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401. Methods White Paper: Improving the Utility of Evidence Synthesis for Decision Makers in the Face of Insufficient Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
     April 01, 2021 - Evidence does not indicate an optimal treatment regimen or duration of therapy, or identify whether … as usual, waitlists, no treatment, or other active treatments, in adults with posttraumatic stress … Improving diabetes- related health care utilization? c. … Use of Cardiac Resynchronization Therapy. … Behavioral Programs for Type 1 Diabetes Mellitus: A Systematic Review and Meta- analysis.

402. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
     August 19, 2011 - Treatment options for CAD include medical therapy and invasive revascularization with either percutaneous … times and initial costs and possibly generate additional unnecessary invasive tests or unnecessary treatments … myocardial infarction [STEMI], non-STEMI, unstable angina, and stable angina) ○ Patients who have diabetes … literature sources such as Scientific Information Packages from manufacturers, Transcatheter Cardiovascular Therapeutics … Further analyses will be stratified based on patient- and lesion-level characteristics (diabetes, length

403. Attention Deficit Hyperactivity Disorder: Diagnosis and Treatment in Children and Adolescents - Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/deficit-hyperactivity-protocol.pdf
     November 01, 2021 - therapies. … , digital gamified cognitive therapies, EndeavorRx, play therapy, play-based interventions, mindfulness-based … ): Specific treatments compared with other treatments as described above or to no treatment KQ 3 (monitoring … Therapies"[MeSH] OR "Combined Modality Therapy"[MeSH] ADHD Systematic Review Protocol … ] OR "alternative therapy"[tiab] OR "alternative therapies"[tiab] OR "Interpersonal skills training"

404. Renal-Function Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
     August 01, 2014 - It may not be ethical to randomize or withhold therapy based on troponin values alone, as ACS treatment … Therapeutic options and likelihood of impact on outcomes may vary across stages of CKD. … Many patients may already have indications for these therapies; what additional treatment should clinicians … next steps regarding how best to manage these patients with elevated troponin levels (how and if treatments … would vary from those treatments indicated by clinical factors alone), the applicability of this screening

405. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - a call for a large randomized trial to evaluate the utility of platelet function testing to guide therapeutic … and to guide antiplatelet therapy in patient populations who are eligible for clopidogrel treatment … and to guide antiplatelet therapy in patient populations who are eligible for clopidogrel treatment … data which is the basis for the US- approved clopidogrel labeling recommendation to consider other therapies … Rather, it is very consistent with how antiplatelet therapies are evaluated for efficacy.

406. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-prevention_research-protocol.pdf
     November 03, 2011 - What are the harms from preventive pharmacologic treatments when compared to placebo or no active treatment … as monodrug therapy or drug therapy combined with nonpharmacological interventions; we clarified comparators …  We added a question addressing the role of dosing regimens and duration of treatments on treatment … factors and social/family support system – Comorbidities (depression, bipolar disorder, anxiety, diabetes … Impact of migraine and migraine therapy on productivity and quality of life.

407. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1406.pdf
     February 01, 2015 - , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … predominantly symptom- management options; however, emerging research aims to identify disease-modifying therapies … AD pathogenesis, leading researchers to investigate intranasally delivered insulin as a potential therapy … Food and Drug Administration (FDA) for treating diabetes, including Humulin® and Humulin R® (Eli Lilly … Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot

408. Horizon Scanning Protocol and Operations Manual January 2013 Revision (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual_130826.pdf
     August 01, 2013 - Diabetes mellitus 8. Functional limitations and disability 9. … Potential to change current treatment models 6. … cardiovascular medicine professionals; reports on emerging technologies, techniques and medical therapies … X X X X X X X Diabetes Technology & Therapeutics 1, 4, 5, 7 Monthly journal that publishes scientific … treatments.

409. Obesity Prevention and Control (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-research-methods_research-protocol.pdf
     February 08, 2017 - with the control group, the group with the voucher had a lower prevalence of extreme obesity and diabetes … stratifying by subgroups: age, race/ethnicity, gender, rural/urban, or clinical conditions (e.g., type 2 diabetes … , pre-diabetes, elevated cardiovascular risk). … selection bias or endogeneity, a term used by economists for treatment selection bias. … Neighborhoods, obesity, and diabetes--a randomized social experiment.

410. Colorectal-Surgery-Preparation Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
     March 26, 2013 - OMBP is also routinely prescribed prior to colonoscopy (screening, diagnostic, and therapeutic) to allow … elderly (≥65 years of age) and those with comorbidities such as cardiovascular and pulmonary disease, diabetes … the elderly), patients who have undergone adjuvant chemotherapy or radiotherapy, and patients with diabetes … We will also report probabilities that the difference (in the odds ratio scale) between pairs of treatments … Simultaneous comparison of multiple treatments: combining direct and indirect evidence.

