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effectivehealthcare.ahrq.gov/products/stem-cell-children/research-protocol
August 05, 2010 - Autoimmune Disease (Key Questions 5 and 6)
P:
Pediatric patients with autoimmune diseases
I: … OR
For inherited metabolic diseases does the article report on disease natural history? … Lipogranulomatosis” OR Gangliosidos* OR “Sandhoff Disease” OR “sandhoff’s disease” OR “Gaucher Disease … ” OR “gaucher’s disease” OR “Niemann-Pick Disease*” OR “Tay-Sachs Disease” OR Aspartylglucosaminuria … OR "Sphingolipidoses"[Mesh]) OR "Lysosomal Storage Diseases"[Mesh]) OR "Glycogen Storage Disease"[Mesh
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_executive.pdf
April 01, 2012 - Background
Rheumatoid arthritis (RA), which
affects 1.3 million adult Americans, is
an autoimmune disease … The disease
tends to affect the small joints of the hands
and feet in a symmetric pattern, but other … RA aims to control
pain and inflammation and, ultimately,
the goal is remission or at least low
disease … Available
therapies for RA include corticosteroids,
oral disease-modifying antirheumatic
drugs or … MTX No differences in ACR 20 response, disease
activity scores and radiographic changes.†
Moderate
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_overview.pdf
March 27, 2014 - Disease-Modifying … Disease-Modifying Antirheumatic Drugs (DMARDs) in Children With Juvenile Idiopathic Arthritis
(JIA). … The outcome measures assessed were:
Measures of disease activity:
Active joint count (AJC)
Physician … global assessment of disease activity (PGA)
Parent/patient global assessment of well-being (PGW) … Activity Score (JADAS)
A consensus-based definition of remission
Flare
Minimal disease activity
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine-update_research-protocol.pdf
May 15, 2017 - activity thresholds: High disease activity >5.1; Low disease activity <3.2; Remission <2. … Atlanta, GA: Centers for Disease Control and Prevention; 2017. … Results from a nationwide study of disease-discordant twins. … The microbiome in infectious disease and inflammation. … Rheumatoid arthritis management of early disease.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0264_01-14-2008.pdf
January 01, 2008 - working group
Nomination
Summary:
The nominator questions the comparative effectiveness of disease-modifying … children diagnosed with juvenile idiopathic
arthritis
Intervention(s): Corticosteroids; Synthetic disease-modifying … harms of drug therapies for juvenile
idiopathic arthritis in subgroups of patients based on stage of disease … )
JIA, previously called juvenile rheumatoid arthritis, is the most common rheumatic disease … The literature suggests there is a lack of evidence-based guidance
for treatment of several disease
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effectivehealthcare.ahrq.gov/get-involved/nominated-topics/1-which-patients-benefit-the-most-from-mtm-services-11-which-factors-or-combinations-of-factors-are-most-predictive-of-the-clinical-benefit-of-mtm-services-111-disease-factors-eg-diabetes-vs-copd-multi-morbidity-vs-single-dis
July 28, 2010 - Disease factors (e.g., diabetes vs COPD ; multi-morbidity vs single disease; recent diagnosis vs long-standing … research would compare different models for assisting patients in managing their medications for chronic diseases … mental health disorders
Diabetes mellitus
Infectious diseases, including HIV/AIDS
Peptic ulcer … Chronic diseases are highly prevalent in the United States where nearly 1 in 2 adults live with at least … 1 chronic disease (CDC, 2009).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_research-protocol.pdf
March 22, 2016 - Additionally, dementia-related expenses exceed those for other diseases, including heart
disease and … kidney
disease, and loss of hearing and/or vision. … We will examine the treatment of diseases such as cardiovascular disease,
cerebrovascular disease, hypertension … Preventing Alzheimer's disease and cognitive
decline. … Advances in the prevention of Alzheimer's
disease and dementia.
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/
August 23, 2021 - Schwannomas
Submitted: June 11, 2021
Surgical Management of Cervical Degenerative Disease … Syndrome in Men
Submitted: May 18, 2021
Comparative Effectiveness and Safety of Disease-Modifying … Submitted: January 18, 2021
Patient Activation Interventions for Chronic Kidney Disease … Treatment for Fecal Incontinence X
Submitted: July 17, 2020
Non-Alcoholic Liver Disease
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0520-131115.pdf
November 15, 2013 - & Next Steps
The topic, Non-invasive Tests to Diagnose Patients with Suspected Coronary Artery Disease … and to
Risk Stratify Patients with Coronary Artery Disease, will go forward for refinement as a systematic … and
Summary: to Risk Stratify Patients with Coronary Artery Disease was ranked as a priority topic … available to aid the
evaluation of patients at intermediate risk of patients with coronary artery disease … Despite recent
decreases in mortality, heart disease remains the leading cause of death in the US for
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-258-diagnostic-errors-summary.pdf
December 01, 2022 - Stroke, the
top serious harm-producing disease, is missed an estimated 17% of the time. … Among these 15 diseases, myocardial infarction is the only one with false
negative rates near zero (1.5% … ), well below the estimated average rate across all
diseases (5.7%) … • For a given disease, nonspecific or atypical symptoms increase the likelihood of
error. … Grouped
by organ system, neurologic diseases were the top category (34%).
