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1. Characteristics of Inpatient Hospital Stays Involving Sickle Cell Disease, 2000-2016 #251
   hcup-us.ahrq.gov/reports/statbriefs/sb251-Sickle-Cell-Disease-Stays-2016.jsp
   September 01, 2019 - STATISTICAL BRIEF #251

2. Statistical Brief #139
   hcup-us.ahrq.gov/reports/statbriefs/sb139.jsp
   July 01, 2012 - related to kidney stone disease. … disease Treat and release ED visits related to kidney stone disease ED visits related to kidney … disease Treat and release ED visits related to kidney stone disease ED visits related to kidney … ICD-9-CM is the International Classification of Diseases, Ninth Revision, Clinical Modification, which … Urologic diseases in America project: urolithiasis.

3. Change Log (v2024.1 to v2025.1) for the Clinical Classifications Software Refined (CCSR) for ICD-10-CM (xls file)
   hcup-us.ahrq.gov/toolssoftware/ccsr/DXCCSR-ChangeLog-v20241-v20251.xlsx
   November 01, 2024 - heart disease and other diseases of the circulatory system FAC028 FAC021 FAC028 Family history of disease … and parasitic diseases FAC028 FAC021 FAC028 Family history of disease Z832 Family history of diseases … ureter FAC028 FAC021 FAC028 Family history of disease Z842 Family history of other diseases of the … Personal history of other disease Z8742 Personal history of other diseases of the female genital tract … FAC030 FAC021 FAC030 Personal history of other disease Z87438 Personal history of other diseases of

4. Statistical Brief #43: Hospital Stays Involving Chronic Pulmonary Heart Disease, 2005 (pdf file)
   hcup-us.ahrq.gov/reports/statbriefs/sb43.pdf
   December 01, 2007 - most often caused by lung disease. … It is important to treat the underlying disease in order to prevent pulmonary heart disease, because … Heart condition as the principal admission in 7 o included pulmo disease; 3 in 10 disease-related pulmonary … rt disease was ut 20,000 in- The in-hospital r patients with t disease was es greater than 4.4 … these additional secondary conditions. 2 ICD-9-CM is the International Classification of Diseases

5. Statistical Brief #139: Emergency Department Visits and Hospital Admissions for Kidney Stone Diseases, 2009 (pdf file)
   hcup-us.ahrq.gov/reports/statbriefs/sb139.pdf
   July 25, 2012 - Statistical Brief #139: Emergency Department Visits and Hospital Admissions for Kidney Stone Diseases … Urologic diseases in America project: urolithiasis. … related to kidney stone disease. … stone disease Treat and release ED visits related to kidney stone disease ED visits related … ICD-9-CM is the International Classification of Diseases, Ninth Revision, Clinical Modification, which

6. HCUP-US Statistical Briefs
   hcup-us.ahrq.gov/reports/statbriefs/sb_blood.jsp
   September 01, 2019 - Topic includes sickle cell disease. …   #251 Characteristics of Inpatient Hospital Stays Involving Sickle Cell Disease … , 2000-2016 ( PDF file, 265 KB; HTML ) #21 Sickle Cell Disease Patients in U.S.

7. Overview of Disease Severity Measures Disseminated with the Nationwide Inpatient Sample (NIS) and Kids' Inpatient Database (KID)
   hcup-us.ahrq.gov/db/nation/nis/severity_overview.jsp
   March 01, 2006 - Disease Staging (Medstat) was selected as a measure of disease severity that is not confounded by use … Disease Staging Disease Staging and the AHRQ comorbidity measures represent clinically based systems … In Disease Staging, severity is defined as the likelihood of death or organ failure resulting from disease … The following measures are included in the NIS and KID, based on Disease Staging software: disease categories … , 2.x, 3.x, 4.0 with substages available for stages 1, 2, and 3; number of subscales varies across diseases

8. CMR Change Log v20231-v20241 (xls file)
   hcup-us.ahrq.gov/toolssoftware/comorbidityicd10/CMR-ChangeLog-v20231-v20241.xlsx
   December 01, 2023 - NEURO_OTH E7528 Canavan disease NEURO_OTH E88A Wasting disease (syndrome) due to underlying condition … NEURO_MOVT G20A1 Parkinson's disease without dyskinesia, without mention of fluctuations NEURO_MOVT … G20A2 Parkinson's disease without dyskinesia, with fluctuations NEURO_MOVT G20B1 Parkinson's disease … DEMENTIA G3781 Myelin oligodendrocyte glycoprotein antibody disease NEURO_OTH G3789 Other specified … demyelinating diseases of central nervous system NEURO_OTH G40C01 Lafora progressive myoclonus epilepsy

