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1. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research-protocol
   May 18, 2011 - than not screening for CRC and that the age to begin screening in average-risk adults is 50 years. … Food and Drug Administration (FDA) for screening or diagnosing CRC. … modalities as a noninvasive, home-based technique for CRC screening. … For relative test performance: any established CRC-screening modality. … KQ 5: Any established CRC-screening modality.

2. Evidence-based Practice Center Systematic Review Protocol (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
   May 18, 2011 - better than not screening for CRC and that the age to begin screening in average-risk adults is 50 … Food and Drug Administration (FDA) for screening or diagnosing CRC. … modalities as a noninvasive, home-based technique for CRC screening. … Comparator KQ 1: No screening or another established CRC-screening modality (colonoscopy, FOBT [high-sensitivity … KQ 5: Any established CRC-screening modality.

3. Colorectal-Cancer-Screening Executive (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
   February 01, 2012 - While different U.S. guideline-issuing organizations agree on the majority of recommended CRC screening … to screen for CRC in reducing morbidity (CRC incidence) or mortality (all-cause or CRC-specific)? … To detect CRC? b. To detect precancerous lesion(s)? Key Question 3. Interval of Screening. … Asymptomatic adults at average risk for Colorectal Cancer (CRC) Fecal DNA Screening Precancerous Lesion … accuracy) in patients at average risk for CRC.

4. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults. (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_disposition-comments.pdf
   February 01, 2012 - Currently, there are no fecal DNA tests approved by the FDA for screening or diagnosing of CRC. … Currently, there are no fecal DNA tests approved by the FDA for screening or diagnosing of CRC. … Currently, there are no fecal DNA tests approved by the FDA for screening or diagnosing of CRC. … We believe this approach should set the standard for any future CRC screening tests. … screening tests for CRC precursor and CRC We have changed all instances of referring to Exact Sciences

5. Disparities-Quality-Improvement Executive (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/disparities-quality-improvement_executive.pdf
   August 01, 2012 - Lasser et al., 20112 RCT Cancer: CRC screening • Patient education • Promotion of self- management … Lasser et al., 201121 RCT Cancer: CRC screening • Patient education Promotion of self- management … • No disparity in CRC screening rate was observed at baseline. • The intervention was associated with … Lasser et al., 201121 RCT Cancer: CRC screening • Patient education • Promotion of self- management … • Patients with adequate health literacy were equally likely to pursue CRC screening when treated

6. Evidence Summary: Management of Colonic Diverticulitis (pdf file)
   effectivehealthcare.ahrq.gov/system/files/cer-233-diverticulitis-evidence-summary.pdf
   October 01, 2020 - with recent diverticulitis, those who undergo colonoscopy may, ultimately, have similar rates of CRC … diagnoses as those who did not; however, no studies evaluated comparative risks of CRC death. … screening in people with a history of diverticulitis. … ; however, no studies evaluated comparative risks of CRC death. … Among these patients, about 2 percent have CRC, 7 percent have advanced colonic neoplasia (CRC or advanced

7. Evidence Summary: Management of Colonic Diverticulitis (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-233-diverticulitis-evidence-summary.pdf
   October 01, 2020 - with recent diverticulitis, those who undergo colonoscopy may, ultimately, have similar rates of CRC … diagnoses as those who did not; however, no studies evaluated comparative risks of CRC death. … screening in people with a history of diverticulitis. … ; however, no studies evaluated comparative risks of CRC death. … Among these patients, about 2 percent have CRC, 7 percent have advanced colonic neoplasia (CRC or advanced

8. Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research
   February 29, 2012 - Feb. 29, 2012 Systematic Review May. 17, 2012 Disposition of Comments Report Fecal DNA Testing in Screening … fecal DNA testing, we found only three studies that examined the test accuracy of fecal DNA testing in screening … accuracy studies (n=5004) evaluating a multi-marker fecal DNA found differing sensitivities to detect CRC … insufficient evidence for the harms, analytic validity, and acceptability of testing in comparison to other screening

9. Evidence-based Practice Center Systematic Review Protocol (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-liver-metastases-therapies_research-protocol.pdf
   September 27, 2012 - Using the study-selection criteria for screening titles and abstracts, each citation will be marked … The first-level title-only screening will be performed by two senior team members. … senior team members disagree, the senior and junior team members will conduct the second-level abstract screening … Medical comorbidities including, but not limited to, cardiac conditions and hepatic reserve Title Screening … Title/Abstract Screening Full Text review/Data Abstraction (Training set of 5) Evidence and

10. Local Therapies for Unresectable Colorectal Cancer Metastases to the Liver: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research-protocol
    January 31, 2012 - Abbreviations: CRC = colorectal cancer; KQ = key question Figure 2. … Using the study-selection criteria for screening titles and abstracts, each citation will be marked as … The first-level title-only screening will be performed by two senior team members. … senior team members disagree, the senior and junior team members will conduct the second-level abstract screening … training set of 25 to 50 will be examined initially by duplicate members to assure uniform application of screening

11. Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research
    December 11, 2012 - of various local hepatic therapies for metastases to the liver from unresectable colorectal cancer (CRC … Results We identified 937 articles through the literature search and excluded 913 at various stages of screening … insufficient to permit conclusions on the comparative effectiveness of these therapies for unresectable CRC

