-
effectivehealthcare.ahrq.gov/products/high-cholestorol-medicines-update/research-protocol
May 17, 2013 - Pravastatin
Rosuvastatin
Simvastatin
Outcomes
Clinical outcomes:
All-cause mortality and vascular death … the study investigator
SAEs as defined by the study investigator (e.g., an event that results in death … Outcomes
Clinical outcomes
All-cause mortality
Vascular death
Fatal MI, nonfatal MI, any or unspecified … independently grade the strength of evidence on key outcomes—including, all-cause mortality, vascular death
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
December 31, 2013 - Rosuvastatin
Simvastatin
• Outcomes
o Clinical outcomes:
All-cause mortality and vascular death … the study investigator
SAEs as defined by the study investigator (e.g., an event that results in death … Outcomes Clinical outcomes
• All-cause mortality
• Vascular death
• Fatal MI, nonfatal MI, any or … independently grade the strength of
evidence on key outcomes—including, all-cause mortality, vascular death
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
October 01, 2011 - Other outcomes of interest
were quality of life and sudden death. … of planned followup found
celecoxib associated with an increased risk of
cardiovascular events (CV death … results with
regard to CV events (nonfatal myocardial infarction,
nonfatal stroke, or cardiovascular death … failure, one large
observational study found celecoxib and diclofenac
associated with a higher risk of death
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-value-of-information_research.pdf
June 01, 2011 - Examples would include
studies that followed all patients to death or that followed all patients until … chosen because
we were able to find published clinical trials that follow patients to an endpoint of death … pancreatic cancer
Background and Setting
Pancreatic cancer is the fourth most common cause of cancer death … Since almost all
of the patients were followed until their death so that there was no difference in … study follows cohorts of patients randomized to the time of treatment from the
time of treatment to death
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-nonsurgical-therapies_research-protocol.pdf
February 22, 2012 - over 1 million deaths per year.1 In the United States, lung cancer is the leading
cause of cancer death … Frameworks and PICOTS above)
○ Response criteria
○ Followup frequency and duration
○ Cause of death
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_executive.pdf
June 01, 2013 - Only one death
was reported—an LAGB patient with complications of a
gastric perforation.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse_research-protocol.pdf
April 28, 2010 - Actual causes of death in the United States, 2000.
JAMA 2004 Mar 10;291(10):1238-45.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-rehospitalization_research.pdf
November 01, 2007 - recent therapeutic advances, it remains the leading cause of hospitalization and a major cause of
death … (17) Patients in the nebivolol arm had a 14%
(P=0.039) lower relative risk of the primary outcome (death … Patients were censored due to death or the end of followup. … Chronic heart failure is also associated with a high risk of death and the need
for hospitalization. … Chronic
kidney disease and the risks of death,
cardiovascular events, and hospitalization.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-228-nonopioid-pharm-chronic-pain-comments.pdf
April 16, 2020 - Even stage 4 cancer patients on their death bed are suffering in
torturous pain because doctors are
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
August 01, 2014 - blood pressure,
lipid, and glucose targets), cardiovascular disease remains
the number one cause of death … In comparison of assays, the rate of
death or acute MI was higher in those with elevated levels
for … on an analysis of
acute MI as primary diagnosis on discharge and of a
composite endpoint including cardiac … death, acute MI,
revascularization, or congestive heart failure. … But what is the precise
cause of death?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_disposition-comments.pdf
December 30, 2015 - Does the strategy of this
review ignore deaths because no patient self-reported his
own death? … We have added text to describe the death
inadvertently omitted from the text.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy_executive.pdf
January 01, 2017 - Another study reported two deaths (out of 36,221
tonsillectomies, 0.006%) but did not report cause of death
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-201-indoor-allergen-reduction-asthma-evidence-summary.pdf
February 01, 2018 - • Exacerbations
• Health care utilization
and cost
• Pulmonary
physiology
• Quality of life
• Death
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
May 19, 2020 - 6
• Discomfort or distress from equipment, e.g., oxygen or masks
• Death … Urinary retention, dry mouth
• Opioid use disorder
• Discomfort or distress from equipment,
• Death
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
April 01, 2015 - Two of the studies found that ICU admissions
and death were higher with combined blood products
versus
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_executive.pdf
June 01, 2013 - Ovarian cancer is the eighth most common
cancer in women and is the fifth leading cause
of cancer death … in a
second study)
Medium Inconsistent Direct Imprecise Insufficient
Mixed results for risk
of death
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19.pdf
December 31, 2022 - Omicron variant (43–56%) but was
more protective against severe disease (88%), hospitalization (47%), or death … by 45 percent (hazard ratio [HR]=0.55; 95% CI: 0.48,
0.63) and reduced the risk of COVID-19 related death … individuals, prior infection had no effect on the
risk of hospitalization but reduced the risk of death … immune protection persisted, as
indicated by the relatively low incidence of serious infection and death … Comparative analysis of the risks of
hospitalisation and death associated with SARS-
CoV-2 omicron (
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
May 31, 2017 - Background and Rationale
In 2014, unintentional injury was the fourth leading cause of death in the … time of field triage cannot be determined conclusively and we
expect that clinical outcomes (e.g., death … These include outcomes, such as death, whether the patient required
treatments and interventions used … pericardiocentesis, cesarean
delivery, intracranial pressure monitoring, interventional radiology, and
in-hospital death
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypofractionated-radiation-therapy-key-question.pdf
December 19, 2023 - incidence rate of 113.4/100,000 men between 2016
and 2020) and the second leading cause of cancer-related death
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
August 01, 2012 - )
44 (45) vs. 92 (65);
p=0.02
Mucositis (RTOG
Grade 3–4)
73 (75%) vs. 111
(77%); p= 0.33
Death … In other words the reduction in the risk of death has
moved from 30% to 10%. … ratios (e.g., if previous OR=0.70
and updated result were OR=0.90, then the new reduction in odds of death … 3–4)
44 (45) vs. 92 (65); p=0.02
Mucositis (RTOG Grade 3–4)
73 (75%) vs. 111 (77%); p= 0.33
Death