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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-urinary-retention_research-protocol.pdf
    November 19, 2012 - controlled trials using an instrument we develop based upon the Cochrane Risk of Bias tool.10 The seven domains … outcome data, selective reporting, and other sources of bias (i.e., problems not covered by other domains … symptom or quality of life scale scores) within each comparison will be evaluated based on four required domains … an estimate).13 A fifth domain, reporting bias, will be assessed when SOE based upon the first four domains
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/joint-replacement-disposition-comments.pdf
    November 03, 2021 - reviewers asked for more details in approaches used for grading the strength of evidence and how certain domains
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
    October 17, 2012 - a range of important outcomes related to stress and well-being.5 The selected outcomes fall into domains … Conducting Comparative Effectiveness Reviews.29 In assigning evidence grades we will consider the domains … We will also consider additional domains such as biological plausibility, dose-response effect and, … Conducting Comparative Effectiveness Reviews.29 In assigning evidence grades we will consider the domains … We will also consider additional domains such as biological plausibility, dose- response effect and
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
    December 23, 2014 - For diagnostic studies, we will use the QUADAS 2 tool.28 Risk of bias domains include patient selection … between medium and high risk of bias will be determined by nuances in study conduct across the four domains … The seven domains included in this tool include sequence generation, allocation concealment, blinding … evidence for primary outcomes of KQ1 within each comparison will be evaluated based on five required domains … the overall body of evidence will take into consideration the differences in strength of evidence domains
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-disposition-comments-inhaled-corticosteroids.pdf
    March 19, 2018 - The specific domains which contributed to the downgrading of all outcomes, organized per KQ, appear … Further description as to the domains that led to downgrading a given outcome are provided in the … The five contributing domains include risk of bias, consistency, directness, precision and publication … ROB was taken into account when SOE was graded, as one of the domains. … ROB was taken into account when SOE was graded, as one of the domains.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
    October 29, 2012 - 95% CI= 0.54, 5.84; p<0.000116 No Signal Quality of life based on King’s Health Questionnaire domains … We identified one RCT that demonstrated significant differences in three domains of quality of life … We identified one RCT that demonstrated significant differences in two domains of quality of life measure … Darifenacin Darifenacin significantly improved urgency UI and several domains of quality of life more … Darifenacin Darifenacin significantly improved urgency UI and several domains of quality of life more
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/bimp-protocol.pdf
    September 27, 2022 - randomized trials for Key Questions 1 and 2 using the Cochrane Risk of Bias 2 (ROB2) tool.13 The five domains … study and assign a risk of bias rating of “high,” “some concerns,” and “low” for each of the above domains … The primary domains assessed include risk of bias, directness, consistency, precision, and reporting … Additional domains may be used when appropriate, including dose-response association, strength of association … Below, we discuss the primary domains and how we will assess them: Risk of bias (see the above section
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/patient-safety-practices_research-protocol.pdf
    November 09, 2011 - Measure high-priority contexts in the 4 domains a) External factors, such as regulatory requirements … develop this with the TEP as the project develops, but it will take into consideration a number of domains
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_research-protocol.pdf
    November 30, 2014 - For RCTs, we will assess the risk of bias using a modified Cochrane Risk of Bias tool.37 The seven domains … data, selective outcome reporting, and other sources of bias (i.e., problems not covered by other domains … Moderate risk of bias will be assigned to studies that are challenged across several of the domains … as moderate or higher, intervention-outcome pairs need a positive response on two out of the three domains … For prior systematic reviews that provided acceptable strength of evidence, strength of evidence domains
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_clinician.pdf
    September 01, 2016 - . ** The overall evidence grade was assessed based on the ratings for the following domains: study limitations … Other domains that were considered, as appropriate, included dose-response association, plausible confounding
  11. effectivehealthcare.ahrq.gov/products/methods-guidance-tests-bias/slides
  12. effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability.ppt
    January 01, 2009 - substantiate its importance To delineate a systematic approach to assessing applicability by using PICOS domains … To recognize common features that may impact the applicability of studies PICOS domains = population … substantiate its importance, delineate a systematic approach to assessing applicability by using PICOS domains … Finally, given the information on the PICOS domains, the judgment that this is an efficacy trial is made … For our purposes, assume that four other studies were also available with similar PICOS domains.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
    December 17, 2013 - literature, using an instrument we develop based upon the Cochrane Risk of Bias tool.11 The seven domains … outcome data, selective reporting, and other sources of bias (i.e., problems not covered by other domains … to sustained disease progression) within each comparison will be evaluated based on four required domains … an estimate).16 A fifth domain, reporting bias, will be assessed when SOE based upon the first four domains
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults_research-protocol.pdf
    December 20, 2011 - We will compare across settings characteristics of those served in the domains of physical function … We will compare results across settings for specific outcome domains. … In brief, the EPC approach requires assessment of four domains:  Risk of bias (internal validity) … We will evaluate individual domains listed above qualitatively and assess a summary rating of “high
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypertension-pulmonary-arterial_research-protocol.pdf
    January 30, 2013 - QUADAS-2 describes risk of bias in four key domains: patient selection, index test(s), reference standard … Results will be described for individual domains. … If the distribution of ratings permits, methodological domains will be examined for association with … Additional domains are to be used when appropriate: coherence, dose-response association, impact of … These domains will be considered qualitatively, and a summary rating of “high,” “moderate,” or “low
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
    August 01, 2012 - the body of evidence is moderate for IMRT reducing late xerostomia and improving quality-of-life domains … Quality of life was reported in three observational studies and generally favored IMRT in domains … the body of evidence is moderate for IMRT reducing late xerostomia and improving quality of life domains … shows that greater conformality of radiation reduces late xerostomia and improves quality-of-life domains … the body of evidence is moderate for IMRT reducing late xerostomia and improving quality-of-life domains
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/pwd-care-interventions-protocol.pdf
    February 22, 2019 - rated using modified Cochrane risk of bias tools as high, medium, or low for each of the following domains … For these complex interventions, risk of bias will include domains similar to those outlined in a risk … select outcomes for KQs 1 through 10 within each comparison will be evaluated based on five required domains … studies were randomized controlled trials with a low risk of bias, with consistent, direct, and precise domains … NIH Stage Assessment Tool Table: PRECIS-2 scores for trial domains, with modification for Care Delivery
  18. Braddock (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/braddock.pdf
    January 01, 2011 - Slide 12: Medical Decision Making  Domains Domain Basic Decisions Intermediate   Decisions Complex
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
    July 01, 2012 - An updated version of this scale, called QUADAS-2, identifies four key domains (patient selection, index
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_executive.pdf
    April 01, 2012 - studies using a modified version of the Newcastle Ottawa Scale.11 The Newcastle Ottawa Scale includes domains … assessment for diagnostic accuracy studies.12 The QUADAS tool includes 14 items that evaluate numerous domains … The authors also note that no studies were at low risk of bias for all of the modified QUADAS domains … without knowledge of the candidate test(s) in 44 percent of included studies, but we judged these domains

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