-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper-2015.pdf
January 01, 2015 - Results of stratified analyses based on sample size, risk of bias, and magnitude of
effect estimates … To determine the influence of risk of bias, sample sizes of first and pooled subsequent
trial, and the … Sample sizes of the first trials varied
greatly (from 20 to 46,500 participants; median 112) and often … Results of stratified analyses based on sample size, risk of bias, and magnitude of
effect estimates … Influence of trial sample size on
treatment effect estimates: meta-
epidemiological study.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
September 01, 2011 - sizes
or give some other indicator of precision. … We agree, and we have added a sample size
column to these summary tables. … George 2005; Excluded from KQ2 for wrong
study design (observational study). … sizes
or give some other indicator of precision. … We agree, and we have added a sample size
column to these summary tables.
-
effectivehealthcare.ahrq.gov/sites/default/files/s96.pdf
October 01, 2007 - Findings
from NEISS-CADES can help design and prioritize patient safety
interventions for outpatient … attributes
(acceptability, flexibility, representativeness, simplicity, and
stability) based on the system’s design … between reporting steps
Sensitivity Proportion of true cases detected Limitations
Simplicity System design … The NEISS sample (design and implementation)
1997 to present. … Epidemiology: Study Design and Data Analysis. 2nd ed.
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effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-child-adolesc-mental-health-grand-rounds.pptx
May 22, 2025 - Brief Assessment Tools
Characteristic Range Across Studies
Risk of Bias 1 low, 9 moderate, 8 high
Sample … Size 50-2,512 (8-489 with OCD)
Mean Age Range 9-16
Male 32%-71%
White 88%-98%
Source
outpatient … Was a case-control design avoided? Did the study avoid inappropriate exclusions? … intervention/exposure and comparison (n=176) or outcomes (n=83) were not of interest, if the study design … Our review identified important gaps in the literature to inform future research design.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cesarean-birth-2010_disposition-comments.pdf
January 01, 2010 - The major impact is on the
design and assessment of future research . … The
issue of adequate sample size in individual studies was not
well described, e.g. notation of whether … or not each study's
sample size was base on an appropriate power analysis. … The
focus on over sample size vs a criterion of power analysis
base on primary outcome should be rethought … The 2 issues of mixed parity and sample size determination
via power analysis were appropriately addressed
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
December 01, 2015 - size cutoff (48)
No human subjects (4)
No primary data (922)
No reference standard or reference
standard … Nine of the studies
had a paired design and 44 had a parallel-group design. … Four of the
studies had a paired design and four had a parallel-group
design. … Many had sample sizes that were too
small to reliably detect small or moderate differences
between … • In contrast to the RCTs, NRCSs of alternative testing
strategies attained large sample sizes but
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-disposition-comments.pdf
July 31, 2024 - Shelton
Nutrition
Counselor,
Emergence
Functional
Nutrition
Alvin, TX
General I agree that sample … size was not large enough,
nor was duration of study long enough to
determine harms. … captured this article and it
was evaluated for eligibility, however
it was excluded due to study design
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
February 01, 2013 - Reviewers may decide to restrict study inclusion based on sample size (e.g.,> 1,000 patients) or
publication … match studies in gray
literature documents based on characteristics such as unique study identifies, sample … size
(by group), and study duration, to those found in published literature to remove any
duplicates … Because the study is
registered at the beginning of the study, the intended primary outcome measures, sample … size, and
other trial characteristics are known prior to reading reports of results.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-reconstruction-mastectomy-protocol.pdf
April 09, 2020 - the remaining 19 percent of patients receive AR.4 IBR can be further divided based on the
physical design … versus no chemotherapy
Timing
• Any
Setting
• Any, including single- and multicenter
Design … Timing
• Any
Page 13 of 24
Setting
• Any, including single- and multicenter
Design … there are no eligible
citations identified in a consecutive sample of 370 consecutive citations (this sample … size chosen because
the upper 97.5% confidence interval bound for a proportion of 0/370 is less than
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
May 20, 2013 - Study Design Criteria
Single test performance. … For questions about test performance, studies of any design—randomized,
cross-sectional, case-control … Any study design, including
modeling, will be acceptable for inclusion for questions about harms. … Empirical evidence of design-related bias in studies of diagnostic
tests. … Was an a priori design or protocol provided?
