-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
December 23, 2014 - Category Criteria for Inclusion
Study Enrollment Studies that enroll adults with suspected CDI
Study Design … This selection strategy,
with its focus on strong study design, means we do not expect a significant … Therefore,
study questions, design, and methodological approaches do not necessarily represent the … 20 18 not 19
21 3 and 20
22 17 or 21
Search String for Diagnostics (not filtered for study design … Study design:
prospective,
retrospective or
mixed?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
November 02, 2018 - PICOTS (Populations, Interventions, Comparators, Outcomes, Timing, Settings/Study Design)
9 … quality, the quality of the evidence is low since statistical adjustment is not
possible with very small sample … sizes because models become unstable when the number of
cases is not much larger than the number of … is the degree of certainty around an outcome effect estimate based on the sufficiency of
the total sample … size and/or number of events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-prognostic-tests_research.pdf
August 22, 2012 - Leonard for their graphic
design expertise.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/deliberative-methods_presentation-2011.pdf
January 01, 2011 - Using Deliberative Methods to Engage Patients, Consumers, and the Public
Community Forum Community Forum
Agency for Healthcare Research and Quality
Community Forum
December 6, 2011
Using Deliberative Methods to
Engage Patients, Consumers, and
the Public
Community Forum Community Forum Community …
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bimp-protocol.pdf
September 27, 2022 - included
trial, we will abstract general study characteristics (e.g., author, year of publication, design … is appropriate will be based on the number of
studies, our judgment regarding population, research design … the width of confidence intervals relative to a clinically important effect
estimate, sufficiency of sample … size, and number of events. … Therefore, study questions, design, and methodological
approaches do not necessarily represent the views
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-226-labor-dystocia-comments.pdf
May 14, 2020 - And for
most of the outcomes compared, it is likely that RCTs are the optimal
research design. … 2020
15
Section
Commentator
& Affiliation
Comment Response
Methods Peer Reviewer #1 Why was sample … size, e.g. power analyses for various outcomes, not
discussed? … Sample size is implicitly
included in the rating of
strength of evidence—
measures of association for … Reviewer #1 The discussion/conclusion is much too broad without an inadequate
consideration of the many design
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_disposition-comments.pdf
March 25, 2013 - Peer Reviewer
1
Results I assume that the size of the effect symbol reflects the
sample size for … remaining
Figures, a footnote has been added to indicate that the size of
the effect symbol reflects the sample … size (Renee to add
footnotes). … We included this design issue in our assessment of
Directness for this reason. … Public
Comment
(NHLBI)
Methods Studies with any sample size were accepted,
suggesting that some
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
September 23, 2016 - § If no systematic reviews available for particular interventions, RCTs
will be included
§ Sample … size of >50 for Key Question 2
• Settings:
o U.S. … , year, setting, country, sample size,
eligibility criteria, population and clinical characteristics … They will have a serious or “fatal” flaw in
design, analysis, or reporting; large amounts of missing … If the studies in a given
intervention category, when grouped by similar PICO and study design, is
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
April 01, 2014 - the number of available studies, the number
of studies contributing information for each outcome,
sample … size, and the statistical significance of reported
comparisons. … This uncertainty is explained by
the relatively small sample size of included studies and
the relative … Its results could
be used to inform the design of future primary trials. … Such studies should have large sample
sizes (to account for the low incidence of most outcome
events
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
January 01, 2014 - We did not have any restrictions based on
language or sample size for the studies with a comparison … Studies of a biodegradable mesh containing
fibroblasts (Dermagraft®) were limited in their sample
size … The difference
was not significant between the four groups because of
the small sample sizes. … The studies were all limited by sample size
issues, selection bias, data heterogeneities, and lack of … size calculations.
