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161. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
     March 15, 2010 - Treatment Continuous positive airway pressure (CPAP) is the standard 1st-line therapy for most patients … Treatment KQ5: What is the comparative effect of different treatments for obstructive sleep apnea (OSA … KQ6: In OSA patients prescribed non-surgical treatments, what are the associations of pre- treatment … Non-insulin dependent diabetes (diagnosis, resolution, start or end treatment) d. … Treatment, therapy, or intervention (No KQ) (KQ 5) (KQ 5) (KQ 5) Health

162. Medication-Adherence-Interventions Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-adherence-interventions_executive.pdf
     September 01, 2012 - Adherence to Long Term Therapies: Evidence for Action. … Adherence to Long Term Therapies: Evidence for Action. … or therapeutic compliance? … Integrating type 2 diabetes mellitus and depression treatment among African Americans: a randomized … Effects of enhanced depression treatment on diabetes self-care.

163. Disposition of Comments for CER 176 Management of Gout (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-management-disposition-160721.pdf
     March 15, 2016 - I agree that potential discontinuation (“drug holiday”) of urate-lowering therapy after effective treatment … also approved RA treatments). … Doherty M, Bardin T, et al; EULAR Standing Committee for International Clinical Studies Including Therapeutics … Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. … Given our experience in this therapeutic area, we are submitting a comment to provide updates, since

164. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - There was no difference in diabetes risk for MTX. No issues identified. … Conclusion is possibly out of date if diabetes risk is a concern to stakeholders. … RA in subgroups of patients based on stage of disease, prior therapy, demographics, concomitant therapies … : a multiple-treatment Bayesian metaanalysis. … based on stage of disease, prior therapy, demographics, concomitant therapies, or comorbidities?

165. Rheumatoid-Arthritis-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
     March 01, 2013 - There was no difference in diabetes risk for MTX. No issues identified. … Conclusion is possibly out of date if diabetes risk is a concern to stakeholders. … RA in subgroups of patients based on stage of disease, prior therapy, demographics, concomitant therapies … : a multiple-treatment Bayesian metaanalysis. … based on stage of disease, prior therapy, demographics, concomitant therapies, or comorbidities?

166. Evidence-based Practice Center Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ongoing-studies-evidence_research.pdf
     December 01, 2010 - Pharmacological treatment of dementia. … Acute stroke: evaluation and treatment. … Center EPC No No Year: 2005 3 4 Effectiveness of Antimicrobial Adjuncts to Scaling and Root- Planing Therapy … Narrative “Research and Clinical Implications” Year: July 2005 7 2 Diagnosis, Prognosis, and Therapy … 1 0 1 0 2 PAION Deutschland GmbH 0 0 2 0 2 Pfizer 0 0 2 0 2 Sanofi-Aventis 0 0 2 0 2 Transition Therapeutics

167. Survey of Medicare Part D Plans’ Medication Therapy Management Programs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management-1_research-2007.pdf
     January 01, 2007 - Management (MTM) programs, focused on optimizing therapeutic outcomes for patient with multiple medications … Diabetes Care 2002;25(7):1159-71. 43. … Impact of automated calls with nurse follow-up on diabetes treatment outcomes in a Department of Veterans … other prescribing physician when a potential DTP exists and provision of recommended alternative therapies … physician prescribing pattern feedback, therapeutic guidelines, and other tools designed to influence

168. Antipsychotics-Adults Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_executive.pdf
     August 01, 2012 - Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … • Specific AEs: – Major: mortality, cerebrovascular disease- related events, development of diabetes … changes (including changes in glucose levels, triglycerides, lipids, and the risk of developing diabetes … • Treatment of a first episode versus treatment in the context of previous episodes (previous exposure … • Treatment resistance.

169. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypothyroidism-hyperthyroidism-screening-treatment_research-protocol.pdf
     March 11, 2010 - Risk factors Risk factors for subclinical hypothyroidism include previous hyperthyroidism, type 1 diabetes … This uncertainty impacts the decision-making for clinicians who are considering treatments for subclinical … Adverse reactions are usually due to therapeutic overdosage and resulting hyperthyroidism. … cold intolerance, etc.) ------------- High-risk individuals without known thyroid disease (Diabetes … OR 1-9 11. therapeutic use [sh] 12. treatment [tiab] 13. therapy [tiab] 14.