2. Was a comprehensive search strategy performed?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
February 04, 2014 - may vary by KQ, but, the tables will contain common
elements such as author, year of publication, sample … size, study type,
intervention(s), and comparator(s). … certainty
surrounding an effect estimate with
respect to a given outcome, based on the
sufficiency of sample … size and number of
events. … Therefore study questions, design and/or methodological
approaches do not necessarily represent the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/aggression_executive.pdf
October 01, 2016 - Their inputs addressed
points such as sample size thresholds for eligible studies
and whether and how … sizes, attrition, settings,
geographic locations, and study funders. … size).64
Time to OAS
improvement
20
Insufficient Low risk of bias,
consistency
unknown—single … size).64
11
Intervention
and
Comparison
Primary
Outcome of
Interest
Outcome
N of
Patients … sizes
for comparative trials of these types of interventions
(perhaps apart from medication protocols
-
effectivehealthcare.ahrq.gov/sites/default/files/mcda_webinar_transcript2.pdf
August 27, 2012 - sizes for MCDA? … We don’t
need any sample sizes here. … In general, sample size has to
do with the precision of the estimate score, the weights,
and I am not … That determines the sample size. … JOHNSON: Can I very quickly followup on a question that was
asked earlier on sample size, how many
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
January 01, 2009 - Experimental and quasi-experimental design for generalized causal inference. … size to assess minimally important differences from a patient perspective
Use intention-to-treat analysis … duration and clinically relevant treatment modalities
Assess for adverse events
Have an adequate sample … size to assess minimally important differences from a patient perspective
Use intention-to-treat analysis … Experimental and quasi-experimental design for generalized causal inference.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendix-c-prepub-final.xlsx
January 01, 2025 - History of Cancer Other Relevant Population Characteristics Control Population Description Total Study Sample … Size Enrolled at Baseline Cancer Confirmation With Tissue/Specimen Diagnosis Followup Length (In Diagnostic … Salat, 2022 No No Yes High concerns Case-control design using a convenience sample. … Were all restrictions in eligibility criteria based on study characteristics appropriate (e.g., date, sample … size, study quality, outcomes measured)?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-final-app-c.xlsx
January 01, 2025 - History of Cancer Other Relevant Population Characteristics Control Population Description Total Study Sample … Size Enrolled at Baseline Cancer Confirmation With Tissue/Specimen Diagnosis Followup Length (In Diagnostic … Salat, 2022 No No Yes High concerns Case-control design using a convenience sample. … Were all restrictions in eligibility criteria based on study characteristics appropriate (e.g., date, sample … size, study quality, outcomes measured)?
-
effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
February 24, 2016 - opinions and the best studies available at the
time, which were observational and retrospective in design … EORTC is
an exception due to its randomized control trial
design with the most valid analysis being … Precision
is based more on sample size and number of
studies. … Heterogeneity in study design and reported
outcomes prevent meta-analysis. … Specifically,
each study had different study design and follow-
up times.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
April 01, 2013 - , in particular including those related to
administration or monitoring of treatment; whether the
sample … size was sufficient to assess minimally important
differences from a patient perspective; and the use … elevated sPAP
by echocardiography;24 however, this finding is limited by
the lack of replication, small sample … size (wide confidence
limits) and confounding with RV strain on ECG. … Finally,
the studies that compared combination therapy with
monotherapy were all of similar design,
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cerebral-palsy-feeding_executive.pdf
March 01, 2013 - Effects on eating
efficiency and swallowing were not consistent, and the
small sample sizes suggest … sizes. … sizes. … sizes. … sizes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
May 01, 2013 - Sample size ranged from
99 recruited at a single site to 4,084 enrolled from
101 practices. … was a cross-sectional
study, one was a pre-post intervention study, one was
a quasi-experimental design … Defining sample size for the study based on
detecting clinically relevant differences in
test performance … here is between the
increased generalizability of having subjects take a
single test versus overall sample … size.
5.