12. EPC Systematic Review Protocol: Achieving Health Equity in Preventive Services: Systematic Evidence Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-equity-protocol.pdf
    January 01, 2020 - Aspirin use to prevent cardiovascular disease (CVD) and colorectal cancer (CRC): preventive … 10% 10-year CVD risk Use of low-dose aspirin for prevention purposes CVD events (MI, CVD); CRC … mortality; and quality of life, harms of interventions Abbreviations: CHD=coronary heart disease; CRC … ): preventive medication CVD: 2007 CRC: 2009 B April 2016 Breast cancer screening 2002 B: Ages … B-11 27 Mass Screening/ 28 early diagnosis/ 29 (screen* or test* or diagnosis).ti

13. Colorectal-Cancer-Liver-Metastases-Therapies Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
    December 01, 2012 - the effectiveness and harms of several local hepatic therapies for unresectable colorectal cancer (CRC … In the sections that follow, we describe CRC and its diagnosis and treatment to orient the reader to … This is followed by a discussion of the treatment of CRC liver metastasis. … In cases where there was disagreement, a second-level abstract screening was completed by two independent … Of the 937 records identified through the literature search, we excluded 913 at various stages of screening

14. Disposition of Comments: Management of Colonic Diverticulitis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/diverticulitis-comments.pdf
    October 12, 2020 - o The reviewer also suggested evaluating colorectal cancer (CRC) rates found on colonoscopy by country … : The key points (5th bullet point) highlights a finding that older people are at higher risk for CRC … the reason for the age 50 cutpoint (used by 5 studies) is to match general population guidance for CRC … screening. … or advanced colonic neoplasia (CRC or advanced adenomas).”

15. Appendices A-E (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/healthcare-system-appendixes-draft-technical-brief.pdf
    February 01, 2023 - Evaluating Two Evidence-Based Intervention Strategies to Promote CRC Screening Among Latino Adults … 10 months Patient + Health Head-to-head Process of care CRC screening completion within six … Head-to-head Care utilization; process of care Scheduling a clinic appointment, and completion of CRC … Computer-tailored intervention assessed a participant’s perceived risk, benefits and barriers to CRC … Evaluating Two Evidence-Based Intervention Strategies to Promote CRC Screening Among Latino Adults in

16. CER 222: Evidence Summary: Achieving Health Equity in Preventive Services (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-222-evidence-summary-health-equity.pdf
    January 01, 2020 - United States is well known including disparities in preventive health services,3 such as routine screenings … cancer screening 0 10 2 3 26b Cervical cancer screening 0 7 3 1 13c Lung cancer screening 0 … Tobacco smoking cessation 0 3 1 2 0 Cardio- vascular disease Aspirin to prevent CVD and CRC … and management 0 0 1d 2 7 Abbreviations: CRC = colorectal cancer; CVD = cardiovascular disease; KQ … cancer screening, six of smoking cessation, seven of obesity screening and management, and single

17. CER 222: Evidence Summary: Achieving Health Equity in Preventive Services (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-222-evidence-summary-health-equity.pdf
    January 01, 2020 - United States is well known including disparities in preventive health services,3 such as routine screenings … cancer screening 0 10 2 3 26b Cervical cancer screening 0 7 3 1 13c Lung cancer screening 0 … Tobacco smoking cessation 0 3 1 2 0 Cardio- vascular disease Aspirin to prevent CVD and CRC … and management 0 0 1d 2 7 Abbreviations: CRC = colorectal cancer; CVD = cardiovascular disease; KQ … cancer screening, six of smoking cessation, seven of obesity screening and management, and single

18. Appendices (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-clinician-level-strategies-appendixes-draft-tech-brief.pdf
    February 01, 2023 - patient navigation NR Patient Peer navigator Standard/usual care Process of care CRC … , up-to- date CRC screening NR Mixed Yes No No Government Turner, 201876 (29299814) RCT … Intervention to Improve Awareness, Knowledge, and Utilization of Breast, Cervical, and Colorectal Cancer Screenings … client reminders, social media, in-clinic or mailed distribution of FIT/FOBT Colorectal Cancer (CRC … American, Multicultural Multicomponent interventions can effectively increase fecal testing for CRC

19. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectiousdisease_hi_impact.pdf
    December 01, 2013 - (CRC) is crucial. … Patients treated surgically for localized CRC have a long-term survival of 91%, compared with patients … common symptoms are confirmed with either barium enema radiography or colonoscopy. 64 Localized CRC … Patients attending HIV clinics for routine treatment and monitoring can be screened for CRC with anal … Pap smears to reduce the incidence of advanced CRC. 12 AHRQ Healthcare Horizon Scanning

20. Fleisher (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/fleisher.pdf
    January 01, 2010 - low-­‐income pregnant women • Web-­‐based interventions (e.g., Healing Choices, Colorectal Cancer Screening … Slide  23: Colorectal Cancer Screening  Decision Aid http://www.temple.edu.chpsw/departments/publichealth … credible voices from communities • Connect Web 2.0  to  online resources (e.g., Healing  Choices, CRC