-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
October 05, 2012 - The first two research gaps are straightforward
although not easy studies to design. … But
difficult to design and implement in the real world. … appropriately
note that definitively determining a mortality difference
would require a very large sample … size. … and standard therapy and have a confidence interval that is narrow
would require a large sample size
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
October 17, 2012 - In a situation where double blinding may not be feasible, the burden of the design
issues is higher … Furthermore, given the anticipated large number of trials that have
moved to a more rigorous design … This review will also identify those areas in which there are inadequate
evidence to inform the design … They had serious errors in design, analysis, or reporting; large amounts of missing
information; or … Therefore study
questions, design and/or methodological approaches do not necessarily represent the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/public-reporting-cost-measures_disposition-comments.pdf
March 05, 2015 - is able to
address them, or what methodological/framework problems need to be resolved in
order to design … Given, the small
sample size of semipublic websites
that we had access to, we could not
make definitive
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
March 01, 2012 - Peer Reviewer #1 Executive
Summary
In the methods section, please justify how the sample
size of … Peer Reviewer #1 Methods Please justify how the sample size of 750 was chosen
for the observational … Peer Reviewer #1 Results 3.Study design and characteristics: When only a
selection of included studies … Peer Reviewer #1 Results 2.Study design and characteristics: When only a
selection of included studies … Peer Reviewer #1 Results 3.It is already stated in the study design and
characteristics section that
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-infertility_research-protocol.pdf
September 02, 2016 - For
unmatched studies, we will conduct a manual match using the condition, intervention, sample
size … record, we will abstract selected variables from the
CT.gov record to determine whether key study design … Published online: September 2, 2016
3
• Number of study arms
• Intervention description
• Study design … interventions] Methods: Intervention 2 M/D/P
[Assigned interventions] Methods: Comparators M/D/P
[Study design
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-childhood-protocol.pdf
August 06, 2018 - Inpatient care, studies conducted
in countries without a very high
Human Development Index
Study design … All other designs and studies
using included designs that do
not meet the sample size
criterion … When studies with sample sizes of 1,000 or more participants are available
for a given intervention … If large samples are not
available, we plan to include studies with smaller sample sizes
http://hdr.undp.org … Therefore, study questions, design, and methodological approaches do not
necessarily represent the views
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-strength-evidence.ppt
June 01, 2012 - Risk of bias
How study type/design/conduct may have contributed to systematic bias must be considered … The type and design of the study and how it is conducted can each contribute to systematic bias. … It is integrally related to sample size. … Precision is affected by the width of the confidence intervals and sample size. … Variability in study results is explained by differences in study design, patient population or test
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-strength-evidence.ppt
June 01, 2012 - Risk of bias
How study type/design/conduct may have contributed to systematic bias must be considered … The type and design of the study and how it is conducted can each contribute to systematic bias. … It is integrally related to sample size. … Precision is affected by the width of the confidence intervals and sample size. … Variability in study results is explained by differences in study design, patient population or test
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-protocol-amended.pdf
June 10, 2018 - Feasibility will be determined by the
number and sample size of clinical trials available per topic.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/living-systematic-reviews-full-text-articles-white-paper.pdf
January 01, 2024 - Among the uncontrolled
studies, sample sizes ranged from 7 to 8,165 (mean 551, median 151). … A
randomized, double-blind, placebo-
controlled, parallel-group, enriched-design
study of Nabiximols … Trial
Novotna, A.52 2011 A randomized, double-blind, placebo-controlled,
parallel-group, enriched-design … A
randomized, double-blind, placebo-
controlled, parallel-group, enriched-design
study of nabiximols
-
effectivehealthcare.ahrq.gov/sites/default/files/searching.ppt
January 01, 2011 - Searching for Relevant Studies
Searching for Relevant Studies
Agency for Healthcare Research and Quality (AHRQ)
Training Modules for Methods Guide for Effectiveness and Comparative Effectiveness Reviews
Searching for Relevant Studies
Systematic Review Process Overview
*
Systematic Review Process Overview
…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-1.pdf
June 01, 2022 - Comparative observational studies
Systematic reviews or meta-analyses (evaluating triptans and NSAIDs)
Any sample … size
Relevant systematic reviews, or meta-analyses (used for identifying
additional studies)
In … [Study design not of
interest]
16. … [Study design not of
interest]
33. … [Study
design not of interest]
177.
-
effectivehealthcare.ahrq.gov/sites/default/files/coronary-artery-disease-testing_executive.pdf
March 01, 2011 - Systematic Reviews of
Interventions.12 Comparative observational studies were
assessed for study design … Given the low incidence of mortality and MI in the studies
previously noted, sample sizes in even the … As mentioned
previously, study sample sizes and short-term followup
may preclude evaluation of rare … Sufficient
sample size may be a challenge, given the low prevalence of
CAD that is likely in this group … RCTs or pragmatic trials with sufficient sample size to
compare differential effectiveness and safety
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-201-indoor-allergen-asthma-disposition-comments.pdf
February 15, 2018 - When the body of evidence is small,
such as a single trial with an
inadequate sample size, or a few
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_disposition-comments.pdf
January 27, 2016 - 105)
as this study compared both POCT CRP and
communication skills with usual care in a
factorial design … was also able
to do a head-to-head comparison of CRP and
communication skills due to the factorial
design … to compare all
interventions using all outcomes, this would
probably lead to an almost impossible design … The sample size
of this study was less than
2000 patients, and as noted
hospitalization is somewhat … The needed sample
size would be about double.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_disposition-comments.pdf
July 10, 2012 - PMID:
20042299; excluded for wrong study design
Peer Reviewer #1 Results The summary for KQ2 reports … for important
potential confounders; unable to separate
results for zone 1 vs zone 2 vs zone 3; by
design … These included
randomised controlled trials and other studies adopting
experimental design.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_disposition-comments.pdf
April 02, 2013 - Instead, we
assessed critical domains for each study
design (see methods).
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - • We included randomized trials that used a crossover design, with some exceptions.
• Only studies … Because of low event rates and
sample size, the pooled studies for most comparisons on
these outcomes … considered current.
22
Database requirements for such observational studies
include sufficient sample … size, followup of patients over
time, detailed data on treatments (including doses and
duration),
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
March 01, 2013 - used established
concepts of the quantity of evidence (e.g., numbers of
studies, aggregate ending-sample … sizes), the quality of
evidence (i.e., from the quality ratings of individual
articles), directness
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
April 15, 2021 - estimates)” when talking about precision in
general terms or “(i.e., the results relied on
small sample … sizes, few events, or had
wide CIs suggestive of both benefits and
harms) when talking about imprecision … lack of
adjustment for confounding, were any of the
comparison studies sufficiently large in their sample … size or sufficiently reasonable in their design that they
offer any useful information to clinicians