9. HCUP Statistical Brief #21: Sickle Cell Disease Patients in U.S. Hospitals, 2004 (pdf file)
   hcup-us.ahrq.gov/reports/statbriefs/sb21.pdf
   December 01, 2006 - HCUP Statistical Brief #21: Sickle Cell Disease Patients in U.S. … Sickle Cell Disease Patients in U.S. Hospitals, 2004 Claudia A. … Table 1 compares patient and 1Sickle Cell Disease Guideline Panel. … ICD-9-CM is the International Classification of Diseases, Ninth Revision, Clinical Modification, which … Principal diagnosis of sickle cell disease All-listed diagnosis of sickle cell disease

10. Com-ICD10CMChgLg-v20211-v20221 (xls file)
    hcup-us.ahrq.gov/toolssoftware/comorbidityicd10/CMR-ChangeLog-v20211-v20221.xlsx
    October 01, 2021 - disease, right elbow AUTOIMMUNE M02322 Reiter's disease, left elbow AUTOIMMUNE M02329 Reiter's disease … , left wrist AUTOIMMUNE M02339 Reiter's disease, unspecified wrist AUTOIMMUNE M02341 Reiter's disease … M02359 Reiter's disease, unspecified hip AUTOIMMUNE M02361 Reiter's disease, right knee AUTOIMMUNE … M02362 Reiter's disease, left knee AUTOIMMUNE M02369 Reiter's disease, unspecified knee AUTOIMMUNE … AUTOIMMUNE M02379 Reiter's disease, unspecified ankle and foot AUTOIMMUNE M0238 Reiter's disease,

11. Com-ICD10CMChgLg-v20201-v20211 (xls file)
    hcup-us.ahrq.gov/toolssoftware/comorbidityicd10/Com-ICD10CMChgLg-v20201-v20211.xlsx
    October 01, 2020 - disease CBVD I69828 Other speech and language deficits following other cerebrovascular disease CBVD … cerebrovascular disease CBVD I69922 Dysarthria following unspecified cerebrovascular disease CBVD … Reiters disease, left elbow ARTH M02329 Reiters disease, unspecified elbow ARTH M02331 Reiters disease … disease, unspecified hand ARTH M02351 Reiters disease, right hip ARTH M02352 Reiters disease, left … Reiters disease, left knee ARTH M02369 Reiters disease, unspecified knee ARTH M02371 Reiters disease

12. Com-ICD10CM-User-Guide-v2021-1 (pdf file)
    hcup-us.ahrq.gov/toolssoftware/comorbidityicd10/Com-ICD10CM-User-Guide-v2021-1.pdf
    October 01, 2020 - Prior description was Rheumatoid arthritis/collagen vascular diseases.) … Elixhauser Comorbidity Software Refined for ICD-10-CM; ICD-10-CM, International Classification of Diseases … %LET POA=1 Abbreviation: ICD-10-CM, International Classification of Diseases, Tenth Revision, Clinical … diseases must be present on admission … • Sequela codes for cerebral infarction and other cerebrovascular diseases are used if and only

13. Com-ICD10CMChgLg-v20211-v20221 (xls file)
    hcup-us.ahrq.gov/toolssoftware/comorbidityicd10/CMR-ChangeLog-v20221-v20231.xlsx
    December 01, 2022 - and failure, moderate to severe CMR_LIVER_SEV Liver disease, moderate to severe CMR_LIVER_SEV Renal … , unspecified COAG D6801 Von Willebrand disease, type 1 COAG D68020 Von Willebrand disease, type 2A … COAG D68021 Von Willebrand disease, type 2B COAG D68022 Von Willebrand disease, type 2M COAG D68023 … Von Willebrand disease, type 2N COAG D68029 Von Willebrand disease, type 2, unspecified COAG D6803 … Von Willebrand disease, type 3 COAG D6804 Acquired von Willebrand disease COAG D6809 Other von Willebrand

14. HCUP Statistical Brief #126: Hospital Stays for Circulatory Diseases, 2004 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb26.pdf
    February 01, 2007 - Introduction Circulatory diseases—conditions including heart disease, stroke, and peripheral vascular … Circulatory diseases causing hospitalization Table 2 highlights the specific circulatory diseases that … common circulatory diseases. … – 102 Nonspecific chest pain – 103 Pulmonary heart disease – 104 Other and ill-defined heart disease … ,” “111 Other and ill-defined cerebrovascular disease,” “117 Other circulatory disease,” and “121 Other

