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1. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research-protocol
   December 01, 2019 - than not screening for CRC and that the age to begin screening in average-risk adults is 50 years. … Food and Drug Administration (FDA) for screening or diagnosing CRC. … modalities as a noninvasive, home-based technique for CRC screening. … Comparator KQ 1: No screening or another established CRC-screening modality (colonoscopy, FOBT [high-sensitivity … KQ 5: Any established CRC-screening modality.

2. Evidence-based Practice Center Systematic Review Protocol (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
   May 18, 2011 - better than not screening for CRC and that the age to begin screening in average-risk adults is 50 … Food and Drug Administration (FDA) for screening or diagnosing CRC. … modalities as a noninvasive, home-based technique for CRC screening. … Comparator KQ 1: No screening or another established CRC-screening modality (colonoscopy, FOBT [high-sensitivity … KQ 5: Any established CRC-screening modality.

3. Colorectal-Cancer-Screening Executive (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
   February 01, 2012 - While different U.S. guideline-issuing organizations agree on the majority of recommended CRC screening … to screen for CRC in reducing morbidity (CRC incidence) or mortality (all-cause or CRC-specific)? … To detect CRC? b. To detect precancerous lesion(s)? Key Question 3. Interval of Screening. … Asymptomatic adults at average risk for Colorectal Cancer (CRC) Fecal DNA Screening Precancerous Lesion … accuracy) in patients at average risk for CRC.

4. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults. (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_disposition-comments.pdf
   February 01, 2012 - Currently, there are no fecal DNA tests approved by the FDA for screening or diagnosing of CRC. … Currently, there are no fecal DNA tests approved by the FDA for screening or diagnosing of CRC. … Currently, there are no fecal DNA tests approved by the FDA for screening or diagnosing of CRC. … We believe this approach should set the standard for any future CRC screening tests. … screening tests for CRC precursor and CRC We have changed all instances of referring to Exact Sciences

5. Disparities-Quality-Improvement Executive (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/disparities-quality-improvement_executive.pdf
   August 01, 2012 - Lasser et al., 20112 RCT Cancer: CRC screening • Patient education • Promotion of self- management … Lasser et al., 201121 RCT Cancer: CRC screening • Patient education Promotion of self- management … • No disparity in CRC screening rate was observed at baseline. • The intervention was associated with … Lasser et al., 201121 RCT Cancer: CRC screening • Patient education • Promotion of self- management … • Patients with adequate health literacy were equally likely to pursue CRC screening when treated

6. Evidence Summary: Management of Colonic Diverticulitis (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-233-diverticulitis-evidence-summary.pdf
   October 01, 2020 - with recent diverticulitis, those who undergo colonoscopy may, ultimately, have similar rates of CRC … diagnoses as those who did not; however, no studies evaluated comparative risks of CRC death. … screening in people with a history of diverticulitis. … ; however, no studies evaluated comparative risks of CRC death. … Among these patients, about 2 percent have CRC, 7 percent have advanced colonic neoplasia (CRC or advanced

7. Evidence-based Practice Center Systematic Review Protocol (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-liver-metastases-therapies_research-protocol.pdf
   September 27, 2012 - Using the study-selection criteria for screening titles and abstracts, each citation will be marked … The first-level title-only screening will be performed by two senior team members. … senior team members disagree, the senior and junior team members will conduct the second-level abstract screening … Medical comorbidities including, but not limited to, cardiac conditions and hepatic reserve Title Screening … Title/Abstract Screening Full Text review/Data Abstraction (Training set of 5) Evidence and

8. Health Outcomes of Biologic Agents for Metastatic Colorectal Cancer | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-hepatic-therapy/abstract
   December 01, 2019 - and bevacizumab by studying the balance of benefits and harms of adding biologic therapy to standard CRC … chemotherapy regimens treatments for CRC. … stakeholders with a comprehensive understanding of the ramifications of integrating biologic therapy into the CRC … Adenocarcinoma Research Protocol Jul 22, 2024 Blood-based Tests for Multiple Cancer Screening

9. Local Therapies for Unresectable Colorectal Cancer Metastases to the Liver: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research-protocol
   December 01, 2019 - Using the study-selection criteria for screening titles and abstracts, each citation will be marked as … The first-level title-only screening will be performed by two senior team members. … senior team members disagree, the senior and junior team members will conduct the second-level abstract screening … training set of 25 to 50 will be examined initially by duplicate members to assure uniform application of screening … Adenocarcinoma Research Protocol Jul 22, 2024 Blood-based Tests for Multiple Cancer Screening

10. Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research
    December 01, 2019 - of various local hepatic therapies for metastases to the liver from unresectable colorectal cancer (CRC … Results We identified 937 articles through the literature search and excluded 913 at various stages of screening … insufficient to permit conclusions on the comparative effectiveness of these therapies for unresectable CRC … Adenocarcinoma Research Protocol Jul 22, 2024 Blood-based Tests for Multiple Cancer Screening

11. Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research
    December 01, 2019 - Home Evidence Reports Fecal DNA Testing in Screening … SHARE: Fecal DNA Testing in Screening … accuracy studies (n=5004) evaluating a multi-marker fecal DNA found differing sensitivities to detect CRC … Project Timeline Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer … https://effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research  

