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1061. Evidence Report on the (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_research-protocol.pdf
      October 18, 2010 - support status, working status), singleton vs. multiple gestations, gestational age at preterm labor, definition … control for important confounders5 x Criteria for assessment of neonatal or maternal harms: definition … Definition of Terms Not applicable VII.

1062. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
      September 13, 2012 - We will use the standard definition of a chronic venous leg ulcer, which is the presence of an active … Definition of Terms FDA = U.S. … We will use the standard definition of chronic venous leg ulcer: o Presence of an active ulcer for

1063. Radiotherapy Treatments for Head and Neck Cancer Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_disposition.pdf
      December 09, 2014 - We are not aware of a consensus definition of “conventional” RT so will avoid mention. … sense, the problem arises when generalizing study findings to other populations. 2. - p.14, L.7: Definition … of SBRT: “…generally compromise…by definition…” this statement is self- contradictory 1. … The line “Regimens generally comprise a total dose by definition in five or fewer fractions” does … An interested reader would be better off with the average Wikipedia definition of the same terms.

1064. Breast-Biopsy-Update Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
      September 01, 2014 - Two issues related to the definition of diagnostic test categories merit additional description. … This operational definition was adopted by several of the primary studies we reviewed and the original … To assess the impact of this operational definition on our findings we performed a sensitivity analysis

1065. Disposition of Comments for CER 157 Appendicitis (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
      December 14, 2015 - Disposition of Comments for CER 157 Appendicitis Comparative Effectiveness Review Disposition of Comments Report Research Review Title: Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis Draft review available for public comment from November 4, 2014 to December 2, 2014. Re…

1066. Dementia-Agitation-Aggression Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
      November 13, 2014 - Confusion in the definition of agitation and aggression extends to the instruments used to evaluate … For behavioral health trials, the presence of treatment fidelity, that is, treatment definition and … Definition of Terms Not applicable. VII.

1067. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-disposition.pdf
      June 22, 2017 - Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update” because: (1) the definition … Jiranek, MD, FACS) General Comments The systematic review’s definition of “sufficient” evidence … This systematic review has endorsed industry’s intentional exclusion of aspirin by their “a priori” definition … it is unclear from the methodology how an adverse bleeding event was identified and, in fact, the definition … for example, for total VTE (page 18, lines 53-54), the event rate could be 1.1 – 43.8% -- different definition

1068. Diagnosis and Treatment of Clinical Alzheimer's-type Dementia (CATD) (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
      November 02, 2018 - Definition of Terms AAFP American Academy of Family Physicians Aß beta amyloid ACP American College … composite outcome of SAEs We changed the wording to help the reader know this was a very specific definition … (1253) 1 X-1 Appendix 4 Risk of Bias Assessment Decision Aid Selection Bias DEFINITION … High Overall Attrition >30% High Unknown Overall Attrition High 5 X-5 Performance Bias DEFINITION … Detection Bias DEFINITION Systematic differences in outcomes assessment among groups being compared

1069. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
      March 01, 2011 - taking anticoagulants or as VTE prophylaxis in patients without an increased bleeding risk. 4 Definition … Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical … Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical … Definition of Terms DVT = deep vein thrombosis, LMWH = low-molecular-weight heparin PE = pulmonary

1070. S66 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s66.pdf
      October 01, 2007 - studies of NSAIDs use applied similar 90 days periods to define drug discontinuation,30 no standard definition … Patients could contribute more than 1 episode of use of the same regimen, as long as they met our definition … the study period 2,915,378 TennCare enrollees were potentially eligible and 26,837 (0.9%) met our definition … Toward a definition and method of assessment of treatment failure and treatment effectiveness: the case

1071. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
      October 01, 2010 - However, RR is not a reversible measure in terms that if the definition of an outcome event and nonevent … Therefore, while the definition of the outcome event needs to be consistent among the included studies … when using any measure, the investigators should be particularly attentive to the definition of an … factors: (1) factors that apply equally to all patients in a study, e.g., study design, quality and definition

1072. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
      October 01, 2010 - However, RR is not a reversible measure in terms that if the definition of an outcome event and nonevent … Therefore, while the definition of the outcome event needs to be consistent among the included studies … when using any measure, the investigators should be particularly attentive to the definition of an … factors: (1) factors that apply equally to all patients in a study, e.g., study design, quality and definition

1073. Prostate-Cancer-Test Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
      October 14, 2011 - followup  Measurements: equal, reliable, and valid (includes masking of outcome assessment)  Clear definition … following criteria for nonrandomized comparative intervention studies13,17:  Were the sample definition … Strength of evidence grades and definitions20 Grade Definition High High confidence that evidence … Definition of Terms Area under the curve (AUC) — area under the receiver operating characteristic

1074. Technical Brief 16 Disposition of Comments Report (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/advanced-care-decision-aids_disposition-comments.pdf
      July 29, 2014 - We chose to use a common, broad definition and kept the discussion of ACP itself brief to support the

1075. Multidisciplinary Rehabilitation Programs for Moderate to Severe Traumatic Brain Injury in Adults: Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/traumatic-brain-injury-rehabilitation-future_research.pdf
      January 01, 2013 - By definition, multidisciplinary rehabilitation programs involve several provider types; therefore a … By definition, multidisciplinary rehabilitation programs involve several provider types; therefore, … Reporting guidance in published comparativeness studies with particular attention to intervention definition … Treatment definition in complex rehabilitation interventions.

1076. Disposition of Comments for CERs 155 156 Contast-Induced Nephropathy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_disposition-comments.pdf
      January 07, 2016 - This is a very broad definition obviously and assumes that whoever was conducting the study(-ies) is … The definition of CIN (0.5 mg/dL or 25% change) is historical and although should be used for this review … It may be worth mentioning this context when the definition of "CIN" is described. … questionable, driven in large part by the nature of the clinical trials and issues related to the definition

1077. Disposition of Comments for CER 196 The Role of Immunotherapy in the Treatment of Asthma (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-196-disposition-comments-immunotherapy-asthma.pdf
      March 23, 2018 - Peer Reviewer #2 Introduction On page 12 line 10---Perhaps further definition/elaboration on … We added the definition of hypersensitivity Peer Reviewer #1 Results The … paragraph; "Recent alterations in grading of systemic versus local reactions, with a more liberal definition … We added the definition of the WAO grading of systemic reactions to the Methods section.

1078. S89 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s89.pdf
      October 01, 2007 - - atively clear criteria for diagnosis, whereas “dizziness” is a symptom with only a vague clinical definition

1079. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
      February 01, 2012 - The stakeholders stated that there is a need for a new definition of the OSA syndrome that identifies … It should be noted that the definitive definition of OSA will remain unclear because whether the functional … Thus, the definition of the OSA syndrome requires information beyond the currently used measurements … A better definition of OSA syndrome will more specifically target therapy at those who are at risk and … It should be noted that the definitive definition of OSA will remain unclear because whether the functional

1080. Disposition of Comments Report for Recurrent Nephrolithiasis in Adults (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
      July 26, 2012 - was directed at patients who had excess urine Ca as a stone risk, even if not formally meeting the definition … Although the issue is complicated, for future carefully designed trials, we tend to favor a strict definition