15. EXHIBIT 4.1 Costs for the Most Frequent Diagnoses
    hcup-us.ahrq.gov/reports/factsandfigures/figures/2005/2005_4_1A.jsp
    January 01, 2005 - 3.5 2 2 2 122 Pneumonia (except that caused by tuberculosis or sexually transmitted disease … and bronchiectasis (chronic obstructive lung disease) $3,167.2664 $3,784.0214 $4,152.5490 … 1.5 1.2 1.3 14 17 15 149 Biliary tract disease (gall bladder disease) $3,171.6540 … and bronchiectasis (chronic obstructive lung disease) 99.661254 97.522933 104.795673     …         149 Biliary tract disease (gall bladder disease) 85.046076 96.855055 100.565098

16. Microsoft Word - Table1-FY2004-V2_1.doc (pdf file)
    hcup-us.ahrq.gov/toolssoftware/comorbidity/Table1-FY2004-V2_1.pdf
    August 01, 2004 - ICD-9-CM Diagnosis Code Label Comorbidity Assignment 07022 HPT B CHRN COMA WO DLTA Liver disease … 07023 HPT B CHRN COMA W DLTA Liver disease 07044 CHRNC HPT C W HEPAT COMA Liver disease 25080 DMII … disease 53141 CHR STOM ULC W HEM-OBSTR Chronic Peptic ulcer disease (includes bleeding only if obstruction … is also present) 53151 CHR STOM ULC W PERF-OBST Chronic Peptic ulcer disease (includes bleeding … only if obstruction is also present) 53161 CHRSTOM ULC HEM-PERF-OB Chronic Peptic ulcer disease

17. Overview of Severity Measurement Systems (pdf file)
    hcup-us.ahrq.gov/db/nation/nis/OverviewofSeveritySystems.pdf
    December 09, 2005 - Disease Staging (Medstat) was selected as a measure of disease severity that is not confounded by use … Disease Staging Disease Staging and the AHRQ comorbidity measures represent clinically based systems … In Disease Staging, severity is defined as the likelihood of death or organ failure resulting from disease … The following measures are included in the NIS and KID, based on Disease Staging software: disease categories … .x, 3.x, 4.0 with substages available for stages 1, 2, and 3; number of subscales varies across diseases

18. Hospital Stays for Stroke and Other Cerebrovascular Diseases, 2005 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb51.pdf
    May 01, 2008 - Hospital Stays for Stroke and Other Cerebrovascular Diseases, 2005 HEALTHCARE COST … These cerebrovascular account for 95 p admissions for c disease. … Stays for cerebr disease originat emergency room were discharged homes and reha facilities at a hig resulted … admissions for cerebrovascular disease. … and ill-defined cerebrovascular disease and late effects of cerebrovascular disease.

19. Exhibit 4.3 Average Length of Stay and Average Charges
    hcup-us.ahrq.gov/reports/factsandfigures/figures/2006/2006_4_3.jsp
    January 01, 2006 - Acute and chronic tonsillitis 2.0 10,021 Immunizations and screening for infectious diseases … Inflammation, infection of eye (except that caused by tuberculosis and sexually transmitted diseases … aftercare 10.0 22,438 Pneumonia (except that caused by tuberculosis and sexually transmitted diseases … Other non-epithelial cancer of skin 5.1 30,639 Osteoporosis 5.7 30,724 Other liver diseases … ) 6.6 53,924 Encephalitis (except that caused by tuberculosis and sexually transmitted diseases

20. Exhibit 2.5 Circulatory Conditions
    hcup-us.ahrq.gov/reports/factsandfigures/figures/2005/2005_2_5b.jsp
    January 01, 2005 - Thousands Standard Errors in Thousands Discharges per 100,000 Population All circulatory disease … 100.798 2,319.20 3,235.00 84.997 2,150.80 101 Coronary atherosclerosis (coronary artery disease … (other blood vessel disease) 63.2 1.802 43.3 69.9 2.14 46.5 103 Pulmonary heart … disease (heart disease due to lung disorders) 62.3 1.88 42.7 82.1 2.434 54.6 115 … 0.667 11.3 120 Hemorrhoids 15.8 0.568 10.8 17 0.669 11.3 121 Other diseases