-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
September 06, 2016 - • Any sample size
• RCTs, cohort or comparative
effectiveness, case reports
• Cross-sectional studies … linear
regression of log transformed diagnostic odds ratio (logDOR) on inverse root of effective
sample … size in addition to asymmetry test of funnel plots. … Based on this assessment and the initial study design, we will assign a strength of
evidence rating … Therefore
study questions, design, and methodological approaches do not necessarily represent the
views
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/anal-cancer-protocol.pdf
September 26, 2023 - Population, Intervention, Comparator, Outcome, Timing, Setting/Study
Design (PICOTS)
Inclusion … case series,
commentaries, cross-sectional studies,
reviews, qualitative studies, studies
with sample … size less than 30 patients
(or less than 15 per treatment
group/arm), non-randomized studies
with … sponsorship,
setting, subject inclusion and exclusion criteria, intervention and control
characteristics, sample … size, followup duration, participant baseline age,
race/ethnicity, clinical characteristics including
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
May 07, 2010 - be included if all of the following criteria apply:
• The study is a direct comparison (any study design … renal
function, angioedema, cough, hyperkalemia
• Tolerability
• Persistence
• Adherence
6) Sample … size:
- We will not exclude articles based on sample size during the full text screening but may … To assess quality, we
will employ the strategy to: (1) classify the study design, (2) apply predefined … Therefore study
questions, design and/or methodological approaches do not necessarily represent the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/lumbar-fusion-protocol.pdf
June 20, 2024 - , year, setting, country, funding, sample size, eligibility criteria, attrition, patient
characteristics … Significant flaws that imply biases of various kinds that may invalidate results; “fatal flaws” in
design … This
may be based on sample size sufficiency and number of events. … When
quantitative synthesis is not possible, sample size and assessment of variance
within individual … Therefore, study questions, design, and methodological approaches do not
necessarily represent the views
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
June 01, 2011 - studies of LV mass/
Low (ACEI vs. function, these were dominated by poor-quality studies with
ARB); small sample … sizes, and only one study included evaluation of
Insufficient a direct renin inhibitor. … Future research should utilize large
databases with sufficient sample sizes to obtain
more precise estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/genitourinary-symptoms-protocol_0.pdf
July 10, 2023 - subject inclusion and exclusion criteria, intervention and control
10
characteristics, sample … size, follow-up duration, participant baseline age, race, and
results of primary outcomes and adverse … PICOTS)
Allowed inclusion of
systematic reviews
(SRs) of any eligible
primary study design
for … Therefore,
study questions, design, and methodological approaches do not necessarily represent the … Draft Population, Intervention, Comparator, Outcome, Timing, Setting/Study Design (PICOTS)
B.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
January 01, 2011 - The cohort design is also easy to conceptualize and
readily compared to the RCT, a design with which … Case-Control Study Design
Description
Nested within an underlying cohort, the case-
control design … This may not be a major issue if the design is
used in addition to the full case-control design. … To do
so, the design uses controls as in a case-control
design but estimates a case-crossover odds … include the reduction
in sample size leading to reduced precision of
treatment effect estimates and
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2025-update-disposition-comments.pdf
January 01, 2025 - Treatments are
categorized as active
control or active
treatment based on
the study design. … Peer Reviewer
#3
Methods One might wonder what would be the point of including
something with a sample … size of 8-might consider
having a minimum. … Sample size was not
limited as novel
treatments may be
evaluated in smaller
studies and
information … TEP Reviewer
#2
General This report is iterative, by design and not meant
pejoratively.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/presentations-future_research.pdf
April 01, 2012 - presented as a recommendation, the panel included a rationale and did not include specifics in
terms of sample … size or other details.
10
Recommendations
General Recommendations
The FRN, whether methodological … There may be design tradeoffs or specific
issues to consider. … Most direct
way to address less
common
comorbidities; allows
for adjustment for
confounding; sample … size and resources
needed for longer
follow-up are
potential limitations
Yes: Most efficient
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting_research-protocol.pdf
August 19, 2011 - eligible:
o RCTs
o Nonrandomized comparative cohort (observational) studies
• No minimum sample … size requirement (to be re-evaluated when the literature is being
screened; if there are sufficient … size will be imposed
after consulting with the TEP)
Settings
• Application of IVDx techniques … effectiveness reviews and will include fields that address population characteristics, sample size, … study design, analytic details, and outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/noninvasive-nonpharm-pain-summary.pdf
April 01, 2020 - Key Questions and PICOTS
(populations, interventions, comparators,
outcomes, timing, setting, study design … size), the results are
interpreted as showing no clear difference between
treatments. … and research recommendations
Research Component Evidence Gap Future Research Recommendation
Study design … size designed to
evaluate differential effectiveness and safety
of treatments in subpopulations of … Documentation of coexisting conditions
and factors in trials with sufficient sample-
size to evaluate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_executive.pdf
September 01, 2011 - Sample
sizes ranged from 9 to 1,366, but greater than 70
percent of studies included at least 200 participants … size, and
selective outcome reporting, were unclear.22,23
Neonatal Health Outcomes (Key Question 1) … However, given the small number of
events and limited sample size (n=42), the RCT was
underpowered and … size (false negative). … feasible for a number of
reasons, such as a prohibitive sample size requirements
and ethical considerations
-
effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
January 01, 2018 - d Downgraded for ROB and imprecision because of small sample size, typically < 200 patients in total. … b Downgraded for ROB.
c Downgraded for ROB and imprecision because of small sample size, typically < … b Downgraded for ROB and imprecision because of small sample size (typically < 200 patients).
21 … Few
studies having small sample sizes reported on major AEs
which were often rare outcomes. … c Downgraded for ROB.
d Downgraded for ROB and imprecision due to small sample sizes.
e Downgraded for
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-protocol.pdf
August 15, 2023 - maximum prediction score is <0.40, we will screen at least 400 additional
consecutive citations (this sample … size is chosen because the upper 97.5% confidence
interval bound for a proportion of 0/400 is less … The only eligible study design is randomized controlled trials. … following for each life stage (as feasible),
each analyzed fiber type, and each outcome: study types and sample … sizes, overall
methodological limitations, consistency, precision, directness, SoE rating, and conclusions
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
June 12, 2013 - size ≥25 patients randomized per arm
a Women with breast cancer are excluded. … RCTs = randomized controlled trials
For nonhormone nonprescription/CAM therapies, any study design … size None
RCTs = randomized controlled trials
Table 6. … perspective here is that a
qualitative appraisal of observational studies that scrutinizes both the design … Therefore study questions, design, and/or methodological
approaches do not necessarily represent the
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/menopause_research-protocol.pdf
March 25, 2012 - size ≥25 patients randomized per arm
a Women with breast cancer are excluded. … size >250
a Longitudinal studies of colorectal, breast, or ovarian cancers; and fracture outcomes ( … RCTs = randomized controlled trials
For nonhormone nonprescription/CAM therapies, any study design … perspective here is that a
qualitative appraisal of observational studies that scrutinizes both the design … Therefore study questions, design, and/or methodological
approaches do not necessarily represent the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-treatment_disposition-comments.pdf
May 08, 2013 - size but we included them if they met the predefined
inclusion criteria. … sizes, we felt it necessary to review and
report on lower quality and smaller studies. … As mentioned by the reviewer, for most interventions, the number of studies and
sample sizes were not … I don't
agree that it is realistic to apply an
arbitrary sample size of 50 subjects
for singlecentre … sizes, more rigorous adherence to
methodological standards for
clinical trials, longer follow-up
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-231-dementia-interventions-evidence-summary_0.pdf
August 01, 2020 - The vast majority of studies had small sample size,
were pilots that had not undergone traditional efficacy … Dementia care research has been slow to incorporate key elements of rigorous
intervention design.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-active-infection-rapid-response.pdf
May 01, 2024 - Sample sizes for surveillance of
S. aureus transmission to monitor effectiveness and provide feedback … size; OR = odds ratio; PSP = patient safety
practice; RR = risk ratio; US = United States … size; OR = odds ratio; PSP = patient safety practice; US = United States
38 … = confidence interval; CRE = Carbapenem-resistant enterobacterales; ICU = intensive care unit; n = sample … size; OR = odds ratio; PSP = patient safety practice
Pub.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
April 01, 2013 - Study design evaluations for PCA3 research need 1, research questions 1.1–1.3 .......... 15
Table 4. … Study design evaluations for PCA3 research need 2, research question 2.1:
What information does PCA3 … Study design evaluations for PCA3 research need 1, research question 2.2:
Does the addition of PCA3 … Research Question Development and Study Design
Considerations
Research questions for each research … Study design evaluations for PCA3 Research Need 1, Research Questions 1.1–1.3
Study Design
Considerations