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101. ADHD-Update-protocol-160818 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
     August 18, 2016 - and Statistical Manual of Mental Disorders (DSM-5)2 has revised the diagnostic criteria. … by specialty experts, as measured by diagnostic concordance. … This categorization may differ from the diagnostic classification provided by a specialist. … • Timing: o To assess diagnostic accuracy, diagnostic follow-up must be within 4 months of the … Diagnostic and Statistical Manual of Mental Disorders. 5th ed.

102. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
     July 19, 2023 - accuracy and diagnostic impact analyses KQ2-4: Randomized controlled trials (RCTs), clinical trials … We will document the diagnostic approaches and their diagnostic performance in detail for all suggested … We will also abstract adverse events associated with the diagnostic procedure. … For the diagnostic studies, we will apply criteria consistent with QUADAS-2. … We will order our findings by diagnostic and treatment strategy and then by outcome.

103. Disposition of Comments for CER 167 Renal Masses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
     February 24, 2016 - Non- diagnostic biopsies were NOT included as “negative” in these calculations. … We do not count normal fat or kidney as a diagnostic biopsy; instead it is labeled “non-diagnostic” … We merely report the non-diagnostic rates in the current body of literature. … A biopsy that does not yield a definitive diagnosis is non-diagnostic. … and non- diagnostic biopsies has been most scrutinized by the reviewers.

104. Liver-Cancer Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
     October 01, 2014 - What are the adverse effects or harms associated with imaging-based diagnostic strategies? … We identified 274 studies that evaluated diagnostic accuracy of imaging tests. … QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. … Empirical evidence of the importance of comparative studies of diagnostic test accuracy. … Evaluating diagnostic accuracy in the face of multiple reference standards.

105. Prostate-Cancer-Test Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
     October 14, 2011 - The paramount diagnostic challenge in dealing with prostate cancer is deciding which patients to biopsy … Having a tool with enhanced diagnostic specificity has the potential, at least partially, to reduce …  Intermediate outcomes: Diagnostic accuracy; impact on decisionmaking that provides information … In the indirect chain of evidence, Link B addresses the diagnostic accuracy (clinical validity) of … Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies.

106. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
     September 06, 2016 - However, the diagnosis remains clinical; there is no single gold standard diagnostic test. … Specifically, 1.a: What is the diagnostic accuracy of FeNO measurement(s) for making the diagnosis … In diagnostic studies, observational studies can start as high strength of evidence for diagnostic accuracy … QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. … A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations.

107. Disposition of Comments_Blood-Based Tests for Multiple Cancer Screening: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-disposition-comments.pdf
     May 14, 2025 - All studies that we labeled as “diagnostic accuracy” derived sensitivity estimates from MCST samples … or pre-diagnostic), the stage of the cases, the lead time (for pre-diagnostic studies), the type of … The division of diagnostic vs. pre-diagnostic studies is important and should be maintained. … The distribution of cancer types identified by diagnostic performance designs is not depicted as it … It is not possible to depict sensitivity and specificity on an ROC plot from any of the diagnostic

108. Hepatitis-C-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
     November 01, 2012 - We also included studies that reported the diagnostic accuracy of noninvasive tests for evaluating … No study evaluated the diagnostic accuracy of FibroSpect II for cirrhosis. … Diagnostic tests 3: receiver operating characteristic plots. BMJ. 1994;309(6948):188. … QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. … Meta-analyses of FibroTest diagnostic value in chronic liver disease.

109. Disposition of Comments for Technical Brief 23 Genetic Testing (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/genetic-testing-developmental-disabilities_disposition-comments.pdf
     June 30, 2015 - We revised the question to clarify standard-of- care diagnostic strategy. … We revised the question to clarify standard-of- care diagnostic strategy. … We do not agree that we have overemphasized the disadvantages of diagnostic yield studies. … compared to the standard-of-care diagnostic strategy or no testing. … accuracy using phenotype or other acceptable diagnostic standards as reference methods.”

110. Chapter 7: Grading a Body of Evidence on Diagnostic Tests | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-grading/methods

111. Considering the Range of Decision-Relevant Effects (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-choosing-outcomes.ppt
     June 01, 2012 - Diagnostic tests are applied to confirm or refute a disease in a symptomatic person. … Diagnostic Tests Segal JB. … Diagnostic Tests Diagnostic tests from are differentiated from screening tests largely by the population … Diagnostic Test Example: Computerized Tomography Versus Coronary Angiography (1 of 3) In the diagnostic … All of these may be appropriate outcomes to include in evaluating a diagnostic test.

