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421. Disposition of Comments for Comparative Effectiveness Review No. 240: Treatments for Acute Pain: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-revised-comments.pdf
     December 29, 2020 - therapy evaluated a single treatment session, potentially limiting the applicability of findings … Most alternative therapies are not covered by insurance. … • Heat therapy and massage: - A carefully designed active treatment plan has a greater impact … The report does not address multimodal therapies and in many cases treatments were not administered … The report does not address multimodal therapies and in many cases treatments were not administered

422. autism-update-protocol-130920 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-update_research-protocol.pdf
     September 20, 2013 - Individual goals for treatment vary for different children and may include combinations of therapies … context, components of multicomponent therapies that drive effectiveness, and predictors of treatment … providing the therapy? … a single treatment or across treatments? … , therapeutics, etc.).

423. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
     August 19, 2011 - Treatment options for CAD include medical therapy and invasive revascularization with either percutaneous … times and initial costs and possibly generate additional unnecessary invasive tests or unnecessary treatments … myocardial infarction [STEMI], non-STEMI, unstable angina, and stable angina) ○ Patients who have diabetes … literature sources such as Scientific Information Packages from manufacturers, Transcatheter Cardiovascular Therapeutics … Further analyses will be stratified based on patient- and lesion-level characteristics (diabetes, length

424. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
     January 01, 2016 - Background The administration of iodinated contrast media is an essential component of many diagnostic and therapeutic … object is to help consumers, health care providers, and others in making informed choices among treatment … Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus … J Diabetes Complications. 2008 May- Jun;22(3):171-7. PMID: 18413220. 29.

425. VU EPC DBD Protocol_AHRQ comments_revised_clean (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
     January 30, 2014 - We added inactive treatments and usual care (e.g., wait list controls, placebo, and treatment as usual … [sh] OR therapeutics[mh] OR teaching[mh] OR psychotherapy[mh] OR treatment outcome[mh] 6618402 #3 … [sh] OR therapeutics[mh] OR teaching[mh] OR psychotherapy[mh] OR treatment outcome[mh] OR “Adolescent … [sh] OR therapeutics[mh] OR teaching[mh] OR psychotherapy[mh] OR treatment outcome[mh] OR “Adolescent … "[Mesh:NoExp] OR treatment[tiab] OR therapy[tiab] OR training[tiab] OR "Treatment Outcome"[Mesh] OR

426. AHRQ's Evidence-based Practice Center Division Annual Report 2021: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2021.pdf
     January 01, 2021 - living with limb loss—a number expected to double by 2050—mostly due to the rising prevalence of diabetes … Management of COPD Exacerbations (AAFP) https://bit.ly/37tQUYE Pharmacologic and Nonpharmacologic Therapies … Radiation Therapy for Brain Metastases DOI: 10.23970/AHRQEPCCER242 20. … Radiation therapy for brain metastases: a systematic review. … Making narrative statements to describe treatment effects.

427. Allergy-Seasonal Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
     July 01, 2013 - headaches, and irritability.4,22 Decongestants are used with caution, if at all, in patients with diabetes … Drugs used for the treatment of SAR have wide therapeutic windows—that is, across the range of doses … Study designs that can more efficiently assess the effects of additive therapies are lacking. … Antihistamine therapy in allergic rhinitis. … Montelukast as an adjuvant to mainstay therapies in patients with seasonal allergic rhinitis.

428. Methods Guide for Medical Test Reviews Chapter 3 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
     July 01, 2012 - for detection of pulmonary embolism: a positive test will result in many months of anticoagulation therapy … These included adverse effects of therapies and beneficial effects—reduction in adverse pregnancy outcomes … Although the prognoses for some diseases are minimally modifiable with current treatments, most prognostic … Similarly, treatments of other conditions may be of less interest if life expectancy is short. … Screening for gestational diabetes mellitus: a systematic review for the U.S.

429. Fecal-Incontinence Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_research-protocol.pdf
     November 30, 2014 - age, female sex, chronic diarrhea, nerve damage (such as from injury, multiple sclerosis, or chronic diabetes … Conversely, the ultimate treatments may be aimed at mitigating earlier FI treatment failures. … Key Questions 1 and 2: • Nonsurgical o Functional enhancement therapies (muscle training/biofeedback … • Combined treatments: any combination Comparators • All other treatment options, alone … and implementation (treatment fidelity) for nonpharmacologic treatments.

