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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/undescended-testicle_research-protocol.pdf
    September 02, 2011 - , the Cochrane Collaboration’s tool for assessing risk of bias will be employed. 14 Fundamental domains … Effectiveness and Comparative Effectiveness Reviews, 17 which emphasizes the following four major domains … comparison of interest will be given an overall evidence grade based on the ratings for the individual domains
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
    May 18, 2011 - Effectiveness and Comparative Effectiveness Reviews. 17 The grade will be based on four major domains … Additional domains—such as dose-response association, plausible confounding, strength of association … applicability for each outcome (including harms) will be performed separately from assessments of the other domains
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
    January 01, 2016 - Quality “Methods Guide for Effectiveness and Comparative Effectiveness Reviews”10 and considered all domains … having low study limitations if most (51% or greater) of the studies scored positive in all five domains … considered high grade if study limitations were low and there were no problems in any of the other domains
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_executive.pdf
    December 01, 2014 - Treatment with IMRT showed a benefit in some general QOL domains, as well as several domains specific … General domains in which IMRT demonstrated a significant benefit included emotional functioning at … No QOL domains were worse with IMRT than 3DCRT at any timepoint. … For both RT techniques, QOL domains generally experienced maximal deterioration after RT, followed … Other domains (pain, appearance, activity, recreation, swallowing, chewing, speech, shoulder, taste,
  5. effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - Investigators in basic science and clinical research domains continue to probe model systems and patient
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
    December 01, 2010 - When compared to FGAs, SGAs have shown greater benefits in many outcome domains,9 and newer medications … will be assessed by using the Cochourane Collaboration Risk of Bias tool.21 This tool consists of six domains … The overall assessment is based on the responses to individual domains. … If one or more individual domains are assessed as having a high risk of bias, the overall score will … This approach assesses the evidence based on four domains: risk of bias, consistency, directness, and
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/public-reporting-cost-measures_disposition-comments.pdf
    March 05, 2015 - I think it would be helpful to the reader to add a sentence that lists the sub domains of PRICE, and … of this framework and analysis of the relative importance of each domain, and each criteria within domains … Reviewer #6 Findings Rather than Figure 2 as it is now summed across all five domains, I think it would … Especially because certain of these domains are, I think, more important to the site being useful and
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-introduction_methods.pdf
    July 01, 2012 - Methods Guide for Medical Test Reviews Chapter 1 1-1 Chapter 1 Introduction to the Methods Guide for Medical Test Reviews David B. Matchar, M.D., FACP, FAHA; Duke-NUS Graduate Medical School Singapore; Duke University Medical Center, Durham, NC Abstract Evaluation of medical tests presents cha…
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/safety-vaccines-protocol.pdf
    January 30, 2020 - The current CTCAE system (version 5) differentiates 837 adverse events within 26 adverse event domains … reporting are often lacking in rigor; thus, we will apply critical appraisal criteria assessing two main domains … The strength of evidence domains are compatible with the GRADE group’s criteria to downgrade the quality … Common Terminology Criteria for Adverse Events classification system (CTCAE) adverse event domains … Common Terminology Criteria for Adverse Events classification system (CTCAE) adverse event domains
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
    June 01, 2012 - Effectiveness and Comparative Effectiveness Reviews.12 That approach requires assessment in four domains … After making assessments in these four domains, we graded the strength of the evidence using the four-point … Most, but not all, of these plans described strategies that fit into one or more of four overarching domains … No State plan addressed all four domains.
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
    July 01, 2016 - * The overall evidence grade was assessed based on the ratings for the following domains: study limitations … Other domains that were considered, as appropriate, included dose-response association, plausible confounding
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol-amendment.pdf
    February 04, 2025 - 5 based on the recommendations given in AHRQ Methods Guide.12 The assessment will consider several domains—the … In case they are relevant, additional domains, such as dose-response association and strength of association … insufficient according to a four-level scale by evaluating and weighing the combined results of the included domains … Below, we discuss the primary domains and how we will assess them: Risk of bias (see the above section
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_research-protocol.pdf
    June 05, 2014 - The overall assessment is based on the responses to individual domains. … If one or more individual domains has a high risk of bias, we will rate the overall score as high risk … We will examine five core domains: study limitations or risk of bias, consistency, directness, precision … We will also consider additional domains such as dose-response association, plausible confounding, and … For all domains we will describe the logic and rationale for our judgments.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-informed-care-protocol.pdf
    April 19, 2023 - For CQs, we will use a thematic approach, noting the principles and domains of the models and then cross-walking … We will note the presence or lack of consistency principles, domains, and the intervention components … overall strength of evidence for outcomes for KQs 1-2 within each comparison, based on five required domains
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
    January 30, 2014 - The tool includes six items from five domains of potential sources of bias (i.e., selection, reporting … The required domains for grading the strength of evidence are: study limitations (previously named risk … A set of domains supplement the five required domains: dose-response association, plausible confounding … These additional domains are most relevant to bodies of evidence consisting of observational studies … When scoring the individual domains, we will reference the definitions and scores outlined in the AHRQ
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/documentation-burden-protocol.pdf
    July 26, 2023 - documentation burden must accurately reflect these important differences, and assessment of validity in the domains … Collating and assessing evidence across these domains will inform efforts by health systems and standard-setting
  17. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/deficit-hyperactivity-protocol.pdf
    November 01, 2021 - bias in intervention studies adapted for the eligible study designs.92, 93 QUADAS 2 evaluates four domains … In determining the strength of a body of evidence, the following domains will be evaluated: • Study … strength of evidence grade will be assigned by evaluating and weighing the combined results of the above domains … Summary tables will include ratings for individual strength of evidence domains (i.e., risk of bias, … Subthreshold attention-deficit/hyperactivity disorder is associated with functional impairments across domains
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-nitrous-oxide_research-protocol.pdf
    August 24, 2011 - For randomized controlled trials, the fundamental domains will include: adequate sequence generation … evaluation will be that stipulated in the EPC Methods Guide 8 , which emphasizes the following four major domains … comparison of interest will be given an overall evidence grade based on the ratings for the individual domains
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
    August 22, 2008 - Two investigators will independently grade each outcome using required domains, comprising 4 major constructs … The domains will include, but may not be limited to: risk of bias, consistency, directness, and precision … We will then use the subsequent domains to modify the overall grade.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nppv-respiratory-failure_research-protocol.pdf
    April 21, 2011 - described in the General Methods Guide. 20,22 In brief, the approach requires assessment of four domains … Additional domains are to be used when appropriate: coherence, dose- response association, impact of … These domains will be considered qualitatively, and a summary rating of “high,” “moderate,” or “low

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