112. Considering the Range of Decision-Relevant Effects (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-choosing-outcomes.ppt
     June 01, 2012 - Diagnostic tests are applied to confirm or refute a disease in a symptomatic person. … Diagnostic Tests Segal JB. … Diagnostic Tests Diagnostic tests from are differentiated from screening tests largely by the population … Diagnostic Test Example: Computerized Tomography Versus Coronary Angiography (1 of 3) In the diagnostic … All of these may be appropriate outcomes to include in evaluating a diagnostic test.

113. breast-biopsy-update-130920 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
     September 20, 2013 - The diagnostic performance of each core biopsy technique (each index test) will be quantified versus … b Most assessments of diagnostic performance quantify the sensitivity and the specificity of each index … Empirical evidence from meta-epidemiological studies suggests that diagnostic case-control studies may … Diagnostic  statistical  procedures  in  medical  meta-­‐analyses.   … Grading  a  body  of  evidence  on  diagnostic  tests.  

114. Research Protocol: Clostridium difficile Infection Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
     December 23, 2014 - CER examined the evidence on the sensitivity and specificity of C. difficile infection laboratory diagnostic … Since there has been some growth in the diagnostic testing literature, and diagnostic testing continues … a search algorithm without study-type filters will be used to screen for diagnostic studies. … positive and negative predictive values of the diagnostic tests for C. … QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies.

115. Prioritization and Selection of Harms for Inclusion in Systematic Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-selection-harms-systematic-reviews.pdf
     February 01, 2018 - Identify the types and number of harms to include for treatments and diagnostic tests. … Check diagnostic tests for imprecision or insensitivity 8. … Check diagnostic tests for imprecision or insensitivity 8. … Check diagnostic tests for Imprecision or insensitivity • Diagnostic tests (e.g. genetic or hematologic … Check diagnostic tests for imprecision or insensitivity For reviews that involve effects of diagnostic

116. Emerging MRI Technologies for Imaging Musculoskeletal Disorders under Loading Stress (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
     November 01, 2011 - There are 2 issues, one, do they add to the diagnostic ability and #2 additional cost of these extra … of false results can still be anticipated: for example, for diagnostic use of the test treatments … Peer Reviewer 3 (Results) Findings, page 37, line 43 Were diagnostic criteria provided? … It is unclear to what extent these new MRI techiques will enhance the diagnostic ability. … We agree that “diagnostic accuracy” would be a more appropriate term.

117. Disposition of Comments_Comparative Effectiveness Review No. 267: ADHD Diagnosis and Treatment in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-disposition-comments.pdf
     March 25, 2024 - The diagnostic criteria are fractions of a cause that has multiple factors. … established as diagnostic tools have been proposed..." … The The reference standard for American question focuses on comparative diagnostic accuracy of all diagnostic … There was no restriction regarding diagnostic interventions, but the diagnostic strategy had to be … The evidence table in the appendix provides more detail on the diagnostic process.

118. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0430_04-22-2011.pdf
     January 01, 2011 - retention Intervention(s): Physical examination Comparator(s): Physical examination with added diagnostic … computed tomography scan, prostate-specific antigen measurement, urodynamic tests) Outcome(s): Diagnostic … What should the diagnostic workup for identification of urinary retention include? 6.

119. Glaucoma-Screening Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_surveillance.pdf
     January 01, 2013 - HRT II and HRT III were found to have a similar diagnostic profile. … Ten studies examined the diagnostic accuracy of the HFA. … TSD restriction to <40um improved diagnostic accuracy. … Eleven studies examined the diagnostic accuracy of HRT III. … Ten studies examined the diagnostic accuracy of the HFA.

120. Renal-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
     April 20, 2015 - Diagnostic Evaluation and Detection of Disease All solid renal masses and cystic lesions with solid … In one retrospective study, percutaneous renal core biopsy was diagnostic in only 81% of cases, with … 79% of diagnostic biopsies showing evidence of malignancy.[23] However, percutaneous renal sampling … Despite the shortcomings in diagnostic testing, management decisions are made based on estimations of … QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies.