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effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-jaw-rapid-response.pdf
May 01, 2025 - : study design, study population eligibility criteria, sample size, follow-up
duration, setting … Sample Size
Medication
Confounder
Adjustment
Exposure Group
MRONJ Occurrence
Prevalence … (%)
(Cases/Sample Size)
Incidence
Summary of Findings
Alblazi38
2024
Malaysia
Medium … Sample Size
Medication
Confounder
Adjustment
Exposure Group
MRONJ Occurrence
Prevalence … sizes.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-future_research.pdf
October 26, 2012 - Design is susceptible to selection bias, but may
be an optimal design if required sample size is
large … Multiple sites may be
needed to reach adequate sample sizes. … Multiple sites may be needed to reach
adequate sample sizes. … Design is susceptible to selection bias, but
may be an optimal design if required
sample size is large … Multiple sites may be needed to
reach adequate sample sizes, but crossover design
may help reduce numbers
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
November 01, 2009 - Four reviewers identified studies of any
design describing clinical outcomes or
adverse events with 10 … Primary outcomes were explicitly stated in
only three trials, which also reported a priori sample
size … All trials enrolled a relatively
small sample size, ranging from 15 to 393 patients, and
studied different … The available slots for particle beam radiotherapy are
very limited, and this may have impacted the design … Most eligible studies were
noncomparative in nature and had small sample sizes.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
September 02, 2016 - This spreadsheet will capture basic intervention, outcome,
study design, sample size, and whether results … ,
intervention type and duration, population, outcomes, and sample size. … We will
make such comparisons only with respect to 1) general design items used to inform risk … We quantify such impact as a potential increase
in total study population sample size (>20%), a change … With input from the TEP, study-design and sample-size filters will be
implemented, as needed, to contain
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
August 10, 2010 - Sample size
There are no restrictions for study sample size. … , sample size, clinical indications; and study duration or
length of follow-up). … history of
treatment(s), age of first diagnosis, etc), study outcomes (both of benefit and of harm),
sample … size, settings, funding sources, treatments (type, dose, duration, and provider),
methodological limitations … size, and 3) high versus low overall quality.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-draft-appendices.pdf
January 01, 2025 - size (less than 30 per arm)
Ala-Opas, 19875 Excluded for ineligible sample size (less than 30 per arm … )
Barcelo, 19936 Excluded for ineligible sample size (less than 30 per arm)
Borghi, 19937 Excluded … ineligible sample size (less than 30 per arm)
Premgamone, 200125 Excluded for ineligible sample size … (less than 30 per arm)
Robertson, 198526 Excluded for ineligible sample size (less than 30 per arm) … Sarica, 200627 Excluded for ineligible sample size (less than 30 per arm)
Scholz, 198228 Excluded
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effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-march-2023-grand-rounds-slides.pdf
January 01, 2023 - of a
patient care recommendation will conform to the generally
accepted standards of experimental design … Considerations con’t
Study Sample Sizes
• Sample size requirements vary by study purpose (establishing … equivalence)
• Sample size requirements vary by outcome measure, and baseline risk for the
outcome … sizes and inability to combine the studies
• Publication bias
• Suspected, but could not be formally … sizes
- Lack of power to detect differences or confirm equivalence
Data limitations
• Use of retrospective
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism_disposition-comments.pdf
November 01, 2010 - With the assistance of
our technical experts, we selected a minimum sample size of 10 in
order to maximize … With the assistance of
our technical experts, we selected a minimum sample size of 10 in
order to maximize … but based upon sample size. … The cut-offs for
sample sizes were not specifically justified; this
might be helpful, given that other … We have added rationale about our decisions regarding sample size
to the Methods section of the review
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effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence.ppt
January 01, 2010 - Precision
Includes sample size, number of studies, and heterogeneity of effect sizes
Reporting bias
Extent … (II)
Precision is the degree of certainty surrounding a result and is determined by sample size, number … Few studies have sufficient sample sizes or duration to adequately assess uncommon or long-term harms … size
Defined threshold for risk of bias
Study design restrictions (cohort and case-control)
Specific … These criteria may include minimum duration of followup, minimum sample size, a defined threshold for
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/selecting-evidence.ppt
January 01, 2010 - Precision
Includes sample size, number of studies, and heterogeneity of effect sizes
Reporting bias
Extent … (II)
Precision is the degree of certainty surrounding a result and is determined by sample size, number … Few studies have sufficient sample sizes or duration to adequately assess uncommon or long-term harms … size
Defined threshold for risk of bias
Study design restrictions (cohort and case-control)
Specific … These criteria may include minimum duration of followup, minimum sample size, a defined threshold for
