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41. Peripheral Nerve Disorders | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/peripheral-nerve-disorders
    September 06, 2016 - Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications … and Treatment of Symptoms of Diabetic Peripheral Neuropathy Research Protocol September … Project To Assess the Transparency of Reporting Requirements for Studies Evaluating the Effectiveness of Treatment … Peripheral Neuropathy Systematic Review Archived March 24, 2017 Effectiveness of Treatments

42. Comparative Effectiveness and Safety of Insulin Delivery and Glucose Monitoring Methods for Diabetes Mellitus | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/insulin-blood-sugar-2010/research-protocol
    June 02, 2011 - in the United States. 3,4 Thus, a large segment of the population requires glucose-lowering therapies … so that therapeutic options can be selected that result in improved process, intermediate, and clinical … of individuals with diabetes who are receiving treatment in a usual care setting. … Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. … Continuous glucose monitoring and intensive treatment of type 1 diabetes.

43. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
    January 01, 2015 - Medications for Adults with Type 2 Diabetes: An Update Focused on Monotherapy and Add-on Therapy to … Food and Drug Administration (FDA) for treatment of type 2 diabetes. … Diabetes Mellitus - Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes … Ambulatory treatment of type 2 diabetes in the U.S., 1997-2012. … Initial antihyperglycemic drug therapy among 241 327 adults with newly identified diabetes from 2005

44. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
    December 16, 2011 - The benefits and harms of treatments will be considered in this review in order to determine the downstream … Effect of treatment of gestational diabetes mellitus on obesity in the next generation. … Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. … A multicenter, randomized trial of treatment for mild gestational diabetes. … or therapy or therapies).mp. 43. manage$.mp. 44. monitor$.mp. 45. exp sulfonylurea compounds/

45. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-patients-including-both-children-and-adult-subgroup-comparisons-with-type-1-diabetes-what-is-the-comparitive-differences-in-hba1c-levels-when-comparing-various-treatment-options-including-multiple-daily-injections-insulin
    July 19, 2009 - pump therapy with continuous glucose monitoring? … Insulin pump therapy only. Multiple daily injections with continuous glucose monitoring. … Insulin pump therapy with continuous glucose monitoring. … Groups of patients include: All people with type 1 diabetes Children with type 1 diabetes Adults … (For example, improvements in patient symptoms or problems from treatment or diagnosis.)

46. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
    April 06, 2010 - It addresses both monotherapy and combination therapy for the management of type 2 diabetes in adults … therapy. … The diagnosis of type 2 diabetes leads to initial medical treatment. … adjustment of therapy: A consensus statement of the American Diabetes Association and the European … The diagnosis of type 2 diabetes leads to initial medical treatment.

47. Chronic Kidney Disease Stages 1-3: Screening, Monitoring, and Treatment (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_disposition-comments.pdf
    August 01, 2012 - New, well-designed RCTs of other treatments, and combination treatments should inform clinical practice … Reducing CVD risk is inferred from treatment of underlying conditions such as diabetes and hypertension … Although the number of persons initiating treatment for kidney failure each year who have diabetes listed … With regard to treatment, JNC7 recommends a blood pressure goal for patients with diabetes or CKD of … The report states that there is evidence to support treatment of CHF, hypertension, diabetes and other

48. Diabetes-Drugs-Utilization Research (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-drugs-utilization_research.pdf
    March 01, 2011 - Utilization of antidiabetic drugs among Medicare beneficiaries with diabetes, 2006-2009 Diabetes Treatment … metformin as a first-line therapy for treating type 2 diabetes until kidney function has declined to … a certain point.5,6 Second-line therapies include combinations of metformin and insulin, or metformin … New approaches to treating type 2 diabetes mellitus in the elderly: role of incretin therapies. … adjustment of therapy: a consensus statement of the American Diabetes Asso- ciation and the European

49. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
    January 01, 2007 - Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … in the treatment of type 2 diabetes. … Do oral diabetes medications for the treatment of adults with type 2 diabetes differ in their ability … Do oral diabetes medications for the treatment of adults with type 2 diabetes differ in their ability … Do oral diabetes medications for the treatment of adults with type 2 diabetes differ in their ability

50. S149 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s149.pdf
    October 01, 2007 - to existing therapies. … We explored the usefulness of these methods in our study of a new drug for treatment of type 2 diabetes … for treatment of type 2 diabetes.1 Exenatide is a peptide that is a partial analog of glucagon-like … In prelicensing trials, up to 20% of patients discontinued therapy due to nausea; however, the efficacy … Statistical Framework We developed methodology to compare a new medi- cation relative to established therapies

51. Kidney-Disease-Medicine Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
    January 01, 2012 - .16 In efforts to reduce the risk of complications from these conditions, therapeutic goals are sometimes … CKD Treatment Benefits and Harms • In RCTs of patients with CKD stages 1–3, several treatments reduced … with macroalbuminuria, ACEI or ARB treatment in combination with other therapy, and treatments other … • Patient-level meta-analyses of treatment RCTs to evaluate the effect of treatments relative to … Effectiveness of statin therapy in adults with coronary heart disease.

