, 2019 - CER 218 Evidence Summary: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention … Key Messages • Evidence on the effects of long-term osteoporosis drug treatment and drug continuation … drug characteristics? … cycles of osteoporosis drug therapy alternating with drug holidays. … drug treatment).

24. Developing Evidence-Based Research Priorities for Off-Label Drug Use | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/off-label-use-research-priorities/research
    June 01, 2020 - The first was the presence of serious side-effects and/or drug-drug interactions. … The second was high drug cost. … of the same drug class. … and drug interactions. … Food and Drug Administration, Center for Drug Evaluation and Review.

25. White Paper: Enhancing Systematic Review Methods by Incorporating Unpublished Drug Trials (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
    December 01, 2024 - Food and Drug Administration (FDA) drug approval packages (i.e., FDA reviews) into three systematic … Food and Drug Administration (FDA). … Food and Drug Administration. 7 4. … Drug Class Reviews. … Food and Drug Administration; 2001.

26. Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug Events | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/mhs4-computerized-cds/rapid-research
    February 01, 2024 - Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug … Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug … associated with reduced medication errors (moderate strength of evidence) and prevention of adverse drug … targeted medication-related CDSSs were associated with reductions of medication errors and adverse drug … | Sep 7, 2023 Making Healthcare Safer IV: Prevention of Transmission of Infection With Multi-Drug

27. Rapid Network Meta-analysis Using Data From Food and Drug Administration Approval Packages Is Feasible but With Limitations | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/grant-manuscripts/rapid-network-abstract
    June 01, 2024 - Evidence Reports Rapid Network Meta-analysis Using Data From Food and Drug … SHARE: Rapid Network Meta-analysis Using Data From Food and Drug … Rapid network meta-analysis using data from Food and Drug Administration approval packages is feasible … White Paper Jan 07, 2025 Enhancing Systematic Review Methods by Incorporating Unpublished Drug … : Abstract: Rapid Network Meta-analysis Using Data From Food and Drug

28. Cancer-Drugs-Utilization-Cost Research (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-drugs-utilization-cost_research.pdf
    January 01, 2011 - Medicare fee-for-service (FFS) payments (excluding Part C advantage plans and Part D prescription drug … costs to prescription drug plans. … Peginterferon alfa-2a ranked highest among anticancer biologics, at #9.7 Although the Food and Drug … Drug Event (PDE) file, a dataset containing summary records of drug dispensing from prescription drug … Biotech drug spending increases 21 percent even as growth in rx expenditure slows.

29. Making Healthcare Safer IV: Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug Events | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/mhs4-computerized-cds/protocol
    September 01, 2023 - Healthcare Safer IV: Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug … Healthcare Safer IV: Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug … related to a drug." 1 , 2 Adverse drug events are a leading type of healthcare-related harm, accounting … Medication Errors and Adverse Drug Events . September 7, 2019. Accessed on May 8, 2023. … Adverse drug events in ambulatory care.

30. Data Points #8: Utilization of antihypertensive drug classes among Medicare beneficiaries with hypertension, 2007 to 2009 | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/hypertension-drugs-utilization/research
    December 01, 2019 - Evidence Reports Data Points #8: Utilization of antihypertensive drug … SHARE: Data Points #8: Utilization of antihypertensive drug … of Medicare beneficiaries with hypertension used at least one prescription for an antihypertensive drug … Beneficiaries with hypertension used on average 1.9 ± 1.3 antihypertensive drug classes within a calendar … In 2009, the total drug cost for antihypertensive agents was $4.3 billion and the out-of-pocket expenditure

31. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/alcohol-misuse-drug-therapy
    June 01, 2022 - https://effectivehealthcare.ahrq.gov/products/alcohol-misuse-drug-therapy  

32. Reducing Adverse Drug Events Related to Anticoagulant Use in Adults | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/high-risk-drugs/rapid-research
    January 01, 2024 - Home Evidence Reports Reducing Adverse Drug … SHARE: Reducing Adverse Drug … Reducing Adverse Drug Events Related to Anticoagulant Use in Adults. Rapid Response. … Making Healthcare Safer IV: Active Infection Surveillance of Clostridioides difficile and Multi-Drug … | Sep 7, 2023 Making Healthcare Safer IV: Prevention of Transmission of Infection With Multi-Drug

33. Club Drugs | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/health-topics/club-drugs
    Methylenedioxymethamphetamine (MDMA), also known as Ecstasy XTC, X, E, Adam, Molly, Hug Beans, and Love Drug … NIH: National Institute on Drug Abuse Source https://medlineplus.gov/clubdrugs.html

34. App-F1-Surv-Report-1-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
    September 20, 2022 - Pain severity for neuropathic pain Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Sleep outcomes for neuropathic pain Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Pain severity for fibroyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 … Anxiety outcomes for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Sleep outcomes for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug

35. App-F1-Surv-Report-2-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
    September 20, 2022 - Pain severity for neuropathic pain Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Sleep outcomes for neuropathic pain Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Pain severity for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 … Anxiety outcomes for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Sleep outcomes for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug

36. Clopidogrel After Drug-Eluting Stent Implantation: Is Current Practice Sufficient? | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/stent-clopidogrel-practice/research
    January 01, 2020 - Recent studies of drug-eluting intracoronary stents suggest that current antiplatelet regimens may not … Of the 4666 patients remaining, 3165 received a bare metal and 1501 a drug-eluting stent. … A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. … an observational study of drug-eluting versus bare-metal stents. … Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.

37. App-F1-Surv-Report-3-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
    September 20, 2022 - Pain severity for neuropathic pain Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Sleep outcomes for neuropathic pain Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Pain severity for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 … Anxiety outcomes for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug … Sleep outcomes for fibromyalgia Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug

38. Drugs and Young People | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/health-topics/drugs-and-young-people
    March 03, 2016 - Y Z Health Topics Drugs and Young People Description Drug … Drug abuse in children and teenagers may pose a greater hazard than in older people. … As a result, the brains of young people may be more susceptible to drug abuse and addiction than adult … But it is better to prevent drug abuse in the first place. … NIH: National Institute on Drug Abuse Source https://medlineplus.gov/drugsandyoungpeople.html

39. Drug Therapy for Rheumatoid Arthritis in Adults: An Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/rheumatoid-arthritis-medicine/research
    December 01, 2019 - EHC FAQs Home Evidence Reports Drug … Update SHARE: Drug … participants, and relevant good- or fair-quality meta-analyses that compared benefits or harms of 14 drug … Literature was synthesized qualitatively within and between the two main drug classes (oral and biologic … Project Timeline Drug Therapy for Rheumatoid Arthritis in Adults: An Update Jun 16, 2010

40. Cocaine | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/health-topics/cocaine
    October 29, 2018 - You also get a strong craving to take the drug again to try to feel better. … Then, even if you get treatment, it can be hard to stay off the drug. … People who stopped using cocaine can still feel strong cravings for the drug, sometimes even years later … NIH: National Institute on Drug Abuse Source https://medlineplus.gov/cocaine.html Products