-
effectivehealthcare.ahrq.gov/sites/default/files/dementia-agitation-aggression_executive.pdf
March 01, 2016 - This
was mainly because of heterogeneous comparisons and
small sample sizes. … Calculation of sample
sizes necessary for appropriately powered RCTs should
incorporate the high attrition … Sample
size calculations should also take into consideration
that individuals with dementia may change … Withdrawals and dropouts created considerable
loss of participants from already small sample sizes in … sizes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-post-transplant-complications-rapid-research.pdf
May 01, 2025 - : study design, study population eligibility criteria, sample size, follow-up
duration, setting
• … Funding
Risk of Bias
Study Design
Sample Size
(Treatment/Control)
Study Inclusion
Criteria … Sample Size
(Treatment/Contr
ol)
Treatment
Comparison
Outcomes
Assessed
Results in the … We rated this
study as being of fair quality due to its retrospective design and small sample size. … , had a small sample size.
-
effectivehealthcare.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
February 01, 2008 - Observational studies will be limited to those with a larger sample size given that
most contemporary … Observational studies will be assessed for sample size, participant selection method,
exposure measurement … This can be
assessed through the evaluation of both design and study limitations. … Source: www.effectivehealthcare.ahrq.gov
Published Online: August 06, 2010
had an adequate sample … size, and used intention to treat analysis.12 Studies meeting
less than 5 criteria would be classified
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
February 01, 2008 - Observational studies will be limited to those with a larger sample size given that
most contemporary … Observational studies will be assessed for sample size, participant selection method,
exposure measurement … This can be
assessed through the evaluation of both design and study limitations. … Source: www.effectivehealthcare.ahrq.gov
Published Online: August 06, 2010
had an adequate sample … size, and used intention to treat analysis.12 Studies meeting
less than 5 criteria would be classified
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment-future_research.pdf
February 01, 2013 - of large enough sample size with stratification of randomization
by sex to allow for meaningful sex-based … of large enough sample size with stratification of
randomization by sex to allow for meaningful sex-based … Considerations include:
• Sample size required for a particular outcome and to include a representative … size to achieve adequate power … size
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
May 01, 2005 - Study Design. … uncertainty surrounding an effect estimate with respect to a
given outcome, based on the sufficiency of sample … size and number of events.24 Both GRADE33
and AHRQ guidance on evaluating the strength of evidence24 … However, instead of equating risk of bias solely with study design, the bias
represented by study design … Does design
matter?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-feature-treatment-future_research.pdf
September 23, 2010 - Likely multicenter
studies will be
necessary to attain
adequately powered
sample sizes. … The sample size was limited by the Paperwork
Reduction Act and Information Collections Policy (44 USC … Instead, we sought to minimize the burden by using a small
sample size and informal discussions via … Sample size est. was 220;
300 envelopes were
generated but only 210
enrolled: groups were
unbalanced … Linkage with other ongoing efforts (e.g., PROMIS)
Design Issues 6.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
February 17, 2016 - The basic elements and design of the extraction form will be the similar to those
used for other AHRQ … exposures, and
comparators analyzed; outcome definitions; effect modifiers; enrolled and analyzed
sample … sizes; study design features; funding source; results; and risk of bias questions.
… These included descriptions of the study design,
sample size, interventions, followup duration, outcomes … Therefore
study questions, design, and methodological approaches do not necessarily represent the
views
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
May 01, 2005 - Study Design. … uncertainty surrounding an effect estimate with respect to a
given outcome, based on the sufficiency of sample … size and number of events.24 Both GRADE33
and AHRQ guidance on evaluating the strength of evidence24 … However, instead of equating risk of bias solely with study design, the bias
represented by study design … Does design
matter?
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-232-breathlessness-cancer-comments.pdf
November 19, 2020 - size etc). … Given the 3 studies with substantial
sample size, and our prespecified criteria, we have kept
the conclusion … The number of studies were already very
limited, the sample sizes were small, not all reported
these … outcomes, and the study design varied a lot. … often used a blinded placebo design.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
April 01, 2010 - Reporting p-
values is probably not helpful as they are more a reflection of sample size than
covariate … and the
predicted value of treatment.
10
The bias is toward the OLS estimate and decreases with sample … size but increases with the number of instruments included in the first-stage model.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
March 13, 2012 - The FDA
addresses the safety and effectiveness of diagnostic tests and the quality of the design
and … (prospective vs. retrospective; cohort vs. convenience sample;
derivation, validation, or both), sample … size, and study goal (analytic validity,
clinical validity, and/or clinical utility)
• Comparator … Sample size (number of patients/specimens)
o If samples are from previous studies, which studies? … • What was the study design?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
September 01, 2013 - size, study design, analytic details,
and outcomes. … We considered evidence to be sparse if it was from only
one study with a small sample size. … The 106 studies had intermediate to large sample sizes:
median number of enrolled individuals = 277, … The sample sizes ranged from 21 to
more than 2,000 participants, and all 14 studies were
relatively … The remaining 12
studies had smaller sample sizes, ranging from 21 to 159
patients, and also had short
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
December 31, 2017 - KQs 1–3: Randomized controlled trials (RCTs) of any sample size,
systematic reviews (for references … nonrandomized controlled trials,
prospective cohort studies with an eligible comparison group and a
sample … size of at least 500,a case-control studies with a sample size
of at least 500a
All other designs … and studies
using included designs that do
not meet the sample size
criterion
Language Studies … For KQ 4, we have
chosen a sample size cutoff of 500 for prospective cohort studies and case-control
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear_disposition-comments.pdf
October 05, 2010 - that the lack of statistically significant difference
between the groups is attributable to the small sample … size; this
study was aborted early since it appeared that augmentation
would not improve the rates … We hope that authors will
find the recommendations for future research helpful in guiding
the design … Discussion [The section on future research provides sound advice on
general principles of study design … In particular,
and appendix would be helpful within which the design of
one or more ideal studies are
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/stakeholder-report_0824.pdf
August 01, 2024 - The intervention
studies, some of which were characterized by small sample sizes, focused on educational … benefits of exploring data harmonization to enable the analysis of data from multiple
studies with small sample … sizes; and
• The need for more qualitative data integrated into research studies, including oral … More broadly, a focus on universal design—in which products, services, and environments are
designed … Curb cuts are one well-known example of universal design.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-mri-utilization_research.pdf
August 01, 2012 - We present results for
the comedo subtype where there is adequate sample size. … Leonard for their graphic design
expertise.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/advanced-care-decision-aids_research-protocol.pdf
December 09, 2013 - We
will include studies published in English of any sample size and any design
(randomized controlled … Studies that examined decision aids in different populations (possibly by study design)
Decision Clinical … Exclusion Sample Comparator Harms (ethical/
Aid/Use population/ criteria- criteria size/Study emotional
design
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
December 20, 2011 - In addition, we will include nonrandomized
controlled trials of any sample size, prospective cohort … studies with an eligible comparison group with a sample
size of at least 500, and case-control studies … with a
sample size of at least 500. … We will not include
observational studies with a sample size of less than 500
or for other KQs due … For KQ 6, we have chosen a sample size cutoff
Source: www.effectivehealthcare.ahrq.gov
Published
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
September 19, 2014 - size, duration of
followup, attrition, intervention characteristics (including
specific opioid and … risk prediction
instruments, we attempted to create two-by-two tables from
information provided (sample … size, prevalence, sensitivity,
and specificity) and compared calculated measures of
diagnostic accuracy … risks
(RR) and associated 95 percent confidence intervals (CI)
based on the information provided (sample … sizes and
6
incidence of outcomes of interest in each intervention
group).