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361. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
     August 05, 2010 - Nonpharmacologic interventions (such as physical therapy, weight reduction, and exercise) also help … Question 2 Do the comparative benefits and harms of oral treatments for osteoarthritis vary for certain … disease; history of previous gastrointestinal bleeding (any cause); renal disease; hepatic disease; diabetes … Note that selection of candidates for therapy is outside the scope of this review. … Am J Therapeutics. Previous Report, 2004;11:17-25. 9.

362. 15 Crosscutting Potential High Impact 2012-12-11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/15_crosscutting_potential_high_impact_2012-12-11.pdf
     January 01, 2012 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … purposes of horizon scanning, AHRQ’s interests are broad and encompass drugs, devices, procedures, treatments … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Intelligent Pills (The Raisin System) to Monitor Patient Medication Adherence Effective medical therapy … Adherence to long-term therapies.

363. Liver-Cancer-Therapy Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
     November 28, 2012 - hereditary hemochromatosis and iron overload syndromes, nonalcoholic fatty liver disease (NAFLD), obesity, diabetes … In the continuum of care, use of liver-directed therapies has traditionally preceded treatment with … brachytherapy, hypofractionated proton beam therapy) • Transarterial therapies (TAE, TACE, RE, DEBs … o Were concurrent/concomitant treatments clearly specified and given equally to treatment groups? … Comparing across these treatment categories assumes patients were eligible for both treatments.

364. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … purposes of horizon scanning, AHRQ’s interests are broad and encompass drugs, devices, procedures, treatments … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … tracked in the system as of November 30, 2014, and pertain to very different types of diagnostic and treatment … preconception and prenatal care; problems that may occur during pregnancy, including gestational diabetes

365. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
     March 08, 2012 - smoke, and cold temperatures.21,23 It also provides the rationale for initiating effective rhinitis therapies … prophylactically before the commencement of pollen season.24,25 Treatment Treatments for allergic … www.effectivehealthcare.ahrq.gov Published Online: March 8, 2012 4 caution, if at all, in patients with diabetes … Decisions about which treatments are best during pregnancy must weigh the potential treatment-related … Antihistamine therapy in allergic rhinitis. Immunol Allergy Clin North Am 2011 Aug;31(3):509-43.

366. Template for Draft Reports (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_appendixes.pdf
     October 06, 2006 - Other Arterial Revascularization Therapies Study (ARTS). Indian Heart J. 2001 Mar-Apr;53(2):239. … presence of diabetes. … Effects of coronary angioplasty, coronary bypass surgery, and medical therapy on employment in patients … Measuring the therapeutic efficacy of coronary revascularization: Implications for future management … Number of subjects who received assigned therapy?

367. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol.pdf
     January 31, 2023 - Similarly, we would consider including a study of occupational or other therapies as an adjunct treatment … , interpersonal psychotherapy, psychodynamic therapy, dialectical behavior therapy, equine- assisted … harms: Unvalidated outcomes measures 6 - Metabolic effects: weight gain, hyperglycemia and diabetes … history (e.g., previous psychosocial and pharmacologic treatments, whether or not treatments are ongoing … " or "multidimensional treatment" or "multisystemic therapy" or "multi-systemic therapy" or "negative

368. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
     September 01, 2011 - as therapies for patients with TRD: electroconvulsive therapy (ECT), repetitive transcranial magnetic … Comparisons of these nonpharmacologic therapies are our main interest. … How do the efficacy, effectiveness, or harms of treatment with nonpharmacologic treatments for TRD differ … – Patients with medical comorbidities (e.g., seizure history, stroke, diabetes, dementia, perinatal depression … Direct comparisons of treatment strategies, holding consistent any coexisting or concomitant therapies

369. Renal Artery Stenosis Management Strategies: An Updated Comparative Effectiveness Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-update_disposition-comments.pdf
     August 16, 2016 - of the treatment trials. … revascularization according to clinical practice and those in whom there was felt to be reasonable therapeutic … One message to patients in conducting a comparative effectiveness trial of two standard treatments … medicaitons as an outcome (given other indications for many of these medications in the setting of diabetes … , CAD, diabetes, etc) may be worthy of mention.

370. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Off-label intranasal insulin for treatment of Alzheimer’s disease No high-impact potential; archived … usage; a July 2014 paper by Jeffrey Cummings and colleagues in the journal Alzheimer’s Research & Therapy … This drug, in various formulations, is approved and widely used to manage diabetes indications; no major

371. Dietary-Supplements Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
     April 01, 2012 - CHD risk (44 participants with statin-induced myalgia38), and high CHD risk (40 participants with diabetes … Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis … Use of complementary therapies in patients with cardiovascular disease. … Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes … omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes

372. Nephropathy-Contrast-Induced Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
     October 01, 2015 - Background The administration of iodinated contrast media is an essential component of many diagnostic and therapeutic … Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … procedures, and the increasing prevalence of populations vulnerable to CIN (i.e., people having CKD, diabetes … did not observe any meaningful difference by age, baseline renal function, presence or absence of diabetes … Effect of short-term rosuvastatin treatment on estimated glomerular filtration rate.

373. Draft Comparative Effectiveness Review Appendicies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_appendixes.pdf
     April 01, 2005 - Therapeutic safety of perindopril in the treatment of mild hypertension with concomitant nephropathy … Enalapril versus triple-drug therapy in the treatment of renovascular hypertension. … Renovascular hypertension: results of medical and surgical therapy. … Stent angioplasty of severe atherosclerotic ostial renal artery stenosis in patients with diabetes … heart failure; CKD, chronic kidney disease (renal insufficiency); CVD, cardiovascular disease; DM, diabetes

374. Disposition of Comments for Progestogens for Prevention of Preterm Birth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
     September 07, 2012 - This is true, but treatment was with vaginal gel rather than intramuscular or suppository therapy. … is some evidence that 17-alpha hydroxyprogesterone caproate may increase the risk of gestational diabetes … It includes the data the reviewer refers to about the incidence of gestational diabetes by study type … about potential for harm and risk does not adequately cover the risk of fetal death or gestational diabetes … Eisenberg Center Results Page 86, Line 19: Summary of KQ2 results, Harms of Progestogen Treatments.

375. Attention Deficit Hyperactivity Disorder: Diagnosis and Treatment in Children and Adolescents - Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/deficit-hyperactivity-protocol.pdf
     November 01, 2021 - therapies. … , digital gamified cognitive therapies, EndeavorRx, play therapy, play-based interventions, mindfulness-based … ): Specific treatments compared with other treatments as described above or to no treatment KQ 3 (monitoring … Therapies"[MeSH] OR "Combined Modality Therapy"[MeSH] ADHD Systematic Review Protocol … ] OR "alternative therapy"[tiab] OR "alternative therapies"[tiab] OR "Interpersonal skills training"

376. S158 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s158.pdf
     October 01, 2007 - outcome and abstract information on additional potential confounders including obesity, hyperten- sion, diabetes … age (continuous), sex, race (white, black, other), myocardial infarc- tion, congestive heart failure, diabetes … infarction 0.9 0.8–0.9 1.1 0.8–1.5 1.1 0.7–1.5 Congestive heart failure 0.9 0.9–1.0 0.9 0.6–1.3 0.8 0.6–1.3 Diabetes … Paradoxical relations of drug treatment with mortality in older persons. … analysis and external adjustment for unmea- sured confounders in epidemiologic database studies of therapeutics

377. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST … Effectiveness Review Disposition of Comments Report Research Review Title: Antiplatelet and Anticoagulant Treatments … Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non–ST Elevation Myocardial Infarction … in this therapeutic approach. … …” These drugs were tested in patients with ACS as an “add on” to standard therapy for the treatment

378. Methods Guide for Medical Test Reviews Chapter 11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
     July 01, 2012 - 11-2 of surgically excised tumors from patients with breast cancer); or (3) predict response to treatments … Some examples include heart disease and diabetes. … decisions, or predicting response to treatments (either effectiveness or harms)—or whether it is used … For example, age, sex, smoking, hypertension, diabetes, and cholesterol are all well established risk … HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review.

379. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
     March 22, 2023 - Similarly, we would consider including a study of occupational or other therapies as an adjunct treatment … , interpersonal psychotherapy, psychodynamic therapy, dialectical behavior therapy, equine- assisted … Adverse effects/harms: - Metabolic effects: weight gain, hyperglycemia and diabetes, hyperlipidemia … history (e.g., previous psychosocial and pharmacologic treatments, whether or not treatments are ongoing … " or "multidimensional treatment" or "multisystemic therapy" or "multi-systemic therapy" or "negative

380. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-prevention_research-protocol.pdf
     November 03, 2011 - What are the harms from preventive pharmacologic treatments when compared to placebo or no active treatment … as monodrug therapy or drug therapy combined with nonpharmacological interventions; we clarified comparators …  We added a question addressing the role of dosing regimens and duration of treatments on treatment … factors and social/family support system – Comorbidities (depression, bipolar disorder, anxiety, diabetes … Impact of migraine and migraine therapy on productivity and quality of life.