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/biorepositories-registries-guide-3rd-ed-addendum-white-paper.pdf
February 01, 2018 - Thus, repository developers need to design processes
for acquisition, processing, and storage that conserve … Project management is based on the underlying biorepository design. … Rationale
and design of the National Registry of
Genetically Triggered Thoracic Aortic
Aneurysms and … The Congenital Heart Disease Genetic
Network Study: rationale, design, and early
results.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/case-management_executive.pdf
January 01, 2013 - Synthesis
Data were abstracted and used to assess applicability
and quality of the study: study design … The sample sizes of the studies of CM were variable,
but many of the studies included fairly small samples … Due to heterogeneity in the characteristics of CM
interventions and the limitation of small sample sizes … cases (particularly the Medicare
Coordinated Care Demonstration [MCCD] trial)13 the
studies had large sample … sizes and overall good quality.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
March 07, 2021 - Reviews, we list the inclusion criteria separately for several
categories: publication type, study design … Study Design Criteria
1. … Elements to be abstracted include:
general study characteristics (e.g., study design, country, setting … certainty surrounding an effect estimate with respect to a
given outcome, based on the sufficiency of sample … size, number of events, and width of
confidence intervals relative to a clinically important effect
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
May 02, 2011 - Time
Any length of followup.9.10
Study Design
o KQ 1: Cross-sectional, RCT, and … The basic elements and design of the forms will be the same as multiple forms we have
used for other … comparative effectiveness reviews and will include elements that address
population characteristics and sample … size, study design, analytic details and outcomes. … Studies of different study designs will be graded within
the context of their study design.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper.pdf
September 01, 2015 - Study design and setting. … true effect can be viewed as the effect size that we would observe if a study had an
infinitely large sample … size (and thus no sampling error).8 Realistically, however, a true treatment
effect can rarely be determined … Sample size calculations indicated that 130 documents
would provide 80 percent power for a 4 x 2 chi-square … size Std diff in means and 95% CI
Std diff Lower Upper
in means limit limit Exercise Control
Pruitt
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
January 01, 2014 - Study-level data will include
PICOTs, inclusion/exclusion criteria, study design, comorbidities, other … Studies will be weighted by sample size. … option, outcomes will be described
narratively, stratified by test comparisons of interest and study design … Therefore
study questions, design, and methodological approaches do not necessarily represent the
views
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
January 30, 2012 - 2007, three large trials comparing novel anticoagulants to VKA have been completed, with
a combined sample … size of ~50,000 subjects:
• Re-LY, with approximately 18,000 subjects and the new direct factor … • Original data
• All sample sizes
• RCTs, prospective and retrospective observational
studies, … We will design the data abstraction forms for this project to collect the data required to
evaluate … They had serious errors in design, analysis, or reporting; large amounts of
missing information; or
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_disposition-comments.pdf
April 22, 2013 - excluded very small studies (n<20)
because these studies are often pilots, where
blinding and other design … inappropriately
exclude studies designed to address both but because
of the need for conservative sample … size estimates
deem their "primary" outcomes as psychiatric
We excluded studies with interventions … better phrased as “There were only a few
studies of antiseizure agents and available studies
had small sample … sizes.”
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/telehealth_disposition-comments.pdf
June 30, 2016 - 6
Commentator
& Affiliation Section Comment Response
Public-
Annonymous
Findings How does sample … size as a
factor of the prevalence and
incidence of certain conditions
play a role in the strength … size
to have the power that a
diabetes intervention might have. … The sample size does not affect
our calculation. … A
collaboration between Continua,
mHealth Summit, and HIMSS,
PCHA publishes the
Continua Design Guidelines
-
effectivehealthcare.ahrq.gov/sites/default/files/s123.pdf
October 01, 2007 - ORIGINAL ARTICLE
Heterogeneity and the Interpretation of Treatment Effect
Estimates From Risk Adjustment and Instrumental
Variable Methods
John M. Brooks, PhD,* and Elizabeth A. Chrischilles, PhD†
Objectives: To contrast the interpretations of treatment effect esti-
mates using risk adjustment and instrumental vari…