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401. Rapid Evidence Product_Assisted Home Dialysis in the United States: New Interest in an Old Idea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/home-dialysis-ESKD-rapid-research.pdf
     April 01, 2025 - Where am I going to put all these supplies that I need for my home therapy? … The person who says, ‘I would like to do home therapy, but there’s nobody to help me.’” … No limit on number of aide visits allowed; the aide only assisted with dialysis treatments that were … National Institute of Diabetes and Digestive and Kidney Diseases; May 2023. … —Chief Medical Officer, Home Therapies, Satellite Healthcare Susan Crowley, M.D., M.B.A.

402. Methods White Paper: Improving the Utility of Evidence Synthesis for Decision Makers in the Face of Insufficient Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
     April 01, 2021 - Evidence does not indicate an optimal treatment regimen or duration of therapy, or identify whether … as usual, waitlists, no treatment, or other active treatments, in adults with posttraumatic stress … Improving diabetes- related health care utilization? c. … Use of Cardiac Resynchronization Therapy. … Behavioral Programs for Type 1 Diabetes Mellitus: A Systematic Review and Meta- analysis.

403. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … ulcerative colitis), and we continue tracking novel drugs and interventions such as fecal microbiota therapy … at-home intravenous PN support for SBS, the manufacturer estimates the number of candidates for this therapy … Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National

404. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1306.pdf
     June 01, 2013 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Helminthic therapy (pig whipworm) for treatment-resistant ulcerative colitis No high-impact potential … Finally, one expert representing a clinical perspective stated that no therapies are available to promote … Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National

405. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
     May 01, 2012 - treatments). … , including the expected beneficial therapeutic effect as well as adverse effects of the treatment. … of adherence to prior therapies, particularly if adherence to therapy can affect the safety or effectiveness … Since they are not in fact candidates for one of the treatments, comparisons of treatment effectiveness … Clinical Pharmacology & Therapeutics 2004;75:234–241.

406. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - a call for a large randomized trial to evaluate the utility of platelet function testing to guide therapeutic … and to guide antiplatelet therapy in patient populations who are eligible for clopidogrel treatment … and to guide antiplatelet therapy in patient populations who are eligible for clopidogrel treatment … data which is the basis for the US- approved clopidogrel labeling recommendation to consider other therapies … Rather, it is very consistent with how antiplatelet therapies are evaluated for efficacy.

407. Evidence Summary-Comparative-Effectiveness-Review-213-Lower-Limb-Prostheses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-213-lower-limb-protheses-evidence-summary.pdf
     September 01, 2018 - living with limb loss, a number expected to double by 2050, mostly due to the rising prevalence of diabetes … least 65 years and those in which the percentage of participants with dysvascular disease (including diabetes … In other words, few studies address the issue of heterogeneity of treatment effect. … typical lower limb amputees with Medicare insurance, many of whom have dysvascular conditions including diabetes … Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence

408. AHRQ Evidence-Based Practice Center (EPC) Program Research Gaps Summary: Pain Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
     January 01, 2023 - , including opioid therapy, nonopioid pharmacologic therapy, and nonpharmacologic therapy. … Interventions • Research to identify effective nonpharmacologic therapies for neuropathic pain. … • Knee osteoarthritis: Exercise, cognitive behavioral therapy (CBT). … • Hip osteoarthritis: Exercise, manual therapies. … to clarify the effectiveness of vertebroplasty, specifically whether some sham interventions have therapeutic

409. Heart-Failure-Natriuretic-Peptide Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_executive.pdf
     November 01, 2013 - Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … summarize the current body of scientific knowledge, this review examined the diagnostic, prognostic, and therapeutic … for patients with or without diabetes. … ) for patients without diabetes. … Biological variation for N-terminal pro- and B-type natriuretic peptides and implications for therapeutic

410. Pharmacologic and Non-pharmacologic Therapies in Adult Patients with Acute Exacerbation of COPD: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
     April 11, 2018 - Examples of emerging treatments for AECOPD, some of which may have an established role in the treatment … from systemic corticosteroids, in particular hyperglycemia, in patients with glucose intolerance and diabetes … will focus on evidence from randomized controlled trials as the gold standard design for evaluating a therapeutic … / or exp Psychotherapy/ or exp Cognitive Therapy/ or exp Cognitive 6840812 Behavior Therapy/ or … Therapies/ or exp Electric Stimulation Therapy/ 7 ((action adj3 plan*) or (disease adj2 manag*)

411. Outcomes in COPD patients treated with theophylline (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-management_research.pdf
     December 01, 2009 - therapy. … arrhythmias, depression, hypertension, ischemic heart disease (IHD), osteoarthritis, rheumatoid arthritis, diabetes … Of these, 35.5% had a level in the therapeutic range. … there has been a lack of information on the effectiveness of theophylline in COPD compared to other therapies … Salmeterol plus theophylline combination therapy in the treatment of COPD.