411. Disposition of Comments for CER 165 Fecal Incontinence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/fecal-incontinence_disposition-comments.pdf
     March 21, 2016 - increasing age, female sex, chronic diarrhea, nerve damage (from injury, multiple sclerosis, or chronic diabetes … We edited the statement to read: Treatments for FI are imperfect and treatment combinations are common … Treatments for FI are imperfect and treatment combinations are common. … Combination therapy with biofeedback, loperamide, and stool-bulking agents is effective for the treatment … engaging patients in a conversation about risks and benefits of each therapeutic option is important

412. Future Research Needs for the Comparative Effectiveness of Breathing Exercises and/or Retraining Techniques in the Treatment of Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-treatment-future_research.pdf
     September 01, 2012 - First, this area of research – the use of breathing techniques and even complementary and alternative therapies … agenda related to the use of breathing techniques and exercises and other complementary and alternative therapies … Kuwait: Dasman Diabetes Institute; 2012. http://clinicaltrials.gov/ct2/show/NCT01509 443. … Heart rate variability biofeedback: its role in asthma therapeutics. … research, new-to-the-field thinking o Relevance to asthma: potential for new insights into causes and treatments

413. Major-Depressive-Disorder Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
     November 24, 2014 - increases the likelihood of chronic conditions such as obesity, smoking, sedentary lifestyles, diabetes … , cognitive therapy, cognitive behavioral therapy, interpersonal therapy, psychodynamic therapies, and … other talk therapies. … The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the … just SGAs and nonpharmacological therapies, they include all of the treatment comparisons of KQ1

414. Omega−3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
     August 01, 2016 - There have been secular trends in the prevention and treatment of CVD over the past several decades, … trends are the lower rates of cardiac and cerebrovascular disease, concomitant with higher rates of treatment … These treatment trends may have contributed to the lower population-level CV benefit of higher n-3 FA … , hormone replacement therapy)? … , hormone replacement therapy)?

415. Horizon-Scan Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-protocol.pdf
     December 01, 2011 - Diabetes mellitus 8. Functional limitations and disability 9. … Potential to change current treatment models b. … cardiovascular medicine professionals; reports on emerging technologies, techniques and medical therapies … X X X X X X X Diabetes Technology & Therapeutics 1, 4, 5, 7 Monthly journal that publishes scientific … treatments.

416. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … ulcerative colitis), and we continue tracking novel drugs and interventions such as fecal microbiota therapy … at-home intravenous PN support for SBS, the manufacturer estimates the number of candidates for this therapy … Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National

417. Pharmacologic and Non-pharmacologic Therapies in Adult Patients with Acute Exacerbation of COPD: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
     April 11, 2018 - Examples of emerging treatments for AECOPD, some of which may have an established role in the treatment … from systemic corticosteroids, in particular hyperglycemia, in patients with glucose intolerance and diabetes … will focus on evidence from randomized controlled trials as the gold standard design for evaluating a therapeutic … / or exp Psychotherapy/ or exp Cognitive Therapy/ or exp Cognitive 6840812 Behavior Therapy/ or … Therapies/ or exp Electric Stimulation Therapy/ 7 ((action adj3 plan*) or (disease adj2 manag*)

418. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
     May 01, 2012 - treatments). … , including the expected beneficial therapeutic effect as well as adverse effects of the treatment. … of adherence to prior therapies, particularly if adherence to therapy can affect the safety or effectiveness … Since they are not in fact candidates for one of the treatments, comparisons of treatment effectiveness … Clinical Pharmacology & Therapeutics 2004;75:234–241.

419. MEDICAL MANAGEMENT OF CONGESTIVE HEART FAILURE AND THE EFFECTIVENESS OF ISOSORBIDE DINITRATE AND HYDRALAZINE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/congestive-heart-failure-medicines_research.pdf
     March 01, 2010 - for very severe HF that had proven refractory to other treatments. … A review of uses of health care utilization databases for epidemiologic research on therapeutics. … Hypertension (uncomplicated) 73.7% 84 <.0001 Hypertension (complicated) 8.5% 18 <.0001 Diabetes … (uncomplicated) 39.7% 54 <.0001 Diabetes (complicated) 15.3% 27 <.0001 Hypothyroidism 5.1% … Mortality hazard ratios for receipt of selected heart failure therapies or combinations versus no therapy

420. Disposition of Comments for Diagnostic Accuracy of Screening and Treatment of Post-Acute Coronary Syndrome Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-200-comments-post-acs.pdf
     November 14, 2017 - "Alternative therapies". Alternative may have negative connotations. … Consider a different word such as "Other therapies....". … We have replaced with “Other therapies.” 38. … the drugs if the patient preferred an antidepressant, or the patient was provided problem solving therapy … very important to highlight the trial of "blended" collaborative care for depression and co-morbid diabetes