170. Evidence Summary: Comparative Effectiveness Review No. 236 Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-236-mental-health-pregnancy-evidence-summary.pdf
     April 01, 2021 - Summary: Comparative Effectiveness Review No. 236 Maternal, Fetal, and Child Outcomes of Mental Health Treatments … Treatment choices for mental health disorders include pharmacotherapy, psychotherapy, and other approaches … Key Question (KQ) 1: Benefits of Pharmacologic Treatments Versus No Treatment or Placebo for Pregnant … KQ 3: Harms of Pharmacologic Treatments Versus No Treatment or Placebo for Pregnant and Postpartum Women … spontaneous abortion; and quetiapine and olanzapine may be associated with an increased risk of gestational diabetes

171. CER 217 Management of Infertility Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-217-infertility-evidence-summary.pdf
     May 01, 2019 - Infertility Evidence Summary Comparative Effectiveness Review Number 217 Background Condition and Therapeutic … • There was no difference between type 1 diabetes mellitus diagnoses in children born to patients … Low (Moderate study limitations) Long-term outcomes: Child (type 1 diabetes mellitus) 1 Obs90 … Live birth is the correct outcome for clinical trials evaluating therapy for the infertile couple. … Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live

172. Strategies To Prevent Weight Gain in Adults: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-future_research.pdf
     January 01, 2020 - Despite this goal, we know of no treatment guidelines for the prevention of weight gain or maintenance … Understanding what strategies are the most effective to prevent weight gain in adults may help establish treatment … the prevalence of obesity among adults to less than 30 percent.5 Despite this goal, we know of no treatment … however, they stipulated that a well-conducted RCT should assess outcomes by individuals blinded to treatment … Optimal Integrated Treatment Study for 3 Major Risk Factors of Cardiovascular Diseases http://ClinicalTrials.gov

173. Treatments for Schizophrenia in Adults: A Systematic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
     January 01, 2017 - Treatments for Schizophrenia in Adults: A Systematic Review Evidence Summary Condition and Treatment … Psychosocial and other nonpharmacological treatments include: assertive community treatment, cognitive … regardless of the length of the followup period, but that the type of intervention (psychoeducation or therapeutic … Defining empirically supported therapies. J Consult Clin Psychol. 1998 Feb;66(1):7-18. … Cognitive behavioural therapy versus other psychosocial treatments for schizophrenia.

174. Abnormal-Uterine-Bleeding Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
     March 01, 2013 - Therapies In a recently published research article examining the practice patterns for medical treatment … Interventions:a • Medical therapies – Nonsteroidal anti-inflammatory drugs – Antifibrinolytics – … or add additional treatments. … Glucagon-like peptide analogues for type 2 diabetes mellitus. … Surgery versus medical therapy for heavy menstrual bleeding.

175. Microsoft Word - ehcrr#2toCSI.doc (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-seniors-death_research.pdf
     August 01, 2007 - Results: 12,882 seniors initiated conventional APM therapy and 24,359 atypical APMs. … Clin Therapeutics 2002; 24(9): 1466- 76. 6 Health Canada. … J Am Stat Assoc 1983; 79: 516-524. 26 Braitman LE, Rosenbaum PR: Rare outcomes, common treatments … A review of uses of health care utilization databases for epidemiologic research on therapeutics. … 1.60 (1.42-1.80) 40-79 Days after beginning therapy 1.31 (1.14-1.51) 80-180 Days after beginning therapy

176. Urinary-Incontinence-Treatment Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
     September 30, 2010 - (Needham, Mass ) The Adjustable Continence Therapy (ACT®) The Adjustable Continence Therapy (ACT®) Uromedica … What are the harms from pharmacologic treatments when compared with no active treatment? 4. … What are the harms from nonpharmacologic treatments when compared with no active treatment? 5. … treatment, education, behavioral therapy, biofeedback, bladder retraining (Kegel exercises), electrical … Eligible interventions of drug therapies or nonsurgical treatments.

177. Venous-Ulcers-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
     January 01, 2014 - exists about which second-line treatments work best. … Clinicians often use empiric therapy or “culture- based treatment” for wounds that are not healing, even … Surgical treatments for chronic venous ulcers Pathology Treatment Description Superficial venous system … algorithms for guiding therapy, and to better understand which therapeutic interventions have value … Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic

178. Pneumonia-Antibiotic-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_executive.pdf
     November 01, 2014 - Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … HAP caused by S. aureus is found with greater frequency in patients with diabetes mellitus, patients … Appropriate antibiotic therapy significantly improves survival for patients with HAP.8-11 Relevant … would benefit from updated information that will point to more effective strategies for using current therapies … Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society

179. Disposition of Comments: Technical Brief No. 38_Automated Entry Patient Generated Health Data for Chronic Conditions: The Evidence on Health Outcomes (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-38-chronic-conditions-comments.pdf
     March 01, 2021 - Despite positive findings, the report assigns “Possible positive effect(s)” to only four therapeutic … Diabetes prevention is included, but not diabetes. … Section Comment Response lengths to recommend against the use of beta blockers as first line therapy … or therapies, even those approved by FDA, that demonstrate long term health outcomes. … used interchangeably in the structured abstract, evidence summary, and introduction) for device and therapy

180. Measuring-Blood-Pressure Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/measuring-blood-pressure_executive.pdf
     January 01, 2012 - mmHg or less in the general population and a lower threshold of 130/80 mmHg or less in patients with diabetes … Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … New meta-analysis of treatment trials of hypertension: improving the estimate of therapeutic benefit … most were male, and the most commonly cited comorbid conditions in these studies were type 1 or 2 diabetes … Another found no difference by age, sex, or diagnosis with diabetes.