430. Liver-Cancer-Therapy Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
     May 01, 2013 - overload syndromes, nonalcoholic fatty Effective Health Care Program 2 liver disease, obesity, diabetes … Three RCTs compared the ablative treatments RFA and PEI/PAI. … for the treatment of HCC is insufficient to support the effectiveness of one local hepatic therapy … The setting in which treatment occurs is a potential factor in the outcomes of local hepatic therapy … However, these clinical events may mark changes in therapies and treatment that may be important to

431. Management of Uterine Fibroids - Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-195-uterine-fibroids-final.pdf
     December 01, 2017 - Four studies evaluated therapies in postmenopausal women. … Among medical therapies, GnRH agonists, mifepristone, and ulipristal reduced fibroid size and improved … trajectories in which all initial treatments can be followed by all possible combinations of next treatments … uterine fibroids, growth patterns, and influences on growth (e.g., concurrent medical conditions like diabetes … No data is available to indicate whether use of therapeutics short of surgery might forestall or prevent

432. RESPONSE TO REQUEST FOR WORK ASSIGNMENT (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
     December 01, 2009 - One prominent gap in clinical information is lack of direct comparisons between treatments, as much … Eighth, treatments were compared among patients with propensity scores from 0.4 to 0.7. … Unlike placebo controlled trials, this study provides evidence as to the comparative effectiveness of treatments … to tailor therapies that are likely to optimize outcomes. … 2,066 (63.8%) Heart Disease 12,665 (32.6%) 1,114 (34.4%) Osteoarthritis 7,552 (19.4%) 567 (17.5%) Diabetes

433. Schedule of Visits and Use of Telemedicine for Routine Antenatal Care: A Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antenatal-care.pdf
     January 01, 2020 - improve the health and wellbeing of pregnant patients and their babies through 1) medical screening and treatment … and second trimester ultrasounds (for dating and viability and to evaluate anatomy, respectively), a diabetes … * Pregnancy complications: maternal mortality, antenatal pregnancy complications (gestational diabetes … All subgroup analyses or other evaluations of heterogeneity of treatment effect will be extracted. … ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus.

434. Abnormal-Uterine-Bleeding Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/abnormal-uterine-bleeding_research-protocol.pdf
     November 21, 2011 - options for AUB. 18 Nonsurgical treatment options–Pharmacologic therapies used for treatment of … , placebo, or no therapy for the treatment of heavy menstrual bleeding. 27 In a clinical review for … The Key Questions address nonsurgical therapeutic approaches (i.e., medical management, behavioral … current and prior contraception, perimenopausal status, fibroid status and comorbidities including diabetes … Tranexamic acid therapy for heavy menstrual bleeding.

435. Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic Review of Pharmacological Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
     December 05, 2018 - Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic … Practice Center Systematic Review Protocol Project Title: Maternal and Fetal Effects of Mental Health Treatments … consequences of perinatal psychiatric disorders, information about the efficacy and side effects of treatments … pharmacotherapy, and psychotherapy KQ 1, KQ 3: Active comparators, no comparators KQ 2, KQ 4: • Treatments … /preterm birth, preeclampsia, gestational hypertensive disorders, glucose intolerance/gestational diabetes

436. Horizon Scanning Protocol and Operations Manual January 2013 Revision (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual_130826.pdf
     August 01, 2013 - Diabetes mellitus 8. Functional limitations and disability 9. … Potential to change current treatment models 6. … cardiovascular medicine professionals; reports on emerging technologies, techniques and medical therapies … X X X X X X X Diabetes Technology & Therapeutics 1, 4, 5, 7 Monthly journal that publishes scientific … treatments.

437. Renal-Function Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
     August 01, 2014 - It may not be ethical to randomize or withhold therapy based on troponin values alone, as ACS treatment … Therapeutic options and likelihood of impact on outcomes may vary across stages of CKD. … Many patients may already have indications for these therapies; what additional treatment should clinicians … next steps regarding how best to manage these patients with elevated troponin levels (how and if treatments … would vary from those treatments indicated by clinical factors alone), the applicability of this screening

438. Rapid Response: Efficacy of Dental Services for Reducing Adverse Events in Those Receiving Chemotherapy for Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-response-chemotherapy-dental.pdf
     July 01, 2023 - prior to beginning acute immunosuppressive therapies or medical therapies for treatment of cancerous … (tooth extractions and periodontal treatments) less than 1 month before the start of radiation therapy … The rationale for providing pre-treatment dental care to patients who will undergo such treatments is … However, some newer cancer treatments, such as targeted therapies or CAR T-cell therapy, have not been … factors include poor oral health, invasive dental procedures, ill-fitting dentures, uncontrolled diabetes

439. Omega−3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
     August 01, 2016 - There have been secular trends in the prevention and treatment of CVD over the past several decades, … trends are the lower rates of cardiac and cerebrovascular disease, concomitant with higher rates of treatment … These treatment trends may have contributed to the lower population-level CV benefit of higher n-3 FA … , hormone replacement therapy)? … , hormone replacement therapy)?

440. App-D-Surv-Report-1-Noninvasive-Nonpharma 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-surv-report-1-noninvasive-nonpharma_0.xlsx
     January 01, 2021 - Physiotherapy (n=45); core stability-based physiotherapy treatment; two sessions of therapy per week … 55% Arthritis in other joints: 24% vs. 21% vs. 15% Cardiovascular disease: 13% vs. 6% vs. 11% Type 2 diabetes … during the last 12 months; (4) previous experience in meditation or other mind-body therapies; (5) presence … therapy referral. … than 12 weeks and with no underlying inflammatory or neoplastic disease Exclusion: Patients with diabetes