412. Outcomes in COPD patients treated with theophylline (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/decide16final-mortality-risk-in-copd-pts-using-theophylline.pdf
     December 01, 2009 - therapy. … arrhythmias, depression, hypertension, ischemic heart disease (IHD), osteoarthritis, rheumatoid arthritis, diabetes … Of these, 35.5% had a level in the therapeutic range. … there has been a lack of information on the effectiveness of theophylline in COPD compared to other therapies … Salmeterol plus theophylline combination therapy in the treatment of COPD.

413. AHRQ’s Evidence-based Practice Center Program Annual Report 2023 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2023.pdf
     January 01, 2023 - Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms 18. … Receipt of Targeted Therapy and Survival Outcomes in Patients With Metastatic Colorectal Cancer. … International Conference on Pharmacoepidemiology and Therapeutic Risk Management. … International Conference on Pharmacoepidemiology and Therapeutic Risk Management. … The Effect of Dietary Digestible Carbohydrate Intake on Risk of Type 2 Diabetes, Growth, Size, and Body

414. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/11_pepticulcer_potential_high_impact_june_2012.pdf
     January 01, 2012 - , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Patients sometimes also use alternative therapies. … nonsurgical therapeutic alternative for patients with treatment-refractory disease. … Some noted that this treatment is priced less expensively than some currently approved UC treatments … Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD), National

415. Nonopioid Pharmacologic Treatments for Chronic Pain: Appendix E (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-ape_0.xlsx
     August 08, 2017 - Nonopioid Pharmacologic Treatments for Chronic Pain: Appendix E Appendix E. … chronic musculoskeletal pain Through February 3, 2016 N = 10631 Double-blind RCT (or crossover with first treatment

416. Disposition of Comments for Diagnostic Accuracy of Screening and Treatment of Post-Acute Coronary Syndrome Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-200-comments-post-acs.pdf
     November 14, 2017 - "Alternative therapies". Alternative may have negative connotations. … Consider a different word such as "Other therapies....". … We have replaced with “Other therapies.” 38. … the drugs if the patient preferred an antidepressant, or the patient was provided problem solving therapy … very important to highlight the trial of "blended" collaborative care for depression and co-morbid diabetes

417. Topic Brief: Updating Pharmacotherapy for Adults with Alcohol Use Disorders in Outpatient Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/nt_docs/topic-brief-updating-pharmacotherapy.pdf
     September 30, 2022 - with alcohol consumption linked to numerous acute and chronic conditions, including heart disease, diabetes … for AUDs (e.g., behavioral counseling, cognitive behavioral therapy, motivational enhancement therapy … / /drug therapy Pharmacotherapy OR pharmacologic From original review Naltrexone/ Acamprosate … "[MeSH Terms] OR "drug therapy"[MeSH Subheading] OR ("naltrexone"[MeSH Terms] OR "naltrexone"[All Fields … the effectiveness of these treatments m...

418. Colorectal-Surgery-Preparation Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
     March 26, 2013 - OMBP is also routinely prescribed prior to colonoscopy (screening, diagnostic, and therapeutic) to allow … elderly (≥65 years of age) and those with comorbidities such as cardiovascular and pulmonary disease, diabetes … the elderly), patients who have undergone adjuvant chemotherapy or radiotherapy, and patients with diabetes … We will also report probabilities that the difference (in the odds ratio scale) between pairs of treatments … Simultaneous comparison of multiple treatments: combining direct and indirect evidence.

419. ADHD Medications and Risk of Serious Coronary Heart Disease in Yough and Middle-Aged Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-heart-disease-children_research.pdf
     January 01, 2023 - Treatment of attention-deficit-hyperactivity disorder. … Treatment of attention-deficit/hyperactivity disorder: Overview of the evidence. … Cardiac safety of methylphenidate versus amphetamine salts in the treatment of ADHD. … Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials … analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics

420. Disposition of Comments for Comparative Effectiveness Review No. 240: Treatments for Acute Pain: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-revised-comments.pdf
     December 29, 2020 - therapy evaluated a single treatment session, potentially limiting the applicability of findings … Most alternative therapies are not covered by insurance. … • Heat therapy and massage: - A carefully designed active treatment plan has a greater impact … The report does not address multimodal therapies and in many cases treatments were not administered … The report does not address multimodal therapies and in many cases treatments were not administered