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-6-protocol.pdf
December 07, 2024 - .10,11,13-15 The
PICOTS (Populations, Interventions, Comparators, Outcomes, Timing, Settings, Study Design … on study duration or length of follow up
• Settings:
o No limitation on study setting
• Study Design … , year, setting, country, sample size, eligibility criteria, source(s) of funding, study
characteristics … Characteristics of
included studies, such as number of publications by year, study sample size, proportion … Study Design
7. Subscale/Symptom Cluster Data
8. Subgroup Analysis
9.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
August 01, 2012 - In addition, the study was not published in a pivotal journal, and the sample size
was not larger than … size
Inclusion
Criteria/Exclusio
n Criteria
Study
Design/Intervention
or Independent
Variable … size
Inclusion
Criteria/Exclusio
n Criteria
Study
Design/Intervention
or Independent
Variable … size
Inclusion
Criteria/Exclusio
n Criteria
Study
Design/Intervention
or Independent
Variable … size
Inclusion
Criteria/Exclusio
n Criteria
Study
Design/Intervention
or Independent
Variable
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prosthesis_research-protocol.pdf
March 16, 2017 - • Any study design
• No minimum sample size (except not case reports)
• No minimum followup time … • Any study design, including qualitative studies
• No minimum sample size (other than no case reports … • Any study design, including qualitative studies
• No minimum sample size (other than no case reports … sizes; study design features; funding source; results; and risk of bias questions. … These included descriptions of the study design,
sample size, interventions, followup duration, outcomes
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting-future_research.pdf
January 01, 2014 - • There is a moderate strength of evidence (on the basis of one large-sample-size
nonrandomized study … , potential sample size, the time required, recruitment, and ethical issues. … The feasibility of such studies, generally, does not depend on the desired sample size. … Resource Use, Size, and Duration
An RCT, especially one with a long duration and large sample size, … Resource Use, Size, and Duration
An RCT, especially one with a long duration and large sample size,
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
September 01, 2012 - Advantages for
producing a
valid result
Benefits of large sample sizes and
allowing for prespecified … Advantages for
producing a
valid result
Benefits of large sample sizes and allowing for
prespecified … The feasibility of such studies generally does not depend on the desired
sample size. … Advantages for
producing a
valid result
Benefits of large sample sizes and allowing for
prespecified … Advantages for
producing a valid
result
Benefits of large sample sizes and allowing for prespecified
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-protein-intake-protocol-amendment.pdf
November 29, 2023 - Additionally, during screening, we will tag studies in PICO portal (using certain
identifiers, such as small sample … size) to help us sort the literature and track study
characteristics that may require revisiting based … (including sample size, age, gender/sex, race/ethnicity,
socioeconomic status, physical activity level … evidence tables, and then assess the clinical and methodological heterogeneity (including
study design … Therefore,
study questions, design, and methodological approaches do not necessarily represent the
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_appendixes.pdf
October 06, 2006 - /ti,ab OR research design/de OR clinical trial! … size at randomization
CABG sample size at randomization
Group 1 outcome
1
Specify: … size at randomization
CABG sample size at randomization
Group 2 outcome
1
Specify: … size at randomization
CABG sample size at randomization
Group 3 outcome
1
Specify: … size at randomization
CABG sample size at randomization
Group 4 outcome
1
Specify:
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
February 01, 2013 - RCTs with sufficient sample sizes can detect meaningful differences in outcomes because
randomization … and
condition characteristics (age, gender, comorbidities, etc.) and the larger sample sizes that are … Resource use, size, and
duration
RCTs are difficult to recruit to,
require large sample sizes and … Sample sizes will need to be large, and
lost-to-follow-up issues will likely be
significant. … Sample size will need to be large given the
number of treatment options available.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/pelvic-pain_research-protocol.pdf
February 16, 2011 - • Loss to followup: varies by study; to maximize acceptable sample size, we will assume
0 percent … • Statistic: use the two-tailed z-test and the t-test for sample size. … • Sample size: for an RCT with 2 groups, with 100 percent meeting the diagnostic criteria
for CPP … • Null hypothesis of effect size of 30 percent: need 176 subjects per group; a total
sample size … Therefore, a conservative lower limit for sample size can be set at 50, to account for potential
meta-analyses
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effectivehealthcare.ahrq.gov/sites/default/files/study-eligibility-criteria.ppt
January 01, 2000 - (United States only)
Setting (hospital-based studies only)
Study population size (N > 200)
Study design … expect to have the intervention implemented; the size of the study population; and potentially the study design … Exercise 3: Impact of Study-Size Criteria on Excluded Studies
The research team required a minimum sample … size N ≥ 50 in each study at study start. … size of 50 for the review on overactive bladder.