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children_research-protocol.pdf
November 01, 2010 - Autoimmune Disease (Key Questions 5 and 6)
P: Pediatric patients with autoimmune diseases
I: Hematopoietic … For inherited metabolic diseases does the article report on disease natural
history? … ” OR “Fabry’s disease” OR “Farber
Lipogranulomatosis” OR “Fabry Disease” OR “Fabry’s disease” OR
“ … Disease” OR “gaucher’s disease”
OR “Niemann-Pick Disease*” OR “Tay-Sachs Disease” OR
Aspartylglucosaminuria … ] OR
"Sphingolipidoses"[Mesh]) OR "Lysosomal Storage Diseases"[Mesh]) OR
"Glycogen Storage Disease"
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
February 01, 2008 - gland (clinically
localized disease). … risk disease. … • Disease-specific survival: RP with ADT did not reduce disease-
specific mortality compared with … <6)
and high-risk disease. … • Trial 2, T2 disease only—disease-specific survival: Difference in
prostate cancer deaths was not
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0107_05-19-2009.pdf
January 01, 2009 - Population(s): Patients with known allergic disease; subgroups of interest include
minorities, inner-city … For patients with allergic disease, what is the comparative effectiveness of
improving health outcomes … and lowering healthcare utilization by treating their
disease with sublingual immunotherapy (allergy … drops taken under the tongue) as
opposed to not receiving any kind of disease modifying immunotherapy … an alternative for patients who
require subcutaneous immunotherapy (injections) to treat allergic disease
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/masks-prevention-covid-healthcare-community-amended-protocol.pdf
July 02, 2020 - COVID-19 from
infected patients is recommended by the World Health Organization and the Centers for
Disease … The Centers for Disease Control and Prevention has
also encouraged the use of masks in the community … Centers for Disease Control and Prevention. … Centers for Disease Control and Prevention. … Centers for Disease Control and Prevention.
-
effectivehealthcare.ahrq.gov/products/icd-categories-prevalence-reimbursement
June 23, 2011 - Data Points #5: Prevalence and Medicare Reimbursement by Recurrent International Classification of Diseases … Data Points #5: Prevalence and Medicare Reimbursement by Recurrent International Classification of Diseases
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0095_04-10-2009.pdf
January 01, 2009 - Results of Topic Selection Process & Next Steps
Noninvasive diagnosis of coronary artery disease … )
Cardiovascular disease is the leading cause of mortality for women in the US. … The literature suggests
that compared to men, women present with more advanced disease due to the lack … Results of Systematic Review of Research on Diagnosis and
Treatment of Coronary Heart Disease in Women … Diagnosis and Treatment of Coronary Heart Disease in Women:
Systematic Reviews of Evidence on Selected
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0359_10-15-2010.pdf
January 01, 2010 - Outcome(s): Diagnostic accuracy, time to diagnosis, patient-oriented outcomes (e.g.,
delay of disease … Population(s): Patients with multiple sclerosis or clinically isolated syndrome
Intervention(s): Disease-modifying … improved function, alleviation of
spasticity, prevention of complications, quality of life, delay of disease … MS is a chronic, autoimmune disease of the central nervous system that can cause significant … ; treatments aim to reduce the frequency and
hasten recovery from relapses and exacerbations, slow disease
-
effectivehealthcare.ahrq.gov/products/gerd-2005/research
December 13, 2005 - Systematic Review Comparative Effectiveness of Management Strategies for Gastroesophageal Reflux Disease … examines alternatives for managing the chronic symptoms of uncomplicated gastroesophageal reflux disease
-
effectivehealthcare.ahrq.gov/sites/default/files/naik.pdf
January 01, 2009 - Smith
• 68 year old
male with
type 2 diabetes mellitus, chronic heart disease with
history … where a patient is along a care pathway
• Integrate iterative changes in health status into a fixed disease … management
plan
• Integrate individual disease management
plan into a disease
management … template” care
Slide 21: Hyperlinking
EHRs: Going
Full Wiki
• Using hyperlinks to integrate disease … management plan without extra inputs
Slide
22: Disease Management and Cost Containment
• Have
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cardiology-health-outcomes_research.pdf
July 01, 2010 - the 365 days preceding
the intervention date for evidence of cancer (International Classification of Diseases … V43.4) and
cerebrovascular disease (codes 434.x-438.x). … disease. … peripheral vascular disease,
and 60.6% had a prior diagnosis of cerebrovascular disease. … 625 (36.9) 3386 (46.0)
Renal disease — 7004 (10.5) 1081 (14.7)
11
12
Table 1.