12. EPC Systematic Review Protocol: Achieving Health Equity in Preventive Services: Systematic Evidence Review (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/health-equity-protocol.pdf
    January 01, 2020 - Aspirin use to prevent cardiovascular disease (CVD) and colorectal cancer (CRC): preventive … 10% 10-year CVD risk Use of low-dose aspirin for prevention purposes CVD events (MI, CVD); CRC … mortality; and quality of life, harms of interventions Abbreviations: CHD=coronary heart disease; CRC … ): preventive medication CVD: 2007 CRC: 2009 B April 2016 Breast cancer screening 2002 B: Ages … B-11 27 Mass Screening/ 28 early diagnosis/ 29 (screen* or test* or diagnosis).ti

13. Achieving Health Equity in Preventive Services: Systematic Evidence Review | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/health-equity-preventive/protocol
    August 31, 2018 - exp Mass Screening/ screen*.ti,ab,kw. … exp Mass Screening/ or exp early diagnosis/ screen*.ti,ab,kw. … exp Mass Screening/ screen*.ti,ab,kw. … Mass Screening/ early diagnosis/ (screen* or test* or diagnosis).ti,ab,kw. 25 or 2 or/27-30 … or/25-27 mass screening/ or mass chest x-ray/ exp early diagnosis/ (screen* or test* or diagnosis

14. Colorectal-Cancer-Liver-Metastases-Therapies Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
    December 01, 2012 - the effectiveness and harms of several local hepatic therapies for unresectable colorectal cancer (CRC … In the sections that follow, we describe CRC and its diagnosis and treatment to orient the reader to … This is followed by a discussion of the treatment of CRC liver metastasis. … In cases where there was disagreement, a second-level abstract screening was completed by two independent … Of the 937 records identified through the literature search, we excluded 913 at various stages of screening

15. Disposition of Comments: Management of Colonic Diverticulitis (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/diverticulitis-comments.pdf
    October 12, 2020 - o The reviewer also suggested evaluating colorectal cancer (CRC) rates found on colonoscopy by country … : The key points (5th bullet point) highlights a finding that older people are at higher risk for CRC … the reason for the age 50 cutpoint (used by 5 studies) is to match general population guidance for CRC … screening. … or advanced colonic neoplasia (CRC or advanced adenomas).”

16. CER 222: Evidence Summary: Achieving Health Equity in Preventive Services (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-222-evidence-summary-health-equity.pdf
    January 01, 2020 - United States is well known including disparities in preventive health services,3 such as routine screenings … cancer screening 0 10 2 3 26b Cervical cancer screening 0 7 3 1 13c Lung cancer screening 0 … Tobacco smoking cessation 0 3 1 2 0 Cardio- vascular disease Aspirin to prevent CVD and CRC … and management 0 0 1d 2 7 Abbreviations: CRC = colorectal cancer; CVD = cardiovascular disease; KQ … cancer screening, six of smoking cessation, seven of obesity screening and management, and single

17. Cell-Free-Dna-Appendix-C (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendix-c.xlsx
    September 01, 2024 - Cervical Cancer Diagnosis from MCST CRC Unknown Diagnosis Method CRC Diagnosis from Clinical Presentation … CRC Diagnosis from Usual Care Screening CRC Diagnosis from MCST Esophageal Cancer Unknown Diagnosis … 40 to 75 years including patients (N=473) diagnosed with any stage of one of the 6 types of cancers (CRC … Cancer signal of origin reporting possible for six cancer types (CRC, esophageal, liver, lung, ovarian … prior to MCST CRC: 4,492/4,888 (91.9) Breast: 2,854/3,547 (80.5) N (%) Smoking status Current: 268

18. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/infectiousdisease_hi_impact.pdf
    December 01, 2013 - (CRC) is crucial. … Patients treated surgically for localized CRC have a long-term survival of 91%, compared with patients … common symptoms are confirmed with either barium enema radiography or colonoscopy. 64 Localized CRC … Patients attending HIV clinics for routine treatment and monitoring can be screened for CRC with anal … Pap smears to reduce the incidence of advanced CRC. 12 AHRQ Healthcare Horizon Scanning

19. Fleisher (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/fleisher.pdf
    January 01, 2010 - low-­‐income pregnant women • Web-­‐based interventions (e.g., Healing Choices, Colorectal Cancer Screening … Slide  23: Colorectal Cancer Screening  Decision Aid http://www.temple.edu.chpsw/departments/publichealth … credible voices from communities • Connect Web 2.0  to  online resources (e.g., Healing  Choices, CRC

20. Technical Brief 13: Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
    December 01, 2012 - ® Systematic Review Tool (Evidence Partners Inc., Manotick, ON, Canada) was used to facilitate the screening … Precision Therapeutics 634 Probe-set signature Formalin-fixed paraffin embedded tissue OncoDefender-CRC … ; the peer-reviewed publication24 for the fifth commercially available assay 12 (OncoDefender-CRC … ]; a secondary objective is to predict response to therapy for various stages of CRC.) … For derivation study only No ColonPRS®+ Yes No No No GeneFx® Colon Yes No No No OncoDefender-CRC