52. Supplemental Project To Assess the Transparency of Reporting Requirements for Studies Evaluating the Effectiveness of Treatment Options for Symptoms of Diabetic Peripheral Neuropathy | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/transparency-neuropathy/research
    July 28, 2017 - Project To Assess the Transparency of Reporting Requirements for Studies Evaluating the Effectiveness of Treatment … ClinicalTrials.gov on the conclusions and strength of evidence (SOE) grading from an ongoing systematic review of treatments … Peer-reviewed publications were identified from an ongoing systematic review of treatments for diabetic … independent reviewers screened ClinicalTrials.gov records for randomized controlled trials evaluating treatments … Project to Assess the Transparency of Reporting Requirements for Studies Evaluating the Effectiveness of Treatment

53. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0283_03-10-2008.pdf
    January 01, 2008 - interested in the evidence base surrounding laparoscopic adjustable gastric banding (LAGB) for the treatment … Many recent studies on the effectiveness of bariatric surgery for the treatment of diabetes have shown … bariatric surgery to be more effective in treating type 2 diabetes than conventional therapy. … bariatric surgery, such as a less invasive laparoscopic gastric banding, should be the first-line treatment … for obese patients with type 2 diabetes.

54. Comparative Effectiveness of Coronary Bypass Surgery and Percutaneous Coronary Interventions for Multivessel Disease: A Pooled Analysis of Individual Patient Data from Ten Randomized Trials (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_addendum.pdf
    February 01, 2010 - Treatment effect was not modified by clinical characteristics, apart from diabetes and age (Figure 2 … The interactions of diabetes with treatment, and age with treatment remained significant when both were … The final analysis of the Arterial Revascularization Therapies (ARTS) randomized trial. … Continuing evolution of therapy for coronary artery disease. … Fibrinolytic Therapy Trialists' (FTT) Collaborative Group.

55. Kidney-Disease-Medicine Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
    October 01, 2012 - to the conclusions involve refinement of original estimates or do the potential changes mean some therapies … Patients with proteinuria, diabetes, and hypertension may benefit from ACEI or ARB treatment. … Patients with proteinuria, diabetes, and hypertension may benefit from ACEI or ARB treatment. … Do Not Know CKD Treatment Benefits and Harms In RCTs of patients with CKD Stages 1-3 several treatments … Patients with proteinuria, diabetes, and hypertension may benefit from ACEI or ARB treatment.

56. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/transparency-neuropathy/research-protocol
    September 06, 2016 - Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications … and Treatment of Symptoms of Diabetic Peripheral Neuropathy Research Protocol September 6, 2016 Download … and Treatment of Symptoms of Diabetic Peripheral Neuropathy on Diabetic Peripheral Neuropathy" (DPN) … options (antidepressants, antiepileptics, and topical and subcutaneous treatments) to improve the symptoms … peripheral neuropathy and health-related quality of life among adults age 18 or older with type 1 or type 2 diabetes

57. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
    March 01, 2011 - therapy is the cornerstone of treatment for type 2 diabetes. … Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … Combination therapies that included a sulfonylurea plus metformin also had an excess hypoglycemia risk … conclusive information to predict which subgroups of patients might differentially respond to alternative treatments … High Combination therapies were better than monotherapy regimens at reducing HbA1c, with an absolute

58. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/diabetic-neuropathy/research-2017
    March 24, 2017 - defined by each individual study) does not prevent foot ulcers more than standard control for type 2 diabetes … For nonpharmacologic treatment options, specific types of therapeutic footwear (moderate SOE), integrated … There is insufficient evidence to evaluate whether physical therapy, exercise, or balance training reduces … For nonpharmacologic treatments, alpha-lipoic acid is more effective than placebo (low SOE) and spinal … We were unable to draw conclusions about quality of life for any of the treatments due to incomplete

59. TND-555-09-03-2013 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-555-09-03-2013.pdf
    January 01, 2013 - cardiovascular outcomes (e.g., heart disease, stroke), comorbidities (e.g., depression, anxiety), adherence to treatment … Does educational counseling help patients improve glucose control and adherence to treatment? … AHRQ systematic reviews were identified: • An archived 2004 AHRQ report entitled: Use of Behavioral Therapies … for Treatment of Medical Disorders: Part 1 – Impact on Management of Patients with Diabetes Mellitus … What is the evidence that medical nutrition therapy education on day-to-day management of diabetes improves

60. Can anything be done to improve diabetic periphheral neuropathy?What is truly effective? What research seems promising? (diabetes type 2,well controlled) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/can-anything-be-done-to-improve-diabetic-periphheral-neuropathywhat-is-truly-effective-what-research-seems-promising-diabetes-type-2well-controlled
    April 02, 2013 - Briefly describe a specific question, or set of related questions, about a health care test or treatment … (diabetes type 2,well controlled) Does your question include a comparison of different health care … Please include specific details such as age range, gender, coexisting diagnoses, and indications for therapy … (For example, improvements in patient symptoms or problems from treatment or diagnosis.) … (check all that apply) EHC Priority Conditions (updated in 2008) Diabetes mellitus AHRQ Priority