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1. Screening for Colorectal Cancer: Consumer Guide (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/Yuj3Md9rNMCvcktoBsWjh3
   June 01, 2016 - and harms of screening for CRC. … CRC screening also has potential harms. … Notes 1 screening Using a test to detect CRC or abnormalities that might lead to CRC. … prior screening history Whether a person has ever had a CRC screening test before. … all Americans by making evidence-based recommendations about clinical preventive services such as screenings

2. Modeling Study: Colorectal Cancer: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/colorectal-cancer-screening
   June 15, 2016 - Screening Analysis (MISCAN) for CRC, and CRC Simulated Population Model for Incidence and Natural History … 24 from a period before the dissemination of CRC screening. … varies at repeat screenings. … In the absence of data to suggest otherwise, conditional independence of repeat screenings was assumed … Outcomes for CRC Screening Strategies With Screening From Ages 50-75 Years...

3. Archived: Modeling Study: Colorectal Cancer: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/colorectal-cancer-screening-june-2016
   June 15, 2016 - Screening Analysis (MISCAN) for CRC, and CRC Simulated Population Model for Incidence and Natural History … 24 from a period before the dissemination of CRC screening. … , 24 a period with little to no CRC screening ( Figure 2B ). … varies at repeat screenings. … In the absence of data to suggest otherwise, conditional independence of repeat screenings was assumed

4. Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the USPSTF (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/vw-LTWCTZ_N5pAaydcNQTx
   June 21, 2016 - Screening Analysis (MISCAN) for CRC, and CRC Simulated Population Model for Incidence and Natural History … from a period before the dis- semination of CRC screening. … a period with little to no CRC screening (Figure 2B). … varies at repeat screenings. … In the absence of data to suggest otherwise, conditional indepen- dence of repeat screenings was assumed

5. Evidence Summary: Colorectal Cancer: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary19/colorectal-cancer-screening
   May 18, 2021 - Objective: To systematically review the effectiveness, test accuracy, and harms of screening for CRC … in the process of updating its CRC screening recommendation. … lagged behind recommended screenings for other cancers. 277 Adherence to a single round of screening … detection), methods to increase screening adherence, prevalence of interval cancers between screenings … with Hemoccult II decreased CRC-specific mortality compared with no screening after 2-9 rounds of screening

6. Evidence Summary: Colorectal Cancer: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/colorectal-cancer-screening
   June 15, 2016 - CRC. … Although CRC screening has a large body of supporting evidence, additional research is still needed. … For KQ1, randomized clinical trials (RCTs) or otherwise controlled trials of CRC screening vs no screening … To date, no CRC screening modality has been shown to reduce all-cause mortality. … CRC screening.

7. Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/ocULFVqnfy4STqcU2DuPzU
   May 18, 2021 - OBJECTIVE To systematically review the effectiveness, test accuracy, and harms of screening for CRC to … in the process of updating its CRC screening recommendation. … with Hemoccult II decreased CRC-specific mortality compared with no screening after 2-9 rounds of screening … lagged behind recom- mended screenings for other cancers.277 Adherence to a single round of screening … early detection), methods to increase screening adher- ence, prevalence of interval cancers between screenings

8. Colorectal Cancer Screening: An Updated Modeling Study for the US Preventive Services Task Force (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/473PPVwoRhapCkN9SC-rue
   May 18, 2021 - cases averted by modality and age to begin screening, mean CRC cases averted if start screening at … age 50 y SimCRC CRC-SPIN MISCAN Mean Additional CRC cases averted if start screening at age 45 y … SimCRC CRC-SPIN MISCAN Mean Screening modality and frequency Stool tests Benefit: CRC cases averted … at age 50 y SimCRC CRC-SPIN MISCAN Mean Additional CRC deaths averted if start screening at age 45 … y SimCRC CRC-SPIN MISCAN Mean Screening modality and frequency Stool tests Benefit: CRC deaths averted

9. Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/Xbtq4oDQwVo7KgmSjnnDbz
   November 01, 2021 - CRC. … Although CRC screening has a large body of supporting evidence, additional research is still needed. … For KQ1, randomized clinical trials (RCTs) or otherwise con- trolled trials of CRC screening vs no screening … To date, no CRC screening modality has been shown to reduce all-cause mortality. … CRC screening.

10. Archived: Evidence Summary: Colorectal Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/colorectal-cancer-screening-june-2016
    June 15, 2016 - CRC. … Although CRC screening has a large body of supporting evidence, additional research is still needed. … For KQ1, randomized clinical trials (RCTs) or otherwise controlled trials of CRC screening vs no screening … To date, no CRC screening modality has been shown to reduce all-cause mortality. … CRC screening.

11. Archived: Final Evidence Summary: Colorectal Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary4/colorectal-cancer-screening-2008
    October 15, 2008 - Mass screening with CT colonography: should the radiation exposure be of concern? … 1996 46 , b ; 3365; fair 4.7 CRC: 90.9 CRC: 83.3 CRC: 71.4 CRC: 95.6 Yes No … tests (e.g., high-sensitivity guaiac FOBT, FIT, or fecal DNA tests) for CRC screening as compared to … tests (e.g., high-sensitivity guaiac FOBT, FIT, or fecal DNA tests) for CRC screening as compared to … Small number of CRC cases (20 total) limits precision of accuracy estimates. 6 screening colonoscopy

12. Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer (pdf file)
    www.uspreventiveservicestaskforce.org/Home/GetFile/11/218/aspr-cvccrc-finalrsfact/pdf
    April 01, 2016 - In addition, regular screening is an important part of preventing CRC. … grades are based on the quality and strength of the evidence about the potential benefits and harms of screening … Task Force recommendations can help you learn about screening tests, counseling services, and preventive … and recommended screenings. … all Americans by making evidence-based recommendations about clinical preventive services such as screenings

13. Screening for Colorectal Cancer: A Targeted, Updated Systematic Review (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/UCajZVxQEKLCgs59HV7ddE
    November 01, 2008 - CRC: 79.4 CRC: 86.7 Yes Yes Polyp �10 mm: 68.6 Polyp �10 mm: 87.5 3.0 CRC: 65.6 CRC: 97.3 Polyp �10 … Polymedco, Cortlandt Manor, NY) 5.3 CRC: 86.5 CRC: 94.9 No No 18.8 CRC: 66.7 CRC: 83.1 No No Advanced … : 30.1 NR CRC: 83.3 CRC and adenoma: 96.0 Adenoma: 50.7 NR CRC: 88.9 CRC and adenoma: 93.9 Adenoma: … 54.8 4.7 CRC: 90.9 CRC: 95.6 Yes No CRC: 83.3 CRC: 71.4 8.2 CRC: 51.6 (34.8–68.0) Minor polyps: 92.4 … Mass screening with CT colonography: should the radiation exposure be of concern?

14. Modeling Study: Colorectal Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-study18/colorectal-cancer-screening
    May 18, 2021 - (SimCRC), CRC Simulated Population Model for Incidence and Natural History (CRC-SPIN), and Microsimulation … by SimCRC and CRC-SPIN. … Natural History of Colorectal Cancer and the Effects of Screening as Simulated by SimCRC, CRC-SPIN, and … Simulation Model of CRC (SimCRC) and Microsimulation Screening Analysis (MISCAN) simulate categorical … Screening Analysis; SimCRC, Simulation Model of CRC. a Analyses assume an increased population incidence

15. Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/DYFdTVu-UY3h7CWGdA7Zkh
    July 20, 2021 - OBJECTIVE To systematically review the effectiveness, test accuracy, and harms of screening for CRC to … associated with a reduction of CRC-specific mortality after 2 to 9 rounds of screening (relative risk … in the process of updating its CRC screening recommendation. … lagged behind recom- mended screenings for other cancers.277 Adherence to a single round of screening … early detection), methods to increase screening adher- ence, prevalence of interval cancers between screenings

16. Use of Decision Models in the Development of Evidence-Based Clinical Preventive Services Recommendations | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/use-decision-models-development-evidence-based-clinical-preventive-services-recommendations
    May 01, 2019 - , screening for CRC and lung cancer) and the estimation of net benefit (for example, the benefit and … strategies (for example, sigmoidoscopy vs. colonoscopy for CRC screening), different starting and stopping … For example, the modeling for the recommendations on CRC screening 1  suggested that screening before … The modeling analyses for lung cancer screening, 17 CRC screening, 16 and aspirin for primary prevention … The modeling analyses for CRC screening 16 assessed the relative benefits and harms of alternative strategies

17. Archived: Evidence Summary: NSAIDs: Aspirin/NSAIDs for Prevention of Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication
    March 15, 2007 - and colorectal adenoma were identified by multilevel screening by 2 independent reviewers. … of routine CRC screening by eligible individuals, using any method, continues to be low in the United … States. 5-8 A CRC chemoprophylactic strategy may be used as a complement to or instead of a screening … A third screening phase was included to discriminate between the different study designs. … Trends in screening for colorectal cancer—United States, 1997 and 1999.

18. Archived: Evidence Summary: NSAIDs: Aspirin/NSAIDs for Prevention of Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
    March 15, 2007 - and colorectal adenoma were identified by multilevel screening by 2 independent reviewers. … of routine CRC screening by eligible individuals, using any method, continues to be low in the United … States. 5-8 A CRC chemoprophylactic strategy may be used as a complement to or instead of a screening … A third screening phase was included to discriminate between the different study designs. … Trends in screening for colorectal cancer—United States, 1997 and 1999.

19. Nonsteroidal Anti-inflammatory Drugs and Cyclooxygenase-2 Inhibitors for Primary Prevention of Colorectal Cancer: A Systematic Review (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/EppFbhnDEX5UtYWrTkLEhT
    March 01, 2007 - and colorectal adenoma were identified by multilevel screening by 2 independent reviewers. … Despite evidence of the effectiveness of several screening methods, adoption of routine CRC screening … A CRC chemoprophylactic strategy may be used as a complement to or instead of a screening strategy. … A third screening phase was included to discriminate between the different study designs. … Trends in screening for colorec- tal cancer—United States, 1997 and 1999.

20. Draft Recommendation: Screening for Colorectal Cancer | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/colorectal-cancer-screening3
    October 27, 2020 - When performed alone, direct visualization tests allow for a much longer time between screenings compared … Colonoscopy allows the longest length between screenings (10 years), while flexible sigmoidoscopy and … CT colonography allow 5 years between screenings if performed alone. … https://www.cdc.gov/cancer/colorectal/pdf/QuickFacts-BRFSS-2016-CRC-Screening-508.pdf . … FIT Every year Evidence from one large cohort study that screening with